LOCUS       NM_001007722             548 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus hemoglobin alpha, adult chain 2 (Hba-a2), mRNA.
ACCESSION   NM_001007722 XM_347149
VERSION     NM_001007722.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 548)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   2  (bases 1 to 548)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   3  (bases 1 to 548)
  AUTHORS   Fornander,L., Ghafouri,B., Kihlstrom,E., Akerlind,B., Schon,T.,
            Tagesson,C. and Lindahl,M.
  TITLE     Innate immunity proteins and a new truncated form of SPLUNC1 in
            nasopharyngeal aspirates from infants with respiratory syncytial
            virus infection
  JOURNAL   Proteomics Clin Appl 5 (9-10), 513-522 (2011)
   PUBMED   21805676
REFERENCE   4  (bases 1 to 548)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 548)
  AUTHORS   Sarvari,M., Kallo,I., Hrabovszky,E., Solymosi,N., Toth,K., Liko,I.,
            Molnar,B., Tihanyi,K. and Liposits,Z.
  TITLE     Estradiol replacement alters expression of genes related to
            neurotransmission and immune surveillance in the frontal cortex of
            middle-aged, ovariectomized rats
  JOURNAL   Endocrinology 151 (8), 3847-3862 (2010)
   PUBMED   20534718
REFERENCE   6  (bases 1 to 548)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   7  (bases 1 to 548)
  AUTHORS   Paszty,C., Mohandas,N., Stevens,M.E., Loring,J.F., Liebhaber,S.A.,
            Brion,C.M. and Rubin,E.M.
  TITLE     Lethal alpha-thalassaemia created by gene targeting in mice and its
            genetic rescue
  JOURNAL   Nat Genet 11 (1), 33-39 (1995)
   PUBMED   7550311
REFERENCE   8  (bases 1 to 548)
  AUTHORS   Sanna,M.T., Giardina,B., Scatena,R., Pellegrini,M., Olianas,A.,
            Manca,L., Masala,B., Castagnola,M. and Corda,M.
  TITLE     Functional alterations in adult and fetal hemoglobin Sassari
            Asp-alpha 126(H9)-->His. The role of alpha 1 alpha 2 contact
  JOURNAL   J Biol Chem 269 (28), 18338-18342 (1994)
   PUBMED   7518430
REFERENCE   9  (bases 1 to 548)
  AUTHORS   Liebhaber,S.A., Cash,F.E. and Main,D.M.
  TITLE     Compensatory increase in alpha 1-globin gene expression in
            individuals heterozygous for the alpha-thalassemia-2 deletion
  JOURNAL   J Clin Invest 76 (3), 1057-1064 (1985)
   PUBMED   4044827
REFERENCE   10 (bases 1 to 548)
  AUTHORS   Pirastu,M., Saglio,G., Chang,J.C., Cao,A. and Kan,Y.W.
  TITLE     Initiation codon mutation as a cause of alpha thalassemia
  JOURNAL   J Biol Chem 259 (20), 12315-12317 (1984)
   PUBMED   6490612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 20, 2019 this sequence version replaced NM_001007722.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225789.1, FQ218140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680428, SAMN06680432
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000010.1  15829011-15829138   c
            129-333             JAXUCZ010000010.1  15828691-15828895   c
            334-548             JAXUCZ010000010.1  15828291-15828505   c
FEATURES             Location/Qualifiers
     source          1..548
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..548
                     /gene="Hba-a2"
                     /gene_synonym="Glnc2; Glnc3; Hba-a1; Hba1; Hba2"
                     /note="hemoglobin alpha, adult chain 2"
                     /db_xref="GeneID:360504"
                     /db_xref="RGD:1359364"
     exon            1..128
                     /gene="Hba-a2"
                     /gene_synonym="Glnc2; Glnc3; Hba-a1; Hba1; Hba2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..462
                     /gene="Hba-a2"
                     /gene_synonym="Glnc2; Glnc3; Hba-a1; Hba1; Hba2"
                     /note="2-alpha-1 globin; 2-alpha globin; hemoglobin alpha
                     2 chain; globin c2; globin c3; Hemoglobin subunit
                     alpha-1/2; Alpha-1/2-globin; Hemoglobin alpha-1/2 chain;
                     hemoglobin, alpha 2"
                     /codon_start=1
                     /product="hemoglobin alpha, adult chain 2"
                     /protein_id="NP_001007723.1"
                     /db_xref="GeneID:360504"
                     /db_xref="RGD:1359364"
                     /translation="MVLSAADKTNIKNCWGKIGGHGGEYGEEALQRMFAAFPTTKTYF
                     SHIDVSPGSAQVKAHGKKVADALAKAADHVEDLPGALSTLSDLHAHKLRVDPVNFKFL
                     SHCLLVTLACHHPGDFTPAMHASLDKFLASVSTVLTSKYR"
     exon            129..333
                     /gene="Hba-a2"
                     /gene_synonym="Glnc2; Glnc3; Hba-a1; Hba1; Hba2"
                     /inference="alignment:Splign:2.1.0"
     exon            334..548
                     /gene="Hba-a2"
                     /gene_synonym="Glnc2; Glnc3; Hba-a1; Hba1; Hba2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acattctcat tctgatagac tcaggaagca atcatggtgc tctctgcagc tgacaaaacc
       61 aacatcaaga actgctgggg gaagattggt ggccatggtg gtgaatatgg cgaggaggcc
      121 ctacagagga tgttcgctgc cttccccacc accaagacct acttctctca cattgatgta
      181 agccccggct ctgcccaggt caaggctcac ggcaagaagg ttgctgatgc cctggccaaa
      241 gctgcagacc acgtcgaaga cctgcctggt gccctgtcca ctctgagcga cctgcatgcc
      301 cacaaactgc gtgtggatcc tgtcaacttc aagttcctga gccactgcct gctggtgacc
      361 ttggcttgcc accaccctgg ggatttcaca cctgccatgc acgcctctct ggacaaattc
      421 cttgcctctg tgagcaccgt gctgacctcc aagtaccgtt aagccacctc ctgtcgggct
      481 tgccttctga ccaggccctt cttccgtccc ctgaaccagt ctttgaataa agcagaagta
      541 ggaaagaa
//
