LOCUS       NM_173149               2538 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hepatitis A virus cellular receptor 1 (Havcr1),
            mRNA.
ACCESSION   NM_173149 XM_213280
VERSION     NM_173149.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2538)
  AUTHORS   Obaid,A.A., Almasmoum,H., Almaimani,R.A., El-Boshy,M., Aslam,A.,
            Idris,S., Ghaith,M.M., El-Readi,M.Z., Ahmad,J., Farrash,W.F.,
            Mujalli,A., Eid,S.Y., Elzubier,M.E. and Refaat,B.
  TITLE     Vitamin D and calcium co-therapy mitigates pre-established cadmium
            nephropathy by regulating renal calcium homeostatic molecules and
            improving anti-oxidative and anti-inflammatory activities in rat
  JOURNAL   J Trace Elem Med Biol 79, 127221 (2023)
   PUBMED   37244046
REFERENCE   2  (bases 1 to 2538)
  AUTHORS   Ramdin,S., Naicker,T., Baijnath,S. and Govender,N.
  TITLE     Kidney injury molecule-1 and podocalyxin dysregulation in an
            arginine vasopressin induced rodent model of preeclampsia
  JOURNAL   Eur J Obstet Gynecol Reprod Biol 284, 58-65 (2023)
   PUBMED   36934678
  REMARK    GeneRIF: Kidney injury molecule-1 and podocalyxin dysregulation in
            an arginine vasopressin induced rodent model of preeclampsia.
REFERENCE   3  (bases 1 to 2538)
  AUTHORS   Edosuyi,O., Choi,M., Edosuyi,V., Igbe,I. and Oyekan,A.
  TITLE     Malate reduced kidney injury molecule (KIM-1) expression and
            selectively upregulated the renal nitric oxide production in
            obstructive nephropathy
  JOURNAL   Bratisl Lek Listy 124 (2), 151-157 (2023)
   PUBMED   36598304
  REMARK    GeneRIF: Malate reduced kidney injury molecule (KIM-1) expression
            and selectively upregulated the renal nitric oxide production in
            obstructive nephropathy.
REFERENCE   4  (bases 1 to 2538)
  AUTHORS   Wang,T., Dai,L., Shen,S., Yang,Y., Yang,M., Yang,X., Qiu,Y. and
            Wang,W.
  TITLE     Comprehensive Molecular Analyses of a Macrophage-Related Gene
            Signature With Regard to Prognosis, Immune Features, and Biomarkers
            for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and
            the LASSO Algorithm
  JOURNAL   Front Immunol 13, 843408 (2022)
   PUBMED   35693827
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2538)
  AUTHORS   Li,X., Chen,S., Feng,D., Fu,Y., Wu,H., Lu,J. and Bao,J.
  TITLE     Calcium-sensing receptor promotes calcium oxalate crystal adhesion
            and renal injury in Wistar rats by promoting ROS production and
            subsequent regulation of PS ectropion, OPN, KIM-1, and ERK
            expression
  JOURNAL   Ren Fail 43 (1), 465-476 (2021)
   PUBMED   33678127
  REMARK    GeneRIF: Calcium-sensing receptor promotes calcium oxalate crystal
            adhesion and renal injury in Wistar rats by promoting ROS
            production and subsequent regulation of PS ectropion, OPN, KIM-1,
            and ERK expression.
REFERENCE   6  (bases 1 to 2538)
  AUTHORS   Graves,P.E., Siroux,V., Guerra,S., Klimecki,W.T. and Martinez,F.D.
  TITLE     Association of atopy and eczema with polymorphisms in T-cell
            immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase
            gene cluster in chromosome 5 q 33
  JOURNAL   J Allergy Clin Immunol 116 (3), 650-656 (2005)
   PUBMED   16159638
REFERENCE   7  (bases 1 to 2538)
  AUTHORS   Khademi,M., Illes,Z., Gielen,A.W., Marta,M., Takazawa,N.,
            Baecher-Allan,C., Brundin,L., Hannerz,J., Martin,C., Harris,R.A.,
            Hafler,D.A., Kuchroo,V.K., Olsson,T., Piehl,F. and Wallstrom,E.
  TITLE     T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1
            molecules are differentially expressed on human Th1 and Th2 cells
            and in cerebrospinal fluid-derived mononuclear cells in multiple
            sclerosis
  JOURNAL   J Immunol 172 (11), 7169-7176 (2004)
   PUBMED   15153541
REFERENCE   8  (bases 1 to 2538)
  AUTHORS   Kuehn,E.W., Park,K.M., Somlo,S. and Bonventre,J.V.
  TITLE     Kidney injury molecule-1 expression in murine polycystic kidney
            disease
  JOURNAL   Am J Physiol Renal Physiol 283 (6), F1326-F1336 (2002)
   PUBMED   12388382
REFERENCE   9  (bases 1 to 2538)
  AUTHORS   Han,W.K., Bailly,V., Abichandani,R., Thadhani,R. and Bonventre,J.V.
  TITLE     Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal
            proximal tubule injury
  JOURNAL   Kidney Int 62 (1), 237-244 (2002)
   PUBMED   12081583
REFERENCE   10 (bases 1 to 2538)
  AUTHORS   Ichimura,T., Bonventre,J.V., Bailly,V., Wei,H., Hession,C.A.,
            Cate,R.L. and Sanicola,M.
  TITLE     Kidney injury molecule-1 (KIM-1), a putative epithelial cell
            adhesion molecule containing a novel immunoglobulin domain, is
            up-regulated in renal cells after injury
  JOURNAL   J Biol Chem 273 (7), 4135-4142 (1998)
   PUBMED   9461608
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF035963.1.
            
            On Aug 30, 2012 this sequence version replaced NM_173149.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF035963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680445, SAMN09345331
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2538              AF035963.1         2-2539
FEATURES             Location/Qualifiers
     source          1..2538
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..2538
                     /gene="Havcr1"
                     /gene_synonym="KIM-1; Kim1"
                     /note="hepatitis A virus cellular receptor 1"
                     /db_xref="GeneID:286934"
                     /db_xref="RGD:708425"
     exon            1..649
                     /gene="Havcr1"
                     /gene_synonym="KIM-1; Kim1"
                     /inference="alignment:Splign:2.1.0"
     CDS             601..1524
                     /gene="Havcr1"
                     /gene_synonym="KIM-1; Kim1"
                     /note="hepatitis A virus cellular receptor 1 homolog;
                     TIMD-1; HAVcr-1; t cell immunoglobulin and mucin
                     domain-containing protein 1; kidney injury molecule 1"
                     /codon_start=1
                     /product="hepatitis A virus cellular receptor 1 homolog
                     precursor"
                     /protein_id="NP_775172.1"
                     /db_xref="GeneID:286934"
                     /db_xref="RGD:708425"
                     /translation="MVQLQVFISGLLLLLPGSVDSYEVVKGVVGHPVTIPCTYSTRGG
                     ITTTCWGRGQCPYSSCQNILIWTNGYQVTYRSSGRYNIKGRISEGDVSLTIENSVDSD
                     SGLYCCRVEIPGWFNDQKMTFSLEVKPEIPTSPPTRPTTTRPTTTRPTTISTRSTHVP
                     TSTRVSTSTPTPEQTQTHKPEITTFYAHETTAEVTETPSYTPADWNGTVTSSEEAWNN
                     HTVRIPLRKPQRNPTKGFYVGMSVAALLLLLLASTVVVTRYIIIRKKMGSLSFVAFHV
                     SKSRALQNAAIVHPRAEDNIYIIEDRSRGAE"
     exon            650..988
                     /gene="Havcr1"
                     /gene_synonym="KIM-1; Kim1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1141
                     /gene="Havcr1"
                     /gene_synonym="KIM-1; Kim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1210
                     /gene="Havcr1"
                     /gene_synonym="KIM-1; Kim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1260
                     /gene="Havcr1"
                     /gene_synonym="KIM-1; Kim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1372
                     /gene="Havcr1"
                     /gene_synonym="KIM-1; Kim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1409
                     /gene="Havcr1"
                     /gene_synonym="KIM-1; Kim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..2523
                     /gene="Havcr1"
                     /gene_synonym="KIM-1; Kim1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcctgtg agtaaataga tcagggtctc cttcacagca cattctccag gaagccgagc
       61 aaacattagt gctattttac ccaggaggaa atctaggtgt agagagctct acggatctaa
      121 ggtttggatc tgtacccagt gcttttttag gtgtctttag acatttctca ggaagatgta
      181 gtctctgtca ccatgtgtgg ctgaattcta gctcagtcca tcttattgtg tttaaggtag
      241 ttgaagttta ggaaccaacc agtatgtctc tgagcagaag agtacagtgt ccatcttgag
      301 gacaagctca tctttaccat tagagggctg gccttggctt agattctacc gagaacatac
      361 tctctaatgg ctgccctcag ttttctctgt ttgctgtctt atttgtgtca tggccagaag
      421 tcatatggat ggctctatgt gagcaaggac ccagatagaa gagtgtattt gggggaacag
      481 gttgccctaa cagagagtcc tgtgggattc atgcagtcag gatgaagacc tgatcagaca
      541 gagtgtgctg agtgccacgg ctaaccagag tgacttgtca ctgtccttca ggtcaacacc
      601 atggttcaac ttcaagtctt catttcaggc ctcctgctgc ttcttccagg ctctgtagat
      661 tcttatgaag tagtgaaggg ggtggtgggt caccctgtca caattccatg tacttactca
      721 acacgtggag gaatcacaac gacatgttgg ggccgggggc aatgcccata ttctagttgt
      781 caaaatatac ttatttggac caatggatac caagtcacct atcggagcag cggtcgatac
      841 aacataaagg ggcgtatttc agaaggagac gtatccttga caatagagaa ctctgttgat
      901 agtgatagtg gtctgtattg ttgccgagtg gagattcctg gatggttcaa cgatcagaaa
      961 atgacctttt cattggaagt taaaccagaa attcccacaa gtcctccaac aagacccaca
     1021 actacaagac ccacaaccac aaggcccaca actatttcaa caagatccac acatgtacca
     1081 acatcaacca gagtctccac ctctactcca acaccagaac aaacacagac tcacaaacca
     1141 gaaatcacta cattttatgc ccatgagaca actgctgagg tgacagaaac tccatcatat
     1201 actcctgcag actggaatgg cactgtgaca tcctcagagg aggcctggaa taatcacact
     1261 gtaagaatcc ctttgaggaa gccgcagaga aacccgacta agggcttcta tgttggcatg
     1321 tccgttgcag ccctgctgct gctgctgctt gcgagcaccg tggttgtcac caggtacatc
     1381 attataagaa agaagatggg ctctctgagc tttgttgcct tccatgtctc taagagtaga
     1441 gctttgcaga acgcagcgat tgtgcatccc cgagctgaag acaacatcta cattattgaa
     1501 gatagatctc gaggtgcaga atgagtccca gaggccttct gtggggcctt ctgcctggga
     1561 ttacagagat cgtgactgat ttcacagagt aaaataccca ttccagctcc tgggagattt
     1621 tgtgttttgg ttcttccagc tgcagtggag agggtaaccc tctaccctgt atatgcaaaa
     1681 ctcgaggtta acatcatcct aattcttgta tcagcaacac ctcagtgtct ccactcactg
     1741 cagcgattct ctcaaatgtg aacattttag aagtttgtgt ttccttttgt ccatgtaatc
     1801 attggtaata caagaatttt atcttgttta ttaaaaccat taatgagagg ggaataggaa
     1861 ttaaaagctg gtgggaaggg cctcctgaat ttagaagcac ttcatgattg tgtttatctc
     1921 ttttattgta atttgaaatg ttacttctat ccttcccaag gggcaaaatc atgggagcat
     1981 ggaggtttta attgccctca tagataagta gaagaagaga gtctaatgcc accaatagag
     2041 gtggttatgc tttctcacag ctctggaaat atgatcattt attatgcagt tgatcttagg
     2101 atgaggatgg gtttcttagg aggagaggtt accatggtga gtggaccagg cacacatcag
     2161 gggaagaaaa caatggatca agggattgag ttcattagag ccatttccac tccacttctg
     2221 tcttgatgct cagtgttcct aaactcaccc actgagctct gaattaggtg cagggaggag
     2281 acgtgcagaa acgaaagagg aaagaaagga gagagagcag gacacaggct ttctgctgag
     2341 agaagtccta ttgcaggtgt gacagtgttt gggactacca cgggtttcct tcagacttct
     2401 aagtttctaa atcactatca tgtgatcata tttattttta aaattatttc agaaagacac
     2461 cacattttca ataataaatc agtttgtcac aattaataaa atattttgtt tgctaagaag
     2521 taaaaaaaaa aaaaaaaa
//
