LOCUS       NM_017015               2481 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus glucuronidase, beta (Gusb), mRNA.
ACCESSION   NM_017015
VERSION     NM_017015.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2481)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   2  (bases 1 to 2481)
  AUTHORS   Peyrol,J., Meyer,G., Obert,P., Dangles,O., Pechere,L., Amiot,M.J.
            and Riva,C.
  TITLE     Involvement of bilitranslocase and beta-glucuronidase in the
            vascular protection by hydroxytyrosol and its glucuronide
            metabolites in oxidative stress conditions
  JOURNAL   J Nutr Biochem 51, 8-15 (2018)
   PUBMED   29078076
  REMARK    GeneRIF: Data suggest beta-glucuronidase and bilitranslocase in
            vascular endothelium are involved in changes in
            endothelium-independent vaso-relaxation induced by dietary
            antioxidants; here, using in vitro studies with thoracic aorta
            rings in oxidative stress, glucuronides of dietary supplement
            antioxidant hydroxytyrosol (HT) are deconjugated by
            beta-glucuronidase before HT is taken up by vascular endothelium
            via bilitranslocase.
REFERENCE   3  (bases 1 to 2481)
  AUTHORS   Thaysen-Andersen,M., Venkatakrishnan,V., Loke,I., Laurini,C.,
            Diestel,S., Parker,B.L. and Packer,N.H.
  TITLE     Human neutrophils secrete bioactive paucimannosidic proteins from
            azurophilic granules into pathogen-infected sputum
  JOURNAL   J Biol Chem 290 (14), 8789-8802 (2015)
   PUBMED   25645918
REFERENCE   4  (bases 1 to 2481)
  AUTHORS   Bohnsack,R.N., Patel,M., Olson,L.J., Twining,S.S. and Dahms,N.M.
  TITLE     Residues essential for plasminogen binding by the
            cation-independent mannose 6-phosphate receptor
  JOURNAL   Biochemistry 49 (3), 635-644 (2010)
   PUBMED   20028034
REFERENCE   5  (bases 1 to 2481)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2481)
  AUTHORS   Wolfe,J.H., Sands,M.S., Barker,J.E., Gwynn,B., Rowe,L.B.,
            Vogler,C.A. and Birkenmeier,E.H.
  TITLE     Reversal of pathology in murine mucopolysaccharidosis type VII by
            somatic cell gene transfer
  JOURNAL   Nature 360 (6406), 749-753 (1992)
   PUBMED   1465145
REFERENCE   7  (bases 1 to 2481)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   8  (bases 1 to 2481)
  AUTHORS   Rees,S., Constantopoulos,G. and Brady,R.O.
  TITLE     The suramin-treated rat as a model of mucopolysaccharidosis.
            Variation in the reversibility of biochemical and morphological
            changes among different organs
  JOURNAL   Virchows Arch B Cell Pathol Incl Mol Pathol 52 (3), 259-272 (1986)
   PUBMED   2879381
REFERENCE   9  (bases 1 to 2481)
  AUTHORS   Sofia,D.R., Knobloch,L.C. and Douglas,J.F.
  TITLE     Effect of concurrent administration of aspirin, indomethacin or
            hydrocortisone with gold sodium thiomalate against adjuvant-induced
            arthritis in the rat
  JOURNAL   Agents Actions 6 (6), 728-734 (1976)
   PUBMED   827200
REFERENCE   10 (bases 1 to 2481)
  AUTHORS   Arrigoni-Martelli,E.
  TITLE     Actinomycin D peritonitis in the rat
  JOURNAL   Fed Proc 35 (13), 2457-2457 (1976)
   PUBMED   185091
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Jul 30, 2021 this sequence version replaced NM_017015.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00717.1, M13962.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               JAXUCZ010000012.1  32337307-32337564
            259-444             JAXUCZ010000012.1  32339426-32339611
            445-626             JAXUCZ010000012.1  32339833-32340014
            627-769             JAXUCZ010000012.1  32340437-32340579
            770-957             JAXUCZ010000012.1  32340972-32341159
            958-1101            JAXUCZ010000012.1  32341974-32342117
            1102-1280           JAXUCZ010000012.1  32342331-32342509
            1281-1427           JAXUCZ010000012.1  32342608-32342754
            1428-1512           JAXUCZ010000012.1  32345670-32345754
            1513-1689           JAXUCZ010000012.1  32347454-32347630
            1690-1825           JAXUCZ010000012.1  32349394-32349529
            1826-2481           JAXUCZ010000012.1  32350183-32350838
FEATURES             Location/Qualifiers
     source          1..2481
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2481
                     /gene="Gusb"
                     /gene_synonym="Ac2-223; Gus-s"
                     /note="glucuronidase, beta"
                     /db_xref="GeneID:24434"
                     /db_xref="RGD:2772"
     exon            1..258
                     /gene="Gusb"
                     /gene_synonym="Ac2-223; Gus-s"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1995
                     /gene="Gusb"
                     /gene_synonym="Ac2-223; Gus-s"
                     /EC_number="3.2.1.31"
                     /note="beta-glucuronidase"
                     /codon_start=1
                     /product="beta-glucuronidase precursor"
                     /protein_id="NP_058711.3"
                     /db_xref="GeneID:24434"
                     /db_xref="RGD:2772"
                     /translation="MSPRRSVCWFVLGQLLCSCALALQGGMLFPKETPSRELKVLDGL
                     WSFRADYSNNRLQGFEKQWYRQPLRESGPTLDMPVPSSFNDITQEAELRNFIGWVWYE
                     REAVLPQRWTQDTDRRVVLRINSAHYYAVVWVNGIHVVEHEGGHLPFEADITKLVQSG
                     PLTTFRVTIAINNTLTPYTLPPGTIVYKTDPSMYPKGYFVQDISFDFFNYAGLHRSVV
                     LYTTPTTYIDDITVTTDVDRDVGLVNYWISVQGSDHFQLEVRLLDEDGKIVARGTGNE
                     GQLKVPRAHLWWPYLMHEHPAYLYSLEVTMTTPESVSDFYTLPVGIRTVAVTKSKFLI
                     NGKPFYFQGVNKHEDSDIRGRGFDWPLLIKDFNLLRWLGANSFRTSHYPYSEEVLQLC
                     DRYGIVVIDECPGVGIVLPQSFGNVSLRHHLEVMDELVRRDKNHPAVVMWSVANEPVS
                     SLKPAGYYFKTLIAHTKALDPTRPVTFVSNTRYDADLGAPYVDVICVNSYLSWYHDYG
                     HLEVIQLQLTSQFENWYKMYQKPIIQSEYGADAVSGLHEDPPRMFSEEYQTALLENYH
                     LILDEKRKEYVIGELIWNFADFMTNQSPLRVTGNKKGIFTRQRNPKMAAFILRERYWR
                     IANETRGYGSVPRTQCMGSRPFTF"
     exon            259..444
                     /gene="Gusb"
                     /gene_synonym="Ac2-223; Gus-s"
                     /inference="alignment:Splign:2.1.0"
     exon            445..626
                     /gene="Gusb"
                     /gene_synonym="Ac2-223; Gus-s"
                     /inference="alignment:Splign:2.1.0"
     exon            627..769
                     /gene="Gusb"
                     /gene_synonym="Ac2-223; Gus-s"
                     /inference="alignment:Splign:2.1.0"
     exon            770..957
                     /gene="Gusb"
                     /gene_synonym="Ac2-223; Gus-s"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1101
                     /gene="Gusb"
                     /gene_synonym="Ac2-223; Gus-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1280
                     /gene="Gusb"
                     /gene_synonym="Ac2-223; Gus-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1427
                     /gene="Gusb"
                     /gene_synonym="Ac2-223; Gus-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1512
                     /gene="Gusb"
                     /gene_synonym="Ac2-223; Gus-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1689
                     /gene="Gusb"
                     /gene_synonym="Ac2-223; Gus-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1825
                     /gene="Gusb"
                     /gene_synonym="Ac2-223; Gus-s"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..2481
                     /gene="Gusb"
                     /gene_synonym="Ac2-223; Gus-s"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgaggcta aaaggcccag ccgctggacg gcgggcatcc cggccagcat gtccccaaga
       61 cggagtgtgt gttggttcgt actgggccag ctgctgtgca gctgcgcgct ggcgctgcag
      121 ggcgggatgc tgttcccgaa ggagacccct tcgcgggaac tcaaggtgct ggacggcctg
      181 tggagcttcc gtgccgatta ctcgaacaat cggttgcagg gcttcgagaa gcagtggtac
      241 cggcagccgc tacgggagtc gggcccaacc ttggacatgc cggtcccttc cagcttcaat
      301 gacatcaccc aagaagcaga gcttcggaac ttcattggct gggtgtggta tgaacgggaa
      361 gcagtgcttc cacagcgatg gacccaggac accgacagga gagtggtgtt gagaatcaac
      421 agcgcccatt actatgcagt tgtgtgggtg aatgggattc atgtggtgga acatgaggga
      481 ggtcacctcc cctttgaggc tgacatcacc aagctggtcc agagtgggcc cctgaccacc
      541 ttccgggtca ccatcgccat caacaacaca ctgacccctt atacccttcc accggggacc
      601 attgtctaca agactgatcc ttccatgtat cccaagggtt acttcgtcca ggacataagc
      661 ttcgacttct tcaactatgc ggggctgcac cggtctgtgg tcctgtacac cacccctacc
      721 acctatatcg atgatatcac tgtgaccact gacgtggacc gggacgttgg gctggtgaac
      781 tactggattt ctgtccaggg cagtgaccat ttccagctag aagtgcgtct tctggatgag
      841 gatggcaaaa ttgtggcccg tggaacaggg aatgagggtc aacttaaggt gccgcgtgcc
      901 cacctctggt ggccttacct gatgcatgag catccagcct acctgtactc cttggaggtg
      961 acgatgacaa cacctgagtc tgtgtctgac ttctataccc tccctgtcgg gattcgaaca
     1021 gtggctgtca caaagagcaa gttcctcata aatgggaagc ctttctactt ccaaggcgtc
     1081 aacaagcatg aggattcaga tatccgaggg agaggcttcg actggcctct gctgataaag
     1141 gatttcaacc tcctccgttg gctcggggca aattcctttc gtaccagcca ctatccctac
     1201 tcggaggagg tacttcagct ctgtgaccga tatggaattg tggtcatcga tgagtgtccc
     1261 ggtgtgggca tcgtgctgcc ccagagtttt ggcaacgtgt ctcttcggca ccacctagag
     1321 gtgatggacg agctggtgcg cagggacaaa aatcaccctg cggtcgtgat gtggtctgtg
     1381 gccaatgagc ctgtctcttc tctgaaacct gccggatatt acttcaagac gctgatcgcc
     1441 cacaccaaag ccctggaccc cacccgtcct gtgacctttg tgagcaatac cagatatgac
     1501 gcagacctgg gggccccgta cgtggacgtg atttgtgtga acagttactt atcctggtat
     1561 catgactacg ggcatctgga ggtgattcag ctgcagctga ctagccagtt tgagaactgg
     1621 tataagatgt accagaagcc aattatccag agcgagtatg gagcagacgc cgtctcgggg
     1681 cttcatgagg atccacctcg catgttcagt gaggagtacc agacagctct cctggagaat
     1741 tatcatttga tcctggatga gaaacgaaaa gaatatgtca tcggagagct catctggaat
     1801 tttgctgact tcatgacgaa ccagtcacca ctgagagtaa caggaaacaa gaaggggatc
     1861 ttcactcgac agagaaaccc caagatggca gccttcattt tgcgagagag atactggagg
     1921 attgccaacg aaaccagagg ttacggttca gtgccgagga cccagtgtat gggaagcaga
     1981 ccgttcacat tctaaagcta cgactacctc accgcagaca gggcctgatg aagtgaaagg
     2041 tattctctca gcagaagagt ttttcctctg gagtttgtga accaacacaa gggggacttt
     2101 agaagtgaca tggaagtttt ccttgtgtgg ggataatgac ttgcagtgcc ttaggctcag
     2161 taatgtgtcc tgctgagaag tgtcccaggt catttctgtc aggttttttt tggccttggc
     2221 tttgtgtact cttgaaaacc tactgtgtga atactcacac taagagctcc tggttaccgg
     2281 ctgagggacg gctcacaatt taagaatact gactgttcta ccaggggttc cagattcgat
     2341 tcctagcacc cacgtggtcg ttaactatga gctgttgccc catttctcag gtgatgtacg
     2401 aacatacatg tggggggagg ggaatagtca tacgtgtaaa atgaaaataa atctaaataa
     2461 aactgttttc tttcattatt a
//
