LOCUS       NM_021840               1579 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus H2A clustered histone 25 (H2ac25), mRNA.
ACCESSION   NM_021840 XM_579450
VERSION     NM_021840.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1579)
  AUTHORS   Park,J.H., Kim,C.K., Lee,S.B., Lee,K.H., Cho,S.W. and Ahn,J.Y.
  TITLE     Akt attenuates apoptotic death through phosphorylation of H2A under
            hydrogen peroxide-induced oxidative stress in PC12 cells and
            hippocampal neurons
  JOURNAL   Sci Rep 6, 21857 (2016)
   PUBMED   26899247
  REMARK    GeneRIF: Akt-mediated H2A phosphorylation has an anti-apoptotic
            function in conditions of H2O2-induced oxidative stress in neurons
            and PC12 cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1579)
  AUTHORS   Lan,L., Nakajima,S., Kapetanaki,M.G., Hsieh,C.L., Fagerburg,M.,
            Thickman,K., Rodriguez-Collazo,P., Leuba,S.H., Levine,A.S. and
            Rapic-Otrin,V.
  TITLE     Monoubiquitinated histone H2A destabilizes photolesion-containing
            nucleosomes with concomitant release of UV-damaged DNA-binding
            protein E3 ligase
  JOURNAL   J Biol Chem 287 (15), 12036-12049 (2012)
   PUBMED   22334663
REFERENCE   3  (bases 1 to 1579)
  AUTHORS   Kido,T. and Lau,Y.F.
  TITLE     The rat Tspy is preferentially expressed in elongated spermatids
            and interacts with the core histones
  JOURNAL   Biochem Biophys Res Commun 350 (1), 56-67 (2006)
   PUBMED   16996029
REFERENCE   4  (bases 1 to 1579)
  AUTHORS   Benedetti,A., Fulceri,R., Allan,B.B., Houston,P., Sukhodub,A.L.,
            Marcolongo,P., Ethell,B., Burchell,B. and Burchell,A.
  TITLE     Histone 2A stimulates glucose-6-phosphatase activity by
            permeabilization of liver microsomes
  JOURNAL   Biochem J 367 (Pt 2), 505-510 (2002)
   PUBMED   12097138
  REMARK    GeneRIF: the results demonstrate that histone 2A stimulates
            glucose-6-phosphatase activity by permeabilizing the microsomal
            membrane.
REFERENCE   5  (bases 1 to 1579)
  AUTHORS   Huh,N.E., Hwang,I.W., Lim,K., You,K.H. and Chae,C.B.
  TITLE     Presence of a bi-directional S phase-specific transcription
            regulatory element in the promoter shared by testis-specific TH2A
            and TH2B histone genes
  JOURNAL   Nucleic Acids Res 19 (1), 93-98 (1991)
   PUBMED   2011515
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099140.1.
            
            On Sep 18, 2005 this sequence version replaced NM_021840.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC099140.1, CV113368.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1579
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1579
                     /gene="H2ac25"
                     /gene_synonym="H2a; Hist3h2a"
                     /note="H2A clustered histone 25"
                     /db_xref="GeneID:64646"
                     /db_xref="RGD:621437"
     exon            1..1553
                     /gene="H2ac25"
                     /gene_synonym="H2a; Hist3h2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..398
                     /gene="H2ac25"
                     /gene_synonym="H2a; Hist3h2a"
                     /note="histone cluster 3, H2a; histone 3, H2a; histone 2a"
                     /codon_start=1
                     /product="histone H2A type 3"
                     /protein_id="NP_068612.2"
                     /db_xref="GeneID:64646"
                     /db_xref="RGD:621437"
                     /translation="MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYSERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
ORIGIN      
        1 ggaagatgtc tggtcgtggc aagcagggcg gcaaagctcg tgcaaaagcg aagtctcgct
       61 catcccgcgc tggcctgcag tttccagtgg gccgtgtgca ccgccttctc cgtaagggca
      121 actactcgga gcgggtgggc gccggcgctc cggtgtacct agcggctgtg ctggaatacc
      181 tgactgctga gatcctggag ctggctggga atgcggcccg cgataataag aagacgcgga
      241 ttatcccgcg ccacctgcag ttggccatcc gcaacgacga ggagctcaac aagctgctgg
      301 gccgcgtgac catcgcgcag ggcggcgtcc tgcccaacat ccaggcggtg ttgctgccca
      361 agaagacgga gagccaccac aaggccaagg gcaagtgagg ccctgctggt cgttagagca
      421 actttacgga caccaaaggc tcttttcaga gccaccccca acctcattag gaagtgctgt
      481 acactgagcc tgtcgccagt tactggccgg ccaggatctc ccgactcctt tccatgcgtt
      541 ccggcatccc agtgcgacgc ctggggagct catgggaggc taacggcttc gcctgcggtc
      601 agttggagac gttcgagttt caaccccgcc acttcagtgt cagacacaag gtttcagtta
      661 acgttcgtgt ttggacttta ttctgtagga attcgcataa ggttctggtt ggtagacact
      721 atagtgtttg cttctactga aacagtaaat tgagatgctc aaatcaaaca tgaagtccac
      781 ttgaattagg atcagtttaa cgccttgggg cttccaaagg tttctgagga gaggcttggg
      841 tatttcaaag ctacttgttt atataaacgt tttgttataa ggcgatttac aactttggag
      901 tttgctggtt tcttttgtgg gggtggggag caggtactta gaagtaggat tacaggtgag
      961 catggtggtc cagcaggcat ttggaattag ttaattggat cacttaagta gcttaatctt
     1021 gggaaacaat aatttgtatg attttggtaa aactaggttt gagagtacag cagtgtcctt
     1081 tgttatatat aaggagaacg gcatcacact aaatgtttag agaggactgt gacttctaca
     1141 gcatgaagaa tggttggagt tccaggtaaa tcaacaggag catgtaagtg agaaagggag
     1201 aagagggtta aatgagttgc ctttaaatcc tttaaaatgt cacagaatcg ggcctctttt
     1261 ccctgttaac tgctgcacgc tatttaaatt ttagcaatac aggtcatcaa gacaattata
     1321 taatattata taatttatat tctaccaaaa ctggatctgt tcaagcctgg ctcctcagac
     1381 accatctata actacaagtc tgcttataaa ctaccaacgt ctcaacccat ttgcctaagg
     1441 ataggcaatt tccttaacag tgagtctcaa cacaacagtg aaaactgcac atagattata
     1501 catttgcaaa tcctggtctc agtaaaataa agccagaggg ttggaccccc agaaaaaaaa
     1561 aaaaaaaaaa aaaaaaaaa
//
