LOCUS       NM_001109291            1356 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  Rattus norvegicus H2A.X variant histone (H2ax), mRNA.
ACCESSION   NM_001109291 XM_001066891 XM_576399
VERSION     NM_001109291.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1356)
  AUTHORS   Nesovic Ostojic J, Zivotic M, Kovacevic S, Ivanov M, Brkic P,
            Mihailovic-Stanojevic N, Karanovic D, Vajic UJ, Miloradovic Z,
            Jovovic D and Radojevic Skodric S.
  TITLE     Immunohistochemical Pattern of Histone H2A Variant Expression in an
            Experimental Model of Ischemia-Reperfusion-Induced Acute Kidney
            Injury
  JOURNAL   Int J Mol Sci 24 (9), 8085 (2023)
   PUBMED   37175793
  REMARK    GeneRIF: Immunohistochemical Pattern of Histone H2A Variant
            Expression in an Experimental Model of Ischemia-Reperfusion-Induced
            Acute Kidney Injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1356)
  AUTHORS   Zhu M, Liu W, Shi L, Xiao X, Wu W, Wu L and Zhou Z.
  TITLE     Expression of DNA doublestrand repair proteins in oral leukoplakia
            and the risk of malignant transformation
  JOURNAL   Oncol Lett 15 (6), 9827-9835 (2018)
   PUBMED   29928356
REFERENCE   3  (bases 1 to 1356)
  AUTHORS   Moruno-Manchon JF, Koellhoffer EC, Gopakumar J, Hambarde S, Kim N,
            McCullough LD and Tsvetkov AS.
  TITLE     The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA
            damage and downregulates transcription of Brca1 in neurons
  JOURNAL   Aging (Albany NY) 9 (9), 1957-1970 (2017)
   PUBMED   28904242
REFERENCE   4  (bases 1 to 1356)
  AUTHORS   Finsterbusch F, Ravindranathan R, Dereli I, Stanzione M, Trankner D
            and Toth A.
  TITLE     Alignment of Homologous Chromosomes and Effective Repair of
            Programmed DNA Double-Strand Breaks during Mouse Meiosis Require
            the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein
  JOURNAL   PLoS Genet 12 (10), e1006393 (2016)
   PUBMED   27760146
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1356)
  AUTHORS   Gilmore JM, Sardiu ME, Groppe BD, Thornton JL, Liu X, Dayebgadoh G,
            Banks CA, Slaughter BD, Unruh JR, Workman JL, Florens L and
            Washburn MP.
  TITLE     WDR76 Co-Localizes with Heterochromatin Related Proteins and
            Rapidly Responds to DNA Damage
  JOURNAL   PLoS One 11 (6), e0155492 (2016)
   PUBMED   27248496
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1356)
  AUTHORS   Saunders PT, Turner JM, Ruggiu M, Taggart M, Burgoyne PS, Elliott D
            and Cooke HJ.
  TITLE     Absence of mDazl produces a final block on germ cell development at
            meiosis
  JOURNAL   Reproduction 126 (5), 589-597 (2003)
   PUBMED   14611631
REFERENCE   7  (bases 1 to 1356)
  AUTHORS   Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen
            HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E,
            Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M,
            Camerini-Otero RD, Tessarollo L, Livak F, Manova K, Bonner WM,
            Nussenzweig MC and Nussenzweig A.
  TITLE     Genomic instability in mice lacking histone H2AX
  JOURNAL   Science 296 (5569), 922-927 (2002)
   PUBMED   11934988
REFERENCE   8  (bases 1 to 1356)
  AUTHORS   Chadwick BP and Willard HF.
  TITLE     Histone H2A variants and the inactive X chromosome: identification
            of a second macroH2A variant
  JOURNAL   Hum Mol Genet 10 (10), 1101-1113 (2001)
   PUBMED   11331621
REFERENCE   9  (bases 1 to 1356)
  AUTHORS   Pina,B. and Suau,P.
  TITLE     Changes in histones H2A and H3 variant composition in
            differentiating and mature rat brain cortical neurons
  JOURNAL   Dev Biol 123 (1), 51-58 (1987)
   PUBMED   3622934
REFERENCE   10 (bases 1 to 1356)
  AUTHORS   Meistrich,M.L., Bucci,L.R., Trostle-Weige,P.K. and Brock,W.A.
  TITLE     Histone variants in rat spermatogonia and primary spermatocytes
  JOURNAL   Dev Biol 112 (1), 230-240 (1985)
   PUBMED   3932111
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000198.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001109291.3.
            
            On Nov 4, 2022 this sequence version replaced NM_001109291.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: FQ184365.1, FQ130663.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1356              JACYVU010000198.1  6485218-6486573
FEATURES             Location/Qualifiers
     source          1..1356
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1356
                     /gene="H2ax"
                     /gene_synonym="H2afx; RGD1566119"
                     /note="H2A.X variant histone"
                     /db_xref="GeneID:500987"
                     /db_xref="RGD:1566119"
     exon            1..1356
                     /gene="H2ax"
                     /gene_synonym="H2afx; RGD1566119"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..500
                     /gene="H2ax"
                     /gene_synonym="H2afx; RGD1566119"
                     /note="H2A histone family, member X"
                     /codon_start=1
                     /product="H2A.X variant histone"
                     /protein_id="NP_001102761.1"
                     /db_xref="GeneID:500987"
                     /db_xref="RGD:1566119"
                     /translation="MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVT
                     IAQGGVLPNIQAVLLPKKTSATVGPKAPAGGKKASQASQEY"
ORIGIN      
        1 gacagttgac tgcggcggtt ggcggtttgt ctcctggcgt ttttctcagc ccttctacct
       61 cgcacacgat gtcgggtcgc ggcaagaccg gcggcaaggc ccgcgccaaa gccaagtcgc
      121 gctcttcgcg cgccggcctt cagttcccgg taggccgcgt gcaccgactg ctgcggaaag
      181 gccattacgc cgagcgcgtg ggcgcaggcg cgcccgtgta cctggcggcg gtgctcgagt
      241 acctcactgc cgagatcctg gagctggcgg gcaacgcggc tcgggacaac aagaagacgc
      301 gcattatccc gcgccacctg cagctggcta tccgcaacga cgaggagctc aacaagctgc
      361 tgggcggcgt gactatcgcg cagggcggcg tcctgcccaa catccaggcc gtgctgctgc
      421 ccaagaagac cagcgccacc gtggggccca aggcgccggc gggcggcaag aaggcctccc
      481 aggcctctca ggagtactga gggagcccgc gccgcggctg cccagccctc ccccacctcc
      541 acaaaggccc ttttaagggc caccacctcc ctcacagaaa gagctgagcc acttcgggct
      601 ccggcccgcc gcgtccccat cccattctct cctctcagtc ctcgcgtctt tacccttccc
      661 tgtgcggcct ccgggtctgc cacaggacgc gggcgccggg gcacctaccc atcccggagc
      721 tcgtgacatc gcttcgccgt tctcagtcgt cgacgggctg tgcggagagg ttgcggcacc
      781 ttccaccttc cagaaatctc ggccctttgc tatgacgtac ggccgaggtg ggcttgaagg
      841 ttagttaacc accaccacca cccccccccc cccgcagcta caaccccagc gttttcagct
      901 tggtgcttag ccctctcctg gacctttcag aagtgagttg attgccggac tttggtgaga
      961 agcggatcat actgtttcac tctgtgtccc ccttactggc ctctcaaacc agttgaccct
     1021 gtcgtcattt gtaggccggc atgttataac gtgaagccaa tttttccaag ataaactgga
     1081 aagggtcagg gaacgcctat tggcctgtgg acagaagaat tgtatacctg ccgcagaaga
     1141 ctagaggagc cgggcctagc tatccctctc ccttaactca aactacaacc caaacaccca
     1201 gataccagca caagtcggtg aatccctgtc tggactgagc ctctggcttc tgaactggaa
     1261 cttttgcagc tattacaagt ttagaacctt aagaagtggg gagattcaat gggctaattt
     1321 tattaaagga tcgtttttgg tttgtttttt tttttt
//
