LOCUS       NM_017159               2136 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus histidine ammonia lyase (Hal), mRNA.
ACCESSION   NM_017159
VERSION     NM_017159.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2136)
  AUTHORS   Aleman,G., Ortiz,V., Langley,E., Tovar,A.R. and Torres,N.
  TITLE     Regulation by glucagon of the rat histidase gene promoter in
            cultured rat hepatocytes and human hepatoblastoma cells
  JOURNAL   Am J Physiol Endocrinol Metab 289 (1), E172-E179 (2005)
   PUBMED   15741241
  REMARK    GeneRIF: This evidence supports that the Hal gene is turned on by
            glucocorticoids and by glucagon either via PKC or PKA, but prefers
            the PKA pathway.
REFERENCE   2  (bases 1 to 2136)
  AUTHORS   Kawai,Y., Moriyama,A., Asai,K., Coleman-Campbell,C.M., Sumi,S.,
            Morishita,H. and Suchi,M.
  TITLE     Molecular characterization of histidinemia: identification of four
            missense mutations in the histidase gene
  JOURNAL   Hum Genet 116 (5), 340-346 (2005)
   PUBMED   15806399
  REMARK    Erratum:[Hum Genet. 2005 Dec;118(3-4):531-2]
REFERENCE   3  (bases 1 to 2136)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   4  (bases 1 to 2136)
  AUTHORS   Tovar,A.R., Ascencio,C. and Torres,N.
  TITLE     Soy protein, casein, and zein regulate histidase gene expression by
            modulating serum glucagon
  JOURNAL   Am J Physiol Endocrinol Metab 283 (5), E1016-E1022 (2002)
   PUBMED   12376330
REFERENCE   5  (bases 1 to 2136)
  AUTHORS   Sano,H., Tada,T., Moriyama,A., Ogawa,H., Asai,K., Kawai,Y.,
            Hodgson,M.E., Kato,T., Wada,Y. and Suchi,M.
  TITLE     Isolation of a rat histidase cDNA sequence and expression in
            Escherichia coli--evidence of extrahepatic/epidermal distribution
  JOURNAL   Eur J Biochem 250 (1), 212-221 (1997)
   PUBMED   9432011
REFERENCE   6  (bases 1 to 2136)
  AUTHORS   Taylor,R.G. and McInnes,R.R.
  TITLE     Site-directed mutagenesis of conserved serines in rat histidase.
            Identification of serine 254 as an essential active site residue
  JOURNAL   J Biol Chem 269 (44), 27473-27477 (1994)
   PUBMED   7961661
REFERENCE   7  (bases 1 to 2136)
  AUTHORS   Taylor,R.G., Grieco,D., Clarke,G.A., McInnes,R.R. and Taylor,B.A.
  TITLE     Identification of the mutation in murine histidinemia (his) and
            genetic mapping of the murine histidase locus (Hal) on chromosome
            10
  JOURNAL   Genomics 16 (1), 231-240 (1993)
   PUBMED   8486363
REFERENCE   8  (bases 1 to 2136)
  AUTHORS   Taylor,R.G., Lambert,M.A., Sexsmith,E., Sadler,S.J., Ray,P.N.,
            Mahuran,D.J. and McInnes,R.R.
  TITLE     Cloning and expression of rat histidase. Homology to two bacterial
            histidases and four phenylalanine ammonia-lyases
  JOURNAL   J Biol Chem 265 (30), 18192-18199 (1990)
   PUBMED   2120224
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M58308.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M58308.1, BC089809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2136
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2136
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /note="histidine ammonia lyase"
                     /db_xref="GeneID:29301"
                     /db_xref="RGD:68363"
     exon            1..255
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1982
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /EC_number="4.3.1.3"
                     /codon_start=1
                     /product="histidine ammonia-lyase"
                     /protein_id="NP_058855.1"
                     /db_xref="GeneID:29301"
                     /db_xref="RGD:68363"
                     /translation="MPRYTVHVRGEWLAVPCQDGKLSVGWLGREAVRRYMKNKPDNGG
                     FTSVDEVRFLVRRCKGLGLLDNEDLLEVALEDNEFVEVVIEGDVMSPDFIPSQPEGVF
                     LYSKYREPEKYIALDGDSLSTEDLVNLGKGHYKIKLTSIAEKKVQQSREVIDSIIKER
                     TVVYGITTGFGKFARTVIPANKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVL
                     AKGYSGISLETLKQVIEVFNASCLSYVPEKGTVGASGDLAPLSHLALGLIGEGKMWSP
                     KSGWADAKYVLEAHGLKPIVLKPKEGLALINGTQMITSLGCEAVERASAIARQADIVA
                     ALTLEVLKGTTKAFDTDIHAVRPHRGQIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQ
                     DAYTLRCCPQVHGVVNDTIAFVKDIITTELNSATDNPMVFASRGETISGGNFHGEYPA
                     KALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTAAALVS
                     ESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVIEHVEQVLAIELLAACQGIEF
                     LRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLDQKVWEVAAPYIEKYR
                     MEHIPESRPLSPTAFSLESLRKNSATIPESDDL"
     exon            256..316
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            317..344
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            345..419
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            420..492
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            493..559
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            560..597
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            598..723
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            724..863
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            864..911
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1059
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1155
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1214
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1295
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1361
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1527
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1662
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1771
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1841
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2136
                     /gene="Hal"
                     /gene_synonym="histidase"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgagccat gcctaggtac acggtgcacg tgcgtgggga atggctggcg gtaccctgcc
       61 aggacgggaa gctcagtgtt ggctggctgg gccgcgaggc tgtgcggcgc tacatgaaga
      121 acaagccgga caacgggggc ttcacctcgg tggatgaagt gcgattcctt gtgcgccggt
      181 gcaagggcct gggcctgttg gacaatgagg acctgctgga ggtggccctg gaggacaatg
      241 agttcgtaga agtggtgatt gaaggcgatg taatgtctcc tgatttcatt ccatcacagc
      301 cagaaggcgt tttcctttac agcaaatacc gggagcctga aaagtacatt gccttggatg
      361 gggacagtct gagcacggag gatctggtca acctaggcaa gggacattac aagataaagc
      421 tcacttcaat agctgagaag aaagtgcagc agtcccggga agtcattgac agcatcataa
      481 aagaaagaac agttgtttac ggcatcacca cgggttttgg aaaatttgcc agaactgtga
      541 tccctgccaa taagctacag gagcttcagg tcaacttagt ccgttcccat tcttcaggtg
      601 ttgggaagcc actcagtcct gagaggtgtc ggatgctctt ggctttgagg atcaatgtct
      661 tagccaaagg atacagtggg atttccttgg agaccctgaa acaagtgatt gaagtattta
      721 atgcctcctg cctgtcctat gttccagaga aagggaccgt tggtgccagc ggagaccttg
      781 ccccactctc ccatcttgct ttggggctca ttggagaagg aaagatgtgg tccccaaaga
      841 gtggctgggc cgatgccaaa tatgtcttag aagcccacgg attgaaacca attgttctga
      901 aaccaaaaga aggcctggca ctcatcaacg ggacacagat gatcacttcc ctgggctgtg
      961 aagccgtgga gcgagccagc gccattgccc ggcaagcgga tatcgtggct gccttgaccc
     1021 tcgaggtgct gaagggcacc accaaagcct tcgataccga catccacgcc gtccgccctc
     1081 accgcgggca aattgaagtt gctttccggt tccggtccct cttggactca gatcaccacc
     1141 cgtcagaaat tgcagaaagc cacaggttct gtgatcgtgt tcaggatgcg tacaccttac
     1201 gctgctgtcc acaggtccac ggtgtggtga acgatacaat tgcctttgtg aaggacatca
     1261 tcaccacaga actgaacagt gccacagaca atcctatggt ctttgccagt cgaggggaga
     1321 caatttcggg aggaaacttc cacggtgaat acccagccaa agccctggac tatttggcca
     1381 ttggcgtcca tgaacttgcg gcaattagtg aaagaagaat cgaaaggctg tgtaatcctt
     1441 ccctcagtga gctgcccgcc ttcctggtgg ctgaaggagg tctcaattct ggattcatga
     1501 tagcccactg taccgcagca gccctggtgt ctgagagcaa ggctctgtgc cacccttcat
     1561 ctgtggactc actctctacc agtgctgcca cggaggacca cgtctccatg ggaggatggg
     1621 cagccaggaa agctctcagg gtcatcgagc acgtggaaca agtgctggcc attgagcttc
     1681 tcgcggcctg ccagggcata gagtttctgc gccccttgaa aacaaccact ccgctggaga
     1741 aggtgtacga cctggtgcgc tccgtagtaa ggccctggat caaagatcgc ttcatggccc
     1801 cggacatcga ggcagcacac aggttgcttc ttgaccagaa ggtttgggag gtggctgccc
     1861 cgtacatcga gaaatacaga atggagcaca ttccggaatc cagaccgctt tctccaacag
     1921 cgttttcact agaatctctg aggaagaatt cagccacaat cccagagtct gacgatcttt
     1981 aacgggcttc ctcgagaaca ggcacatgtg tcggatctgg gcacatcact ggtgtggtga
     2041 cggagagtct caggaaccgc ccatgatgtg tagaactcat ctcttttcaa acaaactctg
     2101 gttaaatcat ggcagcaata cagtcattga acccag
//
