LOCUS       NM_053985               1661 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus H3.3 histone B (H3f3b), mRNA.
ACCESSION   NM_053985
VERSION     NM_053985.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1661)
  AUTHORS   Maehara,K., Harada,A., Sato,Y., Matsumoto,M., Nakayama,K.I.,
            Kimura,H. and Ohkawa,Y.
  TITLE     Tissue-specific expression of histone H3 variants diversified after
            species separation
  JOURNAL   Epigenetics Chromatin 8, 35 (2015)
   PUBMED   26388943
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1661)
  AUTHORS   Jang,C.W., Shibata,Y., Starmer,J., Yee,D. and Magnuson,T.
  TITLE     Histone H3.3 maintains genome integrity during mammalian
            development
  JOURNAL   Genes Dev 29 (13), 1377-1392 (2015)
   PUBMED   26159997
REFERENCE   3  (bases 1 to 1661)
  AUTHORS   Tang,M.C., Jacobs,S.A., Mattiske,D.M., Soh,Y.M., Graham,A.N.,
            Tran,A., Lim,S.L., Hudson,D.F., Kalitsis,P., O'Bryan,M.K.,
            Wong,L.H. and Mann,J.R.
  TITLE     Contribution of the two genes encoding histone variant h3.3 to
            viability and fertility in mice
  JOURNAL   PLoS Genet 11 (2), e1004964 (2015)
   PUBMED   25675407
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1661)
  AUTHORS   Kato,D., Osakabe,A., Tachiwana,H., Tanaka,H. and Kurumizaka,H.
  TITLE     Human tNASP promotes in vitro nucleosome assembly with histone H3.3
  JOURNAL   Biochemistry 54 (5), 1171-1179 (2015)
   PUBMED   25615412
REFERENCE   5  (bases 1 to 1661)
  AUTHORS   Cascante,A., Klum,S., Biswas,M., Antolin-Fontes,B.,
            Barnabe-Heider,F. and Hermanson,O.
  TITLE     Gene-specific methylation control of H3K9 and H3K36 on neurotrophic
            BDNF versus astroglial GFAP genes by KDM4A/C regulates neural stem
            cell differentiation
  JOURNAL   J Mol Biol 426 (20), 3467-3477 (2014)
   PUBMED   24747049
  REMARK    GeneRIF: Data indicate that histone demethylases KDM4A/C regulate
            H3K9 and H3K36 methylation on brain-derived neurotrophic factor
            (BDNF) versus astroglial glial fibrillary acidic protein (GFAP)
            genes in neural stem cells.
REFERENCE   6  (bases 1 to 1661)
  AUTHORS   Preuss,U., Landsberg,G. and Scheidtmann,K.H.
  TITLE     Novel mitosis-specific phosphorylation of histone H3 at Thr11
            mediated by Dlk/ZIP kinase
  JOURNAL   Nucleic Acids Res 31 (3), 878-885 (2003)
   PUBMED   12560483
REFERENCE   7  (bases 1 to 1661)
  AUTHORS   Chen,H.Y., Sun,J.M., Zhang,Y., Davie,J.R. and Meistrich,M.L.
  TITLE     Ubiquitination of histone H3 in elongating spermatids of rat testes
  JOURNAL   J Biol Chem 273 (21), 13165-13169 (1998)
   PUBMED   9582357
REFERENCE   8  (bases 1 to 1661)
  AUTHORS   Scaturro,M., Cestelli,A., Castiglia,D., Nastasi,T. and Di Liegro,I.
  TITLE     Posttranscriptional regulation of H1 zero and H3.3B histone genes
            in differentiating rat cortical neurons
  JOURNAL   Neurochem Res 20 (8), 969-976 (1995)
   PUBMED   8587656
REFERENCE   9  (bases 1 to 1661)
  AUTHORS   Castiglia,D., Cestelli,A., Scaturro,M., Nastasi,T. and Di Liegro,I.
  TITLE     H1(0) and H3.3B mRNA levels in developing rat brain
  JOURNAL   Neurochem Res 19 (12), 1531-1537 (1994)
   PUBMED   7877725
REFERENCE   10 (bases 1 to 1661)
  AUTHORS   Kawabe,T., Naka,T., Yoshida,K., Tanaka,T., Fujiwara,H.,
            Suematsu,S., Yoshida,N., Kishimoto,T. and Kikutani,H.
  TITLE     The immune responses in CD40-deficient mice: impaired
            immunoglobulin class switching and germinal center formation
  JOURNAL   Immunity 1 (3), 167-178 (1994)
   PUBMED   7534202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 29, 2021 this sequence version replaced NM_053985.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078759.1, CF111159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JAXUCZ010000010.1  101757506-101757636 c
            132-269             JAXUCZ010000010.1  101756989-101757126 c
            270-423             JAXUCZ010000010.1  101756730-101756883 c
            424-1661            JAXUCZ010000010.1  101755404-101756641 c
FEATURES             Location/Qualifiers
     source          1..1661
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1661
                     /gene="H3f3b"
                     /gene_synonym="H3-3b; H3.3B"
                     /note="H3.3 histone B"
                     /db_xref="GeneID:117056"
                     /db_xref="RGD:621095"
     exon            1..131
                     /gene="H3f3b"
                     /gene_synonym="H3-3b; H3.3B"
                     /inference="alignment:Splign:2.1.0"
     exon            132..269
                     /gene="H3f3b"
                     /gene_synonym="H3-3b; H3.3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..552
                     /gene="H3f3b"
                     /gene_synonym="H3-3b; H3.3B"
                     /note="H3 histone family member 3B; H3 histone, family 3B"
                     /codon_start=1
                     /product="histone H3.3"
                     /protein_id="NP_446437.1"
                     /db_xref="GeneID:117056"
                     /db_xref="RGD:621095"
                     /translation="MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRP
                     GTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLV
                     GLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA"
     exon            270..423
                     /gene="H3f3b"
                     /gene_synonym="H3-3b; H3.3B"
                     /inference="alignment:Splign:2.1.0"
     exon            424..1661
                     /gene="H3f3b"
                     /gene_synonym="H3-3b; H3.3B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttggagcg cagagcggtt tggtcgttcg ttggaggagc ttcgtcttgt tctgctctgc
       61 gattgcggcg cttgttcgag cgcttacagc ggcgcgtcgg tcccagcaag ggcctcagac
      121 ttcagctttg ggtgagagaa gatggcccga accaagcaga ccgctaggaa gtccaccgga
      181 gggaaagccc cccgcaaaca gctggccacc aaggcggccc ggaaaagcgc gccctctact
      241 ggcggggtga agaaacctca tcgctacagg cccgggaccg tggctctaag agagatccgt
      301 cgttaccaga aatcgactga gctgctcatc cggaagctac ccttccagag gttggtgagg
      361 gagatcgccc aggatttcaa aaccgacttg aggtttcaaa gtgcagccat cggtgccctt
      421 caggaggcta gcgaggcata cctggtgggg ttgtttgaag ataccaatct gtgtgccatc
      481 cacgccaaga gagtcaccat catgcccaaa gacatccagt tggctcgccg gatacggggg
      541 gagagagctt aagttgaagc gatttttatg gcattttgta gtaaattctg taaaatactt
      601 tggtttaatt tgtgactttt tttgtaagaa attgtttata atatgttgca tttgtactta
      661 agtcattcca tctttcactc aggatgaatg gaaagagtga ctgttcacag acctcagtga
      721 tgtgagcact gtggctcagg agtgacaagt tgctaatatg cagaagggat gggtgatact
      781 tcttgcttct catgatgcat gtttctgtat gttaatgact tgttgggtag ctattaaggt
      841 actagaattg ataaatgtgt acagggtcct tttgcaataa aactggttat gacttgatcc
      901 aagtgtttaa ccatacatca ctgtgataga atgtgggctt tttcaaaggt tgaagataca
      961 agttttagcc acagtgtaac agtttccttt aaaaaaaaaa agtaaacctg gcagctatag
     1021 aatacactat gtgcatttat aatagctatt ttatatattg tagtgttcaa catttttaaa
     1081 ttaaatgttt tacattcaca agtggtgggg agtcttgtca ttaaggtgtg tgtaatttag
     1141 tccagttggt atttctgact agactgcatt tgtttttaac aaagtagaag aatgctatgc
     1201 gtattaaacc ttgcataagt cctcattcta ccacatgttc actaacccct gaccctctgg
     1261 ctggtaacac aaaacactaa cggggatttt ctttaagggc tctagagtaa aacaacaagc
     1321 tattcacacc agcatcatct gttcctaatc tagttagtga gcttttcatt gtgtttggtc
     1381 ttacgcctag actgagtttg gttttgtttt taatctttaa gggggaaaac tgtacaaggt
     1441 ttgcttttcc ttgtggagtt tataaacatg ggggtaagag tacagcttga gcttattgga
     1501 ctctgccaat gaagatgggt taggttacac ctggttacta tcctggcaaa aaaatccctt
     1561 ttatagagat ggccttcaag tggtttttaa aagtatccta ttgaagtttt taggtcaatt
     1621 atgtatgttg actaaattta caaataaact tgtttattca a
//
