LOCUS       NM_001107780            1527 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hydroxyacid oxidase 1 (Hao1), mRNA.
ACCESSION   NM_001107780 XM_001081256 XM_230613
VERSION     NM_001107780.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1527)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   2  (bases 1 to 1527)
  AUTHORS   Pennati,A. and Gadda,G.
  TITLE     Involvement of ionizable groups in catalysis of human liver
            glycolate oxidase
  JOURNAL   J Biol Chem 284 (45), 31214-31222 (2009)
   PUBMED   19758989
  REMARK    GeneRIF: The turnover of the enzyme and the rate constant for
            flavin were pH-independent, suggesting the involvement of an
            unprotonated group acting as a base in the chemical step of
            glycolate oxidation.
REFERENCE   3  (bases 1 to 1527)
  AUTHORS   Murray,M.S., Holmes,R.P. and Lowther,W.T.
  TITLE     Active site and loop 4 movements within human glycolate oxidase:
            implications for substrate specificity and drug design
  JOURNAL   Biochemistry 47 (8), 2439-2449 (2008)
   PUBMED   18215067
REFERENCE   4  (bases 1 to 1527)
  AUTHORS   Vignaud,C., Pietrancosta,N., Williams,E.L., Rumsby,G. and
            Lederer,F.
  TITLE     Purification and characterization of recombinant human liver
            glycolate oxidase
  JOURNAL   Arch Biochem Biophys 465 (2), 410-416 (2007)
   PUBMED   17669354
REFERENCE   5  (bases 1 to 1527)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   6  (bases 1 to 1527)
  AUTHORS   Recalcati,S., Tacchini,L., Alberghini,A., Conte,D. and Cairo,G.
  TITLE     Oxidative stress-mediated down-regulation of rat hydroxyacid
            oxidase 1, a liver-specific peroxisomal enzyme
  JOURNAL   Hepatology 38 (5), 1159-1166 (2003)
   PUBMED   14578854
  REMARK    GeneRIF: Down-regulation of Hao1 during oxidative stress may
            provide mechanism to prevent excessive H2O2 formation in liver
            peroxisomes. May be prototype of response to oxidative injury
            involving down-regulation of reactive oxygen species-producing
            enzymes.
REFERENCE   7  (bases 1 to 1527)
  AUTHORS   Jones,J.M., Morrell,J.C. and Gould,S.J.
  TITLE     Identification and characterization of HAOX1, HAOX2, and HAOX3,
            three human peroxisomal 2-hydroxy acid oxidases
  JOURNAL   J Biol Chem 275 (17), 12590-12597 (2000)
   PUBMED   10777549
REFERENCE   8  (bases 1 to 1527)
  AUTHORS   Szymanska,M.
  TITLE     [Evaluation of the usefulness of vitrectomy in the treatment of
            proliferative diabetic retinopathy]
  JOURNAL   Klin Oczna 94 (7-8), 197-198 (1992)
   PUBMED   1300399
REFERENCE   9  (bases 1 to 1527)
  AUTHORS   Duley,J. and Holmes,R.S.
  TITLE     Alpha-hydroxyacid oxidase genetics in the mouse: evidence for two
            genetic loci and a tetrameric subunit structure for the liver
            isozyme
  JOURNAL   Genetics 76 (1), 93-97 (1974)
   PUBMED   4818266
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158804.1.
            
            On Jan 27, 2008 this sequence version replaced NM_001107780.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1527
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1527
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; HAOX1; XDH1"
                     /note="hydroxyacid oxidase 1"
                     /db_xref="GeneID:311446"
                     /db_xref="RGD:1589750"
     exon            1..151
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; HAOX1; XDH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1127
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; HAOX1; XDH1"
                     /EC_number="1.1.3.15"
                     /EC_number="1.2.3.5"
                     /note="glycolate oxidase; hydroxyacid oxidase 1, liver;
                     hydroxyacid oxidase (glycolate oxidase) 1; glyoxylate
                     oxidase"
                     /codon_start=1
                     /product="2-Hydroxyacid oxidase 1"
                     /protein_id="NP_001101250.1"
                     /db_xref="GeneID:311446"
                     /db_xref="RGD:1589750"
                     /translation="MLPRLVCISDYEQHARTVLQKSVYDYYKSGANDQETLADNIRAF
                     SRWKLYPRMLRNVADIDLSTSVLGQRVSMPICVGATAMQCMAHVDGELATVRACQTMG
                     TGMMLSSWATSSIEEVAEAGPEALRWMQLYIYKDREVSSQLVKRAEQMGYKAIFVTVD
                     TPYLGNRFDDVRNRFKLPPQLRMKNFETNDLAFSPKGNFGDNSGLAEYVAQAIDPSLS
                     WDDIKWLRRLTSLPIVVKGILRGDDAQEAVKHGVDGILVSNHGARQLDGVPATIDALP
                     EIVEAVEGKVEVFLDGGVRKGTDVLKALALGARAVFVGRPIIWGLAFQGEKGVQDVLE
                     ILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI"
     exon            152..303
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; HAOX1; XDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..559
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; HAOX1; XDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..735
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; HAOX1; XDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..827
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; HAOX1; XDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..986
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; HAOX1; XDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1056
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; HAOX1; XDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1498
                     /gene="Hao1"
                     /gene_synonym="GOX; Gox1; HAOX1; XDH1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catcccctga cacaatgttg cctcggctgg tctgcatcag tgactatgaa cagcatgccc
       61 ggacagtgct tcagaagtca gtatatgatt attacaagtc tggggcaaat gaccaggaga
      121 ctttggctga taatatcaga gcattttcta ggtggaagct ctatccacgg atgctgcgca
      181 acgttgctga tatcgacctg tcgacttctg ttttaggaca gagagtgagc atgccaatat
      241 gcgttggggc tacggctatg cagtgcatgg ctcatgtgga tggggagctg gccactgttc
      301 gagcctgtca gaccatggga actggcatga tgttgagttc ctgggccact tcctcaatag
      361 aagaggtggc agaggctggc ccggaggcac ttcgctggat gcaactctac atctacaaag
      421 atcgtgaggt cagcagtcag ctagtgaaga gggctgagca gatgggttac aaggccatat
      481 ttgtgactgt ggacacccct tacctgggaa atcgcttcga tgatgtgcgg aacaggttca
      541 agctaccacc acagctcagg atgaaaaact ttgaaaccaa cgatttggca ttttctccta
      601 aggggaattt tggagacaac agtggccttg ctgaatatgt ggcacaagcc atagacccat
      661 ctctcagctg ggatgatatt aaatggctca gacggttgac ctcactgccc attgttgtaa
      721 agggaatttt gagaggtgat gatgcccagg aagctgttaa acatggtgtg gatgggatct
      781 tagtgtcgaa tcatggggca cgacaactgg atggggtgcc agctactatt gatgccctgc
      841 cagagatcgt tgaggctgtg gaagggaagg tagaagtctt cctggatggg ggagtcagga
      901 aaggcaccga tgttctcaaa gctctggccc tgggagccag agctgttttt gtggggagac
      961 ccatcatctg gggcttggct ttccaggggg agaaaggtgt tcaagatgtc ctcgagatac
     1021 tgaaggaaga gttccggctg gccatggctc tgagtgggtg ccagaatgtg aaagtcatcg
     1081 acaagacatt ggtgaggaaa aatcctttgg ctgtttccaa gatctgacag tgcacaatat
     1141 tttcccatct gtattatttt tttccagcat ggattacttg acaaagagac actgtgcaga
     1201 gggtgaccac agactgtaac tccccacttc aacacaaagg gtgtcgttct tttccaacaa
     1261 aatagccacc ccttctcctt cattgctttt gacttttcaa tgggtgtcct aggaaccttc
     1321 tagaaagaaa tggacttgca tcctggaaat atattaactg ttaaaaagaa aacattgaaa
     1381 atgtgtttgg gcaacgtcat cccctggcag gctaaagtga gggggaacaa aagatatcct
     1441 ctggtgagat tggaggtagc atgccgaagt aaaagacact gacctcactg tttattaaaa
     1501 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
