LOCUS       NM_053831               3736 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus guanylate cyclase 2F (Gucy2f), mRNA.
ACCESSION   NM_053831
VERSION     NM_053831.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3736)
  AUTHORS   Arshavsky,V.Y. and Burns,M.E.
  TITLE     Photoreceptor signaling: supporting vision across a wide range of
            light intensities
  JOURNAL   J Biol Chem 287 (3), 1620-1626 (2012)
   PUBMED   22074925
  REMARK    Review article
REFERENCE   2  (bases 1 to 3736)
  AUTHORS   Azadi,S., Molday,L.L. and Molday,R.S.
  TITLE     RD3, the protein associated with Leber congenital amaurosis type
            12, is required for guanylate cyclase trafficking in photoreceptor
            cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (49), 21158-21163 (2010)
   PUBMED   21078983
REFERENCE   3  (bases 1 to 3736)
  AUTHORS   Baehr,W., Karan,S., Maeda,T., Luo,D.G., Li,S., Bronson,J.D.,
            Watt,C.B., Yau,K.W., Frederick,J.M. and Palczewski,K.
  TITLE     The function of guanylate cyclase 1 and guanylate cyclase 2 in rod
            and cone photoreceptors
  JOURNAL   J Biol Chem 282 (12), 8837-8847 (2007)
   PUBMED   17255100
REFERENCE   4  (bases 1 to 3736)
  AUTHORS   Shearstone,J.R., Wang,Y.E., Clement,A., Allaire,N.E., Yang,C.,
            Worley,D.S., Carulli,J.P. and Perrin,S.
  TITLE     Application of functional genomic technologies in a mouse model of
            retinal degeneration
  JOURNAL   Genomics 85 (3), 309-321 (2005)
   PUBMED   15718098
REFERENCE   5  (bases 1 to 3736)
  AUTHORS   Yang,R.B. and Garbers,D.L.
  TITLE     Two eye guanylyl cyclases are expressed in the same photoreceptor
            cells and form homomers in preference to heteromers
  JOURNAL   J Biol Chem 272 (21), 13738-13742 (1997)
   PUBMED   9153227
REFERENCE   6  (bases 1 to 3736)
  AUTHORS   Yang,R.B., Foster,D.C., Garbers,D.L. and Fulle,H.J.
  TITLE     Two membrane forms of guanylyl cyclase found in the eye
  JOURNAL   Proc Natl Acad Sci U S A 92 (2), 602-606 (1995)
   PUBMED   7831337
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053831.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L36030.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000021.1  110604847-110605017 c
            172-987             JAXUCZ010000021.1  110597087-110597902 c
            988-1289            JAXUCZ010000021.1  110588277-110588578 c
            1290-1644           JAXUCZ010000021.1  110569844-110570198 c
            1645-1729           JAXUCZ010000021.1  110568400-110568484 c
            1730-1826           JAXUCZ010000021.1  110564539-110564635 c
            1827-1958           JAXUCZ010000021.1  110559044-110559175 c
            1959-2048           JAXUCZ010000021.1  110551517-110551606 c
            2049-2225           JAXUCZ010000021.1  110539703-110539879 c
            2226-2382           JAXUCZ010000021.1  110537369-110537525 c
            2383-2532           JAXUCZ010000021.1  110532236-110532385 c
            2533-2681           JAXUCZ010000021.1  110528982-110529130 c
            2682-2845           JAXUCZ010000021.1  110526739-110526902 c
            2846-3038           JAXUCZ010000021.1  110525810-110526002 c
            3039-3213           JAXUCZ010000021.1  110522203-110522377 c
            3214-3312           JAXUCZ010000021.1  110519205-110519303 c
            3313-3407           JAXUCZ010000021.1  110516106-110516200 c
            3408-3496           JAXUCZ010000021.1  110510721-110510809 c
            3497-3585           JAXUCZ010000021.1  110510536-110510624 c
            3586-3736           JAXUCZ010000021.1  110507183-110507333 c
FEATURES             Location/Qualifiers
     source          1..3736
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq33"
     gene            1..3736
                     /gene="Gucy2f"
                     /note="guanylate cyclase 2F"
                     /db_xref="GeneID:116556"
                     /db_xref="RGD:620439"
     exon            1..171
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            172..987
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..3584
                     /gene="Gucy2f"
                     /EC_number="4.6.1.2"
                     /note="retinal guanylyl cyclase 2; GC-F; RETGC-2; ROS-GC2;
                     guanylate cyclase F; rod outer segment membrane guanylate
                     cyclase 2; guanylate cyclase 2F, retinal"
                     /codon_start=1
                     /product="retinal guanylyl cyclase 2 precursor"
                     /protein_id="NP_446283.1"
                     /db_xref="GeneID:116556"
                     /db_xref="RGD:620439"
                     /translation="MFLGPWPFSRLLSWFAISSRLSGQHGLTSSKFLRYLCLLALLPL
                     IWWGQALPYKIGVIGPWTCDPFFSKALPEVAAALAIERISRDMSFDRSYSFEYVILNE
                     DCQTSKALTSFISHQQMASGFVGPANPGYCEAASLLGNSWDKGIFSWACVNHELDNKH
                     SYPTFSRTLPSPIRVLVTVMKYFQWAHAGVISSDEDIWVHTANQVSSALRSHGLPVGV
                     VLTSGQDSRSIQKALQQIRQADRIRIIIMCMHSALIGGETQTHFLELAHDLKMTDGTY
                     VFVPYDVLLYSLPYKHSPYQVLRNNQKLREAYDAVLTITVESHEKTFYEAFTEAAAGG
                     EIPEKLDSHQVSPLFGTIYNSIYFIAQAMSNALKENGQASAASLTRHSRNMQFYGFNQ
                     LIRTDSNGNGISEYVILDTNGKEWELRGTYTVDMETELLRFRGTPIHFPGGRPTSADA
                     KCWFAQGKICQGGIDPALAMMVCFALLLALLSINGFAYFIRRRINKIQLIKGPNRILL
                     TLEDVTFINPHFGSKRGSRASVSFQIISEVQSGRSPRLSFSSGSLTPATYENSNIAIY
                     QGDWVWLKKFPPGDFGDIKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSGMFAIVSE
                     FCSRRSLEDILTQDDVKLDWMFKSSLLLDLIKGMKYLHHREFIHGRLKSRNCVVDGRF
                     VLKVTDYGFNNILEMLRLSEEEPSEEELLWTAPELLRAPGGIRLGSFAGDVYSFAIIM
                     QEVMVRGAPFCMMDLSAKEVIDRLKMPPPVYRPVVSPEFAPPECLQLMKQCWAEAAEQ
                     RPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKL
                     LTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYT
                     LFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHM
                     PEVPVRIRIGLHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVT
                     ILRTLSEGYEVELRGRTELKGKGTEETFWLVGKKGFTKPLPVPPPVGKDGQVGHGLQP
                     AEIAAFQRRKAERQLVRNKP"
     exon            988..1289
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1644
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1729
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1826
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1958
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2048
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2225
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2382
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2532
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2681
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2845
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3038
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3213
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3312
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3407
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..3496
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3585
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3736
                     /gene="Gucy2f"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taaaggttta caatgcctca caattattta ctctttcaat ggaatttgtc aacagactgg
       61 agtccttggt gggattatga cagcccaaaa gatgggtgca ttggagtagc tgtgcctgag
      121 atctgcatgt tcaggctgtc cactggagat gattgaatgg tgatttacat ggcactcaga
      181 aacaccactg ttcatgtcca gagggcagag taatcctcca gtatctcatc actaacttgc
      241 tgaagggcag caaggctatg ttcctcggac cctggccttt ttctcgcctt ctgtcctggt
      301 ttgccatttc cagcagactg tcaggacagc atggcctcac ttcctccaag ttcctgagat
      361 acttgtgcct cctggcccta ttacctctca tatggtgggg gcaagcactc ccctacaaga
      421 taggggtcat aggtccctgg acatgtgatc cgttcttttc caaggccctg cctgaggttg
      481 ctgccgcttt agcaattgaa cgaatcagcc gggacatgtc atttgacaga agttactcct
      541 tcgaatatgt gattcttaac gaagattgcc agacttcaaa ggccctcacc agttttattt
      601 cccaccagca gatggcctca ggatttgttg ggcctgccaa ccctggctac tgtgaggcag
      661 cctcactcct gggaaacagc tgggacaaag ggattttctc ttgggcttgt gtgaatcatg
      721 aattagataa caaacatagc tacccgactt tttctcggac acttccttct cctatccggg
      781 tgcttgtaac cgtcatgaag tatttccagt gggctcatgc tggggtcatt tcctcagatg
      841 aagacatttg ggtgcataca gccaatcaag tctcaagtgc tcttcggagc cacggcctac
      901 ctgtaggggt cgtcctgacc tcgggacaag acagccgtag cattcagaaa gctctgcagc
      961 agattcgcca ggcagacaga attcgcataa tcatcatgtg tatgcattca gccttgattg
     1021 ggggagagac tcagacacac ttcttggaat tggctcatga tctgaaaatg acggatggga
     1081 cttacgtctt tgtcccctat gatgtactgc tctacagttt accttataag cacagcccct
     1141 accaggtcct gaggaacaat caaaagctcc gggaagccta tgatgctgtg ttgactatta
     1201 cagtggagtc ccatgaaaag accttctatg aagcctttac agaagcagca gccggtggag
     1261 agattcctga gaagcttgac tcacaccaag tttcaccgtt gtttggaacc atctacaatt
     1321 caatttactt tatcgcacaa gccatgagta atgctctgaa agaaaatgga caggctagcg
     1381 ctgccagcct gactcggcat tccagaaaca tgcagttcta tggattcaac cagttgataa
     1441 ggacagactc aaatggaaat ggaatttctg aatacgtaat cctggacacc aatgggaaag
     1501 aatgggaact ccgtggcacc tacactgtgg acatggaaac tgaactgcta aggttcagag
     1561 ggacccccat tcatttccca ggtggcaggc ctactagcgc agatgcaaaa tgctggtttg
     1621 cacaagggaa gatctgccaa ggaggtattg accctgcctt agccatgatg gtctgctttg
     1681 ctttgcttct agccttgctg tctatcaatg gatttgctta ctttatcagg cgacgtataa
     1741 ataaaatcca gttgattaaa ggacccaaca gaatcctgct gactttggaa gatgtgacat
     1801 ttattaaccc ccactttggc agtaagagag gaagccgtgc cagtgtaagc ttccagatta
     1861 tctcagaagt tcaaagtggg aggtctccaa ggctgtcatt ttcttcaggt agtttaactc
     1921 cagctactta tgagaactcc aacatagcaa tctaccaggg tgactgggta tggctgaaaa
     1981 agttccctcc tggagatttt ggggacatta agtctatcaa atcaagtgca agtgatgtgt
     2041 ttgaaatgat gaaggacctg cggcatgaaa atgtcaaccc tttattgggc ttcttctatg
     2101 attcggggat gtttgccatc gtgtcagaat tttgttctcg aaggagccta gaagacatac
     2161 ttacacaaga cgatgtgaaa cttgattgga tgttcaaatc atcactgctg cttgacctca
     2221 tcaagggaat gaaatactta caccacagag aatttattca tgggaggcta aagtctcgga
     2281 actgtgtggt agacggacgt tttgtactaa aagtgacaga ttatggcttt aataacattt
     2341 tagaaatgct gagactctct gaagaggaac cttctgaaga agagctgctg tggacggccc
     2401 ctgaactgtt aagagcccct gggggtatca ggttaggttc atttgcagga gacgtctata
     2461 gctttgccat catcatgcaa gaagtgatgg tccggggtgc tcctttctgc atgatggatc
     2521 tgtctgccaa agaagtcata gacagactta aaatgcctcc ccctgtgtat agaccagtgg
     2581 tttctcctga gtttgcccct ccagagtgtc tccagctgat gaagcaatgc tgggccgagg
     2641 ctgcagaaca gcgaccaact tttgatgaaa tatttaacca gtttaaaact ttcaacaaag
     2701 ggaaaaaaac taatattatt gattctatgc tccggatgtt ggagcagtat tctagcaact
     2761 tggaagattt gatccgggaa cggactgaag aactggaaat tgaaaaacag aaaacggaaa
     2821 agcttctaac acagatgcta ccaccatcag ttgctgaatc cctcaaaaag ggctgtacag
     2881 tggaacctga gggatttgac ttggtcacct tgtacttcag tgacattgtg ggcttcacca
     2941 ccatctcagc catgagtgag cccattgaag tggtggacct tctgaatgac ctgtacacac
     3001 tctttgatgc catcattggc agtcatgatg tctataaggt agagaccatt ggagatgcct
     3061 atatggtggc ctcaggcctc ccaaagagga acggcagtag gcatgcagct gagattgcaa
     3121 acatgtccct ggatattctg agctctgtgg gtacctttaa gatgcgacac atgccagagg
     3181 tgccagtccg gattcgaata ggtctgcaca cagggcctgt tgttgctgga gtggtgggcc
     3241 ttaccatgcc tagatattgc ttgtttggtg atactgtgaa tacagcttct cgaatggaat
     3301 caacggggct accataccga attcatgtca gtctcagcac agtaacaatt cttcggactc
     3361 tgagtgaagg ctatgaagta gagcttcgtg gaagaacaga gctcaagggt aaaggcacag
     3421 aggagacctt ctggcttgtt ggaaaaaagg gtttcaccaa acctcttcct gtacccccac
     3481 cagtgggcaa agatgggcaa gtgggtcatg gcttgcaacc agcggagatt gcagcattcc
     3541 aaagaagaaa agcagaaagg cagttggtgc gaaacaagcc ataagatgga aagaactcca
     3601 gcatttgaat ctcctcttga caaagcaacg ctgaagctca ttacagatca agatattctt
     3661 cttcttgagc aagatattag tgaatgattg ttcttctgag gttgcctaat gtccagggat
     3721 gggtcaagcc tagtgt
//
