LOCUS       NM_001107215            6196 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus GTP binding elongation factor GUF1 (Guf1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001107215 XM_001077422 XM_223381
VERSION     NM_001107215.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6196)
  AUTHORS   Li,P., Dai,S., Gao,X. and Li,W.
  TITLE     Guf1 overexpression improves pancreatic beta cell functions in type
            2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB)
            surgery
  JOURNAL   J Physiol Biochem 79 (3), 569-582 (2023)
   PUBMED   36905457
  REMARK    GeneRIF: Guf1 overexpression improves pancreatic beta cell
            functions in type 2 diabetes mellitus rats with Roux-en-Y gastric
            bypass (RYGB) surgery.
REFERENCE   2  (bases 1 to 6196)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473981.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_223381.4, XM_001077422.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6196
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..6196
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /note="GTP binding elongation factor GUF1"
                     /db_xref="GeneID:305317"
                     /db_xref="RGD:1310774"
     exon            1..276
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..2121
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /note="GTP-binding protein GUF1 homolog; GUF1 GTPase
                     homolog; GUF1 homolog, GTPase"
                     /codon_start=1
                     /product="translation factor GUF1, mitochondrial"
                     /protein_id="NP_001100685.1"
                     /db_xref="GeneID:305317"
                     /db_xref="RGD:1310774"
                     /translation="MWALAGRALAPWAAGAARLLPPCPRHAGVLEPGVACRLFSAAEL
                     KEKPDMSRFPVEDIRNFSIIAHVDHGKSTLADRLLELTGTIDKTQKNKQVLDKLQVER
                     ERGITVKAQTASLFYSFGGKQYLLNLIDTPGHVDFSYEVSRSLSACQGVLLVVDANEG
                     IQAQTVANFFLAFEAQLSVIPVINKIDLKNADPERVGKQIEKVFDIPSEECIKISAKL
                     GTNVDSVLQAVIERIPPPKVHRANPLKALVFDSTFDQYRGVVASIALFDGMLSKGDKI
                     VSAHTKKTYEVNQVGILNPNEQPTHKLYAGQVGFLIAGMKDVTEAQIGDTLYLHNHPV
                     EPLPGFKSAKPMVFAGVYPIDQSEYNNLKSAIEKLTLNDSSVTVHRDSSLALGAGWRL
                     GFLGLLHMEVFNQRLEQEYNASVILTTPTVPYKAVLSSAKLIKEYKEKEITIINPAQF
                     PDKSKVTEYLEPVVLGTVITPTEYTGKIMELCQARRAIQKNMTFIDENRVMLKYLFPL
                     NEIVVDFYDSLKSLSSGYASFDYEDAGYQTADLIKMDILLNGNIVEELVTVVHREKAY
                     TVGKSICERLKDSLPRQLFEIAVQAAIGSKVIARETVKAYRKNVLAKCYGGDITRKMK
                     LLKRQAEGKKKLRKIGNIEIPKNAFIKVLKTQPNK"
     exon            277..388
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            389..537
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            538..618
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            619..696
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            697..780
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            781..845
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1049
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1189
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1313
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1446
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1590
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1724
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1826
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1946
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..1983
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..6196
                     /gene="Guf1"
                     /gene_synonym="RGD1310774"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgcgctgac gtcataagcg gagcgaccga ctggcagcgc gtttggtttg cgacaggcct
       61 ggttctggct gtgggctcag gcctgagctc agaccttact atgtggtctc cctggcggtc
      121 ccgaccctga gccgcccagg catgtgggcg ctcgcggggc gggctctcgc gccgtgggcc
      181 gctggggctg cgcgcttgct gcctccctgt ccccggcacg cgggtgtctt ggagccaggg
      241 gtcgcctgca ggctcttcag cgcggccgag ctcaaggaga aacctgacat gtctagattt
      301 cccgttgaag atattaggaa tttcagtatc attgcacatg tggatcatgg caaaagtact
      361 ttagctgaca ggctcctgga actaacagga acaattgata agacacagaa aaacaagcag
      421 gttcttgata aattacaagt ggagcgagaa agaggaatca ctgtgaaggc gcagacagcg
      481 tctctgtttt acagctttgg aggaaagcag taccttctaa atctcatcga tacaccaggc
      541 cacgttgatt ttagttatga agtgtctagg tccctttctg cgtgccaagg tgttttactg
      601 gtggttgatg caaatgaggg tattcaagct caaactgtgg caaacttctt tcttgccttt
      661 gaagcacagt tgtcagtaat tccagttata aacaagatag atctgaagaa tgctgatcct
      721 gaaagggttg ggaagcagat tgaaaaagtg ttcgatatcc ctagtgagga atgtattaag
      781 atttctgcga aactcgggac aaacgttgac agtgtgctcc aggcagtcat tgaacgaata
      841 cctcctccaa aagtacatcg tgcaaacccg ctgaaagctt tggtatttga ctccaccttt
      901 gaccagtaca gaggtgtggt agccagcata gcactgtttg atggaatgct ttccaaggga
      961 gataaaattg tgtctgcaca cactaaaaaa acatatgaag tcaatcaagt aggcattttg
     1021 aatcctaatg aacaaccaac tcataaatta tatgcaggac aggtgggctt tctgattgct
     1081 gggatgaaag atgtcactga agcacaaata ggagacacat tatatttaca taatcatcca
     1141 gtggagccct tgcctgggtt taaatcagcg aaaccaatgg tatttgcagg agtgtaccct
     1201 atagaccaat ccgaatataa taacctcaag agtgctatag aaaaactgac cttaaatgac
     1261 tccagtgtga cagtgcatcg ggacagtagt ctggccctgg gtgctggctg gaggttggga
     1321 tttcttggac ttttacatat ggaggtattt aaccagcgac tagagcaaga gtataatgct
     1381 tctgttattt tgacaacccc cactgttcca tacaaggctg ttctttcctc tgccaaatta
     1441 ataaaggagt ataaagaaaa ggaaatcact atcatcaacc ctgcacaatt ccctgataag
     1501 tccaaagtaa cagaatattt ggaacctgtt gttttgggca ctgtcattac accaactgaa
     1561 tacactggaa aaataatgga gctttgtcag gcacgaagag caattcagaa aaatatgact
     1621 tttattgatg aaaacagagt tatgctgaaa tatctcttcc ctttgaatga aatcgtggta
     1681 gacttttatg actctttgaa gtctctgtct tccggatatg caagttttga ctatgaagat
     1741 gccggttacc agactgcaga tctaataaaa atggatattc tgctgaatgg caatatcgtg
     1801 gaggagctgg tgactgtggt ccatagagag aaagcataca ctgttggcaa aagcatatgt
     1861 gaacgtctaa aggattctct tcccagacag ctatttgaga tcgcagttca agcagctatt
     1921 ggaagcaaag taattgcaag agaaactgtg aaagcctata ggaaaaatgt tttggcaaaa
     1981 tgttatggtg gtgatattac tagaaaaatg aaacttttga agagacaagc agaagggaaa
     2041 aaaaagctga ggaagattgg caacattgag attccaaaaa atgcttttat aaaagtcctg
     2101 aaaacccagc ctaataaatg actcaggaaa agcaggactt ctgtttcttg taatttacat
     2161 tgacaacaga ttgaaaactc tgaagtgctt attactttca gggtctgcaa ctatgaccta
     2221 cttcagtgct tctcaacctt cctaaagagg ccacccttta gtacagttcc tcatgttgtg
     2281 gtaatcccaa ccataaaatt attttttgtt gctgtaattc ataactgtaa ttttgctact
     2341 ttcatgaatc ataatgtaaa tatttaaaat gaggatgtca gatacgcacc ctctgtgaaa
     2401 gggttgtttg acctgaggtt gagaagtgct gacgtgttgg tagagaagat cttaaatgta
     2461 tgtacgctac attgcttatt ttcttacgtt ctactcacgg aatctcccca aaatccctca
     2521 cctatctttc agattgagat tatattacta caccctgcat agggagcttt ggaaagtaaa
     2581 ggagcttaat acattttaaa tattcatgaa ggcaggccta ttatacattt aatcacagtg
     2641 aatcttaact ttttcacatg cttttttctt ttttcttttt gttttcagtg ttttgagaca
     2701 ggatcctgcc atgtagcatg gctagcccaa tgtcttagtt tattgctgtg aagagacact
     2761 gtgacctcag taactcttat aaaggcaaac atttccttgg ggctgtctta cagtttcagt
     2821 ggtttagtcc actattgtgg gactggagca tagtgagaag catggcggca ggcaggtaag
     2881 catggtggtg gagaagcagc tgagaggtct gcattctaat ctgcaggtgg cggcagcggc
     2941 agccacacta ggcttagctt gagcatgtgc gatctcaaag ctcatttcca cagggacaca
     3001 cgttcatcaa caaggacaca cttcctaata gtgctacccc acctaagagt accattccct
     3061 atgggccagc attcacacac aggagtttat aggtggtatt tcatgcagga ttccttacac
     3121 aggctaggtt gacctcagac ttgtgacagt cctcccacct tagccttctc actgctggga
     3181 ttttatagcc atgtgctact atcttcaact tctgcatggg ttttcttcca gagactaaga
     3241 ggagccctaa ttacatcaat taactttgca aatcaccttg tttcagtttt tagctcaatc
     3301 actgtatctg atatatagga attgttacta agaaagagac tcaaaagact gtgttaccag
     3361 acatttgttc tggcttttta tgcctataca tttaatcaag catttctgaa actaagttat
     3421 acataccgct taagtttggg atagggcccc atcttgtttt tgacactctt gagtacattc
     3481 atgaaaagtg acatacattt gatattagca ccagctgtta gtaactgtca cctaaacgaa
     3541 cctaaatgac acaactaata agtggtatag tttcatgttc attcacaaca aactgaaaaa
     3601 tgtattcctg caagaaagag tcttgattct ggattttact ttctgccttc tatcttgtac
     3661 atacctagta gcaaaaaagg ttactgatgt gtcttcacgt tttgatggga ttttaaagtg
     3721 aggacttaga agttaggtag ccttagttta tcctcttata taagttgtct cacttctccc
     3781 agcctgattt gctaggtaga aaataccaaa ttcctactgc agtatgtttt taaatggcaa
     3841 tatatttgaa actgagacaa tgcagttgtt aaaatgttct gctcttccat tattgctaag
     3901 ggaaaggcaa aacctggtac acatgtccta atatccagta tcttcagcgt aacccttgcg
     3961 cttttttaga tttcgactat tctttaaccc ataatccttt ggaattaaca tagtgctaac
     4021 agaaaacatt tgcaaggttt aattttaagt tataaatttt gagtttattc ctttgggttc
     4081 tagaatccca atttgtatag ttgtatgacc aaaaaataat tgcaacttac taaatttggt
     4141 atgggctggc cagtgtgctg agttttatat acttttttct aacagcagag ggtaagatgt
     4201 tgccatttat atctcctggt gacagacaga atccagatgt ttttacttca aaggcaaaga
     4261 ttatatcatt gattcatgac atcttcaatg gtttctaagc tttttaagag tatagcacta
     4321 ggatgctcca gtggccaggg aagtgcggag gagagaatgc tgtgagacag catcagtgct
     4381 agaatgaaaa agatctcttt agacctttgg agcacaggag gaatgaatga tacttcagaa
     4441 gagaccatta acttctcacc atgatgctat acagccaaag gtggggtaat ctcgagtaaa
     4501 catgttactg ccaaactcat tcctgcagga ttgatgctac tgatttgact ggttaactaa
     4561 aatatgttaa gggcataggg actccttgaa caaattgttt ttgccaggga ttttgtccaa
     4621 gcggtgagaa gtccaagcat cttagtgtga ctaagacgtc tactaaggga agactgagac
     4681 agggtgatag ggaggaagaa cactactaag gctaacttca ctttgtgggg tgcccatctg
     4741 aatgaatggt gtaccagttt taatattaag aagggaggca gaatagtcta agagagattt
     4801 aaaactcagc ttaattttag tataacccag aatatcccaa tctgatgttc ttcagcaggc
     4861 tgtttgctcc aaagaggttc cagagtatct atgtacgtgc tctgggatgt gaaaccctat
     4921 cacacagcac ctttatactt ccatagttgt ttgatatctc ccaaatacat atatgcatat
     4981 gcattttaat atttataata catatacata taatttatat gtaattggtt tactttgatg
     5041 aataagaaac agctgttaag acatcactgg gaattaatgc accattattg gtggcattgg
     5101 tttgactgcg tgtatgccat ctgtcttatt gtgtgaagta ttggtatgcc tggtaccctc
     5161 agggacaaga gggcattaga ggaacccttg aaacttgaac tacaatgggt ttgtgcgcca
     5221 ccttccctgc cagtgccggg aactgaacgc ttgagctgca agtaccctct atcgctgagc
     5281 cattctccag cccccttact tttccctctt aggccttgtc ttcagtttcc tacctatgtg
     5341 atggcaacga atttgaggca aatgtagtgt catgaggacc attaacgatc tcccccatga
     5401 atgtgatttc aattttagaa aggaaattag ataattgttt tattgtaaac tttaagttaa
     5461 agatagaaaa caatattttt atttgcaact taattatgca agttattgca atttaaacgt
     5521 ttacagtaat tattttagta catacttaat atctctttag acatatataa ggatgattta
     5581 caaaatttaa caataatcag aaaatgtttt tcaaaaggat ttctttacgt ttgtagctaa
     5641 gtataaagct cataattgcc gatataatta ttaagagcat taacccaggt cattaaataa
     5701 aaataagcat atctgtaaaa aagtaccaca gaagaaggtg catagaagca tgcactcaca
     5761 cagactttct gaaaggatgt aaactacttt agggcactgt catctcctca gagttccttg
     5821 attaatgagt aggactcctg atgtccagat gctactgcag aaagatgact aaggcaacta
     5881 caggcaaaaa gcatgtgtct gatgcacaaa caaataccca ttccaagagt gaaggtctgt
     5941 aatgacagca gggtgatatt ggaaaggctt ggagtgtctt caaataagtc aaagagatta
     6001 cgtcactaac aggacctgag agtgcagaaa tctcttaaaa tgcaaacatt tcactgctag
     6061 actctttata ggtagccatg gagcttctat actttagaac agctaaacaa ttttgggatc
     6121 caattacttc tagggcctag tgtaaaacag acacattcta aatgtggaat gtttaacaca
     6181 ccgtgggctt tttctt
//
