LOCUS       NM_057183                952 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus granzyme M (Gzmm), mRNA.
ACCESSION   NM_057183 XM_001076783 XM_001077291
VERSION     NM_057183.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 952)
  AUTHORS   de Koning,P.J., Kummer,J.A., de Poot,S.A., Quadir,R.,
            Broekhuizen,R., McGettrick,A.F., Higgins,W.J., Devreese,B.,
            Worrall,D.M. and Bovenschen,N.
  TITLE     Intracellular serine protease inhibitor SERPINB4 inhibits granzyme
            M-induced cell death
  JOURNAL   PLoS One 6 (8), e22645 (2011)
   PUBMED   21857942
REFERENCE   2  (bases 1 to 952)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 952)
  AUTHORS   Bots,M., Kolfschoten,I.G., Bres,S.A., Rademaker,M.T., de Roo,G.M.,
            Kruse,M., Franken,K.L., Hahne,M., Froelich,C.J., Melief,C.J.,
            Offringa,R. and Medema,J.P.
  TITLE     SPI-CI and SPI-6 cooperate in the protection from effector
            cell-mediated cytotoxicity
  JOURNAL   Blood 105 (3), 1153-1161 (2005)
   PUBMED   15454490
REFERENCE   4  (bases 1 to 952)
  AUTHORS   Ahmed,F., Torrado,M., Zinovieva,R.D., Senatorov,V.V., Wistow,G. and
            Tomarev,S.I.
  TITLE     Gene expression profile of the rat eye iridocorneal angle: NEIBank
            expressed sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 45 (9), 3081-3090 (2004)
   PUBMED   15326124
REFERENCE   5  (bases 1 to 952)
  AUTHORS   Smyth,M.J., Wiltrout,T., Trapani,J.A., Ottaway,K.S., Sowder,R.,
            Henderson,L.E., Kam,C.M., Powers,J.C., Young,H.A. and Sayers,T.J.
  TITLE     Purification and cloning of a novel serine protease, RNK-Met-1,
            from the granules of a rat natural killer cell leukemia
  JOURNAL   J Biol Chem 267 (34), 24418-24425 (1992)
   PUBMED   1447189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV216119.1 and BI278865.1.
            
            On or before Oct 14, 2007 this sequence version replaced
            XM_001076783.1, XM_001077291.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ233430.1, L05175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-637               DV216119.1         1-637
            638-952             BI278865.1         1-315               c
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..952
                     /gene="Gzmm"
                     /note="granzyme M"
                     /db_xref="GeneID:29252"
                     /db_xref="RGD:620022"
     exon            1..94
                     /gene="Gzmm"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..834
                     /gene="Gzmm"
                     /note="met-ase; RNK-Met-1; natural killer cell granular
                     protease; lymphoctye Met-ase 1; granzyme M (lymphocyte
                     met-ase 1)"
                     /codon_start=1
                     /product="granzyme M precursor"
                     /protein_id="NP_476531.1"
                     /db_xref="GeneID:29252"
                     /db_xref="RGD:620022"
                     /translation="MEVRWSLLLLLALKTLWAVGNRFEAQIIGGREAVPHSRPYMVSL
                     QNTKSHVCGGVLVHQKWVLTAAHCLSEPLQQLKLVFGLHSLHDPQDPGLTFYIKQAIK
                     HPGYNLKYENDLALLKLDGRVKPSKNVKPLALPRKPRDKPAEGSRCSTAGWGITHQRG
                     QLAKSLQELDLRLLDTRMCNNSRFWNGVLTDSMLCLKAGAKGQAPCKGDSGGPLVCGK
                     GKVDGILSFSSKNCTDIFKPTVATAVAPYSSWIRKVIGRWSPQPLT"
     exon            95..254
                     /gene="Gzmm"
                     /inference="alignment:Splign:2.1.0"
     exon            255..393
                     /gene="Gzmm"
                     /inference="alignment:Splign:2.1.0"
     exon            394..660
                     /gene="Gzmm"
                     /inference="alignment:Splign:2.1.0"
     exon            661..935
                     /gene="Gzmm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcccctt cccccaggga ccaccagtcc tgtgccagga tggaggtccg ctggtccctg
       61 ctgctcctgc tggccctgaa aacactgtgg gcagtaggca acagatttga ggcccagatc
      121 attgggggtc gagaggcagt cccgcactcc cgcccataca tggtctcgct acagaatacc
      181 aagtcccacg tgtgtggggg agtcctcgtg catcagaagt gggtgttgac cgctgcccac
      241 tgcctgtctg aaccgctaca gcagctgaag ctggtgttcg gcctgcacag ccttcatgat
      301 ccccaagatc ctggccttac cttctacatc aagcaagcca ttaaacaccc tggctacaac
      361 ctcaaatacg agaacgacct ggccctgctt aagctggatg gacgggtgaa gcccagcaag
      421 aatgtcaaac cactggctct gccaagaaag ccccgagaca agcctgcaga aggctcccgg
      481 tgtagcacgg ctggatgggg tataacccac cagaggggac agctagccaa gtccctgcag
      541 gagctcgacc tgcgtcttct ggacacccgg atgtgtaaca acagccgctt ctggaacggt
      601 gtcctcacgg acagcatgct gtgcttaaag gctggggcca agggccaagc tccttgcaag
      661 ggtgactctg gagggcccct ggtgtgtggc aaaggcaagg tggatgggat cctgtctttc
      721 agctccaaaa actgcacaga catcttcaag cccaccgtgg ccactgctgt agccccctac
      781 agctcctgga tcaggaaggt cattggtcgc tggtcacccc agcctctgac ctgatgtccc
      841 aaactatctg ggacatcatt cttgatgtct ggggctggga agggactagg tgtgcctctg
      901 gggatcaata aatcctgata tatctgttga gtctaaaaaa aaaaaaaaaa aa
//
