LOCUS       NM_017090               2666 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus guanylate cyclase 1 soluble subunit alpha 1
            (Gucy1a1), mRNA.
ACCESSION   NM_017090 XM_346628
VERSION     NM_017090.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2666)
  AUTHORS   Galley,J.C., Miller,M.P., Sanker,S., Liu,M., Sharina,I., Martin,E.,
            Gomez,D. and Straub,A.C.
  TITLE     FoxO4 controls sGCbeta transcription in vascular smooth muscle
  JOURNAL   Am J Physiol Heart Circ Physiol 322 (3), H417-H426 (2022)
   PUBMED   35089807
  REMARK    GeneRIF: FoxO4 controls sGCbeta transcription in vascular smooth
            muscle.
REFERENCE   2  (bases 1 to 2666)
  AUTHORS   Dai,Y., Sweeny,E.A., Schlanger,S., Ghosh,A. and Stuehr,D.J.
  TITLE     GAPDH delivers heme to soluble guanylyl cyclase
  JOURNAL   J Biol Chem 295 (24), 8145-8154 (2020)
   PUBMED   32358060
  REMARK    GeneRIF: GAPDH delivers heme to soluble guanylyl cyclase.
REFERENCE   3  (bases 1 to 2666)
  AUTHORS   Du,L. and Roberts,J.D. Jr.
  TITLE     Transforming growth factor-beta downregulates sGC subunit
            expression in pulmonary artery smooth muscle cells via MEK and ERK
            signaling
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 316 (1), L20-L34 (2019)
   PUBMED   30260287
  REMARK    GeneRIF: These studies identify MEK/ERK signaling as an important
            pathway by which TGFbeta regulates sGC expression in pulmonary
            artery smooth muscle cell.
REFERENCE   4  (bases 1 to 2666)
  AUTHORS   Wang,Q., Mergia,E., Koesling,D. and Mittmann,T.
  TITLE     Nitric oxide/cGMP signaling via guanylyl cyclase isoform 1
            modulates glutamate and GABA release in somatosensory cortex of
            mice
  JOURNAL   Neuroscience 360, 180-189 (2017)
   PUBMED   28782641
REFERENCE   5  (bases 1 to 2666)
  AUTHORS   Sanguesa,G., Shaligram,S., Akther,F., Roglans,N., Laguna,J.C.,
            Rahimian,R. and Alegret,M.
  TITLE     Type of supplemented simple sugar, not merely calorie intake,
            determines adverse effects on metabolism and aortic function in
            female rats
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (2), H289-H304 (2017)
   PUBMED   27923787
REFERENCE   6  (bases 1 to 2666)
  AUTHORS   Baltrons,M.A., Pedraza,C.E., Heneka,M.T. and Garcia,A.
  TITLE     Beta-amyloid peptides decrease soluble guanylyl cyclase expression
            in astroglial cells
  JOURNAL   Neurobiol Dis 10 (2), 139-149 (2002)
   PUBMED   12127152
  REMARK    GeneRIF: treatment of rat brain astrocytes with betaA decreases
            their capacity to accumulate cyclic GMP (cGMP) in response to NO as
            a result of a decreased expression of soluble guanylyl cyclase
            alpha-1 and beta-1 subunits at the protein and mRNA levels.
REFERENCE   7  (bases 1 to 2666)
  AUTHORS   Tao,Y.X. and Johns,R.A.
  TITLE     Activation and up-regulation of spinal cord nitric oxide receptor,
            soluble guanylate cyclase, after formalin injection into the rat
            hind paw
  JOURNAL   Neuroscience 112 (2), 439-446 (2002)
   PUBMED   12044461
  REMARK    GeneRIF: peripheral inflammation activates and later up-regulates
            soluble guanylate cyclase expression in the spinal cord
REFERENCE   8  (bases 1 to 2666)
  AUTHORS   Azam,M., Gupta,G., Chen,W., Wellington,S., Warburton,D. and
            Danziger,R.S.
  TITLE     Genetic mapping of soluble guanylyl cyclase genes: implications for
            linkage to blood pressure in the Dahl rat
  JOURNAL   Hypertension 32 (1), 149-154 (1998)
   PUBMED   9674652
REFERENCE   9  (bases 1 to 2666)
  AUTHORS   Smigrodzki,R. and Levitt,P.
  TITLE     The alpha 1 subunit of soluble guanylyl cyclase is expressed
            prenatally in the rat brain
  JOURNAL   Brain Res Dev Brain Res 97 (2), 226-234 (1996)
   PUBMED   8997507
REFERENCE   10 (bases 1 to 2666)
  AUTHORS   Nakane,M., Arai,K., Saheki,S., Kuno,T., Buechler,W. and Murad,F.
  TITLE     Molecular cloning and expression of cDNAs coding for soluble
            guanylate cyclase from rat lung
  JOURNAL   J Biol Chem 265 (28), 16841-16845 (1990)
   PUBMED   1698769
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085746.1.
            
            On Jun 10, 2007 this sequence version replaced NM_017090.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085746.1, U60835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN16676788
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2666
                     /gene="Gucy1a1"
                     /gene_synonym="Gucy1a3; SGC"
                     /note="guanylate cyclase 1 soluble subunit alpha 1"
                     /db_xref="GeneID:497757"
                     /db_xref="RGD:68436"
     exon            1..33
                     /gene="Gucy1a1"
                     /gene_synonym="Gucy1a3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            34..389
                     /gene="Gucy1a1"
                     /gene_synonym="Gucy1a3; SGC"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..2210
                     /gene="Gucy1a1"
                     /gene_synonym="Gucy1a3; SGC"
                     /EC_number="4.6.1.2"
                     /note="guanylate cyclase soluble subunit alpha-3;
                     guanylate cyclase 1 soluble subunit alpha 3; Guanylate
                     cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase);
                     GCS-alpha-1; GCS-alpha-3; guanylate cyclase 1, soluble,
                     alpha 3; soluble guanylate cyclase large subunit"
                     /codon_start=1
                     /product="guanylate cyclase soluble subunit alpha-1"
                     /protein_id="NP_058786.2"
                     /db_xref="GeneID:497757"
                     /db_xref="RGD:68436"
                     /translation="MFCRKFKDLKITGECPFSLLAPGQVPTEPIEEVAGVSESCQATL
                     PTCQEFAENAEGSHPQRKTSRNRVYLHTLAESIGKLIFPEFERLNLALQRTLAKHKIK
                     ENRNSSEKEDLERIIAEEAIAAGVPVEALKDSLGEELFKICYEEDEHILGVVGGTLKD
                     FLNSFSTLLKQSSHCQEAERRGRLEDASILCLDKDQDFLNVYYFFPKRTTALLLPGII
                     KAAARILYESHVEVSLMPPCFRSECTEFVNQPYLLYSVHVKSTKPSLSPGKPQSSLVI
                     PTSLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGKPNFEEFFEILTPKINQTF
                     SGIMTMLNMQFVIRVRRWDNLVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDF
                     TGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEHAHQALEEEKKKTV
                     DLLCSIFPSEVAQQLWQGQIVQAKKFNEVTMLFSDIVGFTAICSQCSPLQVITMLNAL
                     YTRFDQQCGELDVYKVETIGDAYCVAGGLHRESDTHAVQIALMALKMMELSNEVMSPH
                     GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRL
                     LKDCPGFVFTPRSREELPPNFPSDIPGICHFLDAYQHQGPNSKPWFQQKDAEDGNANF
                     LGKASGVD"
     exon            390..451
                     /gene="Gucy1a1"
                     /gene_synonym="Gucy1a3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            452..510
                     /gene="Gucy1a1"
                     /gene_synonym="Gucy1a3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            511..1220
                     /gene="Gucy1a1"
                     /gene_synonym="Gucy1a3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1706
                     /gene="Gucy1a1"
                     /gene_synonym="Gucy1a3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1850
                     /gene="Gucy1a1"
                     /gene_synonym="Gucy1a3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..2005
                     /gene="Gucy1a1"
                     /gene_synonym="Gucy1a3; SGC"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2639
                     /gene="Gucy1a1"
                     /gene_synonym="Gucy1a3; SGC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggatgcccc tggcctcccg tgaccgcatc atgatgctgg gccactcgtg tctttgagtc
       61 agtagaagca gatcttcatc agtccacatc aacaccggct aataaggagg aaaccactgc
      121 caagctccag gaacaccatg ttctgcagga agttcaaaga tctcaagatc acgggggagt
      181 gtcctttctc cttactggct cctggtcagg ttcctacgga gccaatagag gaggtggccg
      241 gagtctctga gagctgccag gccactctgc ccacctgcca ggagtttgct gagaatgcag
      301 aagggagtca cccccaaaga aagacaagcc gcaacagagt ctacctacac accctggcag
      361 agagtattgg caagctcatt ttcccagagt ttgagagact gaaccttgca cttcagagaa
      421 cattggcaaa gcacaaaata aaggaaaaca ggaattcttc agaaaaagaa gaccttgaaa
      481 gaataattgc agaagaagca attgcggcag gtgtcccagt ggaggcgctc aaagactctc
      541 tgggtgagga actgttcaag atctgttatg aggaagatga gcacatcctg ggcgtggttg
      601 gcggcaccct gaaggacttt ctcaacagct tcagcacgct cctgaagcag agcagccact
      661 gccaggaggc ggagaggcgg gggcgactgg aagatgcctc catcttgtgc ctggacaagg
      721 accaggactt tctaaatgtt tactacttct tcccgaagag aaccacagcc ctgcttctcc
      781 ccggtatcat taaagcggct gctcgcatac tgtacgaaag ccacgtggag gtgtccctga
      841 tgcctccctg cttccgaagt gagtgtaccg aattcgtgaa ccagccctat ttgctctact
      901 cggtccacgt gaagagcacc aagccttctc tgtccccagg caaaccccag tcctcgctag
      961 tgatccctac ttcgctcttc tgcaaaactt tcccattcca cttcatgctg gaccgtgacc
     1021 tggccattct gcagctgggt aatggcatca gaaggctggt gaacaagagg gacttccaag
     1081 ggaagcccaa ctttgaagag ttctttgaaa ttctaactcc caaaatcaac cagacattta
     1141 gcggcatcat gacaatgttg aatatgcagt ttgtcatacg ggtgaggaga tgggataact
     1201 tagtgaagaa atcttcaagg gttatggacc tcaaaggtca aatgatctac atcgttgaat
     1261 ccagtgccat cttgttctta gggtcgccgt gtgtggacag attggaagat ttcacaggac
     1321 ggggtctcta tctgtctgac atcccgattc ataatgccct gagggatgtt gtcttgatag
     1381 gggaacaggc acgggctcaa gatggcctca agaagaggtt gggaaagctg aaggcaacct
     1441 tggagcatgc ccaccaagcc ctggaggagg agaagaagaa gacggtagat ctcctgtgtt
     1501 ctatctttcc ctctgaggtt gctcagcagc tctggcaagg acaaattgtg caagccaaga
     1561 agttcaatga ggtcaccatg ctcttctcag atatcgtagg gttcactgcc atctgctctc
     1621 agtgttcacc tctgcaggtc atcaccatgc tcaacgctct ctatactcgc tttgaccaac
     1681 agtgtggaga gctggatgtc tacaaggtgg agaccatcgg agatgcatat tgtgtggcag
     1741 ggggattgca cagagagagt gacacacatg ctgtccagat agcactgatg gccctgaaga
     1801 tgatggagct ctccaatgag gtcatgtctc cccacggaga acctatcaag atgcgaatcg
     1861 gactgcattc tgggtcagtg tttgctggag ttgttggagt gaagatgccc cgatattgcc
     1921 tgtttggaaa caatgtcact ctggctaaca aatttgagtc ctgcagtgtg cctcggaaaa
     1981 tcaatgtcag ccccacgaca tacaggttac tcaaagactg tcctggcttt gtgttcaccc
     2041 cgagatcgag ggaggagctt ccaccaaact tccctagtga cattcctgga atctgtcact
     2101 ttctggatgc ttatcaacat caaggaccta attctaaacc atggttccag cagaaagatg
     2161 cagaagatgg aaacgctaac ttcttaggca aagcatcagg ggtagattag tgagccgcat
     2221 gtttctgtgt ttgatgcctt tgagggtgcg cagaatctct gaaatgactt taggattgca
     2281 gaagataaaa aactgtgtta aaattgcagg ggtgaaaccc agtttcctct gtttcccatt
     2341 taagatggaa aaaaaaaagt gttcaatgct tcagcgcttt caaccttctt ctctatttaa
     2401 gaaacaaacc tcaaaagtga cttgtgactt ttggggacat agctttgttc tagagcagtc
     2461 actacctgca ctcgaaatcc aacacagtgt acatattcca gacaattgta gtcaagttta
     2521 agtgtcaaag taatgtactc acctgtggcc tgtgaccagt gcaaactgtg gttattacag
     2581 tgtgtctgtg gtagtgttgc ctgtaaatct ctgaatagaa atgacagtgt ttaattctga
     2641 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
