LOCUS       NM_133618               1996 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus hydroxyacyl-CoA dehydrogenase trifunctional
            multienzyme complex subunit beta (Hadhb), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_133618
VERSION     NM_133618.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1996)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 1996)
  AUTHORS   Seo,J.Y., Yaneva,R., Hinson,E.R. and Cresswell,P.
  TITLE     Human cytomegalovirus directly induces the antiviral protein
            viperin to enhance infectivity
  JOURNAL   Science 332 (6033), 1093-1097 (2011)
   PUBMED   21527675
REFERENCE   3  (bases 1 to 1996)
  AUTHORS   Asano,J., Kudo,T., Shimizu,T., Fan,Y., Nanashima,N., Yamana,D.,
            Miura,T., Yamada,T. and Tsuchida,S.
  TITLE     Histone acetylation and steroid receptor coactivator expression
            during clofibrate-induced rat hepatocarcinogenesis
  JOURNAL   Cancer Sci 101 (4), 869-875 (2010)
   PUBMED   20132223
REFERENCE   4  (bases 1 to 1996)
  AUTHORS   Liu,X., Wu,L., Deng,G., Li,N., Chu,X., Guo,F. and Li,D.
  TITLE     Characterization of mitochondrial trifunctional protein and its
            inactivation study for medicine development
  JOURNAL   Biochim Biophys Acta 1784 (11), 1742-1749 (2008)
   PUBMED   18640292
  REMARK    GeneRIF: The catalytic residues of the MTP beta-subunit are
            positioned in the active site similarly to those of monofunctional
            3-ketoacyl-CoA thiolase.
REFERENCE   5  (bases 1 to 1996)
  AUTHORS   Bogenhagen,D.F., Rousseau,D. and Burke,S.
  TITLE     The layered structure of human mitochondrial DNA nucleoids
  JOURNAL   J Biol Chem 283 (6), 3665-3675 (2008)
   PUBMED   18063578
REFERENCE   6  (bases 1 to 1996)
  AUTHORS   Frackowiak,J., Mazur-Kolecka,B., Kaczmarski,W. and Dickson,D.
  TITLE     Deposition of Alzheimer's vascular amyloid-beta is associated with
            decreased expression of brain L-3-hydroxyacyl-coenzyme A
            dehydrogenase (ERAB)
  JOURNAL   Brain Res 907 (1-2), 44-53 (2001)
   PUBMED   11430884
REFERENCE   7  (bases 1 to 1996)
  AUTHORS   Eaton,S., Bursby,T., Middleton,B., Pourfarzam,M., Mills,K.,
            Johnson,A.W. and Bartlett,K.
  TITLE     The mitochondrial trifunctional protein: centre of a beta-oxidation
            metabolon?
  JOURNAL   Biochem Soc Trans 28 (2), 177-182 (2000)
   PUBMED   10816122
  REMARK    Review article
REFERENCE   8  (bases 1 to 1996)
  AUTHORS   Ushikubo,S., Aoyama,T., Kamijo,T., Wanders,R.J., Rinaldo,P.,
            Vockley,J. and Hashimoto,T.
  TITLE     Molecular characterization of mitochondrial trifunctional protein
            deficiency: formation of the enzyme complex is important for
            stabilization of both alpha- and beta-subunits
  JOURNAL   Am J Hum Genet 58 (5), 979-988 (1996)
   PUBMED   8651282
REFERENCE   9  (bases 1 to 1996)
  AUTHORS   Kamijo,T., Aoyama,T., Miyazaki,J. and Hashimoto,T.
  TITLE     Molecular cloning of the cDNAs for the subunits of rat
            mitochondrial fatty acid beta-oxidation multienzyme complex.
            Structural and functional relationships to other mitochondrial and
            peroxisomal beta-oxidation enzymes
  JOURNAL   J Biol Chem 268 (35), 26452-26460 (1993)
   PUBMED   8253773
REFERENCE   10 (bases 1 to 1996)
  AUTHORS   Uchida,Y., Izai,K., Orii,T. and Hashimoto,T.
  TITLE     Novel fatty acid beta-oxidation enzymes in rat liver mitochondria.
            II. Purification and properties of enoyl-coenzyme A (CoA)
            hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase
            trifunctional protein
  JOURNAL   J Biol Chem 267 (2), 1034-1041 (1992)
   PUBMED   1730633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM050540.1, FM038662.1, JAXUCZ010000006.1, FM105991.1 and
            FM118580.1.
            
            On Feb 12, 2015 this sequence version replaced NM_133618.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060545.1, D16479.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-600               FM050540.1         1-600
            601-983             FM038662.1         57-439
            984-987             JAXUCZ010000006.1  31873404-31873407   c
            988-1128            FM038662.1         441-581
            1129-1541           FM105991.1         242-654
            1542-1995           FM118580.1         114-567
            1996-1999           JAXUCZ010000006.1  31873404-31873407   c
FEATURES             Location/Qualifiers
     source          1..1996
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..1996
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /note="hydroxyacyl-CoA dehydrogenase trifunctional
                     multienzyme complex subunit beta"
                     /db_xref="GeneID:171155"
                     /db_xref="RGD:620513"
     exon            1..80
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            81..155
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1516
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /EC_number="2.3.1.16"
                     /EC_number="2.3.1.155"
                     /note="trifunctional enzyme subunit beta, mitochondrial;
                     mitochondrial trifunctional protein, beta subunit;
                     hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA
                     thiolase/enoyl-CoA hydratase (trifunctional protein), beta
                     subunit; hydroxyacyl-Coenzyme A
                     dehydrogenase/3-ketoacyl-Coenzyme A
                     thiolase/enoyl-Coenzyme A hydratase (trifunctional
                     protein), beta subunit"
                     /codon_start=1
                     /product="trifunctional enzyme subunit beta, mitochondrial
                     precursor"
                     /protein_id="NP_598302.1"
                     /db_xref="GeneID:171155"
                     /db_xref="RGD:620513"
                     /translation="MTTILTSTFRNLSTTSKWALRFSVRPLSCSSQVQSAPAVQTKSK
                     KTLAKPNLKNIVVVEGVRIPFLLSGTSYKDLMPHDLARAALSGLLYRTNIPKDVVDYI
                     IFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISSNQAMTTAVGLIASGQCDV
                     VVAGGVELMSDVPIRHSRNMRKMMLDLNKAKTLAQRLSLLTKFRLNFLSPELPAVAEF
                     STNETMGHSADRLAAAFAVSRMEQDKYALRSHSLAKKAQDEGHLSDIVPFKVPGKDTV
                     SKDNGIRPSSLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMSEDRALAMGYKP
                     KAYLRDFIYVSQDPKDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFK
                     AMDSDWFAQNYMGRKTKVGAPPLEKFNIWGGSLSLGHPFGATGCRLVMAAANRLRKDG
                     GQYALVAACAAGGQGHAMIVEAYPK"
     exon            156..200
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            201..300
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            301..345
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            346..445
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            446..533
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            534..721
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            722..902
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1024
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1104
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1152
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1240
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1315
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1480
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1996
                     /gene="Hadhb"
                     /gene_synonym="TP-beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccgccct tcgtcgtggg cgggcgttta tcagtctgga cttgaccttc ttgggggccg
       61 catccttcgc agactctaag atttcagaat gactaccatc ttgacttcca cttttagaaa
      121 cctttctact acatcaaaat gggccctcag attttctgta agacctctga gctgttcttc
      181 acaagtacag tctgccccag ctgtccagac caagtcaaag aagactttag caaaacctaa
      241 tctaaagaac attgtggtgg tggaaggtgt ccgaattcca tttctgctgt caggcacttc
      301 gtataaagac ctaatgccac atgatttggc tagagccgca ctttcgggtt tgttgtatcg
      361 gaccaatatt ccaaaggatg ttgttgatta tatcattttt ggtacagtta ttcaggaagt
      421 aaaaacaagc aatgtggcta gagaggctgc cctgggagct ggcttctctg ataagactcc
      481 agctcacact gtcaccatgg cttgtatctc ttcaaaccaa gccatgacca cagctgttgg
      541 tctgatagct tctggccagt gtgatgtcgt cgtggctggt ggtgttgagt taatgtctga
      601 cgtccctatt cgtcattcaa gaaatatgag gaaaatgatg cttgatctca ataaagccaa
      661 gactctggcc cagcgcctgt ccttactcac taaattcaga ttgaattttc tgtcccctga
      721 gctccctgca gtggctgagt tctccactaa cgagacaatg ggccactctg ccgaccgtct
      781 ggctgctgcc tttgctgttt ctcgaatgga acaggataaa tatgcactgc gttctcacag
      841 tctggccaag aaggcacagg atgaaggaca tctttctgat attgtaccct tcaaagtacc
      901 aggaaaagac acagttagca aagataacgg gatccgtcct tcctcactgg agcaaatggc
      961 caaactaaag cctgcattca tcaaacccta tggcacagtg acagcagcga attcttcttt
     1021 cctgactgat ggcgcttctg cgatgctaat catgtcagag gacagagctc tggccatggg
     1081 ttataagcca aaggcatatt tgagggattt tatatatgtg tctcaggatc caaaagatca
     1141 gcttttactt ggaccaacat atgctactcc aaaagttcta gaaaaggcag gattaaccat
     1201 gaatgatatt gacgcttttg aatttcatga agccttctca ggtcagattt tggctaactt
     1261 taaagctatg gattctgatt ggtttgcaca aaactacatg ggtaggaaaa ccaaggttgg
     1321 agcacctcct ctggagaagt ttaatatctg gggcggatca ctctctctgg gacacccttt
     1381 tggagccact ggctgtcggt tggtcatggc agctgccaac agactgagga aggatggagg
     1441 ccagtatgct ttagtggctg cctgtgcagc tggaggacag ggtcatgcta tgattgtgga
     1501 agcctaccca aaatgactgc tctggaagga ggcaactgat ctctgcagca ctcgcactgg
     1561 gcaatgccat ttcaatgcac taccaagtga tacctgcagt tcctagctct tcttaggaaa
     1621 caacatttgt ggccttctct taaatatttt gcggtcaagc cttgccagtg ttcgagcttt
     1681 ccgataatca cagcttctgc tctctaagtt ccagactatc acagatgtgt acacagttct
     1741 tgttatctct tgtctctaag actaatgact gccagctgct tggagagagg ttagctgagg
     1801 tttagaacca tctttgtaac atttgcagaa tctcctcctt cctgtcagtg tcctacagag
     1861 aattattttt tctaaaatac aatccaatgt gcctacatta agttactata gaaaaaaata
     1921 atctaaacat ctcctaaaac tgacttgctt agagacatgt ttgttgacct taataaagta
     1981 gacatgtatt agagga
//
