LOCUS       NM_033349               1136 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus hydroxyacyl glutathione hydrolase (Hagh), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_033349
VERSION     NM_033349.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1136)
  AUTHORS   Skapare E, Konrade I, Liepinsh E, Makrecka M, Zvejniece L, Svalbe
            B, Vilskersts R and Dambrova M.
  TITLE     Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal
            tissue samples from experimental animal models of obesity and type
            2 diabetes mellitus
  JOURNAL   J Physiol Sci 62 (6), 469-478 (2012)
   PUBMED   22893478
  REMARK    GeneRIF: Changes in glyoxalase 1 and glyoxalase 2 activities and
            the development of diabetic complications in experimental animal
            models of obesity.
REFERENCE   2  (bases 1 to 1136)
  AUTHORS   Belanger M, Yang J, Petit JM, Laroche T, Magistretti PJ and Allaman
            I.
  TITLE     Role of the glyoxalase system in astrocyte-mediated neuroprotection
  JOURNAL   J Neurosci 31 (50), 18338-18352 (2011)
   PUBMED   22171037
REFERENCE   3  (bases 1 to 1136)
  AUTHORS   Cordell PA, Futers TS, Grant PJ and Pease RJ.
  TITLE     The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both
            cytosolic and mitochondrial forms of glyoxalase II
  JOURNAL   J Biol Chem 279 (27), 28653-28661 (2004)
   PUBMED   15117945
REFERENCE   4  (bases 1 to 1136)
  AUTHORS   Ji X, Moore HD, Russell RG and Watts DJ.
  TITLE     cDNA cloning and characterization of a rat
            spermatogenesis-associated protein RSP29
  JOURNAL   Biochem Biophys Res Commun 241 (3), 714-719 (1997)
   PUBMED   9434774
REFERENCE   5  (bases 1 to 1136)
  AUTHORS   Ridderstrom M, Saccucci F, Hellman U, Bergman T, Principato G and
            Mannervik B.
  TITLE     Molecular cloning, heterologous expression, and characterization of
            human glyoxalase II
  JOURNAL   J Biol Chem 271 (1), 319-323 (1996)
   PUBMED   8550579
REFERENCE   6  (bases 1 to 1136)
  AUTHORS   Kawase M, Tada M, Akagi S and Ohmori S.
  TITLE     Changes in concentrations of methylglyoxal, D-lactate and
            glyoxalase activities in liver and plasma of rats fed a
            3'-methyl-4-dimethylaminoazobenzene-rich diet
  JOURNAL   Res Exp Med (Berl) 196 (4), 251-259 (1996)
   PUBMED   8903102
REFERENCE   7  (bases 1 to 1136)
  AUTHORS   Kawase M, Kondoh C, Matsumoto S, Teshigawara M, Chisaka Y,
            Higashiura M, Nakata K and Ohmori S.
  TITLE     Contents of D-lactate and its related metabolites as well as enzyme
            activities in the liver, muscle and blood plasma of aging rats
  JOURNAL   Mech Ageing Dev 84 (1), 55-63 (1995)
   PUBMED   8719777
REFERENCE   8  (bases 1 to 1136)
  AUTHORS   Yasue M, Serikawa T and Yamada J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB715597.1 and BC097301.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_033349.3.
            
            On Dec 30, 2010 this sequence version replaced NM_033349.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ229806.1, BC097301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                CB715597.1         30-77
            49-1136             BC097301.1         1-1088
FEATURES             Location/Qualifiers
     source          1..1136
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1136
                     /gene="Hagh"
                     /gene_synonym="Glo2; RSP29"
                     /note="hydroxyacyl glutathione hydrolase"
                     /db_xref="GeneID:24439"
                     /db_xref="RGD:2779"
     exon            1..110
                     /gene="Hagh"
                     /gene_synonym="Glo2; RSP29"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..964
                     /gene="Hagh"
                     /gene_synonym="Glo2; RSP29"
                     /EC_number="3.1.2.6"
                     /note="hydroxyacylglutathione hydrolase, mitochondrial;
                     glx II; glyoxalase II; round spermatid protein RSP29"
                     /codon_start=1
                     /product="hydroxyacylglutathione hydrolase, mitochondrial
                     precursor"
                     /protein_id="NP_203500.2"
                     /db_xref="GeneID:24439"
                     /db_xref="RGD:2779"
                     /translation="MVLGRGSLCLRSLSVLGAACARRGLGQALLGLSLCHTDFRKNLT
                     VQQDMMKIELLPALTDNYMYLIIDEDTQEAAVVDPVQPQKVIETVKKHRVKLTTVLTT
                     HHHWDHAGGNEKLVKLEPGLKVYGGDDRIGALTHKVTHLSTLQVGSLSVKCLSTPCHT
                     SGHICYFVSKPGSSEPSAVFTGDTLFVAGCGKFYEGTADEMYKALLEVLGRLPPDTKV
                     YCGHEYTVNNLKFARHVEPGNTAVQEKLAWAKEKNAIGEPTVPSTLAEEFTYNPFMRV
                     KEKTVQQHAGETDPVTTMRAIRREKDQFKVPRD"
     exon            111..286
                     /gene="Hagh"
                     /gene_synonym="Glo2; RSP29"
                     /inference="alignment:Splign:2.1.0"
     exon            287..351
                     /gene="Hagh"
                     /gene_synonym="Glo2; RSP29"
                     /inference="alignment:Splign:2.1.0"
     exon            352..469
                     /gene="Hagh"
                     /gene_synonym="Glo2; RSP29"
                     /inference="alignment:Splign:2.1.0"
     exon            470..578
                     /gene="Hagh"
                     /gene_synonym="Glo2; RSP29"
                     /inference="alignment:Splign:2.1.0"
     exon            579..682
                     /gene="Hagh"
                     /gene_synonym="Glo2; RSP29"
                     /inference="alignment:Splign:2.1.0"
     exon            683..784
                     /gene="Hagh"
                     /gene_synonym="Glo2; RSP29"
                     /inference="alignment:Splign:2.1.0"
     exon            785..864
                     /gene="Hagh"
                     /gene_synonym="Glo2; RSP29"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1117
                     /gene="Hagh"
                     /gene_synonym="Glo2; RSP29"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1117
                     /gene="Hagh"
                     /gene_synonym="Glo2; RSP29"
ORIGIN      
        1 ggactccgcg acccggctgt gcaccccgtg ggtcatggtg ctgggtcgcg ggtcgctgtg
       61 cctccggagc ctgtcagtgc tgggagccgc ctgcgcgcgc cgcggtctgg gtcaggctct
      121 gctgggactc tctctctgtc acacagactt caggaagaat ctgaccgtgc agcaagacat
      181 gatgaagatc gaactactgc ctgccctgac tgacaactac atgtacctga tcattgatga
      241 ggacacccag gaggccgccg ttgtggaccc agtgcagcca cagaaggtta tagaaactgt
      301 gaaaaagcac cgtgtgaagc tgaccacagt gctcaccact caccaccact gggaccacgc
      361 tggtgggaac gagaagttgg tgaagctgga acctgggctg aaggtttatg gaggtgatga
      421 ccgcattggg gccttgaccc acaaggtcac acacctttcc acactgcagg tggggtctct
      481 cagtgtcaaa tgtctgtcaa caccctgcca tacttcaggg cacatctgtt actttgtgag
      541 caagcctggt agctcagagc cttctgctgt gttcacaggt gacacattgt ttgttgctgg
      601 ctgtgggaag ttctatgagg gaaccgcaga cgagatgtac aaggcgctgc ttgaagtctt
      661 aggccggctt cctccagaca caaaagtcta ctgtggccat gaatacaccg taaacaacct
      721 taagtttgcg cgccatgtgg agcccggcaa taccgccgtt caagagaaac tggcctgggc
      781 caaggagaag aatgccatcg gggagcccac ggtgccatcc accctggcag aggagttcac
      841 ttacaacccc ttcatgagag tgaaggagaa gaccgtgcag cagcacgctg gagagaccga
      901 ccctgtgacc accatgaggg ccatccgcag ggagaaagac cagtttaagg tgcctcggga
      961 ctgaggaaca cggggacagg gacttttaac tgactgtcct gctgctaaag caggacctag
     1021 tctaatttta agttaattca aagcccttag cttgtgttgt caaatgttct aatgcatatt
     1081 tataagagaa aaaggtttaa agtatttatt cccataaaaa aaaaaaaaaa aaaaaa
//
