LOCUS       NM_138517               1476 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus granzyme B (Gzmb), mRNA.
ACCESSION   NM_138517
VERSION     NM_138517.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1476)
  AUTHORS   Zhang,Y., Cai,X., Wang,B., Zhang,B. and Xu,Y.
  TITLE     Exploring the molecular mechanisms of the involvement of
            GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid
            arthritis
  JOURNAL   Mol Immunol 161, 82-90 (2023)
   PUBMED   37531918
  REMARK    GeneRIF: Exploring the molecular mechanisms of the involvement of
            GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid
            arthritis.
REFERENCE   2  (bases 1 to 1476)
  AUTHORS   Fraser,D.D., Cepinskas,G., Slessarev,M., Martin,C., Daley,M.,
            Miller,M.R., O'Gorman,D.B., Gill,S.E., Patterson,E.K. and Dos
            Santos,C.C.
  TITLE     Inflammation Profiling of Critically Ill Coronavirus Disease 2019
            Patients
  JOURNAL   Crit Care Explor 2 (6), e0144 (2020)
   PUBMED   32696007
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1476)
  AUTHORS   Mao,M., Zhang,M., Ge,A., Ge,X., Gu,R., Zhang,C., Fu,Y., Gao,J.,
            Wang,X., Liu,Y. and Zhu,D.
  TITLE     Granzyme B deficiency promotes osteoblastic differentiation and
            calcification of vascular smooth muscle cells in hypoxic pulmonary
            hypertension
  JOURNAL   Cell Death Dis 9 (2), 221 (2018)
   PUBMED   29445095
  REMARK    GeneRIF: Granzyme B deficiency promotes osteoblastic
            differentiation and calcification of vascular smooth muscle cells
            in hypoxic pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1476)
  AUTHORS   Dotiwala,F., Sen Santara,S., Binker-Cosen,A.A., Li,B.,
            Chandrasekaran,S. and Lieberman,J.
  TITLE     Granzyme B Disrupts Central Metabolism and Protein Synthesis in
            Bacteria to Promote an Immune Cell Death Program
  JOURNAL   Cell 171 (5), 1125-1137 (2017)
   PUBMED   29107333
REFERENCE   5  (bases 1 to 1476)
  AUTHORS   Durand,J., Huchet,V., Merieau,E., Usal,C., Chesneau,M., Remy,S.,
            Heslan,M., Anegon,I., Cuturi,M.C., Brouard,S. and Chiffoleau,E.
  TITLE     Regulatory B Cells with a Partial Defect in CD40 Signaling and
            Overexpressing Granzyme B Transfer Allograft Tolerance in Rodents
  JOURNAL   J Immunol 195 (10), 5035-5044 (2015)
   PUBMED   26432892
  REMARK    GeneRIF: Regulatory B Cells with a Partial Defect in CD40 Signaling
            and Overexpressing Granzyme B Transfer Allograft Tolerance in
            Rodents
REFERENCE   6  (bases 1 to 1476)
  AUTHORS   Grigorenko,V.G., Yarovoi,S.V., Paulauskaite,R. and Amerik,A.Yu.
  TITLE     Cloning of cDNA for granzyme-like protein III, a novel serine
            proteinase from rat duodenum
  JOURNAL   FEBS Lett 342 (3), 278-280 (1994)
   PUBMED   8150084
REFERENCE   7  (bases 1 to 1476)
  AUTHORS   Amerik,A.Yu., Yarovoi,S.V., Grigorenko,V.G. and Antonov,V.K.
  TITLE     Identification, sequence analysis, and characterization of cDNA
            clones encoding two granzyme-like serine proteinases from rat
            duodenum
  JOURNAL   FEBS Lett 324 (2), 226-230 (1993)
   PUBMED   8508925
REFERENCE   8  (bases 1 to 1476)
  AUTHORS   Shi,L., Kraut,R.P., Aebersold,R. and Greenberg,A.H.
  TITLE     A natural killer cell granule protein that induces DNA
            fragmentation and apoptosis
  JOURNAL   J Exp Med 175 (2), 553-566 (1992)
   PUBMED   1732416
REFERENCE   9  (bases 1 to 1476)
  AUTHORS   Sayers,T.J., Wiltrout,T.A., Sowder,R., Munger,W.L., Smyth,M.J. and
            Henderson,L.E.
  TITLE     Purification of a factor from the granules of a rat natural killer
            cell line (RNK) that reduces tumor cell growth and changes tumor
            morphology. Molecular identity with a granule serine protease
            (RNKP-1)
  JOURNAL   J Immunol 148 (1), 292-300 (1992)
   PUBMED   1727874
REFERENCE   10 (bases 1 to 1476)
  AUTHORS   Zunino,S.J., Bleackley,R.C., Martinez,J. and Hudig,D.
  TITLE     RNKP-1, a novel natural killer-associated serine protease gene
            cloned from RNK-16 cytotoxic lymphocytes
  JOURNAL   J Immunol 144 (5), 2001-2009 (1990)
   PUBMED   2307850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Mar 11, 2021 this sequence version replaced NM_138517.3.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ221957.1, FQ228927.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000015.1  34462325-34462469   c
            146-296             JAXUCZ010000015.1  34461309-34461459   c
            297-432             JAXUCZ010000015.1  34460804-34460939   c
            433-693             JAXUCZ010000015.1  34460418-34460678   c
            694-1476            JAXUCZ010000015.1  34459007-34459789   c
FEATURES             Location/Qualifiers
     source          1..1476
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1476
                     /gene="Gzmb"
                     /gene_synonym="RNKP-1"
                     /note="granzyme B"
                     /db_xref="GeneID:171528"
                     /db_xref="RGD:620018"
     exon            1..145
                     /gene="Gzmb"
                     /gene_synonym="RNKP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..837
                     /gene="Gzmb"
                     /gene_synonym="RNKP-1"
                     /EC_number="3.4.21.79"
                     /note="granzyme-like protein 1; natural killer cell
                     protease 1; fragmentin; GLP I; GLP-1; granzyme-like
                     protein I; GLP III; granzyme B (granzyme 2, cytotoxic
                     T-lymphocyte-associated serine esterase 1)"
                     /codon_start=1
                     /product="granzyme B precursor"
                     /protein_id="NP_612526.2"
                     /db_xref="GeneID:171528"
                     /db_xref="RGD:620018"
                     /translation="MKLLLLLLSFSLAPKTEAGEIIGGHEAKPHSRPYMAYLQIMDEY
                     SGSKKCGGFLIREDFVLTAAHCSGSKINVTLGAHNIKEQEKMQQIIPVVKIIPHPAYN
                     SKTISNDIMLLKLKSKAKRSSAVKPLNLPRRNVKVKPGDVCYVAGWGKLGPMGKYSDT
                     LQEVELTVQEDQKCESYLKNYFDKANEICAGDPKIKRASFRGDSGGPLVCKKVAAGIV
                     SYGQNDGSTPRAFTKVSTFLSWIKKTMKKS"
     exon            146..296
                     /gene="Gzmb"
                     /gene_synonym="RNKP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..432
                     /gene="Gzmb"
                     /gene_synonym="RNKP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..693
                     /gene="Gzmb"
                     /gene_synonym="RNKP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..1476
                     /gene="Gzmb"
                     /gene_synonym="RNKP-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctcact ctgccttctt cctttcctag aggtgaagag agcaaggaca atactctcga
       61 cgctgggacc taggtggcct tccagggaag atgaagctcc tcttgctcct gctgagcttc
      121 tctctggccc ccaagacaga ggcaggggag atcatcgggg gacatgaagc caagccccac
      181 tctcgaccct acatggccta tcttcagatc atggatgagt attctgggag taagaagtgt
      241 ggcggcttcc ttatacgaga agactttgtg ctgactgctg ctcactgttc gggaagcaaa
      301 ataaatgtca cgttgggggc ccacaacatc aaagaacagg agaagatgca acaaatcatc
      361 cctgtggtga aaatcattcc ccacccagcg tataattcta agacaatctc caatgacatc
      421 atgctgttaa agctgaagag taaggccaag aggtctagcg ctgtgaagcc tctcaatctg
      481 cccagacgca acgtcaaagt gaaaccagga gatgtgtgct atgtggctgg ttggggaaag
      541 ctgggcccaa tgggcaaata ctcagacaca ctacaagagg ttgagctaac agtacaggag
      601 gatcagaagt gtgagtccta cttaaaaaat tatttcgaca aagccaatga gatatgtgca
      661 ggggacccaa agatcaaacg tgcttccttt cggggggact ctggagggcc tcttgtgtgt
      721 aaaaaagtgg ccgcgggcat cgtctcctat ggacaaaatg atggttcaac tccacgggca
      781 ttcaccaaag tctcgacttt cctatcatgg ataaagaaaa ctatgaaaaa gagctaacta
      841 caagaagcaa catggatcat ttcctgacta accatctgcc ctatagctga gtccaggatt
      901 gctctaggac agatggcagc aactgaataa agcacttttt ttctgactgg aagactggtt
      961 tcatgtccat tcacagtgat caaccctgtc cttggcagat gaatggaata cttctgccac
     1021 aaggctgtga caacccagct gacatctggt agttcaccct ctctacaaga gaagaagaat
     1081 gtttgattgt cccaaacatg tactacttcc cctcaaagac cttagaacat tatttaatgc
     1141 aagtcatcat taacagctac ctacagtatt ttcatacagt ttgacccaag tcactggtgt
     1201 gctctttgga acagagcaag aagtgataga tagaattcct tttgattctc tgtgctattt
     1261 ttccccaata gaaggctttt atgttttatc aggctaattt ccttatcaag tgaaatgttt
     1321 ccatttttac attaattgct caaggtacaa cctgatcttt tatgtaaatg atataaaatg
     1381 attaaagtaa actaattaac atgtccacta atttaaatac tttttatttt tgaagggagt
     1441 acataaaagt ttgtttgata aaagttatga aatgta
//
