LOCUS       NM_021592               1102 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus heart and neural crest derivatives expressed 1
            (Hand1), mRNA.
ACCESSION   NM_021592
VERSION     NM_021592.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1102)
  AUTHORS   Hu,D., Scott,I.C., Snider,F., Geary-Joo,C., Zhao,X., Simmons,D.G.
            and Cross,J.C.
  TITLE     The basic helix-loop-helix transcription factor Hand1 regulates
            mouse development as a homodimer
  JOURNAL   Dev Biol 382 (2), 470-481 (2013)
   PUBMED   23911935
REFERENCE   2  (bases 1 to 1102)
  AUTHORS   Reamon-Buettner,S.M., Ciribilli,Y., Traverso,I., Kuhls,B., Inga,A.
            and Borlak,J.
  TITLE     A functional genetic study identifies HAND1 mutations in septation
            defects of the human heart
  JOURNAL   Hum Mol Genet 18 (19), 3567-3578 (2009)
   PUBMED   19586923
REFERENCE   3  (bases 1 to 1102)
  AUTHORS   Omoteyama,K. and Takagi,M.
  TITLE     FGF8 regulates myogenesis and induces Runx2 expression and
            osteoblast differentiation in cultured cells
  JOURNAL   J Cell Biochem 106 (4), 546-552 (2009)
   PUBMED   19170063
  REMARK    GeneRIF: Foxc2 is directly involved in the regulation of Hand1
            expression.
REFERENCE   4  (bases 1 to 1102)
  AUTHORS   Funato,N., Chapman,S.L., McKee,M.D., Funato,H., Morris,J.A.,
            Shelton,J.M., Richardson,J.A. and Yanagisawa,H.
  TITLE     Hand2 controls osteoblast differentiation in the branchial arch by
            inhibiting DNA binding of Runx2
  JOURNAL   Development 136 (4), 615-625 (2009)
   PUBMED   19144722
REFERENCE   5  (bases 1 to 1102)
  AUTHORS   Reamon-Buettner,S.M., Ciribilli,Y., Inga,A. and Borlak,J.
  TITLE     A loss-of-function mutation in the binding domain of HAND1 predicts
            hypoplasia of the human hearts
  JOURNAL   Hum Mol Genet 17 (10), 1397-1405 (2008)
   PUBMED   18276607
REFERENCE   6  (bases 1 to 1102)
  AUTHORS   Riley,P.R., Gertsenstein,M., Dawson,K. and Cross,J.C.
  TITLE     Early exclusion of hand1-deficient cells from distinct regions of
            the left ventricular myocardium in chimeric mouse embryos
  JOURNAL   Dev Biol 227 (1), 156-168 (2000)
   PUBMED   11076684
REFERENCE   7  (bases 1 to 1102)
  AUTHORS   Firulli,B.A., Hadzic,D.B., McDaid,J.R. and Firulli,A.B.
  TITLE     The basic helix-loop-helix transcription factors dHAND and eHAND
            exhibit dimerization characteristics that suggest complex
            regulation of function
  JOURNAL   J Biol Chem 275 (43), 33567-33573 (2000)
   PUBMED   10924525
REFERENCE   8  (bases 1 to 1102)
  AUTHORS   Riley,P., Anson-Cartwright,L. and Cross,J.C.
  TITLE     The Hand1 bHLH transcription factor is essential for placentation
            and cardiac morphogenesis
  JOURNAL   Nat Genet 18 (3), 271-275 (1998)
   PUBMED   9500551
REFERENCE   9  (bases 1 to 1102)
  AUTHORS   Firulli,A.B., McFadden,D.G., Lin,Q., Srivastava,D. and Olson,E.N.
  TITLE     Heart and extra-embryonic mesodermal defects in mouse embryos
            lacking the bHLH transcription factor Hand1
  JOURNAL   Nat Genet 18 (3), 266-270 (1998)
   PUBMED   9500550
REFERENCE   10 (bases 1 to 1102)
  AUTHORS   Oude Elferink,R.P., Ottenhoff,R., van Wijland,M., Smit,J.J.,
            Schinkel,A.H. and Groen,A.K.
  TITLE     Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the
            mouse
  JOURNAL   J Clin Invest 95 (1), 31-38 (1995)
   PUBMED   7814632
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097324.1.
            
            On Jun 12, 2005 this sequence version replaced NM_021592.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097324.1, Y08140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132301, SAMD00132304
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1102
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1102
                     /gene="Hand1"
                     /gene_synonym="eHand"
                     /note="heart and neural crest derivatives expressed 1"
                     /db_xref="GeneID:59112"
                     /db_xref="RGD:621206"
     exon            1..753
                     /gene="Hand1"
                     /gene_synonym="eHand"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..861
                     /gene="Hand1"
                     /gene_synonym="eHand"
                     /note="extraembryonic tissues, heart, autonomic nervous
                     system and neural crest derivatives-expressed protein 1;
                     heart and neural crest derivatives expressed transcript 1"
                     /codon_start=1
                     /product="heart- and neural crest derivatives-expressed
                     protein 1"
                     /protein_id="NP_067603.1"
                     /db_xref="GeneID:59112"
                     /db_xref="RGD:621206"
                     /translation="MNLVGSYAHHHHHHHSHPPHPMLHEPFLFGPASRCHQERPYFQS
                     WLLSPADAAPDFPAGGPPPTTAVAAAAYGPDARPSQSPGRLEALGGRLPRRKGSGPKK
                     ERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQAGDPE
                     AFKAELKKTDGGRESKRKRESPQQHEGLPPALGPSEKRIKGRTGWPQQVWALELNQ"
     exon            754..1073
                     /gene="Hand1"
                     /gene_synonym="eHand"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgctcttt ggaaatccga acccttctct ctcgctgcct acagaaacct tcaagaagtc
       61 cgcaggtcct tcgtgtcatc tccagccttg ctcaggactc ctccaaaacc cagccaattc
      121 gctgcattgg agcccacggt gacccccttc tgtggggcgc atggggcggt gctaattggg
      181 ctggcagcac aggccaggag gctctccaac atgaacctcg tgggcagcta cgcacaccat
      241 caccaccatc accactcaca cccgccgcac cccatgctgc acgaaccctt cctctttggt
      301 ccggcctcgc gttgccacca ggagcggcct tacttccaga gctggctgct gagcccggct
      361 gatgctgccc cagatttccc tgccggcggg ccaccaccta ccaccgcagt agcagcggct
      421 gcctatggtc ccgatgccag gccgagtcag agcccaggtc ggctggaggc tcttggaggc
      481 cgcctgccca ggcgaaaagg ttcaggaccc aaaaaggagc ggaggcgcac agagagcatt
      541 aacagtgcgt tcgcggagct gcgtgagtgc atccccaatg tgcctgcgga caccaagctc
      601 tccaagatca agactctgcg cctggccacc agctacatcg cctacttgat ggacgtgctg
      661 gccaaggatg cacaagcagg tgaccccgag gccttcaagg ctgaactaaa aaagacggat
      721 ggcggtcgcg aaagcaagcg gaaaagggag tcgcctcagc agcacgaagg ccttcctcct
      781 gccctggggc caagcgagaa gaggattaaa ggacgcactg gctggcctca gcaagtctgg
      841 gcgctggagc taaatcagtg agaagaggcc ggcaccgagg acccggccaa ggctggccca
      901 cctggctatc cggagaggag agggcaggac gcagcggcca cggcaagtct ccgggtaccc
      961 gcgcgcgtct tgcccagtct ctgcgagcgc cggcgggtcg gcggttgcaa ctacccacta
     1021 gaatcgcacg tgcaatgtca tttgaatttg ttaatacata agagaaagag aaaaaaaaaa
     1081 aaaaaaaaaa aaaaaaaaaa aa
//
