LOCUS       NM_172319               2465 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus hyaluronan synthase 3 (Has3), mRNA.
ACCESSION   NM_172319 XM_001076370
VERSION     NM_172319.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2465)
  AUTHORS   Bart,G., Vico,N.O., Hassinen,A., Pujol,F.M., Deen,A.J., Ruusala,A.,
            Tammi,R.H., Squire,A., Heldin,P., Kellokumpu,S. and Tammi,M.I.
  TITLE     Fluorescence resonance energy transfer (FRET) and proximity
            ligation assays reveal functionally relevant homo- and heteromeric
            complexes among hyaluronan synthases HAS1, HAS2, and HAS3
  JOURNAL   J Biol Chem 290 (18), 11479-11490 (2015)
   PUBMED   25795779
REFERENCE   2  (bases 1 to 2465)
  AUTHORS   Torronen,K., Nikunen,K., Karna,R., Tammi,M., Tammi,R. and Rilla,K.
  TITLE     Tissue distribution and subcellular localization of hyaluronan
            synthase isoenzymes
  JOURNAL   Histochem Cell Biol 141 (1), 17-31 (2014)
   PUBMED   24057227
REFERENCE   3  (bases 1 to 2465)
  AUTHORS   Rauhala,L., Hamalainen,L., Salonen,P., Bart,G., Tammi,M.,
            Pasonen-Seppanen,S. and Tammi,R.
  TITLE     Low dose ultraviolet B irradiation increases hyaluronan synthesis
            in epidermal keratinocytes via sequential induction of hyaluronan
            synthases Has1-3 mediated by p38 and Ca2+/calmodulin-dependent
            protein kinase II (CaMKII) signaling
  JOURNAL   J Biol Chem 288 (25), 17999-18012 (2013)
   PUBMED   23645665
  REMARK    GeneRIF: Data indicate that p38 and Ca(2+)/calmodulin-dependent
            protein kinase II pathways were found to be involved in the
            UVB-induced up-regulation of Has2 and Has3 expression.
REFERENCE   4  (bases 1 to 2465)
  AUTHORS   Ormiston,M.L., Slaughter,G.R., Deng,Y., Stewart,D.J. and
            Courtman,D.W.
  TITLE     The enzymatic degradation of hyaluronan is associated with disease
            progression in experimental pulmonary hypertension
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 298 (2), L148-L157 (2010)
   PUBMED   19915162
REFERENCE   5  (bases 1 to 2465)
  AUTHORS   Mrabat,H., Beagle,J., Hang,Z., Garg,H.G., Hales,C.A. and Quinn,D.A.
  TITLE     Inhibition of HA synthase 3 mRNA expression, with a
            phosphodiesterase 3 inhibitor, blocks lung injury in a septic
            ventilated rat model
  JOURNAL   Lung 187 (4), 233-239 (2009)
   PUBMED   19572173
  REMARK    GeneRIF: Inhibition of HA synthase 3 mRNA expression, with a
            phosphodiesterase 3 inhibitor, blocks lung injury in a septic
            ventilated rat model.
REFERENCE   6  (bases 1 to 2465)
  AUTHORS   Karvinen,S., Pasonen-Seppanen,S., Hyttinen,J.M., Pienimaki,J.P.,
            Torronen,K., Jokela,T.A., Tammi,M.I. and Tammi,R.
  TITLE     Keratinocyte growth factor stimulates migration and hyaluronan
            synthesis in the epidermis by activation of keratinocyte hyaluronan
            synthases 2 and 3
  JOURNAL   J Biol Chem 278 (49), 49495-49504 (2003)
   PUBMED   14506240
  REMARK    GeneRIF: belongs to the targets of keratinocyte growth factor in
            keratinocytes, and support the idea that enhanced hyaluronan
            synthesis acts an effector for the migratory response of
            keratinocytes in wound healing
REFERENCE   7  (bases 1 to 2465)
  AUTHORS   Pasonen-Seppanen,S., Karvinen,S., Torronen,K., Hyttinen,J.M.,
            Jokela,T., Lammi,M.J., Tammi,M.I. and Tammi,R.
  TITLE     EGF upregulates, whereas TGF-beta downregulates, the hyaluronan
            synthases Has2 and Has3 in organotypic keratinocyte cultures:
            correlations with epidermal proliferation and differentiation
  JOURNAL   J Invest Dermatol 120 (6), 1038-1044 (2003)
   PUBMED   12787132
  REMARK    GeneRIF: Epidermal hyaluronan synthesis, controlled by epidermal
            growth factor and transforming growth factor beta through changes
            in expression of Has2 and Has3, correlates with epidermal
            proliferation, thickness, and differentiation.
REFERENCE   8  (bases 1 to 2465)
  AUTHORS   Oishi,Y., Kato,H. and Noguchi,T.
  TITLE     Dietary protein as a potent regulator of the hyaluronan synthase
            gene in rat skin
  JOURNAL   Biosci Biotechnol Biochem 67 (4), 736-742 (2003)
   PUBMED   12784612
  REMARK    GeneRIF: protein malnutrition has a primary impact on the gene
            expression of Has2 and Has3, which leads to the reduction of
            hyaluronan content and to disfunction of the skin
REFERENCE   9  (bases 1 to 2465)
  AUTHORS   Itano,N., Sawai,T., Yoshida,M., Lenas,P., Yamada,Y., Imagawa,M.,
            Shinomura,T., Hamaguchi,M., Yoshida,Y., Ohnuki,Y., Miyauchi,S.,
            Spicer,A.P., McDonald,J.A. and Kimata,K.
  TITLE     Three isoforms of mammalian hyaluronan synthases have distinct
            enzymatic properties
  JOURNAL   J Biol Chem 274 (35), 25085-25092 (1999)
   PUBMED   10455188
REFERENCE   10 (bases 1 to 2465)
  AUTHORS   Hoock,T.C., Peters,L.L. and Lux,S.E.
  TITLE     Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate
            with mouse macrophage lysosomes
  JOURNAL   J Cell Biol 136 (5), 1059-1070 (1997)
   PUBMED   9060470
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB097569.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001076370.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB097569.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2465
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2465
                     /gene="Has3"
                     /note="hyaluronan synthase 3"
                     /db_xref="GeneID:266805"
                     /db_xref="RGD:628656"
     exon            1..171
                     /gene="Has3"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1836
                     /gene="Has3"
                     /EC_number="2.4.1.212"
                     /codon_start=1
                     /product="hyaluronan synthase 3"
                     /protein_id="NP_758822.1"
                     /db_xref="GeneID:266805"
                     /db_xref="RGD:628656"
                     /translation="MPVQLTTALRVVGTSLFALVVLGGILAAYVTGYQFIHTEKHYLS
                     FGLYGAILGLHLLIQSLFAFLEHRRMRRAGRPLKLHCSQRRRSVALCIAAYQEDPEYL
                     RKCLRSAQRIAFPNLKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAG
                     EGETEASLQEGMERVRAVVWASTFSCIMQKWGGKREVMYTAFKALGNSVDYIQVCDSD
                     TVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQS
                     YFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKY
                     TARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPF
                     FLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSS
                     LLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSE
                     TELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV"
     exon            172..810
                     /gene="Has3"
                     /inference="alignment:Splign:2.1.0"
     exon            811..912
                     /gene="Has3"
                     /inference="alignment:Splign:2.1.0"
     exon            913..2465
                     /gene="Has3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagctcagc tagtcacaat agttaacacc ttctttgacc agcctccagc tatttgacaa
       61 tttttctttt ctgcccttct ttcttgccac cgggaaggtt tttagggagt cccctcccat
      121 agcgagccgc cccttgacgt taagattttt ctggggtagc cggcttgcag gatgccggtg
      181 cagctgacta cagcccttcg tgtggtgggc accagtctgt ttgccctggt agtgctgggg
      241 ggcatcctgg cagcctatgt cacaggctac cagtttatcc acacggaaaa gcactatctg
      301 tccttcggcc tctacggtgc catcctgggt ctgcatctgc tcatccagag cctgtttgcc
      361 ttcctggagc accgtcgcat gcgcagggca gggcgcccac tgaagctgca ctgctctcag
      421 agacggcgtt cggtggcact ctgcatcgct gcctaccaag aggaccctga gtacttgcgc
      481 aagtgccttc gctcagctca gcgcattgcc ttcccaaacc tcaaggtggt catggtagtg
      541 gatggcaatc gccaggaaga tgcctacatg ctggacatct tccatgaggt cctgggtggc
      601 actgagcaag ctggcttctt tgtgtggcgt agcaatttcc atgaggcggg tgaaggagag
      661 acagaggcca gcttgcagga aggcatggag cgtgttcgag ctgtggtgtg ggccagcacc
      721 ttctcatgca tcatgcagaa gtgggggggc aagcgtgaag tcatgtacac agctttcaag
      781 gcccttggca actcagtgga ctacatccag gtgtgtgact ctgacactgt gctggaccca
      841 gcctgcacca ttgagatgct tcgggtcttg gaggaagatc cccaagtagg aggtgttgga
      901 ggagatgtcc aaatcctcaa caaatacgat tcatggatct ccttcctgag cagcgtgagg
      961 tactggatgg ccttcaacgt ggagcgggcc tgccagtcct actttggctg tgtgcagtgt
     1021 attagtgggc ctctgggcat gtaccgcaac agcctccttc agcagttcct ggaggactgg
     1081 taccatcaga agttcctagg cagcaagtgc agctttgggg atgatcggca ccttaccaac
     1141 cgagtcctga gtcttggcta ccggactaag tatacagcac gctccaagtg cctcacagag
     1201 acccccacta agtatctccg atggctcaac cagcagaccc gctggagcaa gtcttacttt
     1261 cgggagtggc tctacaactc tctgtggttc cataagcacc acctgtggat gacctatgag
     1321 tcagtggtca caggcttctt ccccttcttc ctcatcgcca cagtcataca acttttctac
     1381 cgtggccgca tctggaacat tctcctcttc ctactaacgg tgcagctggt gggcattatc
     1441 aaggctacct atgcctgctt cctccgaggc aatgcagaga tgatcttcat gtccctctac
     1501 tcccttctct atatgtccag cctgctgcca gccaagatct ttgctattgc taccatcaac
     1561 aagtctggct ggggcacttc tggcaggaaa accattgtag tgaacttcat tggcctaatc
     1621 cctgtgtcca tctgggtggc agttcttcta ggggggttag cctacacagc ttattgtcag
     1681 gacctgttca gtgagactga gctagccttc ctggtctctg gggccatctt gtatggctgc
     1741 tactgggtgg ccctcctcat gctgtatttg gccattattg cccggaggtg tgggaaaaag
     1801 ccagaacagt atagcctggc ttttgctgag gtgtgataga accttcaagt aaagtgggaa
     1861 atgtgcaatg ggtaagggag ggaaggggaa tggaaaagaa ggggtgggag ggaggagggc
     1921 gtgttgtgtt ctagtttcat ggctgatagg accaatgtga aaagcgaaga ctagtgactg
     1981 gagtggtctg ggtggcactg gttctgtagg ctcagggcag agagacttgt atgtcacttg
     2041 gctgcttgcc cttgcacagg tagtgaactc ttgagaatct tacttccttc tgggaactat
     2101 agaggaccca gaagtatgct aaactaagtg ctaaactcca tcctgtgtca acttctgata
     2161 cagaagcaag caatgacagc ccatagacag tgtcttcctc cccatgtgag catgacgagc
     2221 tgtaggagtt gttactgtcc agcctggccg gctggtgtcc ccttccctaa ctccaattag
     2281 ccatcaatgc attaagattg tgcctgagat aacaaggctg gaaagcctga cctttggtca
     2341 aaaaacaggg tctaagaagt ggtgctttat gtaattaata tattccactc cacatgaaaa
     2401 catcccaggg atgagccaag acaccaggag taagtactta gtttggtggg gttttttttt
     2461 gtttt
//
