LOCUS       NM_021839                478 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus H2A clustered histone 1 (H2ac1), mRNA.
ACCESSION   NM_021839
VERSION     NM_021839.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Joseph,J.S., Ayeleso,A.O. and Mukwevho,E.
  TITLE     Exercise increases hyper-acetylation of histones on the Cis-element
            of NRF-1 binding to the Mef2a promoter: Implications on type 2
            diabetes
  JOURNAL   Biochem Biophys Res Commun 486 (1), 83-87 (2017)
   PUBMED   28263745
  REMARK    GeneRIF: Animal physical conditioning increases hyper-acetylation
            of histones and increased the expression of NRF-1 and MEF2A genes.
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Pandey,A., Goru,S.K., Kadakol,A., Malek,V., Sharma,N. and
            Gaikwad,A.B.
  TITLE     H2AK119 monoubiquitination regulates Angiotensin II receptor
            mediated macrophage infiltration and renal fibrosis in type 2
            diabetic rats
  JOURNAL   Biochimie 131, 68-76 (2016)
   PUBMED   27693081
  REMARK    GeneRIF: Data indicate the effect of angiotensin II receptors'
            blockade on the macrophage infiltration and histone modifications
            occurring at the promoter region of monocyte chemoattractant
            protein (MCP-1) and transforming growth factor-beta (TGF-beta1).
REFERENCE   3  (bases 1 to 478)
  AUTHORS   Shinagawa,T., Takagi,T., Tsukamoto,D., Tomaru,C., Huynh,L.M.,
            Sivaraman,P., Kumarevel,T., Inoue,K., Nakato,R., Katou,Y., Sado,T.,
            Takahashi,S., Ogura,A., Shirahige,K. and Ishii,S.
  TITLE     Histone variants enriched in oocytes enhance reprogramming to
            induced pluripotent stem cells
  JOURNAL   Cell Stem Cell 14 (2), 217-227 (2014)
   PUBMED   24506885
REFERENCE   4  (bases 1 to 478)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 478)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
REFERENCE   6  (bases 1 to 478)
  AUTHORS   Walter,L., Klinga-Levan,K., Helou,K., Albig,W., Drabent,B.,
            Doenecke,D., Gunther,E. and Levan,G.
  TITLE     Chromosome mapping of rat histone genes H1fv, H1d, H1t, Th2a and
            Th2b
  JOURNAL   Cytogenet Cell Genet 75 (2-3), 136-139 (1996)
   PUBMED   9040779
REFERENCE   7  (bases 1 to 478)
  AUTHORS   Huh,N.E., Hwang,I.W., Lim,K., You,K.H. and Chae,C.B.
  TITLE     Presence of a bi-directional S phase-specific transcription
            regulatory element in the promoter shared by testis-specific TH2A
            and TH2B histone genes
  JOURNAL   Nucleic Acids Res 19 (1), 93-98 (1991)
   PUBMED   2011515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Sep 30, 2022 this sequence version replaced NM_021839.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-478               JAXUCZ010000017.1  41599195-41599672   c
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     gene            1..478
                     /gene="H2ac1"
                     /gene_synonym="Hist1h2aa; Th2a"
                     /note="H2A clustered histone 1"
                     /db_xref="GeneID:24828"
                     /db_xref="RGD:3854"
     exon            1..478
                     /gene="H2ac1"
                     /gene_synonym="Hist1h2aa; Th2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..418
                     /gene="H2ac1"
                     /gene_synonym="Hist1h2aa; Th2a"
                     /note="histone H2A, testis; testis-specific histone 2a;
                     histone cluster 1, H2aa; histone cluster 1 H2A family
                     member a"
                     /codon_start=1
                     /product="histone H2A type 4"
                     /protein_id="NP_068611.1"
                     /db_xref="GeneID:24828"
                     /db_xref="RGD:3854"
                     /translation="MSGRAKQGGKARAKAKSRSFRAGLQFPVGRVHRLLRQGNYAERI
                     GAGTPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVT
                     IAQGGVLPNIQAVLLPKKTESHHKSQTK"
ORIGIN      
        1 acggctttaa ggcttttgaa gaatcatgtc tggccgtgca aagcagggtg gcaaggctcg
       61 tgccaaggcc aagtcccgct ctttcagagc aggtttgcag tttcctgtgg gacgtgtgca
      121 ccggctcctt cgccaaggga actacgcaga gcgaattggg gctggcacac cagtgtactt
      181 ggcggccgtg ctggagtacc tgacggctga gatcctggag ctggcgggca atgcggcgag
      241 ggataacaag aagacgcgca ttatcccgcg ccacctgcag ctggccatcc gcaacgacga
      301 ggagctcaat aagctgctgg gccgcgtgac catcgcgcag ggcggcgtcc tgcccaacat
      361 ccaggccgtg ctgctgccca agaagaccga gagccaccac aagtcccaga ccaagtgact
      421 cccgcacttg tgacagcagc taacagctta aaacaaaaag gctcttttca gagccacc
//
