LOCUS       NM_013170               3775 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus guanylate cyclase 2C (Gucy2c), mRNA.
ACCESSION   NM_013170 XM_346727
VERSION     NM_013170.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3775)
  AUTHORS   Akieda-Asai,S., Ida,T., Miyazato,M., Kangawa,K. and Date,Y.
  TITLE     Interleukin-15 derived from Guanylin-GC-C-expressing macrophages
            inhibits fatty acid synthase in adipocytes
  JOURNAL   Peptides 99, 14-19 (2018)
   PUBMED   29097254
  REMARK    GeneRIF: These results support the hypothesis that IL-15 secreted
            from Gn-GC-C-expressing macrophages contributes to the inhibition
            of fatty acid synthase and lipid accumulation in adipocytes,
            leading to obesity resistance
REFERENCE   2  (bases 1 to 3775)
  AUTHORS   Hasegawa,K., Akieda-Asai,S., Fujii,Y., Bae,C.R., Yasuda,M. and
            Date,Y.
  TITLE     Guanylin-Guanylyl cyclase-C signaling in macrophages regulates
            mesenteric fat inflammation induced by high-fat diet
  JOURNAL   Endocr J 62 (10), 939-947 (2015)
   PUBMED   26249840
  REMARK    GeneRIF: Data (including data from studies in transgenic rats)
            suggest guanylin--guanylyl cyclase-C signaling in macrophages in
            mesenteric fat regulates cGMP--PKG--VASP pathway and mesenteric
            panniculitis/obesity via down-regulation of proinflammatory
            factors.
REFERENCE   3  (bases 1 to 3775)
  AUTHORS   Akieda-Asai,S., Sugiyama,M., Miyazawa,T., Koda,S., Okano,I.,
            Senba,K., Poleni,P.E., Hizukuri,Y., Okamoto,A., Yamahara,K.,
            Mutoh,E., Aoyama,F., Sawaguchi,A., Furuya,M., Miyazato,M.,
            Kangawa,K. and Date,Y.
  TITLE     Involvement of guanylin and GC-C in rat mesenteric macrophages in
            resistance to a high-fat diet
  JOURNAL   J Lipid Res 54 (1), 85-96 (2013)
   PUBMED   23081987
  REMARK    GeneRIF: the macrophagic guanylin-GC-C system contributes to the
            altered expression of genes involved in lipid metabolism, leading
            to resistance to obesity
REFERENCE   4  (bases 1 to 3775)
  AUTHORS   Qian,X., Moss,N.G., Fellner,R.C., Taylor-Blake,B. and Goy,M.F.
  TITLE     The rat kidney contains high levels of prouroguanylin (the
            uroguanylin precursor) but does not express GC-C (the enteric
            uroguanylin receptor)
  JOURNAL   Am J Physiol Renal Physiol 300 (2), F561-F573 (2011)
   PUBMED   21106860
  REMARK    GeneRIF: these studies provide a comprehensive description of Ugn
            and GC-C expression in the kidney of the Sprague-Dawley rat.
REFERENCE   5  (bases 1 to 3775)
  AUTHORS   Saha,S., Biswas,K.H., Kondapalli,C., Isloor,N. and
            Visweswariah,S.S.
  TITLE     The linker region in receptor guanylyl cyclases is a key regulatory
            module: mutational analysis of guanylyl cyclase C
  JOURNAL   J Biol Chem 284 (40), 27135-27145 (2009)
   PUBMED   19648115
  REMARK    GeneRIF: the role of the linker region in receptor guanylyl
            cyclases
REFERENCE   6  (bases 1 to 3775)
  AUTHORS   Li,P., Schulz,S., Bombonati,A., Palazzo,J.P., Hyslop,T.M., Xu,Y.,
            Baran,A.A., Siracusa,L.D., Pitari,G.M. and Waldman,S.A.
  TITLE     Guanylyl cyclase C suppresses intestinal tumorigenesis by
            restricting proliferation and maintaining genomic integrity
  JOURNAL   Gastroenterology 133 (2), 599-607 (2007)
   PUBMED   17681179
REFERENCE   7  (bases 1 to 3775)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   8  (bases 1 to 3775)
  AUTHORS   Lorenz,J.N., Nieman,M., Sabo,J., Sanford,L.P., Hawkins,J.A.,
            Elitsur,N., Gawenis,L.R., Clarke,L.L. and Cohen,M.B.
  TITLE     Uroguanylin knockout mice have increased blood pressure and
            impaired natriuretic response to enteral NaCl load
  JOURNAL   J Clin Invest 112 (8), 1244-1254 (2003)
   PUBMED   14561709
REFERENCE   9  (bases 1 to 3775)
  AUTHORS   Schulz,S., Lopez,M.J., Kuhn,M. and Garbers,D.L.
  TITLE     Disruption of the guanylyl cyclase-C gene leads to a paradoxical
            phenotype of viable but heat-stable enterotoxin-resistant mice
  JOURNAL   J Clin Invest 100 (6), 1590-1595 (1997)
   PUBMED   9294128
REFERENCE   10 (bases 1 to 3775)
  AUTHORS   Schulz,S., Green,C.K., Yuen,P.S. and Garbers,D.L.
  TITLE     Guanylyl cyclase is a heat-stable enterotoxin receptor
  JOURNAL   Cell 63 (5), 941-948 (1990)
   PUBMED   1701694
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M55636.1.
            
            On Dec 17, 2003 this sequence version replaced XM_346727.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M55636.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3775
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q43"
     gene            1..3775
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /note="guanylate cyclase 2C"
                     /db_xref="GeneID:25711"
                     /db_xref="RGD:2771"
     exon            1..224
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..3229
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /EC_number="4.6.1.2"
                     /note="heat-stable enterotoxin receptor; GC-C; STA
                     receptor; intestinal guanylate cyclase; guanylyl cyclase
                     C; Guanylate cyclase 2C (heat stable enterotoxin
                     receptor)"
                     /codon_start=1
                     /product="guanylyl cyclase C precursor"
                     /protein_id="NP_037302.1"
                     /db_xref="GeneID:25711"
                     /db_xref="RGD:2771"
                     /translation="MTSLLGLAVRLLLFQPTLMFWASQVRQKCHNGTYEISVLMMDNS
                     AYKEPLQNLRDAVEEGLDIVRKRLREAELNVTVNATFIYSDGLIHKSGDCRSSTCEGL
                     DLLREITRDRKMGCVLMGPSCTYSTFQMYLDTELNYPMISAGSFGLSCDYKETLTRIL
                     PPARKLMYFLVDFWKVNNAPFKTFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYFSEV
                     LSFKDVLRRSEQFQEILMGRNRKSNVIVMCGTPETFYNVKGDLKVADDTVVILVDLFS
                     NHYFEDDTRAPEYMDNVLVLTLPPEKFIANASVSGRFPSERSDFSLAYLEGTLLFGHM
                     LQTFLENGESVTTPKFARAFRNLTFQGLEGPVTLDDSGDIDNIMCLLYVSLDTRKYKV
                     LMAYDTHKNQTIPVATSPNFIWKNHRLPNDVPGLGPQILMIAVFTLTGIVVVLLLIAL
                     LVLRKYRRDHELRQKKWSHIPSENIFPLETNETNHVSLKIDDDRRRDTIQRVRQCKYD
                     KKKVILKDLKHCDGNFSEKQKIELNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERG
                     SLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSR
                     MVVKITDFGCNSILPPKKDLWTAPEHLRQATISQKGDVYSFSIIAQEIILRKETFYTL
                     SCRDQNEKIFRVENSYGTKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKI
                     ESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFM
                     LLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFD
                     QIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFMGTFELEHLPGL
                     PVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAILR
                     RTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPTPPTVENQQRLQTEFSDMIV
                     SALQKRQASGVKSRRPTRVASYKKGFLEYMQLNNSDHDSTYF"
     exon            225..337
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            338..402
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            403..618
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            619..740
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            741..837
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            838..955
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1091
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1177
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1289
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1371
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1477
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1540
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1612
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1717
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1804
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1937
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2075
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2164
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2256
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2415
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2608
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2783
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2882
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2977
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3054
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3775
                     /gene="Gucy2c"
                     /gene_synonym="GCC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgaggtc atgacgtcac tcctgggctt ggctgtgcgg ttactgctct tccaacccac
       61 gctgatgttc tgggcctccc aggtgaggca gaagtgccac aatggcacct acgagatcag
      121 tgtcctgatg atggataact cagcctacaa agaacctttg caaaacttga gggatgctgt
      181 ggaggaagga ctggacatcg tgcgaaagcg cctgcgcgaa gccgaactaa atgtgactgt
      241 gaacgcaacc ttcatctact ccgatggtct gatccataag tcaggtgact gccggagcag
      301 tacctgtgaa ggccttgacc tcctcaggga aattacaaga gatcgtaaga tgggctgtgt
      361 cctcatgggg ccctcgtgca cgtattccac cttccagatg taccttgaca cagagttgaa
      421 ctatcccatg atttccgctg gaagttttgg attgtcctgt gactataagg aaaccctaac
      481 caggatcctg cctccagcca ggaagctgat gtacttcttg gtcgatttct ggaaagtcaa
      541 caatgcacct ttcaaaacct tttcctggaa ctcttcatat gtttacaaga acggatcgga
      601 gcctgaagat tgtttctggt acctcaacgc tctagaggct ggggtgtcct atttttctga
      661 ggtgctcagc ttcaaggatg tattgagacg cagtgaacag ttccaggaaa tcctaatggg
      721 ccgtaacagg aagagcaatg tgattgttat gtgtggcacg ccagaaacct tctacaatgt
      781 gaaaggtgac ctcaaagtgg ctgacgacac tgttgtcatc ctggtagatc tgttcagtaa
      841 ccattacttt gaggatgaca ccagagctcc tgagtatatg gacaatgtcc tcgtcctgac
      901 actgcctcct gaaaagttca tcgcgaacgc ctctgtctct gggaggtttc catcggaaag
      961 aagcgacttt tctctcgctt acttggaggg gaccttgctg tttggacaca tgctgcagac
     1021 gtttcttgaa aatggagaat ctgtcaccac gcccaagttc gctcgtgcgt tcaggaatct
     1081 cacttttcaa ggcttagagg ggcccgtgac tctggatgac agtggggaca ttgacaacat
     1141 tatgtgtctt ctgtatgtgt ctctggatac caggaaatac aaggttctta tggcgtatga
     1201 cacccataaa aaccaaacga tccctgtggc tacgagcccc aacttcatct ggaagaacca
     1261 cagactccct aatgacgttc ctgggctggg ccctcaaatc ctgatgattg ccgtcttcac
     1321 gctcacgggg attgtggtcg ttctgctgct gattgccctc cttgtgctca gaaaatacag
     1381 aagagatcat gaacttcgac agaagaaatg gtcccacatc ccttctgaaa atatctttcc
     1441 tctggagacc aacgagacca accatgtcag cctgaagatt gacgatgaca ggaggcggga
     1501 tacaatccag agagtgcgac agtgcaaata cgacaagaag aaagtgatcc tgaaagacct
     1561 caagcactgt gatggtaact tcagtgagaa gcagaagata gaactgaaca agctactgca
     1621 gtcagactac tacaacctga ccaagttcta cggcaccgtg aagctagaca ccaggatctt
     1681 tggggtggtc gagtactgcg agagggggtc cctccgggaa gtgttaaatg acacgatttc
     1741 ctaccctgat ggcacgttca tggattggga gtttaagatc tctgtcttaa atgacattgc
     1801 taaggggatg tcctatctgc actccagtaa gattgaagtc cacgggcgtc tgaagtccac
     1861 caactgcgtg gtggacagtc gcatggtggt gaagatcact gattttgggt gcaattccat
     1921 cctgcctcca aagaaagacc tgtggactgc ccccgagcac ctgcgccaag ctactatctc
     1981 tcagaaagga gacgtgtaca gcttcagcat cattgcccag gagatcatcc tccgcaagga
     2041 aactttctac acgctgagct gccgggatca gaatgagaag attttcagag tggaaaattc
     2101 ctatgggacg aaacccttcc gcccagatct cttcctggaa accgcagatg agaaggagct
     2161 ggaggtctat ctattggtca aaagctgttg ggaggaggat ccagaaaaga gaccagattt
     2221 caagaaaatc gagagcacac tagccaagat atttggcctt tttcatgacc aaaaaaatga
     2281 atcttacatg gacaccttga tccgacgtct acagctgtat tctcggaacc tggagcacct
     2341 ggtggaggaa aggactcagc tgtacaaggc cgagagggac agggctgacc accttaactt
     2401 tatgctgctc ccacggctgg tggtaaagtc cctgaaggag aaaggcatcg tggagccaga
     2461 gctgtacgaa gaagtcacaa tctatttcag tgacattgtc ggtttcacga ccatctgcaa
     2521 gtacagcacg cccatggagg tggtggacat gctgaatgac atctacaaga gttttgacca
     2581 gattgtggat caccacgacg tctacaaggt agaaaccatc ggcgatgcct acgtggtggc
     2641 cagcggcctg cctatgagaa acggcaaccg gcatgcagtg gacatttcca agatggcctt
     2701 ggacatcctc agcttcatgg ggacctttga gctggagcat ctccccggcc tccccgtgtg
     2761 gattcgcatt ggggttcatt ctggcccctg tgctgctggt gtggtgggga tcaagatgcc
     2821 tcgttattgc ctgtttggag acactgtcaa cactgcctcc aggatggagt ccaccggcct
     2881 tcccttaagg attcacatga gcagctccac cattgccatc ctgaggagaa cggattgcca
     2941 gttcctgtac gaagtgaggg gagaaacgta cttaaaggga agagggaccg agaccacata
     3001 ctggctgact gggatgaagg accaagagta caacctgcca accccaccaa cagtggagaa
     3061 ccaacagcgt ctgcaaactg agttctcaga catgatcgtt agtgccttac agaaaagaca
     3121 ggcctcgggc gtgaagagcc ggaggcccac tcgggtggcc agctacaaga aaggcttttt
     3181 ggaatacatg cagctgaaca actcagacca cgatagcacc tatttttaga ccacgtgcgg
     3241 tctaagaact gacagtagca acctctgata tcctgaatct gcattttccc agaaacctca
     3301 acaacacaga caagtgctta gccccagtgc cctgtctgga atgtagaacc agcccccaag
     3361 tcatgtgggt gttctgggtt gggttgggtt gggtttggtt ggttggtttt gtttctattg
     3421 agacagagtc tcatgtatcc caaactggcc tcaaactcgc tgaggagcta tggatgacct
     3481 tggacttcta agaccatcca tgtgtgttcc tggctgtgtg atgccctgtc cagagtcgtg
     3541 tcccacagtt ctccacggag catcaacgtc agcctgaagg gaggaaggag gaacgtacta
     3601 tacagaactt ggggtttcat tctaatttca tttctgcttt ttttcatttt gtttactgga
     3661 tccttcctta tgtacacatg aattttttta attgtctgga ttaagtagct tatctccaag
     3721 aaagtgtgtt taactagtga tttttgcaga aaccatgctg gatattaggt aaaaa
//
