LOCUS       NM_057186               1659 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hydroxyacyl-CoA dehydrogenase (Hadh), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_057186 XM_346640
VERSION     NM_057186.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1659)
  AUTHORS   Martin,J., Balmer,M.L., Rajendran,S., Maurhofer,O., Dufour,J.F. and
            St-Pierre,M.V.
  TITLE     Nutritional stress exacerbates hepatic steatosis induced by
            deletion of the histidine nucleotide-binding (Hint2) mitochondrial
            protein
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 310 (7), G497-G509 (2016)
   PUBMED   26767982
REFERENCE   2  (bases 1 to 1659)
  AUTHORS   Schulz,N., Himmelbauer,H., Rath,M., van Weeghel,M., Houten,S.,
            Kulik,W., Suhre,K., Scherneck,S., Vogel,H., Kluge,R., Wiedmer,P.,
            Joost,H.G. and Schurmann,A.
  TITLE     Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase
            in the regulation of body weight and thermogenesis
  JOURNAL   Endocrinology 152 (12), 4641-4651 (2011)
   PUBMED   21990309
REFERENCE   3  (bases 1 to 1659)
  AUTHORS   Seiva,F.R., Ebaid,G.M., Castro,A.V., Okoshi,K., Nascimento,A.,
            Rocha,K.K., Padovani,C.R., Cicogna,A.C. and Novelli,E.L.
  TITLE     Growth hormone and heart failure: oxidative stress and energetic
            metabolism in rats
  JOURNAL   Growth Horm IGF Res 18 (4), 275-283 (2008)
   PUBMED   18191600
REFERENCE   4  (bases 1 to 1659)
  AUTHORS   Martens,G.A., Vervoort,A., Van de Casteele,M., Stange,G.,
            Hellemans,K., Van Thi,H.V., Schuit,F. and Pipeleers,D.
  TITLE     Specificity in beta cell expression of L-3-hydroxyacyl-CoA
            dehydrogenase, short chain, and potential role in down-regulating
            insulin release
  JOURNAL   J Biol Chem 282 (29), 21134-21144 (2007)
   PUBMED   17491019
  REMARK    GeneRIF: analysis of beta cell expression of L-3-hydroxyacyl-CoA
            dehydrogenase, short chain, and its role in down-regulating insulin
            release
REFERENCE   5  (bases 1 to 1659)
  AUTHORS   Dourmashkin,J.T., Chang,G.Q., Gayles,E.C., Hill,J.O., Fried,S.K.,
            Julien,C. and Leibowitz,S.F.
  TITLE     Different forms of obesity as a function of diet composition
  JOURNAL   Int J Obes (Lond) 29 (11), 1368-1378 (2005)
   PUBMED   16088331
REFERENCE   6  (bases 1 to 1659)
  AUTHORS   Hirai,T., Nohara,R., Ogoh,S., Chen,L.G., Kataoka,K., Li,X.H.,
            Fujita,M., Matsumori,A., Taguchi,S. and Sasayama,S.
  TITLE     Serial evaluation of fatty acid metabolism in rats with myocardial
            infarction by pinhole SPECT
  JOURNAL   J Nucl Cardiol 8 (4), 472-481 (2001)
   PUBMED   11481570
REFERENCE   7  (bases 1 to 1659)
  AUTHORS   He,X.Y., Zhang,G., Blecha,F. and Yang,S.Y.
  TITLE     Identity of heart and liver L-3-hydroxyacyl coenzyme A
            dehydrogenase
  JOURNAL   Biochim Biophys Acta 1437 (2), 119-123 (1999)
   PUBMED   10064895
REFERENCE   8  (bases 1 to 1659)
  AUTHORS   Furuta,S. and Hashimoto,T.
  TITLE     Purification and properties of 3-hydroxyacyl coenzyme A
            dehydrogenase-binding protein from rat liver mitochondria
  JOURNAL   J Biochem 118 (4), 810-818 (1995)
   PUBMED   8576097
REFERENCE   9  (bases 1 to 1659)
  AUTHORS   Criswell,D., Powers,S., Dodd,S., Lawler,J., Edwards,W., Renshler,K.
            and Grinton,S.
  TITLE     High intensity training-induced changes in skeletal muscle
            antioxidant enzyme activity
  JOURNAL   Med Sci Sports Exerc 25 (10), 1135-1140 (1993)
   PUBMED   8231758
REFERENCE   10 (bases 1 to 1659)
  AUTHORS   Ianuzzo,C.D., Noble,E.G., Hamilton,N. and Dabrowski,B.
  TITLE     Effects of streptozotocin diabetes, insulin treatment, and training
            on the diaphragm
  JOURNAL   J Appl Physiol Respir Environ Exerc Physiol 52 (6), 1471-1475
            (1982)
   PUBMED   7050060
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF095449.1.
            
            On Feb 21, 2013 this sequence version replaced NM_057186.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF095449.1, FQ212781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1659              AF095449.1         1-1659
FEATURES             Location/Qualifiers
     source          1..1659
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..1659
                     /gene="Hadh"
                     /gene_synonym="Hadhsc"
                     /note="hydroxyacyl-CoA dehydrogenase"
                     /db_xref="GeneID:113965"
                     /db_xref="RGD:69321"
     exon            1..160
                     /gene="Hadh"
                     /gene_synonym="Hadhsc"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..973
                     /gene="Hadh"
                     /gene_synonym="Hadhsc"
                     /EC_number="1.1.1.35"
                     /function="catalyzes third reaction of fatty acid
                     beta-oxidation spiral"
                     /note="monofunctional; NAD-dependent dehydrogenase;
                     hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH;
                     short-chain 3-hydroxyacyl-CoA dehydrogenase; medium and
                     short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase;
                     L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain;
                     hydroxylacyl-Coenzyme A dehydrogenase, short chain"
                     /codon_start=1
                     /product="hydroxyacyl-coenzyme A dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_476534.1"
                     /db_xref="GeneID:113965"
                     /db_xref="RGD:69321"
                     /translation="MAFVTRQFVRSMSSSSSASAAAKKILIKHVTVIGGGLMGAGIAQ
                     VAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAADEFVEKTLSSLST
                     STDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANAT
                     TRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFI
                     VNRLLVPYLIEAIRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDG
                     WHEMDPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK"
     exon            161..289
                     /gene="Hadh"
                     /gene_synonym="Hadhsc"
                     /inference="alignment:Splign:2.1.0"
     exon            290..447
                     /gene="Hadh"
                     /gene_synonym="Hadhsc"
                     /inference="alignment:Splign:2.1.0"
     exon            448..574
                     /gene="Hadh"
                     /gene_synonym="Hadhsc"
                     /inference="alignment:Splign:2.1.0"
     exon            575..664
                     /gene="Hadh"
                     /gene_synonym="Hadhsc"
                     /inference="alignment:Splign:2.1.0"
     exon            665..737
                     /gene="Hadh"
                     /gene_synonym="Hadhsc"
                     /inference="alignment:Splign:2.1.0"
     exon            738..854
                     /gene="Hadh"
                     /gene_synonym="Hadhsc"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1659
                     /gene="Hadh"
                     /gene_synonym="Hadhsc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctggttct cggctgctcc actgagctat ggcgttcgtg accaggcaat tcgtgcgctc
       61 catgtcctcc tcttcctctg cgtcggcggc cgccaagaag atcctgatca agcatgtgac
      121 ggtcatcggc ggcgggctga tgggcgccgg catcgcgcag gtagctgcag caactggcca
      181 tacagtagtg ttggtggacc aaacagagga catcctggca aaatccaaga agggaattga
      241 agagagcctt aagagaatgg caaagaagaa gttcacagaa aaccctaagg ctgccgatga
      301 gtttgtggag aaaaccctga gctccctttc aaccagcacc gatgccgcgt ccgtggtgca
      361 cagcacagac ctggtggtgg aggccattgt ggagaacctg aagttgaaga atgagctatt
      421 ccagaggctg gacaagtttg ctgcagaaca caccatcttt gccagcaaca cgtcttcttt
      481 gcagatcaca aacatagcca atgccaccac cagacaagac cgatttgctg gcctccactt
      541 ttttaacccc gtccccatga tgaagcttgt ggaggtcatt aaaacaccga tgaccagcca
      601 gaagacattt gaatctctgg ttgacttttg taaaacctta gggaagcatc ctgtttcctg
      661 caaggacact cctggattta tcgtgaaccg tctcttggtg ccatacctca tagaagctat
      721 ccggctgcat gagcgaggcg atgcatctaa ggaagacatc gacaccgcaa tgaagctggg
      781 agccgggtat cccatgggtc cctttgagct tcttgactat gttggactgg atactacaaa
      841 gttcatctta gacgggtggc acgaaatgga tccggagaac cccttatttc agcccagtcc
      901 ttccatgaat aatttggtgg cccagaagaa gctgggcaaa aagaccggag aaggatttta
      961 caaatacaag tgatcccccc tcggcagcat ctccagccag ccactggaca aggacaagca
     1021 cgctctgcac tgttgtttcc aggcttgccg tgggctgctc agtggacccc cccttgcagt
     1081 ctctctgacg taatctcttg gctagttacg gtaatggggt tcttccactg atatctaatt
     1141 ctctagttta gtctgttctc tgtgaatttt tctgaaaagc agtataccct gggtgccttg
     1201 gagcaaacat ctttttctct ggaccttgcc actttttgta agaagcaatc attagccgca
     1261 ttcactcagg tctcctgaaa atgagtatgc cgtgtttatc agcgttgaac cccaggggca
     1321 ggcaccatgg tgcctacaga tgcacctgag aggccttgcg tgcctgggaa catttgtagc
     1381 ccgcagcctc gagccttagc ctacattctg ggcgtgacag aaaatgtccc gtctttttta
     1441 ctcctcatca ggacaggact cctggagttt tgggcaagta cctgtgagct tggttcttgg
     1501 cccatcttcg tggccgttcg gatcttaacc gtcactgtct gtctctctca tttcttcagg
     1561 agaaatcagt gctacaaagt gcctctgagc tgactctact aaaatgcagt cttttaatct
     1621 gtaaacattg ggatgggaat aaataaacgt atacgactt
//
