LOCUS       NM_001106698            4724 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus hexose-6-phosphate dehydrogenase (glucose
            1-dehydrogenase) (H6pd), mRNA.
ACCESSION   NM_001106698 XM_001075788 XM_233688
VERSION     NM_001106698.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4724)
  AUTHORS   Ikeda M, Honma K, Mochizuki K and Goda T.
  TITLE     Fasting for 3 days during the suckling-weaning transient period in
            male rats induces metabolic abnormalities in the liver and is
            associated with impaired glucose tolerance in adulthood
  JOURNAL   Eur J Nutr 55 (3), 1059-1067 (2016)
   PUBMED   25943649
REFERENCE   2  (bases 1 to 4724)
  AUTHORS   Lavery GG, Idkowiak J, Sherlock M, Bujalska I, Ride JP, Saqib K,
            Hartmann MF, Hughes B, Wudy SA, De Schepper J, Arlt W, Krone N,
            Shackleton CH, Walker EA and Stewart PM.
  TITLE     Novel H6PDH mutations in two girls with premature adrenarche:
            'apparent' and 'true' CRD can be differentiated by urinary steroid
            profiling
  JOURNAL   Eur J Endocrinol 168 (2), K19-K26 (2013)
   PUBMED   23132696
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4724)
  AUTHORS   Marcolongo P, Senesi S, Giunti R, Csala M, Fulceri R, Banhegyi G
            and Benedetti A.
  TITLE     Expression of hexose-6-phosphate dehydrogenase in rat tissues
  JOURNAL   J Steroid Biochem Mol Biol 126 (3-5), 57-64 (2011)
   PUBMED   21620971
  REMARK    GeneRIF: It was found that H6PD was present in all investigated
            tissues; both expression and activity remained within an order of
            magnitude. Correlation was found between the dehydrogenase activity
            and protein or mRNA levels.
REFERENCE   4  (bases 1 to 4724)
  AUTHORS   Fan Z, Du H, Zhang M, Meng Z, Chen L and Liu Y.
  TITLE     Direct regulation of glucose and not insulin on hepatic
            hexose-6-phosphate dehydrogenase and 11beta-hydroxysteroid
            dehydrogenase type 1
  JOURNAL   Mol Cell Endocrinol 333 (1), 62-69 (2011)
   PUBMED   21163329
  REMARK    GeneRIF: Activation of expression and activity of
            Hexose-6-phosphate dehydrogenase in primary hepatocytes was
            mediated through levels of glucose, not related to insulin levels
            so concluding that glucose instead of insulin directly regulates
            H6PDH.
REFERENCE   5  (bases 1 to 4724)
  AUTHORS   Hyatt T, Chen R, Wang X, Mick G and McCormick K.
  TITLE     Effect of diabetes on enzymes involved in rat hepatic
            corticosterone production
  JOURNAL   J Diabetes 2 (4), 275-281 (2010)
   PUBMED   20923496
REFERENCE   6  (bases 1 to 4724)
  AUTHORS   Czegle I, Piccirella S, Senesi S, Csala M, Mandl J, Banhegyi G,
            Fulceri R and Benedetti A.
  TITLE     Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1
            and hexose-6-phosphate dehydrogenase is based on a common pyridine
            nucleotide pool in the lumen of the endoplasmic reticulum
  JOURNAL   Mol Cell Endocrinol 248 (1-2), 24-25 (2006)
   PUBMED   16337333
  REMARK    GeneRIF: The results demonstrate the existence of a separate
            intraluminal pyridine nucleotide pool in the hepatic endoplasmic
            reticulum and a close cooperation between 11betaHSD1 and H6PDH
            based on their co-localization.
REFERENCE   7  (bases 1 to 4724)
  AUTHORS   Draper N, Walker EA, Bujalska IJ, Tomlinson JW, Chalder SM, Arlt W,
            Lavery GG, Bedendo O, Ray DW, Laing I, Malunowicz E, White PC,
            Hewison M, Mason PJ, Connell JM, Shackleton CH and Stewart PM.
  TITLE     Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase
            type 1 and hexose-6-phosphate dehydrogenase interact to cause
            cortisone reductase deficiency
  JOURNAL   Nat Genet 34 (4), 434-439 (2003)
   PUBMED   12858176
REFERENCE   8  (bases 1 to 4724)
  AUTHORS   Clarke JL and Mason PJ.
  TITLE     Murine hexose-6-phosphate dehydrogenase: a bifunctional enzyme with
            broad substrate specificity and 6-phosphogluconolactonase activity
  JOURNAL   Arch Biochem Biophys 415 (2), 229-234 (2003)
   PUBMED   12831846
REFERENCE   9  (bases 1 to 4724)
  AUTHORS   Hino,Y. and Minakami,S.
  TITLE     Hexose-6-phosphate and 6-phosphogluconate dehydrogenases of rat
            liver microsomes. Involvement in NADPH and carbon dioxide
            generation in the luminal space of microsomal vesicles
  JOURNAL   J Biochem 92 (2), 547-557 (1982)
   PUBMED   6813321
REFERENCE   10 (bases 1 to 4724)
  AUTHORS   Grunwald,M. and Hill,H.Z.
  TITLE     Characterization of the glucose 6-phosphate dehydrogenase activity
            in rat liver mitochondria
  JOURNAL   Biochem J 159 (3), 683-687 (1976)
   PUBMED   1008825
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_233688.4, XM_001075788.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132276,
                              SAMD00132279 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4724
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4724
                     /gene="H6pd"
                     /gene_synonym="H6pdh"
                     /note="hexose-6-phosphate dehydrogenase (glucose
                     1-dehydrogenase)"
                     /db_xref="GeneID:298655"
                     /db_xref="RGD:1306562"
     exon            1..275
                     /gene="H6pd"
                     /gene_synonym="H6pdh"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..2664
                     /gene="H6pd"
                     /gene_synonym="H6pdh"
                     /note="GDH/6PGL endoplasmic bifunctional protein"
                     /codon_start=1
                     /product="GDH/6PGL endoplasmic bifunctional protein
                     precursor"
                     /protein_id="NP_001100168.1"
                     /db_xref="GeneID:298655"
                     /db_xref="RGD:1306562"
                     /translation="MKCTGIWKMLVAAVCLALLGCLQAQEFRGHVSIILLGATGDLAK
                     KYLWQGLFQLYLDEAGKGHSFSFHGAALTAPQQGQKLMDKALESLSCPKDLVPSRCDE
                     LKAQFLQLSQYRQLKTVEDYQTLNKDIETQVQQDGLWEAGRVFYFSVPPFAYADIARN
                     INSSCRPHPGAWLRVVFEKPFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQ
                     ILPFRDQNRKALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGVIRDTLQNHLTEI
                     LTLVAMELPPNISSSAAVLQHKLQAFQALRGLQKSNAILGQYQAYSGQVRQELQKPDG
                     FQSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNRAYCTQGERHWV
                     PERSRCLPQQIVFYIGHGELGHPAILVSKNLFKPSLPAQSWKGVQDQPGLHLFGRPLS
                     DYYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDSLSFEVPRLYP
                     GGAENDHLLDFEFSGGQLTFSQQQLEVLMPELGSVPKPSDFQVLRAQYRKSPLITAWP
                     EELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGHYSFPWAYTHLWL
                     VDERCVPLSDPDSNFQGLQAHLLQHVRVPYYNIHPMPVHLHQRLCAEEDQGAQTYASE
                     ISALVANSSFDLVLLGMGTDGHTASLFPQSPRGLDGDQLVVLTESPFRPHQRMSLSLP
                     LINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPLSGQLVWYMDYEAFLG"
     exon            276..912
                     /gene="H6pd"
                     /gene_synonym="H6pdh"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1030
                     /gene="H6pd"
                     /gene_synonym="H6pdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1300
                     /gene="H6pd"
                     /gene_synonym="H6pdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..4724
                     /gene="H6pd"
                     /gene_synonym="H6pdh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggagagcg cggcgcgggg ccgcggtggc ctgaggcctg cccgctgggc cctgacactg
       61 cgcagctcgc ctctgcggct tcccgggtag aacttggccc cgcgccctgg gctctcgccg
      121 cgtgcccggg cgctctcgga gcgccgaggc gcggccccgc gtgaagcgcg cacctgccga
      181 ggacgaggcg cgggcagggg gtcgcaggtt ccccagcgcc cccgccgcct gtcgtgctag
      241 ccagccctgg ccacttcccg gacgaacgaa atgaagtgca caggcatttg gaagatgctc
      301 gtggcagccg tgtgcttggc ccttctgggc tgcctgcagg cacaggaatt caggggacat
      361 gtttccataa tcctactagg agcaaccggg gacctagcta aaaagtacct gtggcaggga
      421 ctgttccagc tatacctgga tgaggctggg aagggccaca gtttcagctt ccacggggcc
      481 gccctgacag ccccccagca aggccagaag ctcatggata aggctttgga atccctctcc
      541 tgccccaagg acctggtacc cagtcgctgc gatgaactca aggctcagtt tctgcagctg
      601 agccagtacc gccaactgaa gacagtggag gactatcaga ctctcaacaa ggacatcgag
      661 acccaggtcc agcaggatgg gctctgggag gccggcaggg tcttctactt ctccgtgccg
      721 ccgttcgcct acgccgacat tgcccgtaac atcaacagca gctgccgacc acacccaggc
      781 gcctggctac gggttgtttt tgaaaaaccc ttcggccatg accacctctc agcccagcag
      841 ctggcttcag aacttggaag ctttttccag gaagaggaga tgtaccgtgt agatcattac
      901 ctgggcaagc aggcggtggc tcagatcctg cccttccgag atcagaaccg caaggccttg
      961 gatggcctct ggaacaggca ccacgtggag cgggtggaaa tcatcttgaa ggagaccgtg
     1021 gatgcaggag gtcgggccag tttctacgag gagtatggcg tcatccgaga cacgctgcag
     1081 aaccacctga ctgagatcct cacgctggtg gccatggaac tgcccccaaa catcagcagc
     1141 tcagccgccg tgctccagca caagctccag gccttccagg ccctgcgggg gctgcagaag
     1201 agcaacgcca tcctgggcca gtaccaggcc tatagtgggc aggtgcgcca agagctgcag
     1261 aagccagacg gtttccagag cctgacgcca accttcgcag gtgtccttgt ccacatcgac
     1321 aacctgcgct gggagggcgt ccctttcatc ctgatgtctg gcaaggcctt ggacgagaga
     1381 gtgggctatg ttcggatctt gtttaagaat cgggcgtact gcacccaggg cgagagacac
     1441 tgggtgccgg aacggagccg gtgcctgccc cagcagattg tcttctacat tggacacggt
     1501 gagctgggcc accctgccat cctggtcagc aagaacctgt tcaagccctc tctacccgct
     1561 cagagctgga agggggtgca ggaccagcct gggctccacc tctttggccg cccactgtcc
     1621 gattactatg cctataggcc cgtgcgggag caagatgcct actccacgct cctgtcccac
     1681 atcttccact gccgcaagga gtccttcatc accacagaga acctcttggc ctcctgggtc
     1741 ttctggaccc cgttgctgga cagcctgtcc tttgaagtcc cacgcctgta cccaggaggc
     1801 gcggagaacg accatctgct agacttcgag tttagcgggg gtcagctgac cttctcccag
     1861 cagcagctag aggtgctgat gccagaacta gggtcagtgc caaagcccag cgacttccag
     1921 gtccttaggg cccagtatag aaagagccca ctgattactg cctggccaga ggagctgatc
     1981 tccaagctgg ccaatgacat cgaagccgcc gcagtgcagg cggtaaggcg cttcggcaag
     2041 ttccacctgg cactgtcagg gggttcgagc cccatagcgc tcttccagca gctggccacg
     2101 gggcattaca gcttcccctg ggcctacacg cacctctggc tggtcgatga gcgttgtgtc
     2161 cctctgtcag atccagactc caacttccag ggtctgcagg ctcatctgct gcagcacgtc
     2221 agggtgccct actacaatat ccaccccatg ccggtgcacc tgcaccagcg gctctgtgct
     2281 gaggaggacc agggggctca gacctatgcc agcgagatct cagccctggt ggccaacagc
     2341 agctttgacc tggtgctgct aggcatgggc accgatgggc acacggcttc tctgttccca
     2401 cagtcaccca gggggctgga tggtgaccag ttggtggtgc tcacggagag cccattcagg
     2461 ccacaccaac gcatgagcct cagcctgccc ctcatcaacc gggccaagaa ggtagctgtc
     2521 ctggtcatgg gaaggacaaa acgtgagatc accacgctgg tgagccgcgt gggccatgag
     2581 cccaagaagt ggcccatctc gggtgtggtg cctctttctg gacagctggt ttggtacatg
     2641 gactatgagg ccttcctggg atgaccagag tcatcctggt cttagtcact ctcagccgcc
     2701 cagtgtgcct cagctgtgcg gagcctggta ccagggtcag gccccagaga agggacgaca
     2761 aaactgtgat agcttcctgg acccactggt gcctgggatt acggtgtctg tacgtggaaa
     2821 cgaggtagag cccaggcctc aaaacccagg caggagagag gctaaggcct ctaggtgtcc
     2881 cacaccagta tctacaacac acagtaagac tgggaaaagg ctccatgcta aagaaccaaa
     2941 gaggcctgcc aagactggcc caggatcttt gaactggttt ctgtgggaag aggggccagc
     3001 atgggtgagg aggggggtac agagactcct ggtgaaggtc ttgctctgag ccaggccgga
     3061 agagtagaca cgatcctgag attgcaccga gctccctgcc tcttctgata tccgttcatc
     3121 cctctgtgca tctggctgag gtctggccct tctctaggca gcttctatct gctctgggca
     3181 gacattcact gccctctgtg ttccccttga cccctcagcc tctccctctc tacagacact
     3241 cccatgtcaa aggtcccccg gaatctagag accagggctc ccttttccca ccgagaactg
     3301 tcctgccatc tctgggctgt caggcatctc tggtctatag gcaggatggc tctgtctgct
     3361 tctgggtcgg gggtgactcc agctcactgc ctctttctag gacttacgtg gccaattccc
     3421 agcaccgggg caggctgctg ctagctctct tcacactacc tctcgggggc tttaagcctg
     3481 gcagctgacc ccccctgcca ggttctccac ctttcttact cgctaatctg gtgctgctgg
     3541 ggacactata ggcagctcct aatgtcagcc tcctccgggg cttcgggatt tttatttttc
     3601 aacagaaagc caacaataca aagcaatcgt ctgagggcac acagttttcc tttcgggctc
     3661 ctgcttagtc gtggccccct cctcacagtt acctgtgtgt cagtcacaga gtctcagtgt
     3721 cttccagaat tttcccagag aggggtttcc ctgtggtgag gagcatcagg aaatcttgtt
     3781 tctctacttt taattgattg cactttctcc caggcagcgg aaaaacattc ttgctttcac
     3841 tagagatgcg tgcagtgtgt ggcctgagct ggccctctgt gggaaaggta ctcgttaaaa
     3901 ttcggcttac tctggcctcc tgtgacccag actgacagaa aagaggaacg ccctggggtc
     3961 ctttcctggc ctgctttggt caggcttgga cgcaggtagc tgcaggtgca attacacctt
     4021 tggccacgtg ggggagccca cgtgccacca ctcacattcc acccaggagg cgggtttagt
     4081 gccaaacgtc ttttctttgg gtttattttt cgctctctgc ctctctggct tcttggccca
     4141 gtgcgttttc ctctgttctt tacggactca gccttctgca gttgcaacat cagagaggaa
     4201 agggtcttgc atgccttagc agagagggcg cacaggctct gtgtcaccat tctgaataac
     4261 ggtgagtcat tgcccagccc cagcctagaa tgtcctgttc ttacccagaa gaatgactcg
     4321 cctctgtctg tggggagtct gcccagggga ggccagtgtg gggaaatacc aaagatctcc
     4381 tttccggaag caagcactaa taaaatcgca ttggaaaggt tgccggggga cattgtccgt
     4441 gttctttggc atgcacctgt gcgtgccttt cccccttctg ccccgggtga ggaaggagtg
     4501 atgctcagag ccaggaccat ggaggatgct gctcttcaga cctggatcat catccccggg
     4561 aagcagtgtg ctttatgcca ccaatcagtc acatctgtgt ataaatctga gtcttgagtc
     4621 tcaggaagga tttctcggcc ttaagagctt ttttttttta attttttttt catttaaaaa
     4681 ttgttgcttg caaaccattt acattgagtt cctaaacacc gtgg
//
