LOCUS       NM_024380               3545 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus guanylate cyclase 2D, retinal (Gucy2d), mRNA.
ACCESSION   NM_024380
VERSION     NM_024380.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3545)
  AUTHORS   Wimberg,H., Lev,D., Yosovich,K., Namburi,P., Banin,E., Sharon,D.
            and Koch,K.W.
  TITLE     Photoreceptor Guanylate Cyclase (GUCY2D) Mutations Cause Retinal
            Dystrophies by Severe Malfunction of Ca2+-Dependent Cyclic GMP
            Synthesis
  JOURNAL   Front Mol Neurosci 11, 348 (2018)
   PUBMED   30319355
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3545)
  AUTHORS   Arshavsky,V.Y. and Burns,M.E.
  TITLE     Photoreceptor signaling: supporting vision across a wide range of
            light intensities
  JOURNAL   J Biol Chem 287 (3), 1620-1626 (2012)
   PUBMED   22074925
  REMARK    Review article
REFERENCE   3  (bases 1 to 3545)
  AUTHORS   Peshenko,I.V., Olshevskaya,E.V., Azadi,S., Molday,L.L., Molday,R.S.
            and Dizhoor,A.M.
  TITLE     Retinal degeneration 3 (RD3) protein inhibits catalytic activity of
            retinal membrane guanylyl cyclase (RetGC) and its stimulation by
            activating proteins
  JOURNAL   Biochemistry 50 (44), 9511-9519 (2011)
   PUBMED   21928830
REFERENCE   4  (bases 1 to 3545)
  AUTHORS   Peshenko,I.V., Olshevskaya,E.V., Savchenko,A.B., Karan,S.,
            Palczewski,K., Baehr,W. and Dizhoor,A.M.
  TITLE     Enzymatic properties and regulation of the native isozymes of
            retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors
  JOURNAL   Biochemistry 50 (25), 5590-5600 (2011)
   PUBMED   21598940
REFERENCE   5  (bases 1 to 3545)
  AUTHORS   Payne,A.M., Morris,A.G., Downes,S.M., Johnson,S., Bird,A.C.,
            Moore,A.T., Bhattacharya,S.S. and Hunt,D.M.
  TITLE     Clustering and frequency of mutations in the retinal guanylate
            cyclase (GUCY2D) gene in patients with dominant cone-rod
            dystrophies
  JOURNAL   J Med Genet 38 (9), 611-614 (2001)
   PUBMED   11565546
REFERENCE   6  (bases 1 to 3545)
  AUTHORS   Yang,R.B. and Garbers,D.L.
  TITLE     Two eye guanylyl cyclases are expressed in the same photoreceptor
            cells and form homomers in preference to heteromers
  JOURNAL   J Biol Chem 272 (21), 13738-13742 (1997)
   PUBMED   9153227
REFERENCE   7  (bases 1 to 3545)
  AUTHORS   Yang,R.B., Foster,D.C., Garbers,D.L. and Fulle,H.J.
  TITLE     Two membrane forms of guanylyl cyclase found in the eye
  JOURNAL   Proc Natl Acad Sci U S A 92 (2), 602-606 (1995)
   PUBMED   7831337
REFERENCE   8  (bases 1 to 3545)
  AUTHORS   Dizhoor,A.M., Lowe,D.G., Olshevskaya,E.V., Laura,R.P. and
            Hurley,J.B.
  TITLE     The human photoreceptor membrane guanylyl cyclase, RetGC, is
            present in outer segments and is regulated by calcium and a soluble
            activator
  JOURNAL   Neuron 12 (6), 1345-1352 (1994)
   PUBMED   7912093
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L36029.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L36029.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3545
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..3545
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /note="guanylate cyclase 2D, retinal"
                     /db_xref="GeneID:79222"
                     /db_xref="RGD:620438"
     exon            1..56
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            57..795
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..3392
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /EC_number="4.6.1.2"
                     /note="guanylyl cyclase GC-E; guanylyl cyclase 2e; retinal
                     guanylyl cyclase 1; guanylate cyclase 2D, membrane
                     (retina-specific); guanylate cyclase 2E"
                     /codon_start=1
                     /product="retinal guanylyl cyclase 1 precursor"
                     /protein_id="NP_077356.1"
                     /db_xref="GeneID:79222"
                     /db_xref="RGD:620438"
                     /translation="MSAWLLPAGGFPGAGFCIPAWQSRSSLSRVLRWPGPGLPGLLLL
                     LLLPSPSAFSAVFKVGVLGPWACDPIFARARPDLAARLATDRLNRDLALDGGPWFEVT
                     LLPEPCLTPGSLGAVSSALTRVSGLVGPVNPAACRPAELLAQEAGVALVPWGCPGTRA
                     AGTTAPAVTPAADALYVLLKAFRWARVALITAPQDLWVEAGRALSTALRARGLPVALV
                     TSMVPSDLSGAREALRRIRDGPRVRVVIMVMHSVLLGGEEQRYLLEAAEELGLTDGSL
                     VFLPFDTLHYALSPGPEALAAFVNSSKLRRAHDAVLTLTRRCPPGGSVQDSLRRAQEH
                     QELPLDLDLKQVSPLFGTIYDAVFLLAGGVTRARAAVGGGWVSGASVARQMREAQVFG
                     FCGILGRTEEPSFVLLDTDAAGERLFTTHLLDPVLGSLRSAGTPVHFPRGAPAPGPDP
                     SCWFDPDVICNGGVEPGLVFVGFLLVIVVGLTGAFLAHYLRHRLLHMQMVSGPNKIIL
                     TLEDVTFLHPQGGSSRKVAQGSRSSLATRSTSDIRSVPSQPQESTNIGLYEGDWVWLK
                     KFPGEHHMAIRPATKMAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEH
                     CARGSLHDLLAQRDIKLDWMFKSSLLLDLIKGMRYLHHRGVAHGRLKSRNCVVDGRFV
                     LKVTDHGHGRLLEAQRVLPEPPSAEDQLWTAPELLRDPALERRGTLAGDVFSLGIIMQ
                     EVVCRSTPYAMLELTPEEVIQRVRSPPPLCRPLVSMDQAPMECIQLMAQCWAEHPELR
                     PSMDLTFDLFKGINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRLL
                     TQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTL
                     FDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHMP
                     EVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRI
                     LRALDQGFQMECRGRTELKGKGVEDTYWLVGRVGFNKPIPKPPDLQPGASNHGISLQE
                     IPPERRKKLEKARPGQFTGK"
     exon            796..1100
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1452
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1537
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1640
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1742
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1823
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..2030
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2187
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2337
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2486
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2650
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2843
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..3018
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..3117
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3212
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3298
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3409
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3545
                     /gene="Gucy2d"
                     /gene_synonym="Gucy2e; RETGC-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgaagggac atcgaccctg tgacccttta gccaagccct agccccggac ttcccgaaga
       61 gggcaatgag tgcgtggctc ctgccagcgg gagggtttcc cggcgctggg ttctgtatcc
      121 ctgcgtggca gtcccggtcc agcctctcgc gggtcctgcg ctggccaggg cctgggctgc
      181 ccggactcct gctcctgctg ctgctcccat ctccgtctgc cttctccgct gtgttcaaag
      241 tgggggtgct gggcccctgg gcttgcgacc ccatctttgc acgggcccga ccggatctgg
      301 ctgcgcgtct ggccaccgac cgcctgaatc gtgaccttgc cttagacggc ggcccctggt
      361 tcgaggttac gctgctccca gagccctgcc tgactccggg ctcgctaggg gctgtgtcct
      421 ccgcgctgac tcgagtctct ggcttggtgg gtccggtgaa ccccgcggcc tgccggccag
      481 ccgagctatt agcccaggaa gctggagtag cgctggtgcc ctggggctgc cctggcacgc
      541 gggcggcggg tactacagcc ccggcggtga cccccgctgc agatgccctg tatgtcctcc
      601 ttaaagcatt ccgctgggcc cgcgtggccc tgatcaccgc accccaggac ctgtgggtgg
      661 aggcgggacg cgctctgtcc acagcactca gggcccgggg tttgccagtt gccctagtga
      721 cctccatggt gccttcagac ctgtctggag cccgagaggc cctcagaagg atccgagacg
      781 ggcctagagt tagagtggtt atcatggtga tgcactcggt actgctgggc ggcgaggagc
      841 agcgctacct actggaagct gcagaagagc tgggtctgac tgatggctcc ctggtcttcc
      901 tgccctttga cacccttcac tacgcgttgt ctccaggccc ggaggctctg gctgcatttg
      961 tcaacagctc caagctccgc agggctcacg atgcggtgct cacgctgaca cgccgctgtc
     1021 ctcctggagg cagcgtgcaa gacagcttgc gcagggccca agaacaccag gagctgcccc
     1081 ttgacctcga cctgaagcag gtctctccgc tgtttggcac catctatgat gctgtcttcc
     1141 tgttggctgg gggcgtgacg agagcaagag cagcagtggg tggcggctgg gtgtcaggtg
     1201 catctgtggc ccgccaaatg cgggaagctc aagtctttgg cttttgcggg atcctgggaa
     1261 gaaccgaaga gccctccttt gtgctgctgg acacagatgc ggcaggagaa cggctgttca
     1321 caacacacct gctggatcct gtcttaggct ccctgcgttc cgctgggacc cccgtgcact
     1381 tccctagagg tgcacctgct ccgggtcccg atccttcctg ctggttcgat ccagatgtga
     1441 tctgcaacgg aggggtggag ccaggcctgg tctttgttgg cttcctcctg gtgatagtgg
     1501 tgggactgac tggagccttc ctggctcatt acttgaggca caggctgcta cacatgcaaa
     1561 tggtctccgg ccccaataag atcatcctga ccttggaaga tgttactttc ctccacccac
     1621 aagggggcag ctctcgaaag gtggcccagg gaagtagatc cagtctggct acccggagta
     1681 catcagacat tcgcagtgtc cccagccagc cccaagagag caccaacatt ggcctctatg
     1741 agggcgactg ggtttggctg aagaaatttc caggagaaca ccacatggcc atccggccgg
     1801 cgaccaagat ggccttctcc aagctgcggg agctccgcca tgagaatgtg gctctctacc
     1861 tgggactctt cctggcgggt acagcagaca gccctgccac ccctggggag ggaatcttgg
     1921 ctgtggtctc cgagcactgt gctcggggct ccctccatga cctcctggcc cagagagaca
     1981 taaagctgga ctggatgttc aagtcttccc tcctgctgga cctcataaag ggaatgagat
     2041 atctccacca tcgtggtgtg gcccacggga ggcttaagtc acggaattgc gtggtggacg
     2101 ggaggttcgt gctcaaggtg acagatcatg gccacgggcg acttctggaa gcgcagaggg
     2161 ttttacccga acctcccagt gcagaggatc agctatggac agccccagag ctgcttcggg
     2221 acccagctct agagagacgg ggaactctag ctggtgacgt ctttagcctg ggcatcatca
     2281 tgcaggaggt cgtgtgccgc agcacacctt atgccatgct ggagctaacg cccgaggaag
     2341 tgatacagag ggtgcggagc cctcccccac tgtgccggcc cttggtgtca atggaccagg
     2401 cacctatgga atgcatccag ctgatggctc aatgctgggc agagcatcca gagcttcggc
     2461 cttccatgga cctcaccttt gacctgttca agggcatcaa caagggccgg aagacgaaca
     2521 tcattgactc catgcttcgg atgctggagc agtactctag taacctggag gacttgatcc
     2581 gagaacgcac agaggagtta gagcaggaga agcagaagac agacaggctg ctcacacaga
     2641 tgctccctcc atctgtggct gaggccctga aaatggggac atctgtggag cctgaatact
     2701 ttgaagaggt gacactctat ttcagtgaca ttgtgggctt taccaccatt tcagccatga
     2761 gtgagcccat tgaggtggtc gacctgctta atgacctcta tacactcttt gatgccatca
     2821 tcggttccca cgatgtctat aaggtggaaa caattggaga tgcatacatg gtggcctccg
     2881 ggctgccaca gaggaacggg cagcggcatg ctgcagagat tgccaacatg tcactggaca
     2941 tcctcagtgc agtcggctcc ttccgcatgc gccatatgcc ggaggtacca gtgcgcatcc
     3001 gcattggtct gcactcgggc ccgtgcgtgg ccggtgtggt gggcctcacc atgcctcggt
     3061 actgcctgtt tggggacacg gtcaacactg cctcacgaat ggagtccact ggactgcctt
     3121 atcgcatcca tgtaaacatg agcactgttc ggattcttcg ggctctggac caaggcttcc
     3181 agatggaatg ccgaggccgc acagagctga agggcaaggg tgttgaggac acgtactggc
     3241 ttgtgggcag agtcggcttc aacaagccca ttcccaaacc acctgacctg caaccagggg
     3301 ccagcaacca tggcatcagc ctgcaggaga ttcccccaga gagacgcaag aagctagaga
     3361 aagccaggcc aggccagttt actgggaagt gaagctctac tggggacagg attattctgc
     3421 aaggcccttc ctgaagttgc tgtgatatgg gggactaagg cccaaggctt ctgtccaatt
     3481 ctgcctccaa ggattctgag ccaggagtct gctgcaaacc agctctgtga ccctggaaag
     3541 ttctg
//
