LOCUS       NM_022696               1948 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus heart and neural crest derivatives expressed 2
            (Hand2), mRNA.
ACCESSION   NM_022696 XM_008771238 XM_579461
VERSION     NM_022696.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1948)
  AUTHORS   Dirkx,E., Gladka,M.M., Philippen,L.E., Armand,A.S., Kinet,V.,
            Leptidis,S., El Azzouzi,H., Salic,K., Bourajjaj,M., da Silva,G.J.,
            Olieslagers,S., van der Nagel,R., de Weger,R., Bitsch,N.,
            Kisters,N., Seyen,S., Morikawa,Y., Chanoine,C., Heymans,S.,
            Volders,P.G., Thum,T., Dimmeler,S., Cserjesi,P., Eschenhagen,T., da
            Costa Martins,P.A. and De Windt,L.J.
  TITLE     Nfat and miR-25 cooperate to reactivate the transcription factor
            Hand2 in heart failure
  JOURNAL   Nat Cell Biol 15 (11), 1282-1293 (2013)
   PUBMED   24161931
REFERENCE   2  (bases 1 to 1948)
  AUTHORS   Bjorck,H.M., Renner,J., Maleki,S., Nilsson,S.F., Kihlberg,J.,
            Folkersen,L., Karlsson,M., Ebbers,T., Eriksson,P. and Lanne,T.
  TITLE     Characterization of shear-sensitive genes in the normal rat aorta
            identifies Hand2 as a major flow-responsive transcription factor
  JOURNAL   PLoS One 7 (12), e52227 (2012)
   PUBMED   23284944
  REMARK    GeneRIF: HAND2 protein was endothelial specific and showed higher
            expression in the regions exposed to low WSS with disturbed flow.
REFERENCE   3  (bases 1 to 1948)
  AUTHORS   Barnes,R.M., Firulli,B.A., VanDusen,N.J., Morikawa,Y., Conway,S.J.,
            Cserjesi,P., Vincentz,J.W. and Firulli,A.B.
  TITLE     Hand2 loss-of-function in Hand1-expressing cells reveals distinct
            roles in epicardial and coronary vessel development
  JOURNAL   Circ Res 108 (8), 940-949 (2011)
   PUBMED   21350214
REFERENCE   4  (bases 1 to 1948)
  AUTHORS   Pellegrino,M.J., Parrish,D.C., Zigmond,R.E. and Habecker,B.A.
  TITLE     Cytokines inhibit norepinephrine transporter expression by
            decreasing Hand2
  JOURNAL   Mol Cell Neurosci 46 (3), 671-680 (2011)
   PUBMED   21241805
  REMARK    GeneRIF: These data suggest that cytokines can inhibit
            norepinephrine transporter expression through downregulation of
            Hand2 or Gata3 in cultured sympathetic neurons, but axotomy in
            adult animals selectively suppresses Hand2 expression.
REFERENCE   5  (bases 1 to 1948)
  AUTHORS   Holler,K.L., Hendershot,T.J., Troy,S.E., Vincentz,J.W.,
            Firulli,A.B. and Howard,M.J.
  TITLE     Targeted deletion of Hand2 in cardiac neural crest-derived cells
            influences cardiac gene expression and outflow tract development
  JOURNAL   Dev Biol 341 (1), 291-304 (2010)
   PUBMED   20144608
REFERENCE   6  (bases 1 to 1948)
  AUTHORS   Poizat,C., Sartorelli,V., Chung,G., Kloner,R.A. and Kedes,L.
  TITLE     Proteasome-mediated degradation of the coactivator p300 impairs
            cardiac transcription
  JOURNAL   Mol Cell Biol 20 (23), 8643-8654 (2000)
   PUBMED   11073966
REFERENCE   7  (bases 1 to 1948)
  AUTHORS   Russell,M.W., Kemp,P., Wang,L., Brody,L.C. and Izumo,S.
  TITLE     Molecular cloning of the human HAND2 gene
  JOURNAL   Biochim Biophys Acta 1443 (3), 393-399 (1998)
   PUBMED   9878849
REFERENCE   8  (bases 1 to 1948)
  AUTHORS   Thomas,T., Kurihara,H., Yamagishi,H., Kurihara,Y., Yazaki,Y.,
            Olson,E.N. and Srivastava,D.
  TITLE     A signaling cascade involving endothelin-1, dHAND and msx1
            regulates development of neural-crest-derived branchial arch
            mesenchyme
  JOURNAL   Development 125 (16), 3005-3014 (1998)
   PUBMED   9671575
REFERENCE   9  (bases 1 to 1948)
  AUTHORS   Thomas,T., Yamagishi,H., Overbeek,P.A., Olson,E.N. and
            Srivastava,D.
  TITLE     The bHLH factors, dHAND and eHAND, specify pulmonary and systemic
            cardiac ventricles independent of left-right sidedness
  JOURNAL   Dev Biol 196 (2), 228-236 (1998)
   PUBMED   9576835
REFERENCE   10 (bases 1 to 1948)
  AUTHORS   Srivastava,D., Thomas,T., Lin,Q., Kirby,M.L., Brown,D. and
            Olson,E.N.
  TITLE     Regulation of cardiac mesodermal and neural crest development by
            the bHLH transcription factor, dHAND
  JOURNAL   Nat Genet 16 (2), 154-160 (1997)
   PUBMED   9171826
  REMARK    Erratum:[Nat Genet 1997 Aug;16(4):410]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 5, 2021 this sequence version replaced NM_022696.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM385750.1, Y08138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1471              JAXUCZ010000016.1  37930018-37931488   c
            1472-1948           JAXUCZ010000016.1  37928145-37928621   c
FEATURES             Location/Qualifiers
     source          1..1948
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p11"
     gene            1..1948
                     /gene="Hand2"
                     /note="heart and neural crest derivatives expressed 2"
                     /db_xref="GeneID:64637"
                     /db_xref="RGD:621207"
     exon            1..1471
                     /gene="Hand2"
                     /inference="alignment:Splign:2.1.0"
     CDS             917..1570
                     /gene="Hand2"
                     /note="deciduum, heart, autonomic nervous system and
                     neural crest derivatives-expressed protein 2; dHand
                     protein; heart and neural crest derivatives expressed
                     transcript 2; heart- and neural crest
                     derivatives-expressed protein 2-like"
                     /codon_start=1
                     /product="heart- and neural crest derivatives-expressed
                     protein 2"
                     /protein_id="NP_073187.1"
                     /db_xref="GeneID:64637"
                     /db_xref="RGD:621207"
                     /translation="MSLVGGFPHHPVVHHEGYPFAAAAAAAAAAAASRCSHEENPYFH
                     GWLIGHPEMSPPDYSMALSYSPEYASGAAGLDHSHYGGVPPGAGPPGLGGPRPVKRRG
                     TANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQ
                     NGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKTKGRTGWPQHVWALELKQ"
     exon            1472..1948
                     /gene="Hand2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgtacat ggagatctgg ctgggaaaat ctgcttgctc ccctcaccgc gtccagccca
       61 ggagaacagc cgccgccact cgggagcttg ccgggccact gtgcacaccc ctccgagagt
      121 ccattcgccg cttcccagct ccgaggcgcc ttcaggggcc caagattctt gtcgcgaaag
      181 gagaggatct tagaaaatgg atgcgctgag acctctctgc aaagcctccg agagagcctg
      241 agaggagcga ggacggacac gttactcgca gctttaaaaa caaatcacac tcaaggacca
      301 aaacaacaac caaataattt ttattaaaac aataagcgcc caagaaccca cgagctggtg
      361 gggggagggg aaggggcggg aaggggaggg tcgcacggag gtagctccac gctgagtagc
      421 gaccccaccg cctcccggca cagccgtgcc ggctcctcaa gccccggctc ggactcgccc
      481 gggataccag gtcagcttcg gagtcaggag tcccgcgccc ggcatctacc ggacagcctc
      541 gccggagccg gccggcactt ttgcatgagc accggagcgc tccgcctggt cgcggcagcg
      601 gggaaagccg gagccagcgc gcgggctgta gagccgggcg ggcggaggcg gcggccaagg
      661 gcgcacggtg ccgggaccag ctcgccgcgc cccatgggga accggcggcc gcggcacagc
      721 tgaggcgggc cccgcgggcc aggcgcgggc cccgggctac agcggccccc tctgcggctg
      781 cagggccggc ccgggagccc gggggttggg gggtgggggg tgggggaggc cgccgatcgc
      841 cgaggccgga gcccgatcgg agggcacggc ggggctgcgc gcacgctggg gcgcgtggag
      901 ggccacggaa ggcgagatga gtctggtggg gggctttccc caccaccccg tggtgcacca
      961 tgagggctac ccgttcgccg cagccgcagc cgccgctgct gctgccgccg ccagccgctg
     1021 cagtcacgag gagaacccct atttccacgg ctggcttatt ggccacccgg agatgtcgcc
     1081 ccccgactac agcatggccc tgtcctacag tcccgagtac gccagcggtg ccgcgggcct
     1141 ggaccactcc cattatgggg gagtgccgcc cggtgccggg cctcccggcc tgggggggcc
     1201 gcgcccggtg aagcgtcggg gcaccgccaa ccgcaaggag cggcgcagga ctcagagcat
     1261 caacagcgcc ttcgccgagc tgcgcgagtg catccccaac gtgcccgccg acaccaaact
     1321 ctccaaaatc aagacactgc gcctggccac cagctacatc gcctacctca tggatctgct
     1381 ggccaaggac gaccagaacg gagaggcgga ggccttcaag gcggagatca agaagaccga
     1441 cgtgaaagag gagaagagga agaaagagct gaatgaaatc ttgaaaagta cagtgagcag
     1501 caacgacaag aaaaccaaag gccggacagg ctggccacag cacgtctggg ccctggagct
     1561 caagcagtga cgaagaggag agctagtgag ccgggggcca aggcgccaga tgctgaccca
     1621 ggactccccg aaagcccttg gtctctgttc tgaggacttc ttgcagttgg atcatccggt
     1681 ttatttatgt gcaatttcct tttccctctt tctgcccccc ccccaacctt tgaggcatct
     1741 gctccccacc tccctctcaa aaaaaagtgg atatttgaag aaaagcattc catattttaa
     1801 tatgaagagg acactcccgt gtggtaaggg accccgtcat tctgtgtgtg tgaatgttcc
     1861 ctcttggctg tgtagacacc agcgttatcc cccccccgcc cctttaccca actctttcca
     1921 gataaaaaaa aagtggacac tagtgcat
//
