LOCUS       NM_181627               1096 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus HCLS1 associated protein X-1 (Hax1), mRNA.
ACCESSION   NM_181627
VERSION     NM_181627.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1096)
  AUTHORS   Choi,H.Y., Park,N., Lee,B., Choe,Y.I., Woo,D.K., Park,J.Y. and
            Yoo,J.C.
  TITLE     CPNE1-mediated neuronal differentiation can be inhibited by HAX1
            expression in HiB5 cells
  JOURNAL   Biochem Biophys Res Commun 533 (3), 319-324 (2020)
   PUBMED   32958249
  REMARK    GeneRIF: CPNE1-mediated neuronal differentiation can be inhibited
            by HAX1 expression in HiB5 cells.
REFERENCE   2  (bases 1 to 1096)
  AUTHORS   Lu,X., Xue,P., Fu,L., Zhang,J., Jiang,J., Guo,X., Bao,G., Xu,G.,
            Sun,Y., Chen,J. and Cui,Z.
  TITLE     HAX1 is associated with neuronal apoptosis and astrocyte
            proliferation after spinal cord injury
  JOURNAL   Tissue Cell 54, 1-9 (2018)
   PUBMED   30309497
  REMARK    GeneRIF: our data indicated that HAX1 might play significant roles
            in pathological process of neuronal apoptosis and astrocyte
            proliferation during spinal cord injury
REFERENCE   3  (bases 1 to 1096)
  AUTHORS   Cui,L., He,W.J., Xu,F., Jiang,L., Lv,M.L., Huang,H., Xu,J.P.,
            Wu,Y., Zhong,H.B., Zhang,S.Y., Chen,L.F., Shen,C.L., Yao,G., Li,L.,
            Li,M. and Zeng,S.M.
  TITLE     Alterations in the expression of Hs1-associated protein X-1 in the
            rat retina after optic nerve crush
  JOURNAL   Mol Med Rep 14 (5), 4761-4766 (2016)
   PUBMED   27748880
  REMARK    GeneRIF: these results suggested that Hax1 may participate in
            regulating RGC apoptosis via interacting with caspase3 and HtrA2
            following ONC.
REFERENCE   4  (bases 1 to 1096)
  AUTHORS   Abdelwahid,E., Li,H., Wu,J., Irioda,A.C., de Carvalho,K.A. and
            Luo,X.
  TITLE     Endoplasmic reticulum (ER) stress triggers Hax1-dependent
            mitochondrial apoptotic events in cardiac cells
  JOURNAL   Apoptosis 21 (11), 1227-1239 (2016)
   PUBMED   27654581
  REMARK    GeneRIF: Hax1 is significantly downregulated in cardiac cells upon
            endoplasmic reticulum stress induction.
REFERENCE   5  (bases 1 to 1096)
  AUTHORS   Koontz,J. and Kontrogianni-Konstantopoulos,A.
  TITLE     Competition through dimerization between antiapoptotic and
            proapoptotic HS-1-associated protein X-1 (Hax-1)
  JOURNAL   J Biol Chem 289 (6), 3468-3477 (2014)
   PUBMED   24347163
  REMARK    GeneRIF: Hax-1 is a family of anti- and proapoptotic regulators
            that may modulate cell survival and death through homo- or
            heterodimerization.
REFERENCE   6  (bases 1 to 1096)
  AUTHORS   Ortiz,D.F., Moseley,J., Calderon,G., Swift,A.L., Li,S. and
            Arias,I.M.
  TITLE     Identification of HAX-1 as a protein that binds bile salt export
            protein and regulates its abundance in the apical membrane of
            Madin-Darby canine kidney cells
  JOURNAL   J Biol Chem 279 (31), 32761-32770 (2004)
   PUBMED   15159385
  REMARK    GeneRIF: HAX-1 binds bile salt export protein (BSEP), cortactin,
            MDR1, and MDR2. HAX-1 and cortactin regulate BSEP abundance in the
            apical membrane of cells.
REFERENCE   7  (bases 1 to 1096)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1096)
  AUTHORS   Yin,H., Morioka,H., Towle,C.A., Vidal,M., Watanabe,T. and
            Weissbach,L.
  TITLE     Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding
            protein
  JOURNAL   Cytokine 15 (3), 122-137 (2001)
   PUBMED   11554782
REFERENCE   9  (bases 1 to 1096)
  AUTHORS   Gallagher,A.R., Cedzich,A., Gretz,N., Somlo,S. and Witzgall,R.
  TITLE     The polycystic kidney disease protein PKD2 interacts with Hax-1, a
            protein associated with the actin cytoskeleton
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4017-4022 (2000)
   PUBMED   10760273
REFERENCE   10 (bases 1 to 1096)
  AUTHORS   Suzuki,Y., Demoliere,C., Kitamura,D., Takeshita,H., Deuschle,U. and
            Watanabe,T.
  TITLE     HAX-1, a novel intracellular protein, localized on mitochondria,
            directly associates with HS1, a substrate of Src family tyrosine
            kinases
  JOURNAL   J Immunol 158 (6), 2736-2744 (1997)
   PUBMED   9058808
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY291062.1.
            
            On Jun 17, 2003 this sequence version replaced NM_181627.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY291062.1, FQ213378.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132291,
                                           SAMD00132292 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1096
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="LEW"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1096
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1"
                     /note="HCLS1 associated protein X-1"
                     /db_xref="GeneID:291202"
                     /db_xref="RGD:727960"
     exon            1..119
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..903
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1"
                     /note="HS1-binding protein 1; HS1-associating protein X-1;
                     HSP1BP-1; HS1 binding protein"
                     /codon_start=1
                     /product="HCLS1-associated protein X-1"
                     /protein_id="NP_853658.1"
                     /db_xref="GeneID:291202"
                     /db_xref="RGD:727960"
                     /translation="MSVFDLFRGFFGFPGPRSHRDPFFGGMTRDDDDDEDDEEEEDSG
                     AWGRESYAFDGFHPTEEFGFSFSPRGGMRFHGNFGFDDLVRDFNSIFSEMGAWTLPSH
                     SPELPGPESETPGVRLREGQTLRDSMLKYPDSHQPRIFEGVLESHAKPESSKPAPDWG
                     SQGPFHRLDDTWPVSPHSRAREDKDLDSQVSQEGLGPLLQPQPKSYFKSISVTKITKP
                     DGTVEEHRTVVDSEGRRETTVTHQEAHDSSRSDPDPPRSSALDDPFSILDLLLGRWFR
                     SR"
     exon            120..379
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            380..567
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..619
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..726
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..817
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1083
                     /gene="Hax1"
                     /gene_synonym="HAX-1; Hs1bp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaaactggt ggtctcgtgt tgcccatggg ctgcagagtt tcaaagtttc tagtacccct
       61 acgggaatga gcgtctttga tcttttccga ggctttttcg gcttccctgg acctcggagc
      121 cacagagatc ctttttttgg agggatgact cgagatgatg acgatgatga agacgacgaa
      181 gaggaggaag acagtggtgc gtggggtcga gagagctatg cgtttgatgg ttttcaccct
      241 acagaggaat tcggtttcag cttcagcccc agaggaggga tgcgattcca tggcaacttt
      301 ggctttgatg atctagttcg agattttaat agcatcttca gcgagatggg ggcctggacc
      361 ttgccttccc actctcctga acttccaggt cctgagtcag aaacacctgg tgtgagattg
      421 cgagaggggc agacacttcg tgactcaatg cttaagtacc cagatagtca ccaacccagg
      481 atctttgagg gggtcttgga gagtcatgca aaacctgaat cctccaaacc agctccagat
      541 tgggggtccc agggaccttt tcataggttg gatgatacat ggcctgtgag tccccattct
      601 agagccagag aggacaagga tcttgactcc caggtttccc aggaaggtct gggtccactt
      661 cttcaacccc agcctaaatc ctatttcaaa agcatctctg tgaccaagat cactaagcca
      721 gatgggacag tggaggaaca ccgcactgtg gtggacagtg agggccggag agagaccaca
      781 gtgacccatc aagaagccca tgacagttcc agaagtgatc cagatcctcc aagatcttca
      841 gctttggatg atcccttttc catcctggac ctgcttctag gacgttggtt tcggtcccga
      901 tagctttctt gaacttcaga ggccttcagg tccttccacc ccctccctcc ctgttgccca
      961 ttgccaataa gcataagctt ttgctgtcat cctggggtct taaatgtgtg gaacaattaa
     1021 tcgagcttat gccagtctgt cattcatccg gaactgaaca ataaagcctt tatttatgtt
     1081 aaaaaaaaaa aaaaaa
//
