LOCUS       NM_130737               3640 bp    mRNA    linear   ROD 02-JAN-2025
DEFINITION  Rattus norvegicus guanylate cyclase 2E (Gucy2e), mRNA.
ACCESSION   NM_130737 XM_006229710
VERSION     NM_130737.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3640)
  AUTHORS   Azadi,S., Molday,L.L. and Molday,R.S.
  TITLE     RD3, the protein associated with Leber congenital amaurosis type
            12, is required for guanylate cyclase trafficking in photoreceptor
            cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (49), 21158-21163 (2010)
   PUBMED   21078983
REFERENCE   2  (bases 1 to 3640)
  AUTHORS   Munger,S.D., Leinders-Zufall,T., McDougall,L.M., Cockerham,R.E.,
            Schmid,A., Wandernoth,P., Wennemuth,G., Biel,M., Zufall,F. and
            Kelliher,K.R.
  TITLE     An olfactory subsystem that detects carbon disulfide and mediates
            food-related social learning
  JOURNAL   Curr Biol 20 (16), 1438-1444 (2010)
   PUBMED   20637621
REFERENCE   3  (bases 1 to 3640)
  AUTHORS   Duda,T. and Sharma,R.K.
  TITLE     ONE-GC membrane guanylate cyclase, a trimodal odorant signal
            transducer
  JOURNAL   Biochem Biophys Res Commun 367 (2), 440-445 (2008)
   PUBMED   18178149
REFERENCE   4  (bases 1 to 3640)
  AUTHORS   Leinders-Zufall,T., Cockerham,R.E., Michalakis,S., Biel,M.,
            Garbers,D.L., Reed,R.R., Zufall,F. and Munger,S.D.
  TITLE     Contribution of the receptor guanylyl cyclase GC-D to chemosensory
            function in the olfactory epithelium
  JOURNAL   Proc Natl Acad Sci U S A 104 (36), 14507-14512 (2007)
   PUBMED   17724338
REFERENCE   5  (bases 1 to 3640)
  AUTHORS   Hu,J., Zhong,C., Ding,C., Chi,Q., Walz,A., Mombaerts,P.,
            Matsunami,H. and Luo,M.
  TITLE     Detection of near-atmospheric concentrations of CO2 by an olfactory
            subsystem in the mouse
  JOURNAL   Science 317 (5840), 953-957 (2007)
   PUBMED   17702944
REFERENCE   6  (bases 1 to 3640)
  AUTHORS   Duda,T., Jankowska,A., Venkataraman,V., Nagele,R.G. and Sharma,R.K.
  TITLE     A novel calcium-regulated membrane guanylate cyclase transduction
            system in the olfactory neuroepithelium
  JOURNAL   Biochemistry 40 (40), 12067-12077 (2001)
   PUBMED   11580282
REFERENCE   7  (bases 1 to 3640)
  AUTHORS   Fulle,H.J., Vassar,R., Foster,D.C., Yang,R.B., Axel,R. and
            Garbers,D.L.
  TITLE     A receptor guanylyl cyclase expressed specifically in olfactory
            sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3571-3575 (1995)
   PUBMED   7724600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 3, 2020 this sequence version replaced
            XM_006229710.1, NM_130737.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L37203.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760389,
                                           SAMN14984043 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000001.1  162150967-162151066
            101-859             JAXUCZ010000001.1  162153984-162154742
            860-1155            JAXUCZ010000001.1  162160206-162160501
            1156-1510           JAXUCZ010000001.1  162161987-162162341
            1511-1595           JAXUCZ010000001.1  162164014-162164098
            1596-1692           JAXUCZ010000001.1  162164650-162164746
            1693-1821           JAXUCZ010000001.1  162164830-162164958
            1822-1902           JAXUCZ010000001.1  162166075-162166155
            1903-2079           JAXUCZ010000001.1  162168431-162168607
            2080-2236           JAXUCZ010000001.1  162168786-162168942
            2237-2395           JAXUCZ010000001.1  162169160-162169318
            2396-2544           JAXUCZ010000001.1  162171957-162172105
            2545-2708           JAXUCZ010000001.1  162173857-162174020
            2709-2901           JAXUCZ010000001.1  162175354-162175546
            2902-3076           JAXUCZ010000001.1  162179796-162179970
            3077-3175           JAXUCZ010000001.1  162180732-162180830
            3176-3270           JAXUCZ010000001.1  162181616-162181710
            3271-3356           JAXUCZ010000001.1  162182990-162183075
            3357-3640           JAXUCZ010000001.1  162185383-162185666
FEATURES             Location/Qualifiers
     source          1..3640
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3640
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /note="guanylate cyclase 2E"
                     /db_xref="GeneID:113911"
                     /db_xref="RGD:69322"
     exon            1..100
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..3465
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /EC_number="4.6.1.2"
                     /note="olfactory guanylyl cyclase GC-D; guanylate cyclase,
                     olfactory; guanylate cyclase 2D; guanylate cyclase 2E,
                     pseudogene"
                     /codon_start=1
                     /product="guanylate cyclase 2D precursor"
                     /protein_id="NP_570093.2"
                     /db_xref="GeneID:113911"
                     /db_xref="RGD:69322"
                     /translation="MAGLQQGCHPEGQDWTAPHWKTCRPCQGPRGLTVRHLRTVSSIS
                     VFSVVFWGVLLWADSLSLPAWARETFTLGVLGPWDCDPIFAQALPSMATQLAVDRVNQ
                     DASLLLGSQLDFKILPTGCDTPHALATFVAHRNTVAAFIGPVNPGYCPAAALLAQGWG
                     KSLFSWACGAPEGGGALVPTLPSMADVLLSVMRHFGWARLAIVSSHQDIWVTTAQQLA
                     TAFRAHGLPIGLITSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTVLLR
                     CARKEGLTDGRLVFLPYDTLLFALPYRNRSYLVLDDDGPLQEAYDAVLTISLDTSPES
                     HAFTATKMRGGTAANLGPEQVSPLFGTIYDAVILLAHALNHSEAHGTGLSGAHLGNHI
                     RALDVAGFSQRIRIDGKGRRLPQYVILDTNGEGSQLVPTHILDVSTQQVQPLGTAVHF
                     PGGSPPARDASCWFDPNTLCIRGVQPLGSLLTLTITCVLALVGGFLAYFIRLGLQQLR
                     LLRGPHRILLTPQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPQSVIQGSTRSVPAF
                     LEHTNVALYQGEWVWLKKFEAGTAPDLRPSSLSLLRKMREMRHENVTAFLGLFVGPEV
                     SAMVLEHCARGSLEDLLRNEDLRLDWTFKASLLLDLIRGLRYLHHRHFPHGRLKSRNC
                     VVDTRFVLKITDHGYAEFLESHCSFRPQPAPEELLWTAPELLRGPRRPWGPGKATFKG
                     DVFSLGIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQ
                     LCWEEAPDDRPSLDQIYTQFKSINQGKKTSVADSMLRMLEKYSQSLEGLVQERTEELE
                     LERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEV
                     VGFLNDLYTMFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANMALEILSY
                     AGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYR
                     IHVSRNTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKTGFCRSLPTPLSIQPG
                     DPWQDHINQEIRTGFAKARQSLAEPRSSGDTGPGP"
     exon            101..859
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1155
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1510
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1595
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1692
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1821
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1902
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2079
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2236
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2395
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2544
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2708
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2901
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3076
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3175
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3270
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            3271..3356
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3640
                     /gene="Gucy2e"
                     /gene_synonym="GC-D; Gucy2d; Gucy2ep; ONE-GC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagagagt gctcagaaag tgtgacctct gaggaccctg gtgtgagacc ctcccggctg
       61 acaaagatcc agcgccaact ctgagaggcc accatggcag gtctgcagca gggctgtcac
      121 cccgaaggcc aggactggac agcgccacac tggaagacct gccggccctg ccagggccca
      181 cggggactca cggtcagaca tctgaggaca gtctcttcca tatcggtctt ctctgtggta
      241 ttttggggtg tcttgctgtg ggctgactct ctttccctgc cagcatgggc aagagagacc
      301 ttcacccttg gggtgctggg tccctgggac tgtgacccta tctttgccca ggcactccct
      361 agcatggcta cccagttggc tgtagatcga gtcaatcagg acgcctcact gctgctgggc
      421 tcacagttgg atttcaagat cctccctaca ggctgtgaca cccctcatgc cctggccaca
      481 tttgtggccc acaggaacac agtggctgct tttataggcc ctgtcaatcc tgggtattgt
      541 ccagcagcag ctctgctggc ccaaggctgg ggcaagtccc tcttctcctg ggcctgtgga
      601 gctccagagg gaggaggtgc cttagtgccc actttgcctt ctatggccga cgtgctactg
      661 tctgtcatga gacactttgg ctgggctcgc ttggccatcg tgtcctctca ccaggacatc
      721 tgggtaacca cagcccagca gctagccaca gctttcaggg cccatgggct gcctatcgga
      781 ctgatcacct ccttgggacc tggagagaag ggggccacgg aggtttgcaa gcagctccac
      841 agtgtgcatg gtctgaaaat cgtggttctg tgcatgcact cagcgctgct tggaggccta
      901 gagcagacag tcctgctgcg ctgcgcaagg aaggagggcc tgacagatgg cagactggtc
      961 ttcttgccct acgacacgct gctctttgcc ctgccctatc gtaaccgctc ttacctggtc
     1021 ctggatgatg acgggcccct tcaggaggcc tacgatgcag tactcaccat cagtctggac
     1081 accagtcctg agagccatgc cttcactgct accaagatga gaggagggac agctgccaac
     1141 ttggggcccg agcaggtgtc cccactcttt ggaactatct acgatgccgt catcctgttg
     1201 gcccatgccc tgaaccactc tgaggcccat ggaacggggc tctcaggggc tcacttaggg
     1261 aaccatataa gagctcttga tgtggctggt tttagccaga gaatccggat agatgggaaa
     1321 ggcagaaggc taccccaata cgtcatcctg gacacaaatg gtgaaggaag ccagttggtt
     1381 cccacccaca tcctggacgt gagcacacag caggtgcagc ccctgggaac ggcggtacac
     1441 ttccctggag ggagccctcc agcccgtgat gccagctgct ggttcgaccc caacacacta
     1501 tgcatacgag gtgtgcagcc cctgggcagc ctcctgactc tgacgataac ctgtgtcctg
     1561 gctctggttg gtggattcct tgcttacttt atcaggttag gcctccagca gctgcggctg
     1621 ctgcggggcc cccatcggat cctgctgaca cctcaagagc tcaccttcct ccagcgaacc
     1681 cccagccggc ggaggccaca tgtggacagt ggcagcgagt caagaagtgt ggtagatggt
     1741 gggagtccac agtcagtgat ccaggggtca acaaggagcg taccagcctt cctggagcac
     1801 accaacgtgg ccctgtacca gggagagtgg gtgtggctga agaagtttga ggcaggcacg
     1861 gctcctgatc tgcggcccag cagcctcagc ctcctgagaa agatgcggga gatgcggcat
     1921 gagaatgtca ccgccttcct gggtctcttt gtgggccctg aggttagtgc gatggtgctg
     1981 gagcactgtg cccgtggcag cctggaggac ctgctacgga atgaggacct gaggctagac
     2041 tggaccttca aggcctcctt actgttggat ctgatccgag gtttgcggta tctgcaccat
     2101 cgacatttcc cccatgggcg cctcaagtcc aggaactgtg tggtggacac tcgctttgtg
     2161 ctcaagatca ctgaccatgg ttatgcagag ttcctggagt ctcactgctc tttcaggccc
     2221 cagccggccc cagaagagct tctgtggacg gctcctgagc tgttgcgggg gcctcggagg
     2281 ccttgggggc ctgggaaggc caccttcaaa ggtgatgttt tcagcctggg catcatcctg
     2341 caggaggtac tgacccgaga cccaccctac tgctcctggg gactctcagc agaagagatc
     2401 atccggaagg tggcatctcc ccctcctctg tgccggcctc tggtgtcccc tgaccagggt
     2461 cccctggagt gcatccagtt gatgcagctg tgctgggagg aagctccaga tgacaggcca
     2521 agcttggacc agatctacac acagttcaaa agcatcaacc aaggcaagaa gacaagtgtt
     2581 gctgactcca tgctgcggat gctggagaag tattcccaaa gcctggaagg tctggtccag
     2641 gagcggactg aggagctgga actggagagg cggaagacag agaggctgct ctcacagatg
     2701 ctccccccgt ctgtcgccca tgctctaaag atgggaacaa ctgtggagcc cgagtacttt
     2761 gaccaagtca ccatctattt cagtgacatc gtgggcttta ccaccatctc agccttgagt
     2821 gagcccattg aggtggtggg cttcctcaat gatctctaca cgatgtttga tgctgttcta
     2881 gacagccatg atgtgtataa ggtagaaacc ataggggatg cctacatggt ggcatctggg
     2941 ctccctcggc gcaacggaaa tcggcatgct gctgagattg ccaacatggc tctggagatc
     3001 cttagctacg caggcaactt ccggatgagg catgcacctg atgtgcccat ccgtgtcagg
     3061 gccggtctgc attcagggcc ctgtgtggca ggtgttgtgg gtctcaccat gcctcggtac
     3121 tgcctctttg gggacaccgt gaacactgct tccaggatgg aatccactgg actgccatac
     3181 agaatccacg tcagccgaaa cactgtccag gccctgctta gccttgacga aggctacaaa
     3241 attgatgtca gaggtcagac cgaactgaag gggaagggct tggaggagac ttactggctg
     3301 acagggaaga caggattttg cagatccctc cctacacctc tgtccatcca gcctggagac
     3361 ccatggcagg accatataaa ccaagaaatc cggactggct ttgccaaagc tcgccagagt
     3421 ctggctgagc ccaggagttc aggggacact gggccaggtc cctgatagca agtcggtggg
     3481 caggtgccaa ggcagccaag atgcccccat cacccctgcc tcctacgaat gtctgcctgc
     3541 caccatgagt ggtatgagga gctgctgtct tccctagtga ctctgggggt gtccttgcct
     3601 cctgtcagga aaacaataaa aatggaaata ctcccttcca
//
