LOCUS       NM_001101001             951 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus 3-hydroxyacyl-CoA dehydratase 1 (Hacd1), mRNA.
ACCESSION   NM_001101001 XM_001056393 XM_001056514
VERSION     NM_001101001.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 951)
  AUTHORS   Montoya G, Arenas J, Romo E, Zeichner-David M, Alvarez M, Narayanan
            AS, Velazquez U, Mercado G and Arzate H.
  TITLE     Human recombinant cementum attachment protein (hrPTPLa/CAP)
            promotes hydroxyapatite crystal formation in vitro and bone healing
            in vivo
  JOURNAL   Bone 69, 154-164 (2014)
   PUBMED   25263524
REFERENCE   2  (bases 1 to 951)
  AUTHORS   Valdes De Hoyos A, Hoz-Rodriguez L, Arzate H and Narayanan AS.
  TITLE     Isolation of protein-tyrosine phosphatase-like member-a variant
            from cementum
  JOURNAL   J Dent Res 91 (2), 203-209 (2012)
   PUBMED   22067203
REFERENCE   3  (bases 1 to 951)
  AUTHORS   Lin X, Yang X, Li Q, Ma Y, Cui S, He D, Lin X, Schwartz RJ and
            Chang J.
  TITLE     Protein tyrosine phosphatase-like A regulates myoblast
            proliferation and differentiation through MyoG and the cell cycling
            signaling pathway
  JOURNAL   Mol Cell Biol 32 (2), 297-308 (2012)
   PUBMED   22106411
  REMARK    Erratum:[Mol Cell Biol. 2017 Jul 28;37(16):. PMID: 28754770]
REFERENCE   4  (bases 1 to 951)
  AUTHORS   Ikeda M, Kanao Y, Yamanaka M, Sakuraba H, Mizutani Y, Igarashi Y
            and Kihara A.
  TITLE     Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases
            involved in very long-chain fatty acid synthesis
  JOURNAL   FEBS Lett 582 (16), 2435-2440 (2008)
   PUBMED   18554506
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AM260199.1.
            
            On or before Aug 13, 2007 this sequence version replaced
            XM_001056393.1, XM_001056514.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM260199.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..951
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..951
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /note="3-hydroxyacyl-CoA dehydratase 1"
                     /db_xref="GeneID:680115"
                     /db_xref="RGD:1595507"
     exon            1..228
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..838
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /EC_number="4.2.1.134"
                     /note="protein tyrosine phosphatase-like protein A;
                     protein-tyrosine phosphatase-like member A; protein
                     tyrosine phosphatase-like (proline instead of catalytic
                     arginine), member a"
                     /codon_start=1
                     /product="very-long-chain (3R)-3-hydroxyacyl-CoA
                     dehydratase 1"
                     /protein_id="NP_001094471.1"
                     /db_xref="GeneID:680115"
                     /db_xref="RGD:1595507"
                     /translation="MASSEEDGTNGASEASDEKEATGKRRRLGFLATAWLTFYNIAMT
                     AGWLVLAIAMVRFYMEKGTHRGLYKSIQKTLKFFQTFALLEVVHCLIGIVPTSVLVTG
                     VQVSSRIFMVWLITHSIKPIQNEESVVLFLVSWTVTEITRYSFYTFSLLDHLPHFIKW
                     ARYNFFIILYPVGVAGELLTIYAALPYVKKSGMFSVRLPNKYNVSFDYYYFLLITMAS
                     YIPLFPQLYFHMLRQRRKVLHGEVIVEKDD"
     exon            229..346
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /inference="alignment:Splign:2.1.0"
     exon            347..365
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /inference="alignment:Splign:2.1.0"
     exon            366..454
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /inference="alignment:Splign:2.1.0"
     exon            455..576
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /inference="alignment:Splign:2.1.0"
     exon            577..755
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /inference="alignment:Splign:2.1.0"
     exon            756..928
                     /gene="Hacd1"
                     /gene_synonym="Ptpla"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgcgg gcagcggcgc ttcagtggcg cgctcagccg gcccctcccg ctcctgtgcg
       61 ctgctcctcc ggctccgcgt gcgcggtcac catggcgtcc agtgaggagg acggcaccaa
      121 cggcgcctcc gaggccagcg acgagaagga agccaccggc aagcggagac gcctaggctt
      181 cctggccacc gcctggctca ccttctacaa tatcgccatg accgccgggt ggttggttct
      241 agctattgca atggtacgct tttatatgga aaaaggaaca cacagaggtt tatataaaag
      301 cattcagaag acacttaaat ttttccaaac atttgctttg cttgaggtag tccactgtct
      361 gattggaatc gtacccactt ctgtgcttgt gactggggtc caagtgagtt cacgaatctt
      421 catggtatgg ctcattactc acagtataaa acccatccag aacgaagaga gcgtggtgct
      481 ttttctggtc tcctggactg tgaccgagat cactcgctat tccttctaca cattcagtct
      541 cctcgaccac ttgccgcact tcattaaatg ggccagatac aattttttta tcatcttata
      601 tcccgttgga gttgctggag agcttctcac gatatacgct gccttgcctt acgtaaagaa
      661 atcagggatg ttttcagtaa ggcttcctaa caagtacaac gtctctttcg actactacta
      721 ttttcttctc ataaccatgg cctcgtatat accgctgttt cctcagctct attttcatat
      781 gttacgtcaa agaagaaagg tgcttcatgg cgaggtgatc gtagagaagg acgattaaat
      841 ggtccctaca aacaaggtgc ttttttcaga aaaaccggat tacttgagtc caagttttaa
      901 taataagaat aaacaacttc atgaaataaa aaaaaaaaaa aaaaaaaaaa a
//
