LOCUS       NM_013096                557 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus hemoglobin alpha, adult chain 1 (Hba-a1), mRNA.
ACCESSION   NM_013096
VERSION     NM_013096.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 557)
  AUTHORS   Alauddin,H., Jaapar,N.A., Azma,R.Z., Ithnin,A., Razak,N.F.,
            Loh,C.K., Alias,H., Abdul-Latiff,Z. and Othman,A.
  TITLE     A case series of alpha-thalassemia intermedia due to compound
            heterozygosity for Hb Adana [HBA2: c179G>A (or HBA1); p.Gly60Asp]
            with other alpha-thalassemias in Malay families
  JOURNAL   Hemoglobin 38 (4), 277-281 (2014)
   PUBMED   24829075
REFERENCE   2  (bases 1 to 557)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 557)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 557)
  AUTHORS   Fornander,L., Ghafouri,B., Kihlstrom,E., Akerlind,B., Schon,T.,
            Tagesson,C. and Lindahl,M.
  TITLE     Innate immunity proteins and a new truncated form of SPLUNC1 in
            nasopharyngeal aspirates from infants with respiratory syncytial
            virus infection
  JOURNAL   Proteomics Clin Appl 5 (9-10), 513-522 (2011)
   PUBMED   21805676
REFERENCE   5  (bases 1 to 557)
  AUTHORS   Yang,H., Qiao,H. and Tian,X.
  TITLE     Proteomic analysis of cerebral synaptosomes isolated from rat model
            of alzheimer's disease
  JOURNAL   Indian J Exp Biol 49 (2), 118-124 (2011)
   PUBMED   21428213
REFERENCE   6  (bases 1 to 557)
  AUTHORS   Groff,P., Galacteros,F., Kalmes,G., Blouquit,Y. and Wajcman,H.
  TITLE     Hb Luxembourg [alpha 24(B5) Tyr----His]: a new unstable variant
  JOURNAL   Hemoglobin 13 (5), 429-436 (1989)
   PUBMED   2599879
REFERENCE   7  (bases 1 to 557)
  AUTHORS   Baklouti,F., Baudin-Chich,V., Kister,J., Marden,M., Teyssier,G.,
            Poyart,C., Delaunay,J. and Wajcman,H.
  TITLE     Increased oxygen affinity with normal heterotropic effects in
            hemoglobin Loire [alpha 88(F9)Ala----Ser]
  JOURNAL   Eur J Biochem 177 (2), 307-312 (1988)
   PUBMED   3142772
REFERENCE   8  (bases 1 to 557)
  AUTHORS   Ohba,Y., Yamamoto,K., Hattori,Y., Kawata,R. and Miyaji,T.
  TITLE     Hyperunstable hemoglobin Toyama [alpha 2 136(H19)Leu----Arg beta
            2]: detection and identification by in vitro biosynthesis with
            radioactive amino acids
  JOURNAL   Hemoglobin 11 (6), 539-556 (1987)
   PUBMED   2833478
REFERENCE   9  (bases 1 to 557)
  AUTHORS   Chua,C.G., Carrell,R.W. and Howard,B.H.
  TITLE     The amino acid sequence of the alpha chain of the major haemoglobin
            of the rat (Rattus norvegicus)
  JOURNAL   Biochem J 149 (1), 259-269 (1975)
   PUBMED   1191258
REFERENCE   10 (bases 1 to 557)
  AUTHORS   Garrick,L.M., Sharma,V.S., McDonald,M.J. and Ranney,H.M.
  TITLE     Rat haemoglobin heterogeneity. Two structurally distinct alpha
            chains and functional behaviour of selected components
  JOURNAL   Biochem J 149 (1), 245-258 (1975)
   PUBMED   242324
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 20, 2019 this sequence version replaced NM_013096.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218968.1, FQ226118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680419
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000010.1  15842453-15842580   c
            129-333             JAXUCZ010000010.1  15842133-15842337   c
            334-557             JAXUCZ010000010.1  15841724-15841947   c
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..557
                     /gene="Hba-a1"
                     /gene_synonym="Hba-a2; Hba1; HBAM"
                     /note="hemoglobin alpha, adult chain 1"
                     /db_xref="GeneID:25632"
                     /db_xref="RGD:2782"
     exon            1..128
                     /gene="Hba-a1"
                     /gene_synonym="Hba-a2; Hba1; HBAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..462
                     /gene="Hba-a1"
                     /gene_synonym="Hba-a2; Hba1; HBAM"
                     /note="alpha-1/2-globin; hemoglobin alpha-1/2 chain;
                     hemoglobin, alpha 1; hemoglobin alpha 1 chain; hemoglobin
                     alpha, adult chain 2"
                     /codon_start=1
                     /product="hemoglobin subunit alpha-1/2"
                     /protein_id="NP_037228.1"
                     /db_xref="GeneID:25632"
                     /db_xref="RGD:2782"
                     /translation="MVLSADDKTNIKNCWGKIGGHGGEYGEEALQRMFAAFPTTKTYF
                     SHIDVSPGSAQVKAHGKKVADALAKAADHVEDLPGALSTLSDLHAHKLRVDPVNFKFL
                     SHCLLVTLACHHPGDFTPAMHASLDKFLASVSTVLTSKYR"
     exon            129..333
                     /gene="Hba-a1"
                     /gene_synonym="Hba-a2; Hba1; HBAM"
                     /inference="alignment:Splign:2.1.0"
     exon            334..557
                     /gene="Hba-a1"
                     /gene_synonym="Hba-a2; Hba1; HBAM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acattctcct tcttatagac tcaggaagca atcatggtgc tctctgcaga tgacaaaacc
       61 aacatcaaga actgctgggg gaagattggt ggccatggtg gtgaatatgg cgaggaggcc
      121 ctacagagga tgttcgctgc cttccccacc accaagacct acttctctca cattgatgta
      181 agccccggct ctgcccaggt caaggctcac ggcaagaagg ttgctgatgc cttggccaaa
      241 gctgcagacc acgtcgaaga cctgcctggt gccctgtcca ctctgagcga cctgcatgcc
      301 cacaaactgc gtgtggatcc tgtcaacttc aagttcctga gccactgcct gctggtgacc
      361 ttggcttgcc accaccctgg agatttcaca cccgccatgc acgcctctct ggacaaattc
      421 cttgcctctg tgagcactgt gctgacctcc aagtaccgtt aagccgcctc ctgccgggct
      481 tgccttctga ccaggccctt cttccctccc ttgcacctat acctcttggt ctttgaataa
      541 agcctgagta ggaagca
//
