LOCUS       NM_001106831            2923 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus 3-hydroxyacyl-CoA dehydratase 3 (Hacd3), mRNA.
ACCESSION   NM_001106831 XM_001076292 XM_217180
VERSION     NM_001106831.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2923)
  AUTHORS   Boutchueng-Djidjou,M., Collard-Simard,G., Fortier,S., Hebert,S.S.,
            Kelly,I., Landry,C.R. and Faure,R.L.
  TITLE     The last enzyme of the de novo purine synthesis pathway
            5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP
            cyclohydrolase (ATIC) plays a central role in insulin signaling and
            the Golgi/endosomes protein network
  JOURNAL   Mol Cell Proteomics 14 (4), 1079-1092 (2015)
   PUBMED   25687571
  REMARK    GeneRIF: PTPLAD1 (HACD3)is in complex with insulin receptor in
            rat's liver plasma membrane and golgi-endosome(G/E). PTPLAD1
            compartmentalization between PM and G/E is insulin-dependent.
            SiRNA-mediated knockdown of PTPLAD1 increased IR tyrosine
            phosphorylation and affect IR endocytosis in HEK293. PTPLAD1
            depletion enhanced insulin effect on Glut2 translocation in HEK293
            cells and it increased AKT-ser473 phosphorylation. [PTPLAD1]
REFERENCE   2  (bases 1 to 2923)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   3  (bases 1 to 2923)
  AUTHORS   Ikeda,M., Kanao,Y., Yamanaka,M., Sakuraba,H., Mizutani,Y.,
            Igarashi,Y. and Kihara,A.
  TITLE     Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases
            involved in very long-chain fatty acid synthesis
  JOURNAL   FEBS Lett 582 (16), 2435-2440 (2008)
   PUBMED   18554506
REFERENCE   4  (bases 1 to 2923)
  AUTHORS   Taguwa,S., Okamoto,T., Abe,T., Mori,Y., Suzuki,T., Moriishi,K. and
            Matsuura,Y.
  TITLE     Human butyrate-induced transcript 1 interacts with hepatitis C
            virus NS5A and regulates viral replication
  JOURNAL   J Virol 82 (6), 2631-2641 (2008)
   PUBMED   18160438
REFERENCE   5  (bases 1 to 2923)
  AUTHORS   Courilleau,D., Chastre,E., Sabbah,M., Redeuilh,G., Atfi,A. and
            Mester,J.
  TITLE     B-ind1, a novel mediator of Rac1 signaling cloned from sodium
            butyrate-treated fibroblasts
  JOURNAL   J Biol Chem 275 (23), 17344-17348 (2000)
   PUBMED   10747961
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217180.4, XM_001076292.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2923
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2923
                     /gene="Hacd3"
                     /gene_synonym="Ptplad1; RGD1565496"
                     /note="3-hydroxyacyl-CoA dehydratase 3"
                     /db_xref="GeneID:300783"
                     /db_xref="RGD:1565496"
     exon            1..288
                     /gene="Hacd3"
                     /gene_synonym="Ptplad1; RGD1565496"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1290
                     /gene="Hacd3"
                     /gene_synonym="Ptplad1; RGD1565496"
                     /EC_number="4.2.1.134"
                     /note="protein tyrosine phosphatase-like A domain
                     containing 1"
                     /codon_start=1
                     /product="very-long-chain (3R)-3-hydroxyacyl-CoA
                     dehydratase 3"
                     /protein_id="NP_001100301.1"
                     /db_xref="GeneID:300783"
                     /db_xref="RGD:1565496"
                     /translation="METQVLTPHVYWAQRHRELYLRVELSDVQNPAISISENVLHFKA
                     QGHGAKGDNVYEFHLEFLDLVKPEPAYRLTQRQVNITVQKKGSHWWERLTKQEKRPLF
                     LAPDFDRWLDESDAEMELRAKEEERLNKLRLESEGSPETLTNLKKGYLFMYNLVQLLG
                     FSWIFVNLTVRFFILGKESFYDTFHTVADMMYFCQMLALVETLNAAIGVTNSPVLPAL
                     IQFLGRNFILFLVFGTMEEMQNKAVVFFVFYSWSAIEIFRYPFYMLSCIDMDWKVLTW
                     LRYTMWIPLYPLGCLSEAVAVIQSIPVFNESGRFSFTLPYPLRMKVRFSFFLQVYLVM
                     LFLGLYINFRHLYKQRRRRYGQKKKKLH"
     exon            289..331
                     /gene="Hacd3"
                     /gene_synonym="Ptplad1; RGD1565496"
                     /inference="alignment:Splign:2.1.0"
     exon            332..405
                     /gene="Hacd3"
                     /gene_synonym="Ptplad1; RGD1565496"
                     /inference="alignment:Splign:2.1.0"
     exon            406..570
                     /gene="Hacd3"
                     /gene_synonym="Ptplad1; RGD1565496"
                     /inference="alignment:Splign:2.1.0"
     exon            571..622
                     /gene="Hacd3"
                     /gene_synonym="Ptplad1; RGD1565496"
                     /inference="alignment:Splign:2.1.0"
     exon            623..733
                     /gene="Hacd3"
                     /gene_synonym="Ptplad1; RGD1565496"
                     /inference="alignment:Splign:2.1.0"
     exon            734..861
                     /gene="Hacd3"
                     /gene_synonym="Ptplad1; RGD1565496"
                     /inference="alignment:Splign:2.1.0"
     exon            862..974
                     /gene="Hacd3"
                     /gene_synonym="Ptplad1; RGD1565496"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1081
                     /gene="Hacd3"
                     /gene_synonym="Ptplad1; RGD1565496"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1213
                     /gene="Hacd3"
                     /gene_synonym="Ptplad1; RGD1565496"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..2923
                     /gene="Hacd3"
                     /gene_synonym="Ptplad1; RGD1565496"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgggttc tcaccgcgct ccctcccccg tcctcactgc gcaagcgcgg gccgcgagcg
       61 tggagcatct cgagacagcc gggctgcggg ctgcggagcg tgcgggtttg cggcctgcgt
      121 tcggctagct ccagcggctc ataggcggag gtaacgaggc gcagcaagcc gagcctcccc
      181 gctcccggga cagcgtgggc catggagact caagtgctga cgccgcacgt ctactgggct
      241 cagcgacacc gcgagctgta tctgcgcgtg gagctgagtg acgtgcagaa ccctgctatc
      301 agcatctcag aaaatgtgct gcatttcaaa gctcagggac acggtgccaa aggagacaat
      361 gtctatgaat ttcacctgga gttcttagac ctcgtgaagc cagagccggc atacaggctg
      421 acccagaggc aggtgaacat cacagtccag aagaagggga gtcattggtg ggagaggctc
      481 accaagcagg agaagcgccc actgtttttg gcccctgact ttgatcgctg gctggatgaa
      541 tctgatgcag aaatggagct gagagccaag gaggaagaac gcctaaataa actcagacta
      601 gaaagcgaag gctcccctga aactcttacc aacttgaaga aagggtacct gttcatgtac
      661 aacctcgtgc agctcctggg cttctcctgg atctttgtca acctcacagt gcggttcttt
      721 attttgggaa aagagtcctt ctatgacacg ttccacaccg tggctgacat gatgtatttc
      781 tgccagatgc tggcactagt ggaaaccctc aatgccgcaa ttggggtaac gaattccccg
      841 gtgctgcctg ctctcatcca gtttcttgga agaaatttta ttctgtttct cgttttcggc
      901 accatggaag aaatgcagaa caaagccgtg gttttctttg tgttttactc atggagcgca
      961 attgaaattt tcaggtaccc cttctacatg ctgtcctgta ttgacatgga ctggaaggtg
     1021 cttacgtggc ttcgttacac tatgtggatt cccttatatc ccctgggatg tctgtcagaa
     1081 gctgtcgcag tgatccagtc tattccagta ttcaacgagt caggaaggtt cagttttact
     1141 ttgccatatc cattgaggat gaaagtcaga ttctccttct tccttcaagt ttatcttgta
     1201 atgttatttt tagggttata tattaacttc cgtcaccttt ataaacagcg cagacggcgg
     1261 tatggacaaa aaaagaaaaa actccactaa ggataaattt ggtagcttcg tttgagcgga
     1321 atctgattct tactgtttta ccttcttgta ctgatgtaag ggttttttgt tttgttttgt
     1381 tttttaaagt aaggctgtct ctttccccag taacattcct gaatttactg tctgttatct
     1441 tagtgctgta cttgcatgac atggatattg gtacctgacg acaagtccct tcttaggtat
     1501 ttaatgacaa aggtggccct gtggtctgtg ctcttcccta cagtcattgt ctgtcttcac
     1561 agttagggct tggtctttct gctactgctt gtgaaaacca aaaaaaaacc aagactacat
     1621 tttccattgt caagtgaccc ggtatgtttt ataaccaagc cgacacttgt gtagtgggat
     1681 agcactgact gtttgaaaat tgggtacacg tggtcactga cattttttga gtcagagtag
     1741 ggctggaaaa cactttctat ttgatgtctt ttggctaaag acatccatta ctttagcact
     1801 tagcaggcat caaaagaggc agagtgattt agagaaagca atcagaacct gggagcacca
     1861 tgactccttc attcctagct aaatcagaac tgcctgcaac actggagaag ggaacattac
     1921 ttgcagaaca gattgtaagt cccaaatgtg aatgactgcc agggtcagaa gggaacaggg
     1981 atgcaggagc caggctggaa tcagctgtgg taatgatgct ggcccgtggc aaacagacac
     2041 tgaagtaggc cagacacacc ttcacgctgt cttgggctac acacacacac acacacacac
     2101 acacacacac acacacacac actctctctc tctctctctc tctctctctc tctctctctc
     2161 aatctataat tcttgggcta gctcagtcca tttacttgtg tatttctctg agtgactggt
     2221 gagactactc ttttgaacta tttttccttg ttattagttg ggtttttttt cccccttttt
     2281 gtttgttttt taagataggg tttttctgtg tagctttggc tttcctagaa ctctctctgt
     2341 agaccaggct ggccttgaac acacagagcc tctgcctcct gagtgctggg attaaaggca
     2401 agagccacca gagcctgttt tgttttgttt ttggtaaaaa ctgtatgtag taggaacctg
     2461 agcttgcaaa tcaccaggat tcctgcaggg agccccccaa agaggaactg gttcagaata
     2521 cacatcttag ggccaccaca agaggtcttg agtctcttca ccacattcca tgtaaccaag
     2581 tggtgaagtg acatgagaaa aaaagagctc gagggtggac gctcccatct tgtgtggttg
     2641 aaatgagccc agagtggatt agcactaaac tggctgcttt gacacacctc atctcaccca
     2701 agtattttcc aggtctgcag cttctgtcaa cggtttttgt gtcaccttct ggcgctcctt
     2761 ccactgactg tggggcaaac ctagcagttc agctttgcag tcagctatgc tgtatccctg
     2821 tgcaaaaccc catgttctag ttgctgttag gaccccctct gttgctgtct gagaaagtga
     2881 aagattgtgt atttctatta aaacatttac agtcaaaatc cta
//
