LOCUS       NM_130826               2560 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hydroxyacyl-CoA dehydrogenase trifunctional
            multienzyme complex subunit alpha (Hadha), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_130826 XM_346786
VERSION     NM_130826.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2560)
  AUTHORS   Choi,J., Ravipati,A., Nimmagadda,V., Schubert,M., Castellani,R.J.
            and Russell,J.W.
  TITLE     Potential roles of PINK1 for increased PGC-1alpha-mediated
            mitochondrial fatty acid oxidation and their associations with
            Alzheimer disease and diabetes
  JOURNAL   Mitochondrion 18, 41-48 (2014)
   PUBMED   25260493
REFERENCE   2  (bases 1 to 2560)
  AUTHORS   Li,L., Lu,D.Z., Li,Y.M., Zhang,X.Q., Zhou,X.X. and Jin,X.
  TITLE     Proteomic analysis of liver mitochondria from rats with
            nonalcoholic steatohepatitis
  JOURNAL   World J Gastroenterol 20 (16), 4778-4786 (2014)
   PUBMED   24782632
REFERENCE   3  (bases 1 to 2560)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   4  (bases 1 to 2560)
  AUTHORS   Taylor,W.A., Mejia,E.M., Mitchell,R.W., Choy,P.C., Sparagna,G.C.
            and Hatch,G.M.
  TITLE     Human trifunctional protein alpha links cardiolipin remodeling to
            beta-oxidation
  JOURNAL   PLoS One 7 (11), e48628 (2012)
   PUBMED   23152787
REFERENCE   5  (bases 1 to 2560)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   6  (bases 1 to 2560)
  AUTHORS   Eaton,S., Bursby,T., Middleton,B., Pourfarzam,M., Mills,K.,
            Johnson,A.W. and Bartlett,K.
  TITLE     The mitochondrial trifunctional protein: centre of a beta-oxidation
            metabolon?
  JOURNAL   Biochem Soc Trans 28 (2), 177-182 (2000)
   PUBMED   10816122
  REMARK    Review article
REFERENCE   7  (bases 1 to 2560)
  AUTHORS   Monstein,H.J., Nylander,A.G. and Hakanson,R.
  TITLE     Widespread tissue expression of gastrin-binding-protein mRNA
  JOURNAL   Eur J Biochem 246 (2), 502-507 (1997)
   PUBMED   9208944
REFERENCE   8  (bases 1 to 2560)
  AUTHORS   Sims,H.F., Brackett,J.C., Powell,C.K., Treem,W.R., Hale,D.E.,
            Bennett,M.J., Gibson,B., Shapiro,S. and Strauss,A.W.
  TITLE     The molecular basis of pediatric long chain 3-hydroxyacyl-CoA
            dehydrogenase deficiency associated with maternal acute fatty liver
            of pregnancy
  JOURNAL   Proc Natl Acad Sci U S A 92 (3), 841-845 (1995)
   PUBMED   7846063
REFERENCE   9  (bases 1 to 2560)
  AUTHORS   Kamijo,T., Aoyama,T., Miyazaki,J. and Hashimoto,T.
  TITLE     Molecular cloning of the cDNAs for the subunits of rat
            mitochondrial fatty acid beta-oxidation multienzyme complex.
            Structural and functional relationships to other mitochondrial and
            peroxisomal beta-oxidation enzymes
  JOURNAL   J Biol Chem 268 (35), 26452-26460 (1993)
   PUBMED   8253773
REFERENCE   10 (bases 1 to 2560)
  AUTHORS   Uchida,Y., Izai,K., Orii,T. and Hashimoto,T.
  TITLE     Novel fatty acid beta-oxidation enzymes in rat liver mitochondria.
            II. Purification and properties of enoyl-coenzyme A (CoA)
            hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase
            trifunctional protein
  JOURNAL   J Biol Chem 267 (2), 1034-1041 (1992)
   PUBMED   1730633
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091697.1.
            
            On Jun 10, 2007 this sequence version replaced NM_130826.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091697.1, D16478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2560
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..2560
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /note="hydroxyacyl-CoA dehydrogenase trifunctional
                     multienzyme complex subunit alpha"
                     /db_xref="GeneID:170670"
                     /db_xref="RGD:620512"
     exon            1..83
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..2308
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /EC_number="4.2.1.17"
                     /EC_number="1.1.1.211"
                     /note="trifunctional enzyme subunit alpha, mitochondrial;
                     hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA
                     thiolase/enoyl-CoA hydratase (trifunctional protein),
                     alpha subunit; TP-alpha; hydroxyacyl-Coenzyme A
                     dehydrogenase/3-ketoacyl-Coenzyme A
                     thiolase/enoyl-Coenzyme A hydratase (trifunctional
                     protein), alpha subunit; monolysocardiolipin
                     acyltransferase"
                     /codon_start=1
                     /product="trifunctional enzyme subunit alpha,
                     mitochondrial precursor"
                     /protein_id="NP_570839.2"
                     /db_xref="GeneID:170670"
                     /db_xref="RGD:620512"
                     /translation="MVASRAIGSLSRFSAFRILRSRGCICHSFTTSSALLSRTHINYG
                     VKGDVAVIRINSPNSKVNTLNKEVQSEFVEVMNEIWANDQIRSAVLISSKPGCFVAGA
                     DINMLASCTTPQEAARISQEGQKMFEKLEKSPKPVVAAISGSCLGGGLELAIACQYRI
                     ATKDRKTVLGVPEVLLGILPGAGGTQRLPKMVGVPAAFDMMLTGRNIRADRAKKMGLV
                     DQLVDPLGPGIKSPEERTIEYLEEVAVNFAKGLADRKVSAKQSKGLMEKLTSYAMTIP
                     FVRQQVYKTVEEKVKKQTKGLYPAPLKIIDAVKTGLEQGNDAGYLAESEKFGELALTK
                     ESKALMGLYNGQVLCKKNKFGAPQKTVQQLAILGAGLMGAGIAQVSVDKGLKTLLKDT
                     TVTGLGRGQQQVFKGLNDKVKKKALTSFERDSIFSNLIGQLDYKGFEKADMVIEAVFE
                     DLAVKHKVLKEVESVTPEHCIFASNTSALPINQIAAVSQRPEKVIGMHYFSPVDKMQL
                     LEIITTDKTSKDTTASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGV
                     DPKKLDALTTGFGFPVGAATLADEVGIDVAQHVAEDLGKAFGERFGGGSVELLKLMVS
                     KGFLGRKSGKGFYIYQSGSKNKNLNSEIDNILVNLRLPAKPEVSSDEDIQYRVITRFV
                     NEAVLCLQEGILATPEEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKVVDRLRKYESAY
                     GTQFTPCQLLRDLANNSSKKFYQ"
     exon            84..125
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            126..196
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            197..330
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            331..469
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            470..589
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            590..692
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            693..815
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            816..934
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            935..991
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1101
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1236
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1408
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1495
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1636
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1705
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1901
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2016
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2162
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2511
                     /gene="Hadha"
                     /gene_synonym="RGD1560655"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctcttctg ctcaagatgg tggcgtcccg ggcaattggc agtctcagtc gcttctctgc
       61 cttcaggatc ctgcgctcca gaggctgcat ttgccacagc tttacaactt cttctgcttt
      121 gctgtctaga acccatatta attatggagt caaaggggat gtggcagtta ttcggattaa
      181 ctcgcccaat tcaaaggtaa atacattgaa taaagaagta caatcagagt tcgtagaagt
      241 aatgaacgaa atctgggcca acgaccaaat caggagcgcc gtccttattt cgtcaaagcc
      301 tggctgcttt gttgcaggtg ctgacatcaa catgctggcc tcttgtacaa cgccccaaga
      361 agcagcacga atatcacaag aaggacagaa aatgtttgag aaacttgaaa agtcaccaaa
      421 gcctgttgtt gccgccatca gtggatcctg cttgggaggc ggacttgagc ttgccatagc
      481 atgtcaatac agaatagcaa caaaagacag aaaaacagta ttaggtgtcc ctgaagtgtt
      541 gctgggaatc ttaccaggag ccggaggtac ccagaggctg cccaaaatgg tgggtgtgcc
      601 tgctgctttt gacatgatgc tgactggtag gaacattcgt gcagacagag caaagaaaat
      661 gggactggtt gaccagttgg tggacccgct aggaccagga ataaaatctc cagaggaaag
      721 gacaattgaa tacctagaag aagttgcagt taattttgcc aaaggcctgg ctgacaggaa
      781 ggtctctgca aagcagagca aaggcctgat ggaaaagctg acatcgtatg ccatgactat
      841 cccatttgtc agacaacagg tttacaaaac agtggaagaa aaagtgaaga agcagaccaa
      901 aggcctttac cctgcacctt tgaagataat tgacgctgtg aagactggac ttgagcaagg
      961 aaatgatgct ggctatcttg ccgaatcaga gaaatttgga gagcttgcat tgaccaaaga
     1021 atcaaaagcc ctgatggggc tttataatgg ccaggtcctg tgcaagaaaa ataaatttgg
     1081 agcgccacag aagactgttc agcagctagc catccttggc gcagggctga tgggggctgg
     1141 cattgcccag gtctctgtgg acaagggact gaaaactctt cttaaagaca ctacagtgac
     1201 agggctgggc cggggacagc aacaagtgtt caaaggactg aatgacaagg taaagaagaa
     1261 ggcactcaca tccttcgaaa gggactccat cttcagcaac ctgatcgggc agctcgacta
     1321 caagggcttc gagaaggctg acatggtgat tgaggctgtc ttcgaggacc tcgctgttaa
     1381 gcacaaagtg ttaaaggaag tggaaagcgt gactccagaa cactgtatct tcgccagcaa
     1441 cacatctgct ctcccaatca atcaaattgc tgctgtgagc caaaggcctg agaaggtgat
     1501 cggcatgcac tacttctctc ctgtggacaa gatgcagctt ctagagatca tcacaactga
     1561 caaaacctcc aaggacacca cagcgtctgc cgtggccgtg ggtctcaagc aggggaaggt
     1621 catcattgtg gtcaaggacg gacctggctt ctacaccacc aggtgtcttg ctcccatgat
     1681 gtcagaagtc ataagaatcc tccaggaagg agttgaccct aagaagctgg acgccttgac
     1741 cacaggcttc ggcttccctg tgggtgctgc caccctggca gatgaagtag ggatagatgt
     1801 agcacagcac gtagcagaag atctaggcaa agccttcggg gagcggtttg gaggtggcag
     1861 cgtagaactg ctgaaactga tggtctccaa gggcttcttg ggtcgcaagt ctgggaaggg
     1921 cttctacatc tatcagtcgg gctcaaagaa taagaatttg aattctgaaa tagataatat
     1981 cttggtaaac ctgaggctgc ctgccaagcc cgaggtctcc tctgatgaag acatccagta
     2041 ccgtgtgata acaaggtttg tgaatgaggc agtcctgtgc ctacaggaag ggatcctagc
     2101 cacgcctgaa gagggagaca tcggagcagt ctttgggctt ggctttcccc cttgtctcgg
     2161 agggcccttc cgctttgtgg atctgtatgg tgctcagaag gtagtggacc ggctccggaa
     2221 gtatgagtct gcctatggga cacagtttac cccgtgtcag ctactccgcg accttgctaa
     2281 caactctagc aagaagttct accagtgagc aggccgtccc gccctgcccc tccacccacg
     2341 tactaaccca gacccggcag tgctgcttct cagccgcgct gtctaaatta tcaggaagca
     2401 ggagaaagac cgaggctagc cttggatttg ctcctccatg atagtgcctt cagccctgtc
     2461 ccgctcttcc tcctggtgaa gtctgactgt gaattaaatg tttgtacttc aaaaaaaaaa
     2521 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
