LOCUS       NM_001100762            2763 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus hepatitis A virus cellular receptor 2 (Havcr2),
            mRNA.
ACCESSION   NM_001100762 XM_001069084 XM_343881
VERSION     NM_001100762.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2763)
  AUTHORS   Ramirez Hernandez,E., Hernandez Zimbron,L.F., Segura Perez,E.,
            Sanchez Salgado,J.L., Pereyra Morales,M.A. and Zenteno,E.
  TITLE     Galectin-9 and Tim-3 are upregulated in response to microglial
            activation induced by the peptide Amyloid-beta (25-35)
  JOURNAL   Neuropeptides 105, 102426 (2024)
   PUBMED   38527407
  REMARK    GeneRIF: Galectin-9 and Tim-3 are upregulated in response to
            microglial activation induced by the peptide Amyloid-beta (25-35).
REFERENCE   2  (bases 1 to 2763)
  AUTHORS   Hu,X.H., Li,Z.H., Muyayalo,K.P., Wang,L.L., Liu,C.Y., Mor,G. and
            Liao,A.H.
  TITLE     A newly intervention strategy in preeclampsia: Targeting PD-1/Tim-3
            signaling pathways to modulate the polarization of decidual
            macrophages
  JOURNAL   FASEB J 36 (1), e22073 (2022)
   PUBMED   34847253
  REMARK    GeneRIF: A newly intervention strategy in preeclampsia: Targeting
            PD-1/Tim-3 signaling pathways to modulate the polarization of
            decidual macrophages.
REFERENCE   3  (bases 1 to 2763)
  AUTHORS   Guo,S., Li,Y., Wei,B., Liu,W., Li,R., Cheng,W., Zhang,X., He,X.,
            Li,X. and Duan,C.
  TITLE     Tim-3 deteriorates neuroinflammatory and neurocyte apoptosis after
            subarachnoid hemorrhage through the Nrf2/HMGB1 signaling pathway in
            rats
  JOURNAL   Aging (Albany NY) 12 (21), 21161-21185 (2020)
   PUBMED   33168786
  REMARK    GeneRIF: Tim-3 deteriorates neuroinflammatory and neurocyte
            apoptosis after subarachnoid hemorrhage through the Nrf2/HMGB1
            signaling pathway in rats.
REFERENCE   4  (bases 1 to 2763)
  AUTHORS   Chen,Z.Q., Yu,H., Li,H.Y., Shen,H.T., Li,X., Zhang,J.Y.,
            Zhang,Z.W., Wang,Z. and Chen,G.
  TITLE     Negative regulation of glial Tim-3 inhibits the secretion of
            inflammatory factors and modulates microglia to antiinflammatory
            phenotype after experimental intracerebral hemorrhage in rats
  JOURNAL   CNS Neurosci Ther 25 (6), 674-684 (2019)
   PUBMED   30677253
  REMARK    GeneRIF: Negative regulation of glial Tim-3 inhibits the secretion
            of inflammatory factors and modulates microglia to antiinflammatory
            phenotype after experimental intracerebral hemorrhage in rats.
REFERENCE   5  (bases 1 to 2763)
  AUTHORS   Li,Z., Li,N., Li,F., Zhou,Z., Sang,J., Jin,Z., Liu,H., Han,Q.,
            Lv,Y. and Liu,Z.
  TITLE     Genetic polymorphisms of immune checkpoint proteins PD-1 and TIM-3
            are associated with survival of patients with hepatitis B
            virus-related hepatocellular carcinoma
  JOURNAL   Oncotarget 7 (18), 26168-26180 (2016)
   PUBMED   27034168
REFERENCE   6  (bases 1 to 2763)
  AUTHORS   Graves,P.E., Siroux,V., Guerra,S., Klimecki,W.T. and Martinez,F.D.
  TITLE     Association of atopy and eczema with polymorphisms in T-cell
            immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase
            gene cluster in chromosome 5 q 33
  JOURNAL   J Allergy Clin Immunol 116 (3), 650-656 (2005)
   PUBMED   16159638
REFERENCE   7  (bases 1 to 2763)
  AUTHORS   Gielen,A.W., Lobell,A., Lidman,O., Khademi,M., Olsson,T. and
            Piehl,F.
  TITLE     Expression of T cell immunoglobulin- and mucin-domain-containing
            molecules-1 and -3 (TIM-1 and -3) in the rat nervous and immune
            systems
  JOURNAL   J Neuroimmunol 164 (1-2), 93-104 (2005)
   PUBMED   15913792
REFERENCE   8  (bases 1 to 2763)
  AUTHORS   Wefer,J., Harris,R.A. and Lobell,A.
  TITLE     Protective DNA vaccination against experimental autoimmune
            encephalomyelitis is associated with induction of IFNbeta
  JOURNAL   J Neuroimmunol 149 (1-2), 66-76 (2004)
   PUBMED   15020066
REFERENCE   9  (bases 1 to 2763)
  AUTHORS   Sabatos,C.A., Chakravarti,S., Cha,E., Schubart,A.,
            Sanchez-Fueyo,A., Zheng,X.X., Coyle,A.J., Strom,T.B., Freeman,G.J.
            and Kuchroo,V.K.
  TITLE     Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1
            responses and induction of peripheral tolerance
  JOURNAL   Nat Immunol 4 (11), 1102-1110 (2003)
   PUBMED   14556006
REFERENCE   10 (bases 1 to 2763)
  AUTHORS   Monney,L., Sabatos,C.A., Gaglia,J.L., Ryu,A., Waldner,H.,
            Chernova,T., Manning,S., Greenfield,E.A., Coyle,A.J., Sobel,R.A.,
            Freeman,G.J. and Kuchroo,V.K.
  TITLE     Th1-specific cell surface protein Tim-3 regulates macrophage
            activation and severity of an autoimmune disease
  JOURNAL   Nature 415 (6871), 536-541 (2002)
   PUBMED   11823861
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Oct 20, 2007 this sequence version replaced
            XM_343881.3, XM_001069084.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2381871.1,
                                           SRR26360194.441971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN09345330
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000010.1  31383925-31384052
            129-470             JAXUCZ010000010.1  31385268-31385609
            471-554             JAXUCZ010000010.1  31388082-31388165
            555-595             JAXUCZ010000010.1  31397720-31397760
            596-722             JAXUCZ010000010.1  31400283-31400409
            723-759             JAXUCZ010000010.1  31407125-31407161
            760-2763            JAXUCZ010000010.1  31408449-31410452
FEATURES             Location/Qualifiers
     source          1..2763
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..2763
                     /gene="Havcr2"
                     /gene_synonym="tim3"
                     /note="hepatitis A virus cellular receptor 2"
                     /db_xref="GeneID:363578"
                     /db_xref="RGD:1305233"
     exon            1..128
                     /gene="Havcr2"
                     /gene_synonym="tim3"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..919
                     /gene="Havcr2"
                     /gene_synonym="tim3"
                     /note="hepatitis A virus cellular receptor 2 homolog; T
                     cell immunoglobulin mucin-3; TIM-3; TIMD-3; HAVcr-2;
                     T-cell membrane protein 3; T-cell immunoglobulin and mucin
                     domain-containing protein 3; T-cell immunoglobulin mucin
                     receptor 3"
                     /codon_start=1
                     /product="hepatitis A virus cellular receptor 2 homolog
                     precursor"
                     /protein_id="NP_001094232.1"
                     /db_xref="GeneID:363578"
                     /db_xref="RGD:1305233"
                     /translation="MFSWLPFSCALLLLQPLPARSLENAYTAEVGKNAYLPCSYTVPA
                     PGTLVPICWGKGSCPLLQCASVVLRTDETNVTYRKSRRYQLKGNFYKGDMSLTIKNVT
                     LADSGTYCCRIQFPGPMNDEKLELKLSITEPAKVIPAGTAHGDSTTASPRTLTTEGSG
                     SETQTLVTLHDNNGTKISTWADEIKDSGETIRTAVHIGVGVSAGLALALILGVLILKW
                     YSSKKKKLQDLSLITLANSPPGGLVNAGAGRIRSEENIYTIEENIYEMENSNEYYCYV
                     SSQQPS"
     exon            129..470
                     /gene="Havcr2"
                     /gene_synonym="tim3"
                     /inference="alignment:Splign:2.1.0"
     exon            471..554
                     /gene="Havcr2"
                     /gene_synonym="tim3"
                     /inference="alignment:Splign:2.1.0"
     exon            555..595
                     /gene="Havcr2"
                     /gene_synonym="tim3"
                     /inference="alignment:Splign:2.1.0"
     exon            596..722
                     /gene="Havcr2"
                     /gene_synonym="tim3"
                     /inference="alignment:Splign:2.1.0"
     exon            723..759
                     /gene="Havcr2"
                     /gene_synonym="tim3"
                     /inference="alignment:Splign:2.1.0"
     exon            760..2763
                     /gene="Havcr2"
                     /gene_synonym="tim3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacgttttca ctgaagagct agcgctctat caacaaggag ctgtcctttg atatccccgg
       61 ccaagcactc atgttttcat ggcttccctt cagctgtgcc ctgctgctgc tgcaaccact
      121 acctgcaagg tccttggaaa atgcttacac agctgaggtc gggaagaatg cctatctgcc
      181 ctgcagctac actgtacctg cccctgggac gctcgtgcct atctgctggg gcaagggatc
      241 ctgtcctttg ttacagtgtg ccagtgtggt gctcagaacg gatgaaacga atgtgacata
      301 tcggaaatcc agaagatacc agctaaaggg gaatttctac aaaggagaca tgtcgctgac
      361 cataaagaat gtgactctag ctgactctgg gacctactgc tgcaggatac aattccctgg
      421 cccaatgaat gatgaaaaat tagagctgaa attaagcatc actgaaccag ccaaagtcat
      481 cccagctggg actgctcatg gggattctac aacagcttct cccagaaccc taaccactga
      541 gggaagtggc tcagagacac agaccctggt gaccctccat gataacaatg gaacaaaaat
      601 ttccacatgg gccgatgaaa ttaaggactc tggagaaact atcagaactg ctgtccacat
      661 tggagtaggc gtctctgctg ggctggccct ggcacttatt cttggtgttt taatccttaa
      721 atggtattcc tctaagaaaa agaagttgca ggatttgagt cttattacac tggccaactc
      781 cccaccagga gggttggtga atgcaggagc aggcaggatt cggtctgagg aaaacatcta
      841 cactatagag gagaacatat atgaaatgga gaattcaaat gagtactact gctatgtcag
      901 cagccagcag ccatcctgac cgcctctggg ctcccgactt taaaggctcc ctttcatttc
      961 tgactttggt actttctttt tcgaaaacta tgagataagt cacctggcaa cctcattgga
     1021 ggttctgtcc acagccacca agaaaagagt tcctgttttc tggggataac gaactcacaa
     1081 ggagattcaa ctgtaaccta tgctacattg aaatgcacca ctttacctga gtttcaggga
     1141 caggatctcc caacccagag actgcactca tggatgttga agctcacatg tgcttcctta
     1201 cattaggaat ggctagtatg atgtctctga gacattaagg tttgtggtat gtccgcaaag
     1261 ctcctgaaca ggtagaggga ataaagggct aagatcggta ggtgcaggtc tttgttggtg
     1321 ctcgaaatct aaaaaagctg gtggttttcc tagagatttc taaccttgaa agattcagag
     1381 ccgggtggca tatgcttaac attccataac ttgggaacct caggcaggag ggtggtgagt
     1441 tcaaggtcag ctggggctat gttggtgaga ctttgtctca aaaacaaaag aagaaaataa
     1501 acacacagac actggagact ggagatatgg ctcagtgagg tgcttgttat aaagcatgag
     1561 gaacctgagt ttggtcccag acctgacata aaaaagctag gcatggtagt gcatgcttgt
     1621 gaactccaga gatagggagg taaaggcaaa gcagatccct ggggcatgat tgacgccacc
     1681 ttagcctaga tggtgagttg caagtccgtg agagtccctg tctcataata agatggactg
     1741 tgttcctggg gaacatcaat ggagactgtc ctgggctctc tgcagacatg cgcatgtacc
     1801 ttacacacgc acatgcgcat gcgcacgcaa atgcgcacgc gcacatgagg ttacacgcaa
     1861 aagattaaaa gaaaggaagg atcagaacag ggctaaatga tagtgaaagt tctctgtgtg
     1921 ccttctgcct ctctataatg tttatctcta tatgactctc ctctgcctct gttaagactg
     1981 cctctgaacg ggagcactga aatgcagacc tgtaattaat tccagcaccc agaaggttga
     2041 agcaggagca tggagaggtc aggagcatgg tgtcctacac tgccagactc tcgtacacaa
     2101 gaaaaacgtt gcccataagt ggcctgctga ctgcgaaagg aaacttttta cgaaagctgc
     2161 accttgcctg ctgtgtgctc aaagggaact gactcagaca acttctccat ttctggagga
     2221 aactggagcc gtgtttctga cagaagaaga accggtgact gggacacacg aaggcagacc
     2281 tcttgcagca atctatatag tcagcaaaag atccttttgg taggacagtg gtcaccaaac
     2341 ttaatttcca agctggtgga gctcagtttc atctggctta caactgcttg gccagtgcct
     2401 tggtctgtgt tggttctcat atataacaga gtcaattaaa tagacccaga gtgaaaatat
     2461 taagtgagca gaaaggtagc tttgttgaaa gactttttgc accggggtgc tactgtgtat
     2521 gtcagaggac gtctgttagt gaaggcactg aaacctgcat gtttggatct tttcttgtat
     2581 gaattttgat gtttaggctg catttagcta gctgtggaac tactggatct tttaggtggg
     2641 tatggaaggg agaccatctg cagaatcaat taggtaacat ctctcatgca gatgggaaaa
     2701 ttaatctcaa gtgttttaaa gtaataaaac caactgtact agtgaagtac tttgagcata
     2761 ttt
//
