LOCUS       NM_012769               3217 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus guanylate cyclase 1 soluble subunit beta 1
            (Gucy1b1), mRNA.
ACCESSION   NM_012769
VERSION     NM_012769.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3217)
  AUTHORS   Galley,J.C., Miller,M.P., Sanker,S., Liu,M., Sharina,I., Martin,E.,
            Gomez,D. and Straub,A.C.
  TITLE     FoxO4 controls sGCbeta transcription in vascular smooth muscle
  JOURNAL   Am J Physiol Heart Circ Physiol 322 (3), H417-H426 (2022)
   PUBMED   35089807
  REMARK    GeneRIF: FoxO4 controls sGCbeta transcription in vascular smooth
            muscle.
REFERENCE   2  (bases 1 to 3217)
  AUTHORS   Wang,X., Du,W., Li,M., Zhang,Y., Li,H., Sun,K., Liu,J., Dong,P.,
            Meng,X., Yi,W., Yang,L., Zhao,R. and Hu,J.
  TITLE     The beta subunit of soluble guanylyl cyclase GUCY1B3 exerts
            cardioprotective effects against ischemic injury via the
            PKCepsilon/Akt pathway
  JOURNAL   J Cell Biochem 120 (3), 3071-3081 (2019)
   PUBMED   30485489
  REMARK    GeneRIF: GUCY1B3 was upregulated in neonatal rat ventricular
            myocytes in response to ischemia and reperfusion (IR) injury, and
            restored IR-induced cell death and apoptosis. Other results suggest
            that GUCY1B3 has an antiapoptotic effect and this effect is
            mediated by the activation of PKCepsilon and Akt.
REFERENCE   3  (bases 1 to 3217)
  AUTHORS   Sagi,Y., Heiman,M., Peterson,J.D., Musatov,S., Scarduzio,M.,
            Logan,S.M., Kaplitt,M.G., Surmeier,D.J., Heintz,N. and Greengard,P.
  TITLE     Nitric oxide regulates synaptic transmission between spiny
            projection neurons
  JOURNAL   Proc Natl Acad Sci U S A 111 (49), 17636-17641 (2014)
   PUBMED   25413364
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1811. doi:
            10.1073/pnas.1504794112.. PMID: 25787251]
REFERENCE   4  (bases 1 to 3217)
  AUTHORS   Allerston,C.K., von Delft,F. and Gileadi,O.
  TITLE     Crystal structures of the catalytic domain of human soluble
            guanylate cyclase
  JOURNAL   PLoS One 8 (3), e57644 (2013)
   PUBMED   23505436
REFERENCE   5  (bases 1 to 3217)
  AUTHORS   Peregud,D.I., Yakovlev,A.A., Stepanichev,M.Y., Onufriev,M.V.,
            Panchenko,L.F. and Gulyaeva,N.V.
  TITLE     Content of mRNA for NMDA glutamate receptor subunits in the frontal
            cortex and striatum of rats after morphine withdrawal is related to
            the degree of abstinence
  JOURNAL   Bull Exp Biol Med 153 (6), 835-838 (2012)
   PUBMED   23113297
REFERENCE   6  (bases 1 to 3217)
  AUTHORS   Russwurm,M., Wittau,N. and Koesling,D.
  TITLE     Guanylyl cyclase/PSD-95 interaction: targeting of the nitric
            oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes
  JOURNAL   J Biol Chem 276 (48), 44647-44652 (2001)
   PUBMED   11572861
REFERENCE   7  (bases 1 to 3217)
  AUTHORS   Koike,G., Chiche,J.D., Shiozawa,M., Simon,J.S., Szpirer,J.,
            Jacob,H.J., Szpirer,C. and Bloch,K.D.
  TITLE     Localization of rat genes in the nitric oxide signaling pathway:
            candidates for the pathogenesis of complex diseases
  JOURNAL   Mamm Genome 10 (1), 71-73 (1999)
   PUBMED   9892738
REFERENCE   8  (bases 1 to 3217)
  AUTHORS   Guala,A., Mittino,D., Ghini,T. and Quazza,G.
  TITLE     [Are metoclopramide dystonias familial?]
  JOURNAL   Pediatr Med Chir 14 (6), 617-618 (1992)
   PUBMED   1298936
REFERENCE   9  (bases 1 to 3217)
  AUTHORS   Nakane,M., Saheki,S., Kuno,T., Ishii,K. and Murad,F.
  TITLE     Molecular cloning of a cDNA coding for 70 kilodalton subunit of
            soluble guanylate cyclase from rat lung
  JOURNAL   Biochem Biophys Res Commun 157 (3), 1139-1147 (1988)
   PUBMED   2905128
REFERENCE   10 (bases 1 to 3217)
  AUTHORS   Arnold,W.P., Mittal,C.K., Katsuki,S. and Murad,F.
  TITLE     Nitric oxide activates guanylate cyclase and increases guanosine
            3':5'-cyclic monophosphate levels in various tissue preparations
  JOURNAL   Proc Natl Acad Sci U S A 74 (8), 3203-3207 (1977)
   PUBMED   20623
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081840.1.
            
            On Sep 16, 2004 this sequence version replaced NM_012769.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081840.1, M22562.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3217
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3217
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /note="guanylate cyclase 1 soluble subunit beta 1"
                     /db_xref="GeneID:25202"
                     /db_xref="RGD:2769"
     exon            1..91
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1948
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /EC_number="4.6.1.2"
                     /note="guanylate cyclase 1, soluble, beta 3; soluble
                     guanylyl cyclase beta 1 subunit; GCS-beta-1; soluble
                     guanylate cyclase small subunit; GCS-beta-3; guanylate
                     cyclase soluble subunit beta-3; guanylate cyclase 1
                     soluble subunit beta 3; guanylate cyclase, soluble, beta
                     1"
                     /codon_start=1
                     /product="guanylate cyclase soluble subunit beta-1"
                     /protein_id="NP_036901.2"
                     /db_xref="GeneID:25202"
                     /db_xref="RGD:2769"
                     /translation="MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYD
                     DSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLD
                     ALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGT
                     EIDMKVIQQRSEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQDSRISPYTFCKAFP
                     FHIIFDRDLVVTQCGNAIYRVLPQLQPGKCSLLSVFSLVRPHIDISFHGILSHINTVF
                     VLRSKEGLLDVEKLECEDELTGAEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLT
                     RRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDT
                     LLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLL
                     NDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAG
                     QVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSE
                     YTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETNQDEN"
     exon            92..165
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            166..266
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            267..385
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            386..583
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            584..814
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            815..931
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1065
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1263
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1501
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1642
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1797
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1924
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..3190
                     /gene="Gucy1b1"
                     /gene_synonym="Gucy1b3; SGC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcgctgtcg ccgctgtagt cgctgtctgg gtcccttccg cggtactctt gcctggaggc
       61 tgcctcccag gctccgggag cggacaccat gtacggtttt gtgaaccatg ccctggagct
      121 gctggtgatc cgcaattacg gtcccgaggt gtgggaagac atcaaaaaag aggcgcagct
      181 ggatgaagaa ggccagtttc ttgtgagaat aatctacgat gattccaaaa cctatgactt
      241 ggtggctgct gcgagcaaag tcctcaacct caatgctggt gaaatcctgc agatgtttgg
      301 gaagatgttt ttcgtcttct gtcaagagtc tggctatgat accatcttgc gtgtcctggg
      361 atctaatgtc agggagtttt tgcagaacct cgacgccctg cacgaccacc tcgccaccat
      421 ctacccaggg atgcgcgcac cttccttccg gtgcaccgat gcagaaaaag gcaaagggct
      481 cattctgcac tactactcgg aaagagaggg gcttcaggac attgtgatcg ggattatcaa
      541 gactgtagct caacagatcc atggcactga gatagacatg aaggttattc agcaaagaag
      601 tgaagaatgt gatcataccc aatttttaat tgaagaaaaa gaatcaaaag aagaggattt
      661 ttatgaagat ctggacaggt ttgaagagaa cggtacccag gactcccgta tcagcccgta
      721 caccttctgc aaagcgtttc cttttcacat catatttgac cgggacctag tagtcacgca
      781 gtgtggaaat gctatctaca gagtgctccc ccagctccag cctgggaagt gcagccttct
      841 gtctgtcttc tctctggtcc gccctcatat tgacatcagt ttccacggga ttctttcaca
      901 catcaatacc gtctttgtac tgagaagcaa ggaagggttg ctggatgttg agaaacttga
      961 atgtgaggat gaactgactg gggcagagat tagctgcctc cgtctcaaag gccaaatgat
     1021 ctatttaccg gaagcagata gcatcctctt cctctgttca ccaagtgtga tgaacttgga
     1081 tgacctaaca agaagaggcc tgtacctgag tgacatccct ctccatgatg ctacacgaga
     1141 cctggtcctt ttgggagaac agttccggga ggagtacaaa ctgacacaag agctggaaat
     1201 cctcacagac aggctgcagc tcacactgag ggctttggag gatgagaaga aaaagacaga
     1261 cacattgcta tattctgttc tccctccatc tgttgccaat gagctgagac acaagcgtcc
     1321 agtgccggcc aaaagatacg acaatgtgac catcctcttc agtggcattg tgggcttcaa
     1381 cgctttctgt agcaagcatg catctggaga aggggccatg aagattgtca atctactcaa
     1441 cgacctctac accagattcg acacactgac tgattcacgg aaaaacccat ttgtttacaa
     1501 ggtggaaaca gttggtgaca agtatatgac agtgagtggt ttgccagaac cttgtatcca
     1561 ccatgcacgg tccatttgcc acctggcttt agacatgatg gaaattgctg gtcaagttca
     1621 agtagatggc gaatctgttc agataaccat cgggatccac actggggagg tggtgacagg
     1681 tgtgattgga cagcggatgc cacggtattg tctcttcgga aatactgtca acctcacaag
     1741 caggacagaa accacaggag aaaaggggaa gataaacgtt tccgaatata catacaggtg
     1801 tctcatgtcc ccagaaaact cggatccaca gttccacttg gagcacagag gtcctgtgtc
     1861 catgaagggc aagaaggagc caatgcaagt ctggtttcta tccaggaaaa acacaggcac
     1921 agaggaaaca aaccaggatg aaaactgaat ggcagccttt gtggggcaaa aagaactgtc
     1981 agctgggctc tggtgacagc ctaatgtgcg tcaagccagg agcacgcctt ccctgtggat
     2041 aacaatttct acttcctgtt ttagtgaccc aagtctttct cctagataca cagatctcac
     2101 agtacggttt atttggtgtt agccctgcct tttgattact tttaaagtct cagtatatct
     2161 tctaaggttt ggtttttgag gtgaatgatt tgagcttcat gtttcttaaa ttctgctaca
     2221 agcgttaccg agactgacaa tctaaaagcg gtaggcaccc tctagtttaa gtttgttaaa
     2281 tctgatgaaa tgagacttaa tagtgtctgg ccatgcgtat atatgccatg gcttggtaga
     2341 tttgttttat gctctgtgta tatgtgtatg tatgtatgtg tatatttaaa tgactataac
     2401 ataaaacaaa gtttatatca tgttggtgca tgtcctgcta gaaaccattt tataaacaag
     2461 tgaatctaag ttttagaaaa aaaggcaatt tatttctaga cttctgaagt aagaactaat
     2521 atgctgtatt aggaaaaaag agtgactatt ttgaagtacg tcagttccct tctggaactc
     2581 taggatacat atttctgtta ttacattggt tgctcattca aatttcatgc cctattacag
     2641 cttctctaac atccatgttg ccctaatttg tactgaagcc cttgatattg agtgttcttg
     2701 accattgtgg ttgtgatggg gactgaattg cttcacactg aatgtttacg tttgcttacg
     2761 caagtgttag tggttaaaat atgtccaaga gcaaggccag gaatacatag ctaggacatt
     2821 gctattagag cccgcttggc ctaactccag gcttgagttt ctttattagc tcagaagaat
     2881 gtcaacttac ccaaggtatc atattcagaa tattcataaa gccattttaa ttctgaatgg
     2941 actgccttcc tgctggaata tttggcctat cattctttaa atgtctccga taagttattg
     3001 atatctatct ttataaaata gaatgaaact gcttttctgt aaaaatgttt gtctttcatt
     3061 tagtatttca tatcagcaca tcattgtatg tataaatgtt acatgttaat tgtggaaaag
     3121 aatctacaat aaattatttt taccacttgt ctacagtgca ctttaattta ataaagtgaa
     3181 attgacacca aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
