LOCUS       NM_172323               2096 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus hyaluronan synthase 1 (Has1), mRNA.
ACCESSION   NM_172323 XM_001057884
VERSION     NM_172323.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2096)
  AUTHORS   Bart,G., Vico,N.O., Hassinen,A., Pujol,F.M., Deen,A.J., Ruusala,A.,
            Tammi,R.H., Squire,A., Heldin,P., Kellokumpu,S. and Tammi,M.I.
  TITLE     Fluorescence resonance energy transfer (FRET) and proximity
            ligation assays reveal functionally relevant homo- and heteromeric
            complexes among hyaluronan synthases HAS1, HAS2, and HAS3
  JOURNAL   J Biol Chem 290 (18), 11479-11490 (2015)
   PUBMED   25795779
REFERENCE   2  (bases 1 to 2096)
  AUTHORS   Torronen,K., Nikunen,K., Karna,R., Tammi,M., Tammi,R. and Rilla,K.
  TITLE     Tissue distribution and subcellular localization of hyaluronan
            synthase isoenzymes
  JOURNAL   Histochem Cell Biol 141 (1), 17-31 (2014)
   PUBMED   24057227
REFERENCE   3  (bases 1 to 2096)
  AUTHORS   Takahashi,N., Tarumi,W. and Ishizuka,B.
  TITLE     Involvement of hyaluronan synthesis in ovarian follicle growth in
            rats
  JOURNAL   Reproduction 147 (2), 189-197 (2013)
   PUBMED   24218629
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2096)
  AUTHORS   Decleves,A.E., Caron,N., Voisin,V., Legrand,A., Bouby,N.,
            Kultti,A., Tammi,M.I. and Flamion,B.
  TITLE     Synthesis and fragmentation of hyaluronan in renal ischaemia
  JOURNAL   Nephrol Dial Transplant 27 (10), 3771-3781 (2012)
   PUBMED   22529164
REFERENCE   5  (bases 1 to 2096)
  AUTHORS   Ormiston,M.L., Slaughter,G.R., Deng,Y., Stewart,D.J. and
            Courtman,D.W.
  TITLE     The enzymatic degradation of hyaluronan is associated with disease
            progression in experimental pulmonary hypertension
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 298 (2), L148-L157 (2010)
   PUBMED   19915162
REFERENCE   6  (bases 1 to 2096)
  AUTHORS   Hellman,U., Hellstrom,M., Morner,S., Engstrom-Laurent,A.,
            Aberg,A.M., Oliviero,P., Samuel,J.L. and Waldenstrom,A.
  TITLE     Parallel up-regulation of FGF-2 and hyaluronan during development
            of cardiac hypertrophy in rat
  JOURNAL   Cell Tissue Res 332 (1), 49-56 (2008)
   PUBMED   18196276
REFERENCE   7  (bases 1 to 2096)
  AUTHORS   Li,L., Asteriou,T., Bernert,B., Heldin,C.H. and Heldin,P.
  TITLE     Growth factor regulation of hyaluronan synthesis and degradation in
            human dermal fibroblasts: importance of hyaluronan for the
            mitogenic response of PDGF-BB
  JOURNAL   Biochem J 404 (2), 327-336 (2007)
   PUBMED   17324121
REFERENCE   8  (bases 1 to 2096)
  AUTHORS   Itano,N., Sawai,T., Atsumi,F., Miyaishi,O., Taniguchi,S.,
            Kannagi,R., Hamaguchi,M. and Kimata,K.
  TITLE     Selective expression and functional characteristics of three
            mammalian hyaluronan synthases in oncogenic malignant
            transformation
  JOURNAL   J Biol Chem 279 (18), 18679-18687 (2004)
   PUBMED   14724275
REFERENCE   9  (bases 1 to 2096)
  AUTHORS   Yoshida,M., Itano,N., Yamada,Y. and Kimata,K.
  TITLE     In vitro synthesis of hyaluronan by a single protein derived from
            mouse HAS1 gene and characterization of amino acid residues
            essential for the activity
  JOURNAL   J Biol Chem 275 (1), 497-506 (2000)
   PUBMED   10617644
REFERENCE   10 (bases 1 to 2096)
  AUTHORS   Itano,N., Sawai,T., Yoshida,M., Lenas,P., Yamada,Y., Imagawa,M.,
            Shinomura,T., Hamaguchi,M., Yoshida,Y., Ohnuki,Y., Miyauchi,S.,
            Spicer,A.P., McDonald,J.A. and Kimata,K.
  TITLE     Three isoforms of mammalian hyaluronan synthases have distinct
            enzymatic properties
  JOURNAL   J Biol Chem 274 (35), 25085-25092 (1999)
   PUBMED   10455188
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_172323.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB097568.1, SRR21887622.1392684.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680429
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000001.1  67378394-67378444   c
            52-759              JAXUCZ010000001.1  67373276-67373983   c
            760-985             JAXUCZ010000001.1  67371205-67371430   c
            986-1118            JAXUCZ010000001.1  67370605-67370737   c
            1119-2096           JAXUCZ010000001.1  67366460-67367437   c
FEATURES             Location/Qualifiers
     source          1..2096
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2096
                     /gene="Has1"
                     /note="hyaluronan synthase 1"
                     /db_xref="GeneID:282821"
                     /db_xref="RGD:708528"
     exon            1..51
                     /gene="Has1"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1794
                     /gene="Has1"
                     /EC_number="2.4.1.212"
                     /codon_start=1
                     /product="hyaluronan synthase 1"
                     /protein_id="NP_758826.1"
                     /db_xref="GeneID:282821"
                     /db_xref="RGD:708528"
                     /translation="MRQDMPKPSEAARCCSGLARRVLTITFALLILGLMTWAYAAGVP
                     LASDPYGLLAFGLYGAFLSAHLVAQSLFAYLEHRRVTVAARRAFAKGPLDAATARSVA
                     LTISAYQEDPTYLRQCLTSARALLYPRTRLRVLMVVDGNRAEDLYMVDMFREVFADED
                     PATYVWDGNYHQPWEPAEAAGAVGEGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWG
                     GKREVMYTAFKALGDSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRILN
                     PLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLGLYRNNLLQQFLEAWYNQKF
                     LGTHCTFGDDRHLTNRMLSMGYATKYTSRSRCYSETPSSFLRWLSQQTRWSKSYFREW
                     LYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLRLFYAGRPWALLWVLLCVQGVALAK
                     AAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLALVTMNQSGWGTSGRKKLAANYVPV
                     LPLALWALLLLGGLIRSVAQEVRADWSGPSRAAEAYHLAAGASAYVAYWVIMLTIYWV
                     GVRRLCRRRSGGYRVQV"
     exon            52..759
                     /gene="Has1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..985
                     /gene="Has1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1118
                     /gene="Has1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..2096
                     /gene="Has1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcaagtc ggaaaagaga aaatccagga ggacccacag ccatgagaca ggacatgcca
       61 aagccctcag aggcagcacg ttgctgctcc ggtctggcca ggcgggtgct cacgatcacc
      121 ttcgccctgc tcatcctggg cctcatgacc tgggcctacg cagcaggagt acctctggct
      181 tctgatccct atggcctcct ggcctttggg ctctatgggg cgttcctcag tgcgcaccta
      241 gtggcacaga gcctcttcgc ttacctggag caccgaaggg tgaccgtggc tgcgcggcgc
      301 gcttttgcga agggacccct ggatgcggcc actgcgcgca gcgtggcact caccatctca
      361 gcctaccagg aggaccccac ttacctgcgc cagtgcttga cctccgcgcg cgccttgctg
      421 tacccgcgca cgcggctgcg cgtgcttatg gttgtagacg gcaatcgcgc ggaggatctg
      481 tacatggtgg acatgttccg agaagtcttc gcagatgagg accctgccac ttatgtgtgg
      541 gatggcaact accatcagcc ttgggagcca gctgaggcgg cgggtgctgt gggtgaaggt
      601 gcctaccgcg aggtggaggc tgaggaccct gggcggctgg cggtagaggc gctggtgagg
      661 acccgcaggt gcgtgtgcgt ggctcagcgc tggggtggca agcgcgaagt catgtacacg
      721 gctttcaagg cactgggtga ctccgtggac tacgtgcagg tctgtgactc agacacaagg
      781 ttagacccca tggcactgct ggagcttgtg cgagtgctgg atgaagaccc ccgggtaggt
      841 gctgttggag gagatgtgag aatccttaac cctctggact cttgggtcag cttcttgagc
      901 agccttcgat actgggtagc cttcaatgtg gagcgagctt gtcagagcta ctttcactgt
      961 gtgtcctgca tcagtggtcc tctgggtcta tacagaaaca atctcctgca gcagttcctg
     1021 gaggcctggt acaaccagaa gttcctgggc acccactgca catttgggga tgacaggcac
     1081 ctcaccaacc gcatgcttag catgggctac gctaccaagt atacctcgcg ctccagatgc
     1141 tattcagaga cgccctcctc tttccttcgt tggctgagcc agcagacccg ctggtccaaa
     1201 tcttatttcc gagagtggct atacaacgcc ctgtggtggc accgccacca cgcgtggatg
     1261 acctatgaag cggtggtttc tggcctcttc cctttctttg tggctgccac ggtgctgagg
     1321 ctcttctatg cagggcgccc atgggctctg ctctgggtgc tgctctgcgt gcagggcgtg
     1381 gcactggcaa aggcagcctt tgcagcctgg ctgcgtggct gcctgcgcat ggtgctgctg
     1441 tcactctatg caccactcta catgtgcggc ctgctgcctg ccaagttcct ggcgttggtt
     1501 accatgaatc aaagtggttg gggcacctcg ggccggaaga aactggctgc taactatgta
     1561 cccgtgttgc ccctggcact ctgggctcta ctgctgcttg gaggcctgat ccgcagtgtg
     1621 gcccaggagg tcagagctga ctggagtggc ccatcacgag cagctgaagc ctaccacctt
     1681 gctgctgggg ccagtgccta tgtggcctac tgggtgataa tgttgactat ctattgggta
     1741 ggtgtaagga gactgtgcag acgtcggagc ggtggctacc gtgtccaagt atgagtctgg
     1801 gtatgaagat gcccctgagg gctgttaaaa gaggcaagag gagtccttat gaggtagccc
     1861 tggagccacg gatttcatgg ggactgagtt taccttcttt ttgaaaagag gaatcattac
     1921 agattcttca ctatggactg tattggaatt ctgacttctc ggtctctggg gaggggtaat
     1981 ttattgatca gggagtggga ttataggacc agggtcagaa ggcctctgct ttctccctgt
     2041 tgctatttaa tgtttgtact gtaagatata ataaaatttt ttaatttatt ttcttc
//
