LOCUS       NM_134332                935 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus granzyme C (Gzmc), mRNA.
ACCESSION   NM_134332
VERSION     NM_134332.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 935)
  AUTHORS   Ewoldt,G.R., Smyth,M.J., Darcy,P.K., Harris,J.L., Craik,C.S.,
            Horowitz,B., Woodard,S.L., Powers,J.C. and Hudig,D.
  TITLE     P-4 and RNKP-7, new granzyme-like serine proteases expressed in
            activated rat lymphocytes
  JOURNAL   J Immunol 158 (10), 4574-4583 (1997)
   PUBMED   9144469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Mar 11, 2021 this sequence version replaced NM_134332.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228922.1, FQ230028.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000015.1  34439879-34440006   c
            129-279             JAXUCZ010000015.1  34439222-34439372   c
            280-415             JAXUCZ010000015.1  34438628-34438763   c
            416-676             JAXUCZ010000015.1  34438153-34438413   c
            677-935             JAXUCZ010000015.1  34437312-34437570   c
FEATURES             Location/Qualifiers
     source          1..935
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..935
                     /gene="Gzmc"
                     /gene_synonym="RGD1563645; Rnpk-4; Rnpk4"
                     /note="granzyme C"
                     /db_xref="GeneID:171290"
                     /db_xref="RGD:620019"
     exon            1..128
                     /gene="Gzmc"
                     /gene_synonym="RGD1563645; Rnpk-4; Rnpk4"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..820
                     /gene="Gzmc"
                     /gene_synonym="RGD1563645; Rnpk-4; Rnpk4"
                     /EC_number="3.4.21.-"
                     /note="natural killer cell protease 4"
                     /codon_start=1
                     /product="granzyme C precursor"
                     /protein_id="NP_599159.1"
                     /db_xref="GeneID:171290"
                     /db_xref="RGD:620019"
                     /translation="MPPVLILLTLLLPLGARAEEIIGGNEVSPHSRPYMAYFEFLNDN
                     GKKTFCGGFLVRDNFVLTAAHCRGRSMTVTLGAHNIKAKEKTQQIIPVANATPHPAYN
                     PDKRSNDIMLLKLVRSAKRTSAVRPLNLPRRNAHVKPGDVCYMAGWGKITPQGEFPNT
                     LREVELTVQKDRVCESQFQRSYIKASEICVGDSKTKGASFEEDSGGPLVCKKAAAGIV
                     SYGKTDGSAPQVFTRVLSFLSWIKKTMKNS"
     exon            129..279
                     /gene="Gzmc"
                     /gene_synonym="RGD1563645; Rnpk-4; Rnpk4"
                     /inference="alignment:Splign:2.1.0"
     exon            280..415
                     /gene="Gzmc"
                     /gene_synonym="RGD1563645; Rnpk-4; Rnpk4"
                     /inference="alignment:Splign:2.1.0"
     exon            416..676
                     /gene="Gzmc"
                     /gene_synonym="RGD1563645; Rnpk-4; Rnpk4"
                     /inference="alignment:Splign:2.1.0"
     exon            677..935
                     /gene="Gzmc"
                     /gene_synonym="RGD1563645; Rnpk-4; Rnpk4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacatcgtt catctccatc caagggctgt gtctgctctg ccctcctcca atctgaacag
       61 ccttgctggg aagatgccac cagtcctgat actcctgacc ctacttctgc ctcttggagc
      121 cagagcagag gagatcatcg gaggcaatga ggtcagtccg cattcccgcc cctacatggc
      181 atattttgag tttctcaatg ataacgggaa gaagacgttc tgcggaggct tcctggtgag
      241 agacaacttc gtgctgacgg ctgctcactg cagaggaaga tcaatgacag tcacactggg
      301 ggcccacaac atcaaggcta aagagaagac acagcagatt atccctgtgg caaacgccac
      361 tccccaccct gcctataatc ctgataaacg ttccaatgac atcatgctat taaagctggt
      421 gagaagtgcc aagaggacta gcgctgtgag gcctctcaac ctgcccaggc gcaatgccca
      481 tgtgaagcca ggagatgtgt gctacatggc tggctgggga aagataaccc cacaggggga
      541 attccccaac acactgcggg aggttgagct gacagtacag aaggatcggg tctgtgagtc
      601 ccagttccaa cgttcttaca tcaaagcgag tgagatatgt gtgggagact caaagaccaa
      661 gggagcttcc tttgaggaag attctggagg gcctcttgtg tgtaaaaagg cagctgcagg
      721 cattgtctcc tacgggaaaa ctgatggatc agctccacag gtcttcacga gagttttaag
      781 ctttttatcc tggataaaga aaactatgaa aaacagctaa atacaagaag cagcatggat
      841 catttcctga ctaaccatct tccctatagc tgagtccagg agtgctctag gacagatggc
      901 agcaactgaa taaagcactt ttttctgact ggaaa
//
