LOCUS       NM_053469                360 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus hepcidin antimicrobial peptide (Hamp), mRNA.
ACCESSION   NM_053469
VERSION     NM_053469.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 360)
  AUTHORS   Flores,S.R.L., Nelson,S., Woloshun,R.R., Wang,X., Ha,J.H.,
            Lee,J.K., Yu,Y., Merlin,D. and Collins,J.F.
  TITLE     Intestinal iron absorption is appropriately modulated to match
            physiological demand for iron in wild-type and iron-loaded Hamp
            (hepcidin) knockout rats during acute colitis
  JOURNAL   PLoS One 16 (6), e0252998 (2021)
   PUBMED   34143808
  REMARK    GeneRIF: Intestinal iron absorption is appropriately modulated to
            match physiological demand for iron in wild-type and iron-loaded
            Hamp (hepcidin) knockout rats during acute colitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 360)
  AUTHORS   Pourmohammad,P., Alipanah-Moghadam,R., Nemati,A., Malekzadeh,V. and
            Mahmoodzadeh,Y.
  TITLE     Comparison of the effects of zinc oxide and zinc oxide
            nanoparticles on the expression of hepcidin gene in rat liver
  JOURNAL   Horm Mol Biol Clin Investig 42 (1), 43-48 (2020)
   PUBMED   33544508
  REMARK    GeneRIF: Comparison of the effects of zinc oxide and zinc oxide
            nanoparticles on the expression of hepcidin gene in rat liver.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 360)
  AUTHORS   Huang,Y., Zhang,H., Wang,C., Zhou,J., Li,Y. and Hu,C.
  TITLE     DNA methylation suppresses liver Hamp expression in response to
            iron deficiency after bariatric surgery
  JOURNAL   Surg Obes Relat Dis 16 (1), 109-118 (2020)
   PUBMED   31839527
  REMARK    GeneRIF: DNA methylation suppresses liver Hamp expression in
            response to iron deficiency after bariatric surgery.
REFERENCE   4  (bases 1 to 360)
  AUTHORS   Liu,J., Wan,M., Zhang,Y., Zhang,S., Zhang,H. and Wu,S.
  TITLE     Dysfunction of Iron Metabolism and Iron-Regulatory Proteins in the
            Rat Hippocampus After Heat Stroke
  JOURNAL   Shock 51 (6), 780-786 (2019)
   PUBMED   29757912
  REMARK    GeneRIF: ata thereby indicate that heat stroke can decrease
            learning ability and memory in rats. The mechanism may be related
            to changes of iron levels, as well as Fpn1 and hepcidin expression,
            in the hippocampus.
REFERENCE   5  (bases 1 to 360)
  AUTHORS   Marmur,J., Beshara,S., Eggertsen,G., Onelov,L., Albiin,N.,
            Danielsson,O., Hultcrantz,R. and Stal,P.
  TITLE     Hepcidin levels correlate to liver iron content, but not
            steatohepatitis, in non-alcoholic fatty liver disease
  JOURNAL   BMC Gastroenterol 18 (1), 78 (2018)
   PUBMED   29871592
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 360)
  AUTHORS   Nicolas,G., Bennoun,M., Devaux,I., Beaumont,C., Grandchamp,B.,
            Kahn,A. and Vaulont,S.
  TITLE     Lack of hepcidin gene expression and severe tissue iron overload in
            upstream stimulatory factor 2 (USF2) knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8780-8785 (2001)
   PUBMED   11447267
REFERENCE   7  (bases 1 to 360)
  AUTHORS   Pigeon,C., Ilyin,G., Courselaud,B., Leroyer,P., Turlin,B.,
            Brissot,P. and Loreal,O.
  TITLE     A new mouse liver-specific gene, encoding a protein homologous to
            human antimicrobial peptide hepcidin, is overexpressed during iron
            overload
  JOURNAL   J Biol Chem 276 (11), 7811-7819 (2001)
   PUBMED   11113132
REFERENCE   8  (bases 1 to 360)
  AUTHORS   Park,C.H., Valore,E.V., Waring,A.J. and Ganz,T.
  TITLE     Hepcidin, a urinary antimicrobial peptide synthesized in the liver
  JOURNAL   J Biol Chem 276 (11), 7806-7810 (2001)
   PUBMED   11113131
REFERENCE   9  (bases 1 to 360)
  AUTHORS   Krause,A., Neitz,S., Magert,H.J., Schulz,A., Forssmann,W.G.,
            Schulz-Knappe,P. and Adermann,K.
  TITLE     LEAP-1, a novel highly disulfide-bonded human peptide, exhibits
            antimicrobial activity
  JOURNAL   FEBS Lett 480 (2-3), 147-150 (2000)
   PUBMED   11034317
REFERENCE   10 (bases 1 to 360)
  AUTHORS   Venta,P.J., Montgomery,J.C., Hewett-Emmett,D., Wiebauer,K. and
            Tashian,R.E.
  TITLE     Structure and exon to protein domain relationships of the mouse
            carbonic anhydrase II gene
  JOURNAL   J Biol Chem 260 (22), 12130-12135 (1985)
   PUBMED   2995362
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053469.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF344185.1, AW534367.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000001.1  95300168-95300271   c
            105-167             JAXUCZ010000001.1  95298608-95298670   c
            168-360             JAXUCZ010000001.1  95298332-95298524   c
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..360
                     /gene="Hamp"
                     /gene_synonym="Hepc"
                     /note="hepcidin antimicrobial peptide"
                     /db_xref="GeneID:84604"
                     /db_xref="RGD:70971"
     exon            1..104
                     /gene="Hamp"
                     /gene_synonym="Hepc"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..272
                     /gene="Hamp"
                     /gene_synonym="Hepc"
                     /codon_start=1
                     /product="hepcidin precursor"
                     /protein_id="NP_445921.1"
                     /db_xref="GeneID:84604"
                     /db_xref="RGD:70971"
                     /translation="MALSTRIQAACLLLLLLASLSSGAYLRQQTRQTTALQPWHGAES
                     KTDDSALLMLKRRKRDTNFPICLFCCKCCKNSSCGLCCIT"
     exon            105..167
                     /gene="Hamp"
                     /gene_synonym="Hepc"
                     /inference="alignment:Splign:2.1.0"
     exon            168..360
                     /gene="Hamp"
                     /gene_synonym="Hepc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggacaga aggcaagatg gcactaagca ctcggatcca ggctgcctgt ctcctgcttc
       61 tcctcctggc cagcctgagc agcggtgcct atctccggca acagacgaga cagactacgg
      121 ctctgcagcc ttggcatggg gcagaaagca agactgatga cagtgcgctg ctgatgctga
      181 agcgaaggaa gcgagacacc aacttcccca tatgcctctt ctgctgtaaa tgctgtaaga
      241 attcctcctg tggtctctgt tgcataacat agagagccaa gagccttgtc ctgacctctc
      301 aacacactgc ctcccctccg ccccattatt tattcctgtc ctaccccagc aatgaccttg
//
