LOCUS       NM_001013115             951 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus guanylate kinase 1 (Guk1), mRNA.
ACCESSION   NM_001013115 XM_220511
VERSION     NM_001013115.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 951)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 951)
  AUTHORS   Khan,N., Shah,P.P., Ban,D., Trigo-Mourino,P., Carneiro,M.G.,
            DeLeeuw,L., Dean,W.L., Trent,J.O., Beverly,L.J., Konrad,M., Lee,D.
            and Sabo,T.M.
  TITLE     Solution structure and functional investigation of human guanylate
            kinase reveals allosteric networking and a crucial role for the
            enzyme in cancer
  JOURNAL   J Biol Chem 294 (31), 11920-11933 (2019)
   PUBMED   31201273
REFERENCE   3  (bases 1 to 951)
  AUTHORS   Wimberg,H., Janssen-Bienhold,U. and Koch,K.W.
  TITLE     Control of the Nucleotide Cycle in Photoreceptor Cell Extracts by
            Retinal Degeneration Protein 3
  JOURNAL   Front Mol Neurosci 11, 52 (2018)
   PUBMED   29515371
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 951)
  AUTHORS   Liu,S.Q., Kang,J., Li,C.J., Tang,E.J., Wen,B., Cai,R. and Yang,H.J.
  TITLE     Differences in expression of retinal proteins between diabetic and
            normal rats
  JOURNAL   World J Gastroenterol 13 (14), 2118-2124 (2007)
   PUBMED   17465459
REFERENCE   5  (bases 1 to 951)
  AUTHORS   Sekulic,N., Shuvalova,L., Spangenberg,O., Konrad,M. and Lavie,A.
  TITLE     Structural characterization of the closed conformation of mouse
            guanylate kinase
  JOURNAL   J Biol Chem 277 (33), 30236-30243 (2002)
   PUBMED   12036965
REFERENCE   6  (bases 1 to 951)
  AUTHORS   Ali,B.R., Tjernberg,A., Chait,B.T. and Field,M.C.
  TITLE     A microsomal GTPase is required for glycopeptide export from the
            mammalian endoplasmic reticulum
  JOURNAL   J Biol Chem 275 (43), 33222-33230 (2000)
   PUBMED   10913137
REFERENCE   7  (bases 1 to 951)
  AUTHORS   Brady,W.A., Kokoris,M.S., Fitzgibbon,M. and Black,M.E.
  TITLE     Cloning, characterization, and modeling of mouse and human
            guanylate kinases
  JOURNAL   J Biol Chem 271 (28), 16734-16740 (1996)
   PUBMED   8663313
REFERENCE   8  (bases 1 to 951)
  AUTHORS   Miller,W.H., Daluge,S.M., Garvey,E.P., Hopkins,S., Reardon,J.E.,
            Boyd,F.L. and Miller,R.L.
  TITLE     Phosphorylation of carbovir enantiomers by cellular enzymes
            determines the stereoselectivity of antiviral activity
  JOURNAL   J Biol Chem 267 (29), 21220-21224 (1992)
   PUBMED   1383219
REFERENCE   9  (bases 1 to 951)
  AUTHORS   Field,A.K., Davies,M.E., DeWitt,C., Perry,H.C., Liou,R.,
            Germershausen,J., Karkas,J.D., Ashton,W.T., Johnston,D.B. and
            Tolman,R.L.
  TITLE     9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective
            inhibitor of herpes group virus replication
  JOURNAL   Proc Natl Acad Sci U S A 80 (13), 4139-4143 (1983)
   PUBMED   6306664
REFERENCE   10 (bases 1 to 951)
  AUTHORS   Buccino,R.J. Jr. and Roth,J.S.
  TITLE     Partial purification and properties of ATP:GMP phosphransferase
            from rat liver
  JOURNAL   Arch Biochem Biophys 132 (1), 49-61 (1969)
   PUBMED   4307347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001013115.2.
            
            Sequence Note: This RefSeq record was created from mixed strain
            transcript data because no single transcript from the same strain
            was available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF354443.1, SRR26643293.62979.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000010.1  44479291-44479355   c
            66-179              JAXUCZ010000010.1  44474000-44474113   c
            180-221             JAXUCZ010000010.1  44473624-44473665   c
            222-318             JAXUCZ010000010.1  44473164-44473260   c
            319-457             JAXUCZ010000010.1  44472429-44472567   c
            458-542             JAXUCZ010000010.1  44472265-44472349   c
            543-628             JAXUCZ010000010.1  44471683-44471768   c
            629-951             JAXUCZ010000010.1  44471085-44471407   c
FEATURES             Location/Qualifiers
     source          1..951
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..951
                     /gene="Guk1"
                     /note="guanylate kinase 1"
                     /db_xref="GeneID:303179"
                     /db_xref="RGD:1309638"
     exon            1..65
                     /gene="Guk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..664
                     /gene="Guk1"
                     /EC_number="2.7.4.8"
                     /note="ATP:GMP-phosphotransferase"
                     /codon_start=1
                     /product="guanylate kinase"
                     /protein_id="NP_001013133.2"
                     /db_xref="GeneID:303179"
                     /db_xref="RGD:1309638"
                     /translation="MLRRPLVGLAVAALGRVPVDGMAGPRPVVLSGPSGAGKSTLLKK
                     LFQEHGSVFGFSVSHTTRNPRPGEEDGKDYYFVTREMMQRDIAAGDFIEHAEFSGNLY
                     GTSKEAVRAVQAMNRICVLDVDLQGVRSIKKTDLHPIYISVQPPSMDVLEQRLRQRNT
                     ETEESLAKRLAAAQADMESSKEPGLFDLVIVNDNLDEAYVTLKQALSEEIKKAEGTEH
                     A"
     exon            66..179
                     /gene="Guk1"
                     /inference="alignment:Splign:2.1.0"
     exon            180..221
                     /gene="Guk1"
                     /inference="alignment:Splign:2.1.0"
     exon            222..318
                     /gene="Guk1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..457
                     /gene="Guk1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..542
                     /gene="Guk1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..628
                     /gene="Guk1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..951
                     /gene="Guk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgatgctg cggcgcccgc tggtcgggct ggcggtggcc gccctgggtc gcgttcccgt
       61 ggacggcatg gcaggaccta ggccagtagt gctgagcggg ccatcagggg cagggaagag
      121 cactctgctc aagaagttgt tccaggaaca tggcagtgtc tttggcttca gcgtatccca
      181 cactacaagg aacccacgac ctggcgaaga agatggcaaa gattactact ttgtgaccag
      241 ggagatgatg cagcgtgata ttgcagcagg ggacttcatt gagcatgctg agttctcagg
      301 gaacctgtat gggacaagca aggaagccgt ccgggctgtg caggccatga accgcatctg
      361 cgtgctagat gtcgacctac aaggagtgcg cagcatcaag aagactgatc tgcatcccat
      421 ctacatctct gtgcagcctc cctcgatgga cgtgctggag caacgactgc ggcagcgcaa
      481 cactgagact gaggagagcc tggcaaagcg gctggcagct gcacaggcag acatggagag
      541 cagcaaggag cctggcttgt ttgacctggt gatcgtcaat gacaacctgg atgaagccta
      601 tgttacactg aagcaggcac tgtctgagga aatcaagaaa gctgagggaa ctgaacatgc
      661 ctgagggcct gctttattcc acagagtgat gcctgtggtc taaatctgcc tggattatga
      721 ggtgggggga actttgccag ggcaccaagg acttgtagta ggcttccact gtggagtaga
      781 aggagctacc ccttgtctgg ccacaaggtg gctctgcacc ctgggctggc ttgctgaggc
      841 ccaatgactc cgaagaagag tacccacatc tattctccct gggctatttg tgttcctctc
      901 cgttcctcct gctggagcgg gactgacatt ctaataaagt aattactgag t
//
