LOCUS       NM_001398936            2788 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus histone H3 associated protein kinase (Haspin),
            mRNA.
ACCESSION   NM_001398936 XM_003750849
VERSION     NM_001398936.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2788)
  AUTHORS   De Antoni,A., Maffini,S., Knapp,S., Musacchio,A. and Santaguida,S.
  TITLE     A small-molecule inhibitor of Haspin alters the kinetochore
            functions of Aurora B
  JOURNAL   J Cell Biol 199 (2), 269-284 (2012)
   PUBMED   23071153
REFERENCE   2  (bases 1 to 2788)
  AUTHORS   Wang,F., Dai,J., Daum,J.R., Niedzialkowska,E., Banerjee,B.,
            Stukenberg,P.T., Gorbsky,G.J. and Higgins,J.M.
  TITLE     Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at
            centromeres in mitosis
  JOURNAL   Science 330 (6001), 231-235 (2010)
   PUBMED   20705812
REFERENCE   3  (bases 1 to 2788)
  AUTHORS   Dai,J., Sultan,S., Taylor,S.S. and Higgins,J.M.
  TITLE     The kinase haspin is required for mitotic histone H3 Thr 3
            phosphorylation and normal metaphase chromosome alignment
  JOURNAL   Genes Dev 19 (4), 472-488 (2005)
   PUBMED   15681610
REFERENCE   4  (bases 1 to 2788)
  AUTHORS   Tanaka,H., Iguchi,N., Nakamura,Y., Kohroki,J., de Carvalho,C.E. and
            Nishimune,Y.
  TITLE     Cloning and characterization of human haspin gene encoding haploid
            germ cell-specific nuclear protein kinase
  JOURNAL   Mol Hum Reprod 7 (3), 211-218 (2001)
   PUBMED   11228240
REFERENCE   5  (bases 1 to 2788)
  AUTHORS   Tanaka,H., Yoshimura,Y., Nozaki,M., Yomogida,K., Tsuchida,J.,
            Tosaka,Y., Habu,T., Nakanishi,T., Okada,M., Nojima,H. and
            Nishimune,Y.
  TITLE     Identification and characterization of a haploid germ cell-specific
            nuclear protein kinase (Haspin) in spermatid nuclei and its effects
            on somatic cells
  JOURNAL   J Biol Chem 274 (24), 17049-17057 (1999)
   PUBMED   10358056
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 28, 2021 this sequence version replaced XM_003750849.5.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26360186.454054.1,
                                        SRR26360181.881016.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2788              JAXUCZ010000010.1  58246244-58249031   c
FEATURES             Location/Qualifiers
     source          1..2788
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2788
                     /gene="Haspin"
                     /gene_synonym="Gsg2"
                     /note="histone H3 associated protein kinase"
                     /db_xref="GeneID:687827"
                     /db_xref="RGD:1596276"
     exon            1..2788
                     /gene="Haspin"
                     /gene_synonym="Gsg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..2278
                     /gene="Haspin"
                     /gene_synonym="Gsg2"
                     /EC_number="2.7.11.1"
                     /note="germ cell associated 2 (haspin)"
                     /codon_start=1
                     /product="serine/threonine-protein kinase haspin"
                     /protein_id="NP_001385865.1"
                     /db_xref="GeneID:687827"
                     /db_xref="RGD:1596276"
                     /translation="MAASHRRSGTRLFRTYAARGVRRSQRQPDSLAVKWFQPPNPKLS
                     FSSSLSDSNLSPAVASDNPEDPDFPGSPVGPRRRRPRGCDSPDLTHTKRVLRLRPRPP
                     QKCSTPCSRLRPPPFLSCSPGCLGSDLNVCIQSRNSNELGTSASLFSPPASPGAPDSL
                     NADSTVPGSLHFRVASLGEASLPCPQEAATEEGKYTRSAPQAEASFRSSLSSRVDPRT
                     TEAKELGTDGENVKESCCERQQTGNRLTDPDLASLGKRTATCKKVVSRGVDQIDYGES
                     SARKDLRVPGKISRPKRTEPLRKRKQQEAVGTSPLRYHQSKKKRKDSFCSRDLNTSCK
                     DSWTKTRASFGFHKKKIITNVAEVCSRSITSSLSRSFQSECSISILNRENSIVSSPCS
                     SMYLLSPLKTLHITDKRPSYAEKVYGECNQEGPIPFSDCLSTEQLEHCEKIGEGVFGE
                     VFQIINDQTPVALKIIAVEGSDLVNGSHQKTFEEILPEIIISKELSLLSNEVYNCTEG
                     FIGLNSVYCVQGLYPPLLLKAWDQYNTTKGSANDRPDFFQEDQLFIILEFEFGGIDLE
                     RMRTKLTSVATAKSILHQITASLAVAEASLHFEHRDLHWGNVLLKKTNLKELHYTLNG
                     KTSTIPTHGLQVNIIDYTLSRLERDGIVVFCDISAEEDLFTGEGDYQFEIYRLMRKEN
                     KNCWGEYHPYNNVLWLHYLTDKILNKMRFKTKCHSAAMKQIKRKLQHFHRTVLNFSSA
                     TDLLCRHSLFK"
ORIGIN      
        1 aaatgacggg cgggcgcccg ccatggcagc gtctcaccgg aggtccggaa cccggctctt
       61 tcgaacgtac gcggcgaggg gcgtccggag gtcgcagcgg cagcctgact cgctggctgt
      121 gaaatggttc cagccgccga acccgaagct ctccttcagc agcagcctca gcgacagtaa
      181 cctgtcaccg gctgtcgctt ccgacaaccc tgaggacccc gacttcccgg gcagcccggt
      241 gggcccgcgg cgcaggcgtc ctcggggctg cgactctccg gacctaacac acactaagag
      301 agtcctgagg ctgcgacctc ggccccctca gaagtgcagc accccgtgca gccggctgcg
      361 accgccacct ttcctcagct gcagcccggg ctgcctcggc tcggacctca acgtgtgcat
      421 ccagtccagg aacagcaacg agctgggcac cagtgcctcc cttttcagcc ctccggcctc
      481 gcccggagcc cccgactctc tgaatgcaga ctctacagtc cccgggagcc tccacttccg
      541 ggtagcctcc ctgggtgaag cgtctctgcc ttgcccccag gaggcagcaa ccgaagaagg
      601 caagtacacc aggagtgccc cccaagccga agccagcttc aggtcatctc tctctagccg
      661 tgtggaccca aggaccacag aagctaagga gttggggact gatggggaga atgtgaagga
      721 atcgtgttgt gaaagacagc agacgggtaa cagactaacg gaccctgatc tggcaagcct
      781 gggaaagaga accgccacat gtaaaaaggt tgtgtcccga ggagtcgacc agatagacta
      841 tggagagtcc agtgctcgca aagaccttcg tgtaccaggg aaaatcagca ggcccaagag
      901 aactgaacca ctccggaaaa ggaaacagca agaagcagtg ggaacatctc ccctccgcta
      961 tcaccaatct aagaagaaaa ggaaagattc attctgctcc agggacttga atactagttg
     1021 taaggattct tggaccaaaa ccagagcatc cttcggtttt cacaagaaga aaattataac
     1081 caacgtggca gaggtatgca gcagatcgat taccagctct ctctctaggt ccttccagtc
     1141 tgaatgttca atttctatcc tgaacagaga aaacagtatt gtttcttctc catgctcttc
     1201 catgtatttg ctaagtccct taaagaccct gcacatcaca gacaaaaggc catcttatgc
     1261 tgaaaaggtt tatggggagt gtaatcagga agggcctatc ccctttagtg attgcctttc
     1321 tacagaacaa ctggaacact gtgagaagat tggggaagga gtgtttgggg aagtgtttca
     1381 aataattaat gaccaaacac ctgtagccct aaagatcatt gctgttgaag gatcagattt
     1441 agtcaatggg tcccaccaaa aaaccttcga ggagatcctg ccagagatca tcatctccaa
     1501 agagctgagt ctcctgtcta acgaggtgta caactgcaca gaaggcttta ttgggctgaa
     1561 ctcagtatac tgtgttcaag gactttaccc tcccttgctg cttaaagcct gggaccaata
     1621 taacacaacc aaagggtctg caaatgaccg gcctgacttt ttccaggaag accagctctt
     1681 tatcatcctg gaatttgagt ttggtgggat tgacttggag cgaatgagga caaagctaac
     1741 ctccgtggcc accgcaaaga gcatcctcca ccagatcacc gcatccctgg cagtagcaga
     1801 ggcctcactg cactttgagc accgggactt acactgggga aatgtgctct taaagaaaac
     1861 caacctcaaa gaactccact acaccctcaa tgggaaaaca agcaccattc ccacccatgg
     1921 gctacaagtc aacatcattg actatactct gtcccgcttg gagcgggatg ggattgtggt
     1981 tttctgtgac atctctgctg aggaggacct atttacaggt gagggtgact accagtttga
     2041 gatctacagg ctcatgagga aggagaacaa aaactgctgg ggcgagtatc acccttacaa
     2101 taacgtgctg tggctgcatt acctcacgga caagattctg aacaagatga ggtttaagac
     2161 taaatgccac agcgcagcca tgaagcagat aaagaggaaa ctgcagcatt tccacaggac
     2221 tgtactgaac ttcagctccg ccactgacct gctctgccga catagtctat ttaagtaagc
     2281 caggaacctg cactttcaga gcctcaccaa gtacactttt taagcctctg gtactattag
     2341 ttaatctctg ccattagagc aggatggagg taaaagcctc cctgtcagcc tcttaaaaga
     2401 gaatcctgtc ttttaaaagg taaccaaaac gtttgttgac gtgattaaac ttgcttttaa
     2461 caaatgttct ttaaaaaagg aaatgaacta gacagaggag aagtgcatgc accctttaag
     2521 ccctcttcct gtcagcggag cctgcaggcc tgagttgttt cttgagcctt gataccttat
     2581 gtaggatgag caaaactgct cttggtgttg tcaagatgca aagcagagag caggagagac
     2641 tagagagtca aaaccaagag ggaggcgtgc acacctgcgt acaggaagtg tgcggaatgt
     2701 ttatcagatt cactcaacaa tcacagaagc acagtttata gattttcaac aggaaaataa
     2761 atgtctctgg tggctctgat gtttgaaa
//
