LOCUS       NM_019189               2191 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus hyaluronan and proteoglycan link protein 1
            (Hapln1), mRNA.
ACCESSION   NM_019189
VERSION     NM_019189.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2191)
  AUTHORS   Yan,T., Song,S., Sun,W. and Ge,Y.
  TITLE     HAPLN1 knockdown inhibits heart failure development via activating
            the PKA signaling pathway
  JOURNAL   BMC Cardiovasc Disord 24 (1), 197 (2024)
   PUBMED   38580957
  REMARK    GeneRIF: HAPLN1 knockdown inhibits heart failure development via
            activating the PKA signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2191)
  AUTHORS   Liu,H., Li,T., Ma,B., Wang,Y. and Sun,J.
  TITLE     Hyaluronan and Proteoglycan Link Protein 1 Activates the
            BMP4/Smad1/5/8 Signaling Pathway to Promote Osteogenic
            Differentiation: an Implication in Fracture Healing
  JOURNAL   Mol Biotechnol 65 (10), 1653-1663 (2023)
   PUBMED   36737556
  REMARK    GeneRIF: Hyaluronan and Proteoglycan Link Protein 1 Activates the
            BMP4/Smad1/5/8 Signaling Pathway to Promote Osteogenic
            Differentiation: an Implication in Fracture Healing.
REFERENCE   3  (bases 1 to 2191)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 2191)
  AUTHORS   Weingarten,J., Lassek,M., Mueller,B.F., Rohmer,M., Lunger,I.,
            Baeumlisberger,D., Dudek,S., Gogesch,P., Karas,M. and Volknandt,W.
  TITLE     The proteome of the presynaptic active zone from mouse brain
  JOURNAL   Mol Cell Neurosci 59, 106-118 (2014)
   PUBMED   24534009
REFERENCE   5  (bases 1 to 2191)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   6  (bases 1 to 2191)
  AUTHORS   Sun,G.W., Kobayashi,H., Suzuki,M., Kanayama,N. and Terao,T.
  TITLE     Follicle-stimulating hormone and insulin-like growth factor I
            synergistically induce up-regulation of cartilage link protein
            (Crtl1) via activation of phosphatidylinositol-dependent kinase/Akt
            in rat granulosa cells
  JOURNAL   Endocrinology 144 (3), 793-801 (2003)
   PUBMED   12586755
  REMARK    GeneRIF: study represents the first report that follicle
            stimulating hormone amplifies insulin-like growth factor-I-mediated
            cartilage link protein Crtl1 production, possibly via
            phosphatidylinositol 3-kinase-Akt signaling cascades in rat
            granulosa cells
REFERENCE   7  (bases 1 to 2191)
  AUTHORS   Watanabe,H. and Yamada,Y.
  TITLE     Mice lacking link protein develop dwarfism and craniofacial
            abnormalities
  JOURNAL   Nat Genet 21 (2), 225-229 (1999)
   PUBMED   9988279
REFERENCE   8  (bases 1 to 2191)
  AUTHORS   Rhodes,C., Doege,K., Sasaki,M. and Yamada,Y.
  TITLE     Alternative splicing generates two different mRNA species for rat
            link protein
  JOURNAL   J Biol Chem 263 (13), 6063-6067 (1988)
   PUBMED   2452158
REFERENCE   9  (bases 1 to 2191)
  AUTHORS   Doege,K., Hassell,J.R., Caterson,B. and Yamada,Y.
  TITLE     Link protein cDNA sequence reveals a tandemly repeated protein
            structure
  JOURNAL   Proc Natl Acad Sci U S A 83 (11), 3761-3765 (1986)
   PUBMED   3459153
REFERENCE   10 (bases 1 to 2191)
  AUTHORS   Neame,P.J., Christner,J.E. and Baker,J.R.
  TITLE     The primary structure of link protein from rat chondrosarcoma
            proteoglycan aggregate
  JOURNAL   J Biol Chem 261 (8), 3519-3535 (1986)
   PUBMED   2419334
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC128740.1.
            
            On Dec 17, 2006 this sequence version replaced NM_019189.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2191
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..2191
                     /gene="Hapln1"
                     /gene_synonym="Crtl1"
                     /note="hyaluronan and proteoglycan link protein 1"
                     /db_xref="GeneID:29331"
                     /db_xref="RGD:2412"
     exon            1..49
                     /gene="Hapln1"
                     /gene_synonym="Crtl1"
                     /inference="alignment:Splign:2.1.0"
     exon            50..173
                     /gene="Hapln1"
                     /gene_synonym="Crtl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1138
                     /gene="Hapln1"
                     /gene_synonym="Crtl1"
                     /note="LP; proteoglycan link protein; cartilage-link
                     protein; cartilage-linking protein 1; cartilage link
                     protein 1"
                     /codon_start=1
                     /product="hyaluronan and proteoglycan link protein 1
                     precursor"
                     /protein_id="NP_062062.2"
                     /db_xref="GeneID:29331"
                     /db_xref="RGD:2412"
                     /translation="MRSLLFLVLISVCRADHLSDSYTPDQDRVIHIQAENGPRLLVEA
                     EQAKVFSHRGGNVTLPCKFYRDPTAFGSGIHKIRIKWTKLTSDYLREVDVFVSMGYHK
                     KTYGGYQGRVFLKGGSDNDASLIITDLTLEDYGRYKCEVIEGLEDDTAVVALELQGVV
                     FPYFPRLGRYNLNFHEACQACLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYP
                     ITKPREPCGGQNTVPGVRNYGFWDKDKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAV
                     QACLNDGAQIAKVGQIFAAWKLLGYDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRF
                     VGFPDKKHKLYGVYCFRAYN"
     exon            174..545
                     /gene="Hapln1"
                     /gene_synonym="Crtl1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..848
                     /gene="Hapln1"
                     /gene_synonym="Crtl1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..2156
                     /gene="Hapln1"
                     /gene_synonym="Crtl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcccagcta agtgggactc gaagcttctg aactggaatt caggacaagc agagaggagt
       61 ctgagctaca aggatgagaa gtctactttt cctggtgctg atttcagtct gtcgggctga
      121 ccacctttca gacagctaca ctccggatca agacagagtt attcacatcc aagctgaaaa
      181 tggcccccgt ctacttgtgg aagcagaaca agccaaggtc ttctcgcaca gaggtggcaa
      241 cgtgacactg ccatgtaaat tttatcgaga ccctacagca tttggctcgg gaatccacaa
      301 aatccgcatt aagtggacca agctaacttc agattacctc agggaagtgg atgtcttcgt
      361 ttccatgggc tatcacaaga aaacctacgg aggttatcaa ggccgagtgt ttctgaaggg
      421 aggcagtgat aatgacgcct ccctgatcat cacagatctc accctggagg attatggaag
      481 atataagtgt gaggtgattg aaggactaga agatgatact gctgtggtgg cattagagtt
      541 acaaggtgtg gtgttccctt actttccacg attgggacgc tacaatctta actttcacga
      601 ggcttgccag gcttgtctgg accaggatgc tgtgattgct tccttcgacc agctgtacga
      661 tgcctggcgg ggcgggctgg attggtgcaa tgctggctgg ctcagtgacg gatctgtgca
      721 gtacccaatc accaaaccac gtgagccctg cgggggccaa aacaccgtgc ctggagtcag
      781 gaactacggg ttctgggaca aggataagag cagatatgat gttttctgtt tcacatccaa
      841 cttcaatggc cgattttact acctgatcca ccccaccaag cttacctacg acgaagcagt
      901 gcaagcttgt ctcaatgatg gtgctcagat tgcgaaagtg ggtcagatat ttgctgcctg
      961 gaagcttctg ggctatgacc gctgcgatgc cggatggctg gcggatggca gtgtccgcta
     1021 ccctatttct cggccaagac ggcgctgtag tccgacagag gctgcagtgc gctttgtggg
     1081 tttcccagat aaaaagcata agctgtacgg ggtctattgc ttccgagcat acaactgagt
     1141 gtgccctgga gtcagttctc gagatacgtg aaagttttgt tcgtttgttt tttgttttta
     1201 atatgaactc atgcaagtta ccaaaactgt gataaccctt tttcacttac tgtaaagagt
     1261 cgttttcata aaggccaatt cattcatttg ttttgtaaag ctatcagtcg atatatatta
     1321 taaattaata taagcatagg ggagctaaaa aagaggggga ggggctttag agcctaactg
     1381 gtttatgcta tgtcatccca acaagatgtc atttcatgaa agggacatgc tgcaggctga
     1441 cagtcaccag gactgtatta ggaaaattaa tgctacttgc cgaagtaact tccacaagca
     1501 caaattttac atatttctac aattttgaaa tgcacttcac taaacaaatt agaacaacga
     1561 atttgaaata caggcttctt tacataaacc aggattctgg gaggtgcaaa aactcagtat
     1621 cataagggaa taacagagac tttttctaaa agttaatact tcaagtctcc agtatacaga
     1681 atagtttact ctttaaaaat ctaccttttt gaccaaaaaa attcatagag actcagatta
     1741 aaattaaaaa ccacggttag atctcctagg tcaactcctt tatataaagt atcgacttaa
     1801 gtacacagat aatactttat caatgaaaga atcctacctt ctaattacaa ttacctatct
     1861 gagaagactt gttttattat ttttaagtag ctttactgaa ttatatttaa attctaagaa
     1921 actttgctaa gcagtattta gaatctactc agggcagtta aaatagtaaa ctgctggaca
     1981 gaaaacaagt acaatgtagc agcttgactt tatgttagtg tatgaaacat tattgtccta
     2041 taaaagtaat tttaatctat ttaatatttc ttatttacat tacatgacaa aagccatcaa
     2101 atgaatgaat aactctacat ttgcctaact aagaaataaa gactcaactt ccaaaaaaaa
     2161 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
