LOCUS       NM_001025414            1957 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus histidyl-tRNA synthetase 1 (Hars1), mRNA.
ACCESSION   NM_001025414 XM_226008
VERSION     NM_001025414.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1957)
  AUTHORS   Abbott JA, Meyer-Schuman R, Lupo V, Feely S, Mademan I, Oprescu SN,
            Griffin LB, Alberti MA, Casasnovas C, Aharoni S, Basel-Vanagaite L,
            Zuchner S, De Jonghe P, Baets J, Shy ME, Espinos C, Demeler B,
            Antonellis A and Francklyn C.
  TITLE     Substrate interaction defects in histidyl-tRNA synthetase linked to
            dominant axonal peripheral neuropathy
  JOURNAL   Hum Mutat 39 (3), 415-432 (2018)
   PUBMED   29235198
REFERENCE   2  (bases 1 to 1957)
  AUTHORS   Xu Z, Wei Z, Zhou JJ, Ye F, Lo WS, Wang F, Lau CF, Wu J, Nangle LA,
            Chiang KP, Yang XL, Zhang M and Schimmel P.
  TITLE     Internally deleted human tRNA synthetase suggests evolutionary
            pressure for repurposing
  JOURNAL   Structure 20 (9), 1470-1477 (2012)
   PUBMED   22958643
REFERENCE   3  (bases 1 to 1957)
  AUTHORS   Pierce SB, Chisholm KM, Lynch ED, Lee MK, Walsh T, Opitz JM, Li W,
            Klevit RE and King MC.
  TITLE     Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause
            ovarian dysgenesis and sensorineural hearing loss of Perrault
            syndrome
  JOURNAL   Proc Natl Acad Sci U S A 108 (16), 6543-6548 (2011)
   PUBMED   21464306
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097969.1.
            
            On Jul 15, 2005 this sequence version replaced XM_226008.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097969.1, SRR8487227.226877.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1957
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..1957
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /note="histidyl-tRNA synthetase 1"
                     /db_xref="GeneID:307492"
                     /db_xref="RGD:1310695"
     exon            1..108
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1545
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /EC_number="6.1.1.21"
                     /note="dead end homolog 1; histidyl-tRNA synthetase,
                     cytoplasmic"
                     /codon_start=1
                     /product="histidine--tRNA ligase, cytoplasmic"
                     /protein_id="NP_001020585.1"
                     /db_xref="GeneID:307492"
                     /db_xref="RGD:1310695"
                     /translation="MADRAALEELVRLQGAHVRGLKEQKASAEQIEEEVTKLLKLKAQ
                     LGHDEGKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKET
                     LTGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDN
                     PAMTRGRYREFYQCDFDIAGQFDPMIPDAECLKIMCEILSSLQIGNFQVKVNDRRILD
                     GMFAVCGVPDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGG
                     VSLVEQLLQDPKLSQNKQAVEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGV
                     IYEAVLLQMPTQAGEEPLGVGSIAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSI
                     VEQKLEASEEKVRTTETQVLVASAQKKLLEERLKLISELWDAGIKAELLYKKNPKLLN
                     QLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIRRRTSQPLSM
                     "
     exon            109..198
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /inference="alignment:Splign:2.1.0"
     exon            199..318
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /inference="alignment:Splign:2.1.0"
     exon            319..414
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /inference="alignment:Splign:2.1.0"
     exon            415..540
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /inference="alignment:Splign:2.1.0"
     exon            541..648
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /inference="alignment:Splign:2.1.0"
     exon            649..747
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /inference="alignment:Splign:2.1.0"
     exon            748..841
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /inference="alignment:Splign:2.1.0"
     exon            842..969
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1212
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1329
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1476
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1929
                     /gene="Hars1"
                     /gene_synonym="Dnd1; Hars"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccggttgg cagacaggat ggcagatcgt gctgcgctgg aggagctggt gcgactccag
       61 ggagcgcatg tgaggggcct taaggagcag aaagcgtccg ctgagcagat cgaggaggag
      121 gtgacgaaac tcctaaaact gaaggcacag ctgggccatg atgaaggcaa acagaagttc
      181 gtcctcaaaa cccccaaggg cacgagagac tatagtcccc ggcagatggc agtccgagaa
      241 aaggtgtttg atgtcatcat ccgctgtttc aaacgccatg gagcagaagt gatcgataca
      301 cctgtgtttg aactaaagga gacactaact ggaaaatacg gagaagactc aaagcttatc
      361 tatgacctga aggaccaggg tggggagctg ctgtccctcc gttatgacct cactgtccct
      421 tttgctcggt atctagcaat gaataaactg accaacatta aacgctacca catagcaaag
      481 gtgtatcgcc gggacaaccc agctatgacc cgaggccgtt accgtgaatt ctatcagtgt
      541 gattttgaca ttgctggaca gttcgacccc atgattcctg atgcagagtg cctaaagatt
      601 atgtgtgaga tcctgagttc acttcagatt ggcaacttcc aggtcaaggt aaatgatagg
      661 cgcatcctag acgggatgtt tgctgtctgt ggtgtccctg atagcaagtt ccgtaccatc
      721 tgctcctccg tggacaagct agacaaggtt tcctgggagg aagtgaagaa tgagatggtg
      781 ggagagaagg gcctcgcacc tgaagtggct gatcgcatcg gggactatgt ccagcagcat
      841 ggtggggtgt ctctggtgga acagttactc caggatccta aactctccca aaacaaacag
      901 gctgtagagg gcttgggaga cctaaagctg ctctttgagt atctaaccct atttggcatt
      961 gatgacaaga tctcctttga cttgagcctt gctcgagggc tggactacta cactggggtc
     1021 atctatgagg cagtgctgct acaaatgcca acccaagctg gggaagagcc cttgggtgtg
     1081 ggcagcatag ctgctggagg gcgctacgat ggactagtag gcatgtttga ccccaaaggg
     1141 cgcaaggtgc catgtgttgg gctcagtatt ggagtggaac ggatcttctc cattgtagag
     1201 caaaaattag aggcttcaga ggaaaaggtg cggaccacag agacgcaggt gcttgtggca
     1261 tctgcacaga agaagctgct ggaggagaga ctgaagctta tctcagagtt atgggatgct
     1321 gggatcaagg ctgagctgct gtacaagaag aacccaaagt tactgaacca gttgcagtac
     1381 tgtgaggaag caggcatccc actggtggcc atcattggtg agcaggagct taaggatggt
     1441 gtcatcaagc tccgttcagt gacgagcaga gaagaggtgg atgtccgaag agaagacctt
     1501 gtggaggaga tcagaagaag aacaagtcag cccctctcca tgtgatgaac tgagcaaact
     1561 agtggaagaa acaggattgg ccttaactga gctaaaacaa aactgcatat gtacttaaac
     1621 agtttggacg tttctgatcc agcagaagac tgaagggtgg tcagaacaga ggctttgtgg
     1681 ggggttgggg ttttttgttt ttgtttttta tcattattat tattattacg ttattatccg
     1741 taatcactgg caagaaatgg ctaggcacta cactttcctt gtgtggggga tggggtcaag
     1801 cagtatagtg gattaatcaa gtctctgcct cctaaactcc tgtttggact tgagatggct
     1861 tcattgaaaa gccacacctc agatgaacaa cctccggcca aaaattccaa taaacgtctc
     1921 tgccgctaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
