LOCUS       NM_022220               2192 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus gulonolactone (L-) oxidase (Gulo), mRNA.
ACCESSION   NM_022220
VERSION     NM_022220.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2192)
  AUTHORS   Fujitsuka,N., Yokozawa,T., Oura,H., Akao,T., Kobashi,K., Ienaga,K.
            and Nakamura,K.
  TITLE     L-gulono-gamma-lactone oxidase is the enzyme responsible for the
            production of methylguanidine in the rat liver
  JOURNAL   Nephron 63 (4), 445-451 (1993)
   PUBMED   8459881
REFERENCE   2  (bases 1 to 2192)
  AUTHORS   Kawai,T., Nishikimi,M., Ozawa,T. and Yagi,K.
  TITLE     A missense mutation of L-gulono-gamma-lactone oxidase causes the
            inability of scurvy-prone osteogenic disorder rats to synthesize
            L-ascorbic acid
  JOURNAL   J Biol Chem 267 (30), 21973-21976 (1992)
   PUBMED   1400508
REFERENCE   3  (bases 1 to 2192)
  AUTHORS   Nishikimi,M., Kawai,T. and Yagi,K.
  TITLE     Guinea pigs possess a highly mutated gene for
            L-gulono-gamma-lactone oxidase, the key enzyme for L-ascorbic acid
            biosynthesis missing in this species
  JOURNAL   J Biol Chem 267 (30), 21967-21972 (1992)
   PUBMED   1400507
REFERENCE   4  (bases 1 to 2192)
  AUTHORS   Nishikimi,M. and Yagi,K.
  TITLE     Molecular basis for the deficiency in humans of gulonolactone
            oxidase, a key enzyme for ascorbic acid biosynthesis
  JOURNAL   Am J Clin Nutr 54 (6 Suppl), 1203S-1208S (1991)
   PUBMED   1962571
  REMARK    Review article
REFERENCE   5  (bases 1 to 2192)
  AUTHORS   Nishikimi,M., Koshizaka,T., Ozawa,T. and Yagi,K.
  TITLE     Occurrence in humans and guinea pigs of the gene related to their
            missing enzyme L-gulono-gamma-lactone oxidase
  JOURNAL   Arch Biochem Biophys 267 (2), 842-846 (1988)
   PUBMED   3214183
REFERENCE   6  (bases 1 to 2192)
  AUTHORS   Koshizaka,T., Nishikimi,M., Ozawa,T. and Yagi,K.
  TITLE     Isolation and sequence analysis of a complementary DNA encoding rat
            liver L-gulono-gamma-lactone oxidase, a key enzyme for L-ascorbic
            acid biosynthesis
  JOURNAL   J Biol Chem 263 (4), 1619-1621 (1988)
   PUBMED   3338984
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089803.1.
            
            On Feb 20, 2005 this sequence version replaced NM_022220.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089803.1, FQ219140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2192
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..2192
                     /gene="Gulo"
                     /note="gulonolactone (L-) oxidase"
                     /db_xref="GeneID:60671"
                     /db_xref="RGD:620701"
     exon            1..37
                     /gene="Gulo"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1357
                     /gene="Gulo"
                     /EC_number="1.1.3.8"
                     /note="GLO; LGO; L-gulono-gamma-lactone oxidase"
                     /codon_start=1
                     /product="L-gulonolactone oxidase"
                     /protein_id="NP_071556.2"
                     /db_xref="GeneID:60671"
                     /db_xref="RGD:620701"
                     /translation="MVHGYKGVQFQNWAKTYGCSPEVYYQPTSVEEVREVLALAREQK
                     KKVKVVGGGHSPSDIACTDGFMIHMGKMNRVLQVDKEKKQVTVEAGILLADLHPQLDE
                     HGLAMSNLGAVSDVTVAGVIGSGTHNTGIKHGILATQVVALTLMTADGEVLECSESRN
                     ADVFQAARVHLGCLGIILTVTLQCVPQFHLQETSFPSTLKEVLDNLDSHLKRSEYFRF
                     LWFPHTENVSIIYQDHTNKAPSSASNWFWDYAIGFYLLEFLLWTSTYLPCLVGWINRF
                     FFWMLFNCKKESSNLSHKIFTYECRFKQHVQDWAIPREKTKEALLELKAMLEAHPKVV
                     AHYPVEVRFTRGDDILLSPCFQRDSCYMNIIMYRPYGKDVPRLDYWLAYETIMKKFGG
                     RPHWAKAHNCTRKDFEEMYPTFHKFCDIREKLDPTGMFLNSYLEKVFY"
     exon            38..139
                     /gene="Gulo"
                     /inference="alignment:Splign:2.1.0"
     exon            140..265
                     /gene="Gulo"
                     /inference="alignment:Splign:2.1.0"
     exon            266..360
                     /gene="Gulo"
                     /inference="alignment:Splign:2.1.0"
     exon            361..451
                     /gene="Gulo"
                     /inference="alignment:Splign:2.1.0"
     exon            452..637
                     /gene="Gulo"
                     /inference="alignment:Splign:2.1.0"
     exon            638..745
                     /gene="Gulo"
                     /inference="alignment:Splign:2.1.0"
     exon            746..822
                     /gene="Gulo"
                     /inference="alignment:Splign:2.1.0"
     exon            823..972
                     /gene="Gulo"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1137
                     /gene="Gulo"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1228
                     /gene="Gulo"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..2159
                     /gene="Gulo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcaagtcgt ctgatcctcc tgatcactgg aatcatggtc catgggtaca aaggggtcca
       61 gttccaaaat tgggcaaaga cctatggttg cagtccagag gtgtactacc agcccacctc
      121 cgtggaggag gtcagagagg tgctggccct ggcccgggag cagaagaaga aagtgaaggt
      181 ggtgggtggt ggccactcgc cttcagacat tgcctgcact gacggtttca tgatccacat
      241 gggcaagatg aaccgggttc tccaggtgga caaggagaag aagcaggtaa cagtggaagc
      301 cggtatcctc ctggctgacc tgcacccaca gctggatgag catggcctgg ccatgtccaa
      361 tctgggagca gtgtctgatg tgacagttgc tggtgtcatt ggatccggaa cacataacac
      421 agggatcaag cacggcatcc tggccactca ggtggtggcc ctgaccctga tgacagctga
      481 tggagaagtt ctggaatgtt ctgagtcaag aaatgcagat gtgttccagg ctgcacgggt
      541 gcacctgggt tgcctgggta tcatcctcac cgtcaccctg cagtgtgtgc ctcagtttca
      601 ccttcaggag acatccttcc cttcgaccct caaagaggtc cttgacaacc tagacagcca
      661 cctgaagagg tctgagtact tccgcttcct ctggtttcct cacactgaga acgtcagcat
      721 catctaccaa gaccacacca acaaggcccc ctcctctgca tctaactggt tttgggacta
      781 tgccatcggg ttctacctac tggagttctt gctctggacc agcacctacc tgccatgcct
      841 cgtgggctgg atcaaccgct tcttcttctg gatgctgttc aactgcaaga aggagagcag
      901 caacctcagt cacaagatct tcacctacga gtgtcgcttc aagcagcatg tacaagactg
      961 ggccatccct agggagaaga ccaaggaggc cctactggag ctaaaggcca tgctggaggc
     1021 ccaccccaaa gtggtagccc actaccccgt agaggtgcgc ttcacccgag gcgatgacat
     1081 tctgctgagc ccctgcttcc agagggacag ctgctacatg aacatcatta tgtacaggcc
     1141 ctatggaaag gacgtgcctc ggctagacta ctggctggcc tatgagacca tcatgaagaa
     1201 gtttggagga agaccccact gggcaaaggc ccacaattgc acccggaagg actttgagga
     1261 aatgtacccc acctttcaca agttctgtga catccgtgag aagctggacc ccactggaat
     1321 gttcttgaat tcgtacctgg agaaagtctt ctactaaagc aggagtggaa acaaaccacc
     1381 ctgacccctc acacttctgc tgcccccggg ggtctgggga gcagagaagt gcctcacaag
     1441 cacaatggga actgacctct cctcctgacc acaaagaaag gctgggctct gggcgggtcc
     1501 tctctgcctt cggcatcatt tcccttacat ccaggcaaga agtggcctct cactcaaatt
     1561 cctgttagca tttccatggg tcacacataa actgcaatcc tctcaggaga agggggatcc
     1621 ctgatacatc atatctatcc agactaagga tgtggttctt cctagattct atggctccac
     1681 caggtataga gagattcctg gggcctgcag ttctccatcc ctcttcagaa gggagggatc
     1741 ccttggcgag agtttggctc agaggtggca tgaagcatgc tctgctctct cttacccttg
     1801 aaggtccttc ggatgcccag agatgtctgc tggtcctggg caagccatca ttcaaacggg
     1861 tccaacctgg ccttctgtct gccatggcct gaccctcgca gtgtctcttc cagaggtgtt
     1921 tagagtggaa ctcgcttcaa cctcttaacc agttgctgat ccctgtgttt ctctcccttc
     1981 tccttggaga ctactcttgg agggggatcc caccatgtcc ttggctttcc ctgggtattg
     2041 ttctcctctt cctcttcaca aatatgattt cagtttgatt tgtggccttt ctggagtgtt
     2101 ccttggagaa ccaagatgtt ccagctactt tgtaagaatt aaaaggcact gaagatgtta
     2161 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
