LOCUS       NM_139042               3442 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus guanylate cyclase 2G (Gucy2g), mRNA.
ACCESSION   NM_139042
VERSION     NM_139042.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3442)
  AUTHORS   Schulz,S., Wedel,B.J., Matthews,A. and Garbers,D.L.
  TITLE     The cloning and expression of a new guanylyl cyclase orphan
            receptor
  JOURNAL   J Biol Chem 273 (2), 1032-1037 (1998)
   PUBMED   9422765
REFERENCE   2  (bases 1 to 3442)
  AUTHORS   Kojima,M., Hisaki,K., Matsuo,H. and Kangawa,K.
  TITLE     A new type soluble guanylyl cyclase, which contains a kinase-like
            domain: its structure and expression
  JOURNAL   Biochem Biophys Res Commun 217 (3), 993-1000 (1995)
   PUBMED   8554626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 13, 2012 this sequence version replaced NM_139042.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF024622.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               JAXUCZ010000001.1  264285223-264285615 c
            394-742             JAXUCZ010000001.1  264281671-264282019 c
            743-852             JAXUCZ010000001.1  264279048-264279157 c
            853-1038            JAXUCZ010000001.1  264276737-264276922 c
            1039-1180           JAXUCZ010000001.1  264274677-264274818 c
            1181-1316           JAXUCZ010000001.1  264273928-264274063 c
            1317-1429           JAXUCZ010000001.1  264272371-264272483 c
            1430-1605           JAXUCZ010000001.1  264271581-264271756 c
            1606-1743           JAXUCZ010000001.1  264269939-264270076 c
            1744-1827           JAXUCZ010000001.1  264267748-264267831 c
            1828-1932           JAXUCZ010000001.1  264266952-264267056 c
            1933-2004           JAXUCZ010000001.1  264265876-264265947 c
            2005-2173           JAXUCZ010000001.1  264260432-264260600 c
            2174-2329           JAXUCZ010000001.1  264258909-264259064 c
            2330-2507           JAXUCZ010000001.1  264254289-264254466 c
            2508-2648           JAXUCZ010000001.1  264252041-264252181 c
            2649-2841           JAXUCZ010000001.1  264250496-264250688 c
            2842-3016           JAXUCZ010000001.1  264248502-264248676 c
            3017-3115           JAXUCZ010000001.1  264247554-264247652 c
            3116-3207           JAXUCZ010000001.1  264245408-264245499 c
            3208-3442           JAXUCZ010000001.1  264244518-264244752 c
FEATURES             Location/Qualifiers
     source          1..3442
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..3442
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /note="guanylate cyclase 2G"
                     /db_xref="GeneID:245708"
                     /db_xref="RGD:621853"
     CDS             1..3312
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /EC_number="4.6.1.2"
                     /note="GC-G; guanylyl cyclase receptor G; kinase-like
                     domain-containing soluble guanylyl cyclase; guanylyl
                     cyclase with kinase-like domain, soluble"
                     /codon_start=1
                     /product="guanylate cyclase 2G"
                     /protein_id="NP_620611.2"
                     /db_xref="GeneID:245708"
                     /db_xref="RGD:621853"
                     /translation="MLPMASRARSEPPLEHRFYGGAESHAGHSSLVLTLFVVMLMTCL
                     EAAKLTVGFHAPWNISHPFSVQRLGAGLQIAVDKLNSEPVGPGNLSWEFTYTNATCNA
                     KESLAAFIDQVQREHISVLIGPACPEAAEVIGLLASEWDIPLFDFVGQMTALEDHFWC
                     DTCVTLVPPKQEIGTVLRESLQYLGWEYIGVFGGSSAGSSWGEVNELWKAVEDELQLH
                     FTITARVRYSSGHSDLLQEGLRSMSSVARVIILICSSEDAKHILQAAEDLGLNSREFV
                     FLLLQQLEDSFWKEVLAEDKVTRFPKVYESVFLIAPSTYGGSAGDDDFRKQVYQRLRR
                     PPFQSSISSEDQVSPYSAYLHDALLLYAQTVEEMMKAEKDFRDGRQLISTLRADQVTL
                     QGITGPVLLDAQGKRHMDYSVYALQKSGNGSRFLPFLHYDSFQKVIRPWRDDLNASGP
                     HGSHPEYKPDCGFHEDLCRTKPPTGAGMTASVTAVIPTVTLLVVASAAAITGLMLWRL
                     RGKVQNHPGDTWWQIHYDSITLLPQHKPSHRGTPMSRCNVSNASTVKISADCGSFAKT
                     HQDEELFYAPVGLYQGNHVALCYIGEEAEARIKKPTVLREVWLMCELKHENIVPFFGV
                     CTEPPNICIVTQCCKKGSLKDVLRNSDHEMDWIFKLSFVYDIVNGMLFLHGSPLRSHG
                     NLKPSNCLVDSHMQLKLAGFGLWEFKHGSTCRIYNQEATDHSELYWTAPELLRLRELP
                     WSGTPQGDVYSFAILLRDLIHQQAHGPFEDLEAAPEEIISCIKDSRAPVPLRPSLLED
                     KGDERIVALVRACWAESPEQRPAFPSIKKTLREASPRGRVSILDSMMGKLEMYASHLE
                     EVVEERTCQLVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFT
                     KLCSLSSPLQVVKLLNDLYSLFDHTIQTHDVYKVETIGDAYMVASGLPIRNGAQHADE
                     IATMSLHLLSVTTNFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMA
                     SRMESSSLPLRIHVSQSTARALLVAGGYHLQKRGTISVKGKGEQTTFWLTGKDGFAVP
                     LPEFTEEEAKVPEIL"
     exon            1..393
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            394..742
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            743..852
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1038
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1180
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1316
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1429
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1605
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1743
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1827
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1932
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2004
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2173
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2329
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2507
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2648
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2841
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..3016
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3115
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3207
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3442
                     /gene="Gucy2g"
                     /gene_synonym="ksGC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttaccca tggcttccag ggcacgctct gagcctccac tagaacatag gttctatggc
       61 ggggctgaaa gccatgcagg tcattcgtct ctggttttga cgctctttgt cgttatgcta
      121 atgacttgtc ttgaagctgc taagctcacc gtggggttcc atgccccctg gaacatctct
      181 catccattta gtgtgcaaag gttgggggca ggcctccaga ttgctgtgga caaactcaac
      241 tcagagccag tgggtcctgg gaacttgagc tgggagttca cgtacaccaa cgcgacctgc
      301 aatgccaagg agtcccttgc agctttcatc gaccaggtcc agagagaaca catttctgtt
      361 ctgattggac cagcatgccc agaagcagca gaggttattg gtttactggc ctccgagtgg
      421 gacatcccct tgtttgactt cgttggacaa atgacagcgc tggaggatca cttctggtgt
      481 gacacctgtg tgacacttgt gccgcccaag caggagatcg gcactgtgct tcgggaaagc
      541 ctgcagtacc tgggctggga atatataggg gtgtttggag gctcctcggc aggttcctcc
      601 tggggagaag tgaatgagct gtggaaggct gtggaggatg aactccagct ccatttcacc
      661 atcacagcca gagtgagata cagcagcggc cactcagacc ttctgcagga aggcctcagg
      721 agcatgtctt ctgttgccag ggttatcatt ctgatctgca gctcagagga cgcaaagcac
      781 attctgcaag cagcagagga cctgggactc aactcgagag aatttgtttt ccttctcttg
      841 cagcagctgg aggacagttt ttggaaggaa gtactggcag aggacaaggt gacacgcttt
      901 cccaaagtct atgagtcggt gtttctcatt gctcccagca cctatggagg gagcgctgga
      961 gatgatgact tccggaagca agtctaccaa aggctgagga ggccaccctt tcaaagctcc
     1021 atctcctcag aggaccaggt gagcccttac tctgcctacc tgcatgatgc tctcttactc
     1081 tacgctcaga ctgtggagga aatgatgaag gctgagaaag acttccggga tgggcggcag
     1141 ctgattagca cactgagagc tgatcaggtc acactgcagg gaatcactgg tcctgtgctc
     1201 ttggacgccc aggggaaaag gcacatggac tactccgtct acgccctaca gaaatctgga
     1261 aacggatccc gcttccttcc ttttcttcat tatgacagtt ttcagaaagt aatcagaccc
     1321 tggagggacg acttgaatgc ctcagggccc catggctccc atcctgaata caaacccgac
     1381 tgtggattcc atgaagacct ttgcaggacg aagcctccga ctggagcagg tatgactgca
     1441 tctgtgactg ctgtgatccc cacggtgaca ctgctggttg ttgcctcagc agctgccatc
     1501 acaggtctga tgttatggag gctgagagga aaagtgcaga accaccctgg agacacctgg
     1561 tggcagatcc attatgacag catcactctt ctgcctcagc ataaaccgtc ccaccgaggc
     1621 acacctatgt caagatgtaa cgttagtaat gcatctactg tgaagatttc tgcagattgt
     1681 ggctcctttg ccaagactca ccaggatgaa gagctgttct atgcccctgt ggggctttac
     1741 cagggaaatc atgtggccct ctgctatatc ggcgaggaag cagaagcacg gattaagaag
     1801 ccaactgttc tgcgggaagt ctggctgatg tgtgaattaa agcatgaaaa catcgtcccc
     1861 ttctttggtg tttgcacaga accacctaac atctgcatcg ttacacagtg ttgcaaaaaa
     1921 ggaagtctca aggatgtttt gaggaactcc gatcatgaga tggattggat attcaagctc
     1981 tctttcgtgt atgacatagt caacggcatg ctgttcctcc acgggagccc actgaggtct
     2041 cacggcaacc tgaaaccttc caactgtctg gtagacagtc acatgcagct gaagctggca
     2101 ggattcgggt tgtgggagtt caagcacggc agcacctgca ggatctacaa ccaggaggcc
     2161 acggaccatt cagagctcta ctggacagcc ccagaactgt tgcggcttcg ggagcttccc
     2221 tggtccggca ccccgcaggg agacgtttac agctttgcca ttctcctgag ggacctgatc
     2281 caccagcagg cccacgggcc ctttgaggac cttgaggcag ctccagagga aatcatcagc
     2341 tgcattaaag actcccgggc accggttcca cttcggccgt ccctgttaga ggataaaggt
     2401 gacgaaagga ttgtggccct ggtgagggca tgttgggctg aatctccaga gcagaggcct
     2461 gccttccctt ccatcaagaa gacgttacga gaagccagtc caagaggcag ggtgagcatc
     2521 ttggatagca tgatgggcaa gctggaaatg tacgccagtc atctggagga agtagtggag
     2581 gagcggacct gccagctggt ggcagagaag agaaaggtgg agaaactcct gtccaccatg
     2641 ttgccaagct tcgttggaga acagctaata gctggaaagt ccgtagaacc agaacatttt
     2701 gagtctgtca ccatcttttt ctctgacatc gtgggattca caaaactatg ttctctcagc
     2761 tcccccttgc aagtggtgaa gctcctcaat gacctgtaca gcttgtttga tcacacaata
     2821 cagacccatg acgtatacaa ggtggaaacc attggtgatg cctatatggt ggccagtggg
     2881 cttcctatcc gaaatggagc tcaacacgcg gatgagattg ccaccatgtc tttgcattta
     2941 ctcagtgtca ccaccaactt ccagattggg cacatgcctg aggagagact caagctccgg
     3001 ataggcctcc acacaggtcc tgtggtggct ggtgtggtgg gaatcaccat gcccaggtac
     3061 tgtctgtttg gagacactgt gaacatggcc tccagaatgg aaagcagcag tttgcctctc
     3121 cggattcatg tttctcagag cactgccaga gctcttctag tagcaggagg gtaccatctt
     3181 cagaagagag gcaccatttc agtcaagggc aagggagaac agacgacctt ctggctgaca
     3241 ggcaaagatg gcttcgctgt cccgctcccc gagtttactg aggaagaagc caaagttcca
     3301 gagatattgt gaggttcttt caagatgttt gtggagcccc actaatgttt gtgggtaccc
     3361 tcttggtggg gaggggagat acatctgaca ttcctcttcc tctgagcagt tgtagtactc
     3421 ggcaatgaat cgatgtccca ct
//
