LOCUS       NM_001001505            2163 bp    mRNA    linear   ROD 16-FEB-2024
DEFINITION  Rattus norvegicus hyaluronan binding protein 2 (Habp2), mRNA.
ACCESSION   NM_001001505 XM_217636
VERSION     NM_001001505.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2163)
  AUTHORS   Ahmad-Nejad,P., Dempfle,C.E., Weiss,C., Bugert,P., Borggrefe,M. and
            Neumaier,M.
  TITLE     The G534E-polymorphism of the gene encoding the factor
            VII-activating protease is a risk factor for venous thrombosis and
            recurrent events
  JOURNAL   Thromb Res 130 (3), 441-444 (2012)
   PUBMED   22421107
REFERENCE   2  (bases 1 to 2163)
  AUTHORS   Kemmochi,S., Yamamichi,S., Shimamoto,K., Onda,N., Hasumi,K.,
            Suzuki,K., Mitsumori,K. and Shibutani,M.
  TITLE     Lac color inhibits development of rat thyroid carcinomas through
            targeting activation of plasma hyaluronan-binding protein
  JOURNAL   Exp Biol Med (Maywood) 237 (6), 728-738 (2012)
   PUBMED   22715430
REFERENCE   3  (bases 1 to 2163)
  AUTHORS   Mu,E., Liu,X., Chen,S., Zhi,L., Li,X., Xu,X. and Ma,X.
  TITLE     Changes in factor VII-activating protease in a bleomycin-induced
            lung injury rat model and its influence on human pulmonary
            fibroblasts in vitro
  JOURNAL   Int J Mol Med 26 (4), 549-555 (2010)
   PUBMED   20818495
  REMARK    GeneRIF: FSAP was observed prominently in alveolar epithelial cells
            as well as microvascular endothelial cells of the lung parenchyma
            and was markedly increased at the early phase of bleomycin-induced
            pulmonary fibrosis, but decreased at the late stage.
REFERENCE   4  (bases 1 to 2163)
  AUTHORS   Thakur,S.C. and Datta,K.
  TITLE     Higher expression of hyaluronan binding protein 1
            (HABP1/p32/gC1qR/SF2) during follicular development and cumulus
            oocyte complex maturation in rat
  JOURNAL   Mol Reprod Dev 75 (3), 429-438 (2008)
   PUBMED   17562559
  REMARK    GeneRIF: HABP1 expressed in rat COCs during maturation may
            facilitate the formation of the HA matrix in the extracellular
            space around the oocyte with cumulus expansion during maturation.
REFERENCE   5  (bases 1 to 2163)
  AUTHORS   Choi-Miura,N.H., Yoda,M., Saito,K., Takahashi,K. and Tomita,M.
  TITLE     Identification of the substrates for plasma hyaluronan binding
            protein
  JOURNAL   Biol Pharm Bull 24 (2), 140-143 (2001)
   PUBMED   11217080
REFERENCE   6  (bases 1 to 2163)
  AUTHORS   Choi-Miura,N.H., Tobe,T., Sumiya,J., Nakano,Y., Sano,Y., Mazda,T.
            and Tomita,M.
  TITLE     Purification and characterization of a novel hyaluronan-binding
            protein (PHBP) from human plasma: it has three EGF, a kringle and a
            serine protease domain, similar to hepatocyte growth factor
            activator
  JOURNAL   J Biochem 119 (6), 1157-1165 (1996)
   PUBMED   8827452
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000054.1.
            
            [WARNING] On Mar 29, 2024 this sequence was replaced by
            NM_001001505.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001001505.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB177406.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JACYVU010000054.1  16409956-16410050
            96-132              JACYVU010000054.1  16421232-16421268
            133-243             JACYVU010000054.1  16430659-16430769
            244-351             JACYVU010000054.1  16432756-16432863
            352-468             JACYVU010000054.1  16433963-16434079
            469-588             JACYVU010000054.1  16434712-16434831
            589-760             JACYVU010000054.1  16435251-16435422
            761-858             JACYVU010000054.1  16436434-16436531
            859-1114            JACYVU010000054.1  16437539-16437794
            1115-1257           JACYVU010000054.1  16438794-16438936
            1258-1392           JACYVU010000054.1  16440266-16440400
            1393-1538           JACYVU010000054.1  16441801-16441946
            1539-2163           JACYVU010000054.1  16443576-16444200
FEATURES             Location/Qualifiers
     source          1..2163
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..2163
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /note="hyaluronan binding protein 2"
                     /db_xref="GeneID:292126"
                     /db_xref="RGD:1302979"
     exon            1..95
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1703
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /EC_number="3.4.21.92"
                     /note="plasma hyaluronan-binding protein; hyaluronic acid
                     binding protein 2; factor VII-activating protease"
                     /codon_start=1
                     /product="hyaluronan-binding protein 2 precursor"
                     /protein_id="NP_001001505.2"
                     /db_xref="GeneID:292126"
                     /db_xref="RGD:1302979"
                     /translation="MSVVMLVFRVLLLIALVGNSAIGLSLMPFIAPPDPDWTPDDYYY
                     SYEQSSPDKDASVTQTSPENPDWYYEDDDPCQSNPCEHGGDCIIRGNTFSCSCPAPFS
                     GSRCQTVQNKCKDNPCVQGDCLITQTPPYYRCACKYPYTGPDCSKVLPVCRPNPCQNG
                     GVCSRHRRRSRFSCACPDQYKGRFCEIGPDDCYVGDGYSYRGKVSRTVNQNPCLYWNS
                     HLLLQENYNMFMEDAETHGIADHNFCRNPDGDHKPWCFVKVNSEKVKWEYCNVEVCPE
                     SDAANPLGSLQEPVMELPGFDSCGKTEMTEHAVKRIYGGFKSTAGKHPWQVSLQTSLP
                     LTTSMPQGHFCGGSLIHPCWVLTAAHCTDMSTKHLKVVLGDQDLKKTESHEQTFRVEK
                     ILKYSQYNERDEIPHNDIALLKLKPVGGHCALESKYVKTVCLPSDPFPSGTECHISGW
                     GVTETGEGSRQLLDAKVKLIANALCNSRQLYDHTIDDSMICAGNLQKPGSDTCQGDSG
                     GPLTCEKDGTYYVYGIVSWGQECGKKPGVYTQVTKFLNWIKTTMHKEAGL"
     exon            96..132
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /inference="alignment:Splign:2.1.0"
     exon            133..243
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /inference="alignment:Splign:2.1.0"
     exon            244..351
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /inference="alignment:Splign:2.1.0"
     exon            352..468
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /inference="alignment:Splign:2.1.0"
     exon            469..588
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /inference="alignment:Splign:2.1.0"
     exon            589..760
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /inference="alignment:Splign:2.1.0"
     exon            761..858
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1114
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1257
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1392
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1538
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..2163
                     /gene="Habp2"
                     /gene_synonym="Fsap; Habp; Phbp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggggagac gccttccacc gcacagatgt ctgtcgtgat gttggtgttc cgtgttctgc
       61 tgctaatcgc cctagtgggg aactcagcca tcgggctctc actgatgcca ttcattgcac
      121 ctccagaccc agattggacc cccgatgact attactacag ttacgagcag tccagtccag
      181 acaaagacgc cagtgtcacg cagacctccc ccgagaaccc cgactggtac tatgaagacg
      241 atgatccatg ccagtccaac ccctgtgaac acggcgggga ctgtatcatc agagggaata
      301 ccttcagttg cagctgcccg gcccccttct cggggagccg gtgtcagacg gtccaaaaca
      361 agtgcaagga caacccatgt gtccagggcg attgcctcat tacccagacg cctccctact
      421 accgctgtgc ctgcaaatac ccttacacgg gaccagactg ctccaaagtg cttccggtat
      481 gcagaccaaa tccctgccag aatggcgggg tctgttcccg acacagacgg aggtccaggt
      541 ttagctgcgc ctgtccagac cagtataagg ggagattctg tgaaataggt ccggacgact
      601 gttatgtcgg tgatggctac tcttaccgag gcaaagtgag taggacagtc aaccagaacc
      661 catgccttta ctggaactcc cacctcctct tgcaggagaa ttacaacatg tttatggagg
      721 atgccgagac ccatgggatc gcagatcaca acttctgcag aaacccagat ggagaccaca
      781 agccgtggtg tttcgttaag gtgaacagtg agaaggtgaa atgggagtat tgtaatgtcg
      841 aggtctgccc agagtccgat gctgctaacc cattgggcag ccttcaggaa cctgtgatgg
      901 agctgccagg attcgactcc tgcgggaaga cagagatgac tgaacacgcg gtcaagcgca
      961 tctacggggg ctttaagagc acagcgggca agcacccgtg gcaggtgtcc ctgcagacct
     1021 cattgccgct gaccacctcc atgccccaag gccacttctg tgggggttcc ctgattcacc
     1081 cttgctgggt gctcactgca gcccactgta ccgacatgag caccaagcat ctgaaagttg
     1141 tgctggggga ccaggacctg aaaaagaccg aatcccacga gcagaccttc agggtggaga
     1201 agatactgaa gtacagtcag tataatgaaa gagatgagat tccccacaat gacatcgctt
     1261 tgctcaagtt aaagccagtg ggcggtcact gtgctctgga atccaaatac gtgaagactg
     1321 tatgcttgcc tagtgacccc tttccctctg ggactgagtg ccacatctct ggctggggcg
     1381 taacggaaac aggggaaggc tcccgccagc tcctggatgc taaagtcaag ctgattgcta
     1441 atgctttgtg caactcccgc caactgtatg accacacgat cgatgacagt atgatctgtg
     1501 cagggaacct gcagaagcct ggatcggaca cctgccaggg tgactcgggg ggccctctaa
     1561 cctgtgagaa ggatggaact tactacgtct atgggattgt aagctggggc caggaatgtg
     1621 ggaagaagcc tggagtctac actcaagtca ccaagttcct gaattggata aaaaccacca
     1681 tgcacaagga ggctggcctc tgaggtgctg tctgcagagc ctcgaagcac ctcctcttct
     1741 gcactaaaca agggggtgct tcctgtgtag ccaaggatat cctgggtcta tgctttagac
     1801 agagacattg ctgaccagcc tgggtctttg cagactggca ctacaccacc tcacgaggcc
     1861 cactctgtcc tcctctccct gagaaccaac aagaaataca ttacctctgc cccgcttctg
     1921 acaagtgtgc cttcgagaaa accagaattc agagatgctc tccaccataa agacctgcag
     1981 atctgagatt tctccctgtc cagtaccaga ggagactgtt actcttctgc ccacaccatc
     2041 agggtcttcc gcagtctcca tgcagccatc agagagaaac cccccccccc ccccgccaag
     2101 gaaaaaacac aagttctgtt tgctttcaga gttgttgttt taataaaggc agatgtggga
     2161 atg
//
