LOCUS       NM_020076               1252 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Rattus norvegicus 3-hydroxyanthranilate 3,4-dioxygenase (Haao),
            mRNA.
ACCESSION   NM_020076
VERSION     NM_020076.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1252)
  AUTHORS   Berg,M., Polyzos,K.A., Agardh,H., Baumgartner,R., Forteza,M.J.,
            Kareinen,I., Gistera,A., Bottcher,G., Hurt-Camejo,E., Hansson,G.K.
            and Ketelhuth,D.F.J.
  TITLE     3-Hydroxyanthralinic acid metabolism controls the hepatic
            SREBP/lipoprotein axis, inhibits inflammasome activation in
            macrophages, and decreases atherosclerosis in Ldlr-/- mice
  JOURNAL   Cardiovasc Res 116 (12), 1948-1957 (2020)
   PUBMED   31589306
REFERENCE   2  (bases 1 to 1252)
  AUTHORS   Shi,H., Enriquez,A., Rapadas,M., Martin,E.M.M.A., Wang,R.,
            Moreau,J., Lim,C.K., Szot,J.O., Ip,E., Hughes,J.N., Sugimoto,K.,
            Humphreys,D.T., McInerney-Leo,A.M., Leo,P.J., Maghzal,G.J.,
            Halliday,J., Smith,J., Colley,A., Mark,P.R., Collins,F.,
            Sillence,D.O., Winlaw,D.S., Ho,J.W.K., Guillemin,G.J., Brown,M.A.,
            Kikuchi,K., Thomas,P.Q., Stocker,R., Giannoulatou,E., Chapman,G.,
            Duncan,E.L., Sparrow,D.B. and Dunwoodie,S.L.
  TITLE     NAD Deficiency, Congenital Malformations, and Niacin
            Supplementation
  JOURNAL   N Engl J Med 377 (6), 544-552 (2017)
   PUBMED   28792876
REFERENCE   3  (bases 1 to 1252)
  AUTHORS   Pidugu,L.S., Neu,H., Wong,T.L., Pozharski,E., Molloy,J.L.,
            Michel,S.L. and Toth,E.A.
  TITLE     Crystal structures of human 3-hydroxyanthranilate 3,4-dioxygenase
            with native and non-native metals bound in the active site
  JOURNAL   Acta Crystallogr D Struct Biol 73 (Pt 4), 340-348 (2017)
   PUBMED   28375145
REFERENCE   4  (bases 1 to 1252)
  AUTHORS   Maddison,D.C. and Giorgini,F.
  TITLE     The kynurenine pathway and neurodegenerative disease
  JOURNAL   Semin Cell Dev Biol 40, 134-141 (2015)
   PUBMED   25773161
  REMARK    Review article
REFERENCE   5  (bases 1 to 1252)
  AUTHORS   Sathyasaikumar,K.V., Stachowski,E.K., Wonodi,I., Roberts,R.C.,
            Rassoulpour,A., McMahon,R.P. and Schwarcz,R.
  TITLE     Impaired kynurenine pathway metabolism in the prefrontal cortex of
            individuals with schizophrenia
  JOURNAL   Schizophr Bull 37 (6), 1147-1156 (2011)
   PUBMED   21036897
REFERENCE   6  (bases 1 to 1252)
  AUTHORS   Nakano,K., Asai,H. and Kitoh,J.
  TITLE     Abnormally high activity of 3-hydroxyanthranilate 3,4-dioxygenase
            in brain of epilepsy-prone El mice
  JOURNAL   Brain Res 572 (1-2), 1-4 (1992)
   PUBMED   1611505
REFERENCE   7  (bases 1 to 1252)
  AUTHORS   Schwarcz,R., Okuno,E. and White,R.J.
  TITLE     Basal ganglia lesions in the rat: effects on quinolinic acid
            metabolism
  JOURNAL   Brain Res 490 (1), 103-109 (1989)
   PUBMED   2527078
REFERENCE   8  (bases 1 to 1252)
  AUTHORS   Schwarcz,R., Okuno,E., White,R.J., Bird,E.D. and Whetsell,W.O. Jr.
  TITLE     3-Hydroxyanthranilate oxygenase activity is increased in the brains
            of Huntington disease victims
  JOURNAL   Proc Natl Acad Sci U S A 85 (11), 4079-4081 (1988)
   PUBMED   2967497
REFERENCE   9  (bases 1 to 1252)
  AUTHORS   Okuno,E., Kohler,C. and Schwarcz,R.
  TITLE     Rat 3-hydroxyanthranilic acid oxygenase: purification from the
            liver and immunocytochemical localization in the brain
  JOURNAL   J Neurochem 49 (3), 771-780 (1987)
   PUBMED   3112306
REFERENCE   10 (bases 1 to 1252)
  AUTHORS   Foster,A.C., White,R.J. and Schwarcz,R.
  TITLE     Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase
            in rat brain tissue in vitro
  JOURNAL   J Neurochem 47 (1), 23-30 (1986)
   PUBMED   2940338
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D44494.1.
            
            On Aug 31, 2012 this sequence version replaced NM_020076.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D44494.1, FQ219702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1252              D44494.1           2-1253
FEATURES             Location/Qualifiers
     source          1..1252
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..1252
                     /gene="Haao"
                     /note="3-hydroxyanthranilate 3,4-dioxygenase"
                     /db_xref="GeneID:56823"
                     /db_xref="RGD:71071"
     exon            1..168
                     /gene="Haao"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..949
                     /gene="Haao"
                     /EC_number="1.13.11.6"
                     /note="HAD; 3-HAO; 3-hydroxyanthranilate oxygenase;
                     3-hydroxyanthranilic acid dioxygenase"
                     /codon_start=1
                     /product="3-hydroxyanthranilate 3,4-dioxygenase"
                     /protein_id="NP_064461.1"
                     /db_xref="GeneID:56823"
                     /db_xref="RGD:71071"
                     /translation="MERCVRVKSWVEENRASFQPPVCNKLMHREQLKIMFVGGPNTRK
                     DYHIEEGEEVFYQLEGDMVLRVLEQGEHRDVVIRQGEIFLLPARVPHSPQRFANTMGL
                     VIERRRMETELDGLRYYVGDTEDVLFEKWFHCKDLGTQLAPIIQEFFHSEQYRTGKPN
                     PDQLLKEPPFPLSTRSVMEPMSLKAWLESHSRELQAGTSLSLFGDSYETQVIAHGQGS
                     SKGPRQDVDVWLWQLEGSSKVTMGGQCVALAPDDSLLVPAGFSYMWERAQGSVALSVT
                     QDPACKKPLG"
     exon            169..247
                     /gene="Haao"
                     /inference="alignment:Splign:2.1.0"
     exon            248..331
                     /gene="Haao"
                     /inference="alignment:Splign:2.1.0"
     exon            332..438
                     /gene="Haao"
                     /inference="alignment:Splign:2.1.0"
     exon            439..528
                     /gene="Haao"
                     /inference="alignment:Splign:2.1.0"
     exon            529..572
                     /gene="Haao"
                     /inference="alignment:Splign:2.1.0"
     exon            573..718
                     /gene="Haao"
                     /inference="alignment:Splign:2.1.0"
     exon            719..787
                     /gene="Haao"
                     /inference="alignment:Splign:2.1.0"
     exon            788..870
                     /gene="Haao"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1252
                     /gene="Haao"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgacaggag acagagcaca ttgtagctct ccaactgccg gattacctgg cgaccacgtt
       61 gtggtcagaa gagtcctgcc tgccggccat ggagcgctgt gtgagagtga agtcttgggt
      121 agaagagaat cgggcctcct ttcagcctcc ggtttgcaac aagcttatgc accgggagca
      181 gctcaaaatc atgttcgtcg gaggccccaa caccaggaag gattatcaca ttgaagaggg
      241 agaggaggtg ttttaccagc tggagggaga catggtgctc cgagtcctcg agcaaggaga
      301 acaccgggat gtggttatac gacagggaga gatattcctc ctgcctgcca gggtgcccca
      361 ctccccgcag aggtttgcca acaccatggg cctggtgatt gagagaaggc gaatggagac
      421 cgagctggat gggctgaggt actatgtggg cgacactgag gatgtcctct tcgagaaatg
      481 gttccactgt aaggaccttg ggacgcagtt agcccccatc atccaagagt tcttccactc
      541 tgagcagtac cgaacaggaa agcccaaccc tgaccaactg ctcaaggagc cgccattccc
      601 gctgagtaca cggtccgtaa tggagcccat gtcactgaag gcctggctgg agagccactc
      661 cagggagctt caggcaggca catccctaag cctgtttggg gacagctatg agactcaggt
      721 catcgcccac ggacaaggca gcagcaaagg cccgagacag gatgtagatg tgtggctgtg
      781 gcaactggag ggctcctcta aggtgacaat gggaggacag tgtgtggccc tggccccaga
      841 tgacagcctg ctggtgcccg ctgggttctc gtacatgtgg gagcgagcgc aaggctctgt
      901 ggccttgtct gtgacacaag accctgcctg taagaagcca ctggggtgac ccttctgtgt
      961 gggcccaaag cagccacagg gtgcctgagt gctgtcctga cagctgccct ttccagacag
     1021 ctctttcagc ctcatgacat ctccgtggac attgacaggg cccctccgtg atcgtgggct
     1081 gtcactggca tccaccctgc tgtcatgctt agctcaggat gcagagggga ttcctaggac
     1141 accagtagtt cccctctctc ctaacagccc tacactgtca gcgaggtgca taccgtcctc
     1201 atgcgcctgt cagcctaaca ctaagaaatc tctcaataaa ggcctcctgc tg
//
