LOCUS       NM_022674               1015 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus H2A.Z variant histone 1 (H2az1), mRNA.
ACCESSION   NM_022674
VERSION     NM_022674.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1015)
  AUTHORS   Nesovic Ostojic,J., Zivotic,M., Kovacevic,S., Ivanov,M., Brkic,P.,
            Mihailovic-Stanojevic,N., Karanovic,D., Vajic,U.J., Miloradovic,Z.,
            Jovovic,D. and Radojevic Skodric,S.
  TITLE     Immunohistochemical Pattern of Histone H2A Variant Expression in an
            Experimental Model of Ischemia-Reperfusion-Induced Acute Kidney
            Injury
  JOURNAL   Int J Mol Sci 24 (9), 8085 (2023)
   PUBMED   37175793
  REMARK    GeneRIF: Immunohistochemical Pattern of Histone H2A Variant
            Expression in an Experimental Model of Ischemia-Reperfusion-Induced
            Acute Kidney Injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1015)
  AUTHORS   Yao,F., Yu,P., Li,Y., Yuan,X., Li,Z., Zhang,T., Liu,F., Wang,Y.,
            Wang,Y., Li,D., Ma,B., Shu,C., Kong,W., Zhou,B. and Wang,L.
  TITLE     Histone Variant H2A.Z Is Required for the Maintenance of Smooth
            Muscle Cell Identity as Revealed by Single-Cell Transcriptomics
  JOURNAL   Circulation 138 (20), 2274-2288 (2018)
   PUBMED   29871976
  REMARK    GeneRIF: H2A.Z occupancy preferentially promotes nucleosome
            turnover, and facilitates the recruitment of SMAD3 and MED1,
            thereby activating VSMC marker gene expression.
REFERENCE   3  (bases 1 to 1015)
  AUTHORS   Dunn,C.J., Sarkar,P., Bailey,E.R., Farris,S., Zhao,M., Ward,J.M.,
            Dudek,S.M. and Saha,R.N.
  TITLE     Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and
            Context-Specific Roles in Neuronal Activity-Induced Transcription
            of Arc/Arg3.1 and Other Immediate Early Genes
  JOURNAL   eNeuro 4 (4) (2017)
   PUBMED   28856239
  REMARK    GeneRIF: In dissociated rat cortical neurons, H2A.Z.1 and H2A.Z.2
            regulate basal expression of largely nonoverlapping gene sets,
            including genes that code for several synaptic proteins. In
            response to neuronal activity, rapid transcription of our model
            gene Arc is impaired by depletion of H2A.Z.2, but not H2A.Z.1. This
            impairment is partially rescued by codepletion of the H2A.Z
            chaperone, ANP32E.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1015)
  AUTHORS   Weber,C.M. and Henikoff,S.
  TITLE     Histone variants: dynamic punctuation in transcription
  JOURNAL   Genes Dev 28 (7), 672-682 (2014)
   PUBMED   24696452
  REMARK    Review article
REFERENCE   5  (bases 1 to 1015)
  AUTHORS   Zerzaihi,O., Chriett,S., Vidal,H. and Pirola,L.
  TITLE     Insulin-dependent transcriptional control in L6 rat myotubes is
            associated with modulation of histone acetylation and accumulation
            of the histone variant H2A.Z in the proximity of the
            transcriptional start site
  JOURNAL   Biochem Cell Biol 92 (1), 61-67 (2014)
   PUBMED   24471919
REFERENCE   6  (bases 1 to 1015)
  AUTHORS   Bonenfant,D., Coulot,M., Towbin,H., Schindler,P. and van Oostrum,J.
  TITLE     Characterization of histone H2A and H2B variants and their
            post-translational modifications by mass spectrometry
  JOURNAL   Mol Cell Proteomics 5 (3), 541-552 (2006)
   PUBMED   16319397
REFERENCE   7  (bases 1 to 1015)
  AUTHORS   Chadwick,B.P. and Willard,H.F.
  TITLE     Histone H2A variants and the inactive X chromosome: identification
            of a second macroH2A variant
  JOURNAL   Hum Mol Genet 10 (10), 1101-1113 (2001)
   PUBMED   11331621
REFERENCE   8  (bases 1 to 1015)
  AUTHORS   Misawa,K., Nosaka,T., Morita,S., Kaneko,A., Nakahata,T., Asano,S.
            and Kitamura,T.
  TITLE     A method to identify cDNAs based on localization of green
            fluorescent protein fusion products
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3062-3066 (2000)
   PUBMED   10716735
REFERENCE   9  (bases 1 to 1015)
  AUTHORS   Lindner,H., Wesierska-Gadek,J., Helliger,W., Puschendorf,B. and
            Sauermann,G.
  TITLE     Identification of ADP-ribosylated histones by the combined use of
            high-performance liquid chromatography and electrophoresis
  JOURNAL   J Chromatogr 472 (1), 243-249 (1989)
   PUBMED   2760138
REFERENCE   10 (bases 1 to 1015)
  AUTHORS   Hatch,C.L. and Bonner,W.M.
  TITLE     Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged
            but highly conserved basal histone H2A isoprotein species
  JOURNAL   Nucleic Acids Res 16 (3), 1113-1124 (1988)
   PUBMED   3344202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 4, 2022 this sequence version replaced NM_022674.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213837.1, FQ229641.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               JAXUCZ010000002.1  229029095-229029242
            149-226             JAXUCZ010000002.1  229029646-229029723
            227-340             JAXUCZ010000002.1  229030012-229030125
            341-470             JAXUCZ010000002.1  229030469-229030598
            471-1015            JAXUCZ010000002.1  229030867-229031411
FEATURES             Location/Qualifiers
     source          1..1015
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..1015
                     /gene="H2az1"
                     /gene_synonym="H2A.Z-1; H2A/z; H2afz"
                     /note="H2A.Z variant histone 1"
                     /db_xref="GeneID:58940"
                     /db_xref="RGD:621464"
     exon            1..148
                     /gene="H2az1"
                     /gene_synonym="H2A.Z-1; H2A/z; H2afz"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..532
                     /gene="H2az1"
                     /gene_synonym="H2A.Z-1; H2A/z; H2afz"
                     /note="H2A histone family, member Z"
                     /codon_start=1
                     /product="histone H2A.Z"
                     /protein_id="NP_073165.1"
                     /db_xref="GeneID:58940"
                     /db_xref="RGD:621464"
                     /translation="MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSH
                     GRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIK
                     ATIAGGGVIPHIHKSLIGKKGQQKTV"
     exon            149..226
                     /gene="H2az1"
                     /gene_synonym="H2A.Z-1; H2A/z; H2afz"
                     /inference="alignment:Splign:2.1.0"
     exon            227..340
                     /gene="H2az1"
                     /gene_synonym="H2A.Z-1; H2A/z; H2afz"
                     /inference="alignment:Splign:2.1.0"
     exon            341..470
                     /gene="H2az1"
                     /gene_synonym="H2A.Z-1; H2A/z; H2afz"
                     /inference="alignment:Splign:2.1.0"
     exon            471..1015
                     /gene="H2az1"
                     /gene_synonym="H2A.Z-1; H2A/z; H2afz"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attctgcagt ataaagggcg cgaggaaggc gggagaaggc gcagtttgaa tcgcggtacg
       61 ccggaggagt gggcgccggg atctcgctga gcgtccccct ggcctcgtct cttcctcgct
      121 tgtccgagct tcagcacagt ccgagatggc tggcggtaag gctggaaagg actccggaaa
      181 ggccaagaca aaggcggttt cccgctccca gcgagcgggc ttgcagttcc ctgtgggccg
      241 tattcatcga cacctgaaat ctaggacaac aagccacgga cgtgtgggcg cgaccgcagc
      301 tgtgtacagc gcagccatcc tggagtacct caccgcagag gtacttgagt tggcaggaaa
      361 tgcatcaaaa gacttgaagg taaagcgtat tacccctcgt cacttgcaac ttgctatccg
      421 cggagatgaa gagttggact ctctgatcaa ggctacgatt gctggtggtg gtgtcatccc
      481 acacatccac aaatcactga ttgggaagaa aggacaacag aagactgtct aaggatgcct
      541 ggattcctta ctatctcagg actctaaata ctcttaacag ctgtccagtg ttggtgattc
      601 cagtggactg tatctctgtg aaaaacacaa ttttgccttt ttgtaattct atttgagcaa
      661 gttggaggct taattagcct tccaaccaac caaatttctg cattcgagtc ttaaccatat
      721 ttaagtgtta ctgtggcttc aaagaagcta ttgaatctga agtggtgggt tttgattgag
      781 ttgactgttt ttaaaaaact gtttggattt taattgtgat gcagaagtta tagtaacaaa
      841 catttggttt tgtacagaca ttatttccac tctggtggat aagctcaata aaggtcagat
      901 cccaaactag ttttaaactt gcttaataat tgggacttat ctcttccatc tccctcagca
      961 acaagtacac tctttgctta ctaattaaac agtgtatctg tagatcaagt cataa
//
