LOCUS       NM_153468                886 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus granzyme A (Gzma), mRNA.
ACCESSION   NM_153468
VERSION     NM_153468.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 886)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   2  (bases 1 to 886)
  AUTHORS   Golec,M., Reichel,C., Mackiewicz,B., Skorska,C., Curzytek,K.,
            Lemieszek,M., Dutkiewicz,J., Gora,A., Ziesche,R., Boltuc,J.,
            Sodolska,K., Milanowski,J. and Spiewak,R.
  TITLE     Cathelicidin LL-37, granzymes, TGF-beta1 and cytokines levels in
            induced sputum from farmers with and without COPD
  JOURNAL   Ann Agric Environ Med 16 (2), 289-297 (2009)
   PUBMED   20047264
REFERENCE   3  (bases 1 to 886)
  AUTHORS   Hirayasu,H., Yoshikawa,Y., Tsuzuki,S. and Fushiki,T.
  TITLE     A role of a lymphocyte tryptase, granzyme A, in experimental
            ulcerative colitis
  JOURNAL   Biosci Biotechnol Biochem 71 (1), 234-237 (2007)
   PUBMED   17213646
  REMARK    GeneRIF: activity for granzyme A, a lymphocyte tryptase, increased
            at an earlier stage than that at which ulcerative colitis markers
REFERENCE   4  (bases 1 to 886)
  AUTHORS   Zhang,M., Park,S.M., Wang,Y., Shah,R., Liu,N., Murmann,A.E.,
            Wang,C.R., Peter,M.E. and Ashton-Rickardt,P.G.
  TITLE     Serine protease inhibitor 6 protects cytotoxic T cells from
            self-inflicted injury by ensuring the integrity of cytotoxic
            granules
  JOURNAL   Immunity 24 (4), 451-461 (2006)
   PUBMED   16618603
REFERENCE   5  (bases 1 to 886)
  AUTHORS   Hink-Schauer,C., Estebanez-Perpina,E., Kurschus,F.C., Bode,W. and
            Jenne,D.E.
  TITLE     Crystal structure of the apoptosis-inducing human granzyme A dimer
  JOURNAL   Nat Struct Biol 10 (7), 535-540 (2003)
   PUBMED   12819770
REFERENCE   6  (bases 1 to 886)
  AUTHORS   Tsuzuki,S., Kokado,Y., Satomi,S., Yamasaki,Y., Hirayasu,H.,
            Iwanaga,T. and Fushiki,T.
  TITLE     Purification and identification of a binding protein for pancreatic
            secretory trypsin inhibitor: a novel role of the inhibitor as an
            anti-granzyme A
  JOURNAL   Biochem J 372 (Pt 1), 227-233 (2003)
   PUBMED   12590650
REFERENCE   7  (bases 1 to 886)
  AUTHORS   Fan,Z., Beresford,P.J., Zhang,D., Xu,Z., Novina,C.D., Yoshida,A.,
            Pommier,Y. and Lieberman,J.
  TITLE     Cleaving the oxidative repair protein Ape1 enhances cell death
            mediated by granzyme A
  JOURNAL   Nat Immunol 4 (2), 145-153 (2003)
   PUBMED   12524539
REFERENCE   8  (bases 1 to 886)
  AUTHORS   Zhang,D., Beresford,P.J., Greenberg,A.H. and Lieberman,J.
  TITLE     Granzymes A and B directly cleave lamins and disrupt the nuclear
            lamina during granule-mediated cytolysis
  JOURNAL   Proc Natl Acad Sci U S A 98 (10), 5746-5751 (2001)
   PUBMED   11331782
REFERENCE   9  (bases 1 to 886)
  AUTHORS   Pasternack,M.S., Bleier,K.J. and McInerney,T.N.
  TITLE     Granzyme A binding to target cell proteins. Granzyme A binds to and
            cleaves nucleolin in vitro
  JOURNAL   J Biol Chem 266 (22), 14703-14708 (1991)
   PUBMED   1860869
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 4, 2022 this sequence version replaced NM_153468.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB082125.1, SRR22582419.1068010.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000002.1  46485596-46485696   c
            102-246             JAXUCZ010000002.1  46478541-46478685   c
            247-385             JAXUCZ010000002.1  46476506-46476644   c
            386-655             JAXUCZ010000002.1  46475701-46475970   c
            656-886             JAXUCZ010000002.1  46473763-46473993   c
FEATURES             Location/Qualifiers
     source          1..886
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..886
                     /gene="Gzma"
                     /note="granzyme A"
                     /db_xref="GeneID:266708"
                     /db_xref="RGD:628640"
     exon            1..101
                     /gene="Gzma"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..817
                     /gene="Gzma"
                     /EC_number="3.4.21.78"
                     /codon_start=1
                     /product="granzyme A precursor"
                     /protein_id="NP_703198.2"
                     /db_xref="GeneID:266708"
                     /db_xref="RGD:628640"
                     /translation="MRNPCAPWVSSLTTVIFLLLIPEGGCERIIGGDTVVPHSRPYMV
                     LLKLKPDSVCAGALIAKNWVLTAAHCIPGKKSEVILGAHSIKKEPEQQILSVKKAYPY
                     PCFDKHTHEGDLQLLRLKKKATLNKNVAILHLPKKGDDVKPGTRCHVAGWGRFHNKSP
                     PSDTLREVNITVIDRKICNDEKHYNFNPVIGLNMICAGNLRGGKDSCYGDSGGPLLCE
                     GIFRGITAFGLEGTCGDPKGPGIYTLLSDKHLDWIRKTAKGAV"
     exon            102..246
                     /gene="Gzma"
                     /inference="alignment:Splign:2.1.0"
     exon            247..385
                     /gene="Gzma"
                     /inference="alignment:Splign:2.1.0"
     exon            386..655
                     /gene="Gzma"
                     /inference="alignment:Splign:2.1.0"
     exon            656..886
                     /gene="Gzma"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccctgctg attgatgtgg ggagagccac gatgaggaac ccctgtgctc cctgggtgtc
       61 ctctcttact actgtcattt ttcttctgct aattcctgaa ggtggctgtg aaagaatcat
      121 tggaggagac acagtagttc ctcactcaag gccatacatg gttctactta aacttaaacc
      181 agacagcgtc tgtgctggcg ctttgattgc aaaaaactgg gtgttgaccg ctgcacattg
      241 tatcccggga aagaaatctg aggtcattct tggggctcac tcaataaaaa aagagccgga
      301 acaacagata ttatctgtta agaaagcata tccctatcct tgctttgaca aacacacaca
      361 tgagggtgat ctacaacttc tacggctaaa gaaaaaagca acacttaaca aaaacgtggc
      421 tatccttcat ctacctaaaa agggggatga tgtgaaacca ggaaccagat gtcatgtagc
      481 agggtggggg cgttttcaca ataagtcacc tccctctgat actctgagag aagtcaacat
      541 cactgtcata gacagaaaaa tctgcaatga tgaaaaacac tataatttta accctgtaat
      601 tggactaaat atgatttgtg ccggaaacct ccgtggtggg aaggactcat gctacggaga
      661 ttctggaggc cctctgctat gtgagggtat tttccgaggc atcacagctt ttggccttga
      721 ggggacatgt ggagatccca aagggcctgg catctatact ttactctcag acaaacacct
      781 cgattggata aggaagactg cgaagggcgc tgtttaaagg gtgactctca ctccatccgc
      841 tgtcgcttct gtatctgagc acaaataaaa tcaacttaaa gagctg
//
