LOCUS       NM_013118                567 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus guanylate cyclase activator 2A (Guca2a), mRNA.
ACCESSION   NM_013118
VERSION     NM_013118.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 567)
  AUTHORS   Akieda-Asai,S., Ida,T., Miyazato,M., Kangawa,K. and Date,Y.
  TITLE     Interleukin-15 derived from Guanylin-GC-C-expressing macrophages
            inhibits fatty acid synthase in adipocytes
  JOURNAL   Peptides 99, 14-19 (2018)
   PUBMED   29097254
  REMARK    GeneRIF: These results support the hypothesis that IL-15 secreted
            from Gn-GC-C-expressing macrophages contributes to the inhibition
            of fatty acid synthase and lipid accumulation in adipocytes,
            leading to obesity resistance
REFERENCE   2  (bases 1 to 567)
  AUTHORS   Brenna,O., Furnes,M.W., Munkvold,B., Kidd,M., Sandvik,A.K. and
            Gustafsson,B.I.
  TITLE     Cellular localization of guanylin and uroguanylin mRNAs in human
            and rat duodenal and colonic mucosa
  JOURNAL   Cell Tissue Res 365 (2), 331-341 (2016)
   PUBMED   27044258
  REMARK    GeneRIF: The specific cellular distribution of both GN and UGN
            differs between duodenum and colon and between human and rat
            intestines.
REFERENCE   3  (bases 1 to 567)
  AUTHORS   Hasegawa,K., Akieda-Asai,S., Fujii,Y., Bae,C.R., Yasuda,M. and
            Date,Y.
  TITLE     Guanylin-Guanylyl cyclase-C signaling in macrophages regulates
            mesenteric fat inflammation induced by high-fat diet
  JOURNAL   Endocr J 62 (10), 939-947 (2015)
   PUBMED   26249840
  REMARK    GeneRIF: Data (including data from studies in transgenic rats)
            suggest guanylin--guanylyl cyclase-C signaling in macrophages in
            mesenteric fat regulates cGMP--PKG--VASP pathway and mesenteric
            panniculitis/obesity via down-regulation of proinflammatory
            factors.
REFERENCE   4  (bases 1 to 567)
  AUTHORS   Akieda-Asai,S., Sugiyama,M., Miyazawa,T., Koda,S., Okano,I.,
            Senba,K., Poleni,P.E., Hizukuri,Y., Okamoto,A., Yamahara,K.,
            Mutoh,E., Aoyama,F., Sawaguchi,A., Furuya,M., Miyazato,M.,
            Kangawa,K. and Date,Y.
  TITLE     Involvement of guanylin and GC-C in rat mesenteric macrophages in
            resistance to a high-fat diet
  JOURNAL   J Lipid Res 54 (1), 85-96 (2013)
   PUBMED   23081987
  REMARK    GeneRIF: the macrophagic guanylin-GC-C system contributes to the
            altered expression of genes involved in lipid metabolism, leading
            to resistance to obesity
REFERENCE   5  (bases 1 to 567)
  AUTHORS   Schwabe,K. and Cetin,Y.
  TITLE     Guanylin and functional coupling proteins in the hepatobiliary
            system of rat and guinea pig
  JOURNAL   Histochem Cell Biol 137 (5), 589-597 (2012)
   PUBMED   22310983
  REMARK    GeneRIF: guanylin is synthesized as an intrinsic peptide in
            epithelial cells of the hepatobiliary system and released luminally
            into the hepatic and cystic bile to regulate electrolyte secretion
            by a paracrine/luminocrine signaling pathway
REFERENCE   6  (bases 1 to 567)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   7  (bases 1 to 567)
  AUTHORS   Vaccaro,R., Cetin,Y. and Renda,T.G.
  TITLE     Ontogeny of guanylin-immunoreactive cells in rat salivary glands
  JOURNAL   Anat Embryol (Berl) 208 (1), 65-73 (2004)
   PUBMED   14986129
  REMARK    GeneRIF: The early diffuse guanylin immunoreactivity we observed in
            ducts and acinar anlage, before the secretory set is operative,
            suggests guanylin has a role in cell differentiation. (Guanylin)
REFERENCE   8  (bases 1 to 567)
  AUTHORS   Schulz,S., Chrisman,T.D. and Garbers,D.L.
  TITLE     Cloning and expression of guanylin. Its existence in various
            mammalian tissues
  JOURNAL   J Biol Chem 267 (23), 16019-16021 (1992)
   PUBMED   1379587
REFERENCE   9  (bases 1 to 567)
  AUTHORS   Wiegand,R.C., Kato,J. and Currie,M.G.
  TITLE     Rat guanylin cDNA: characterization of the precursor of an
            endogenous activator of intestinal guanylate cyclase
  JOURNAL   Biochem Biophys Res Commun 185 (3), 812-817 (1992)
   PUBMED   1378267
REFERENCE   10 (bases 1 to 567)
  AUTHORS   Currie,M.G., Fok,K.F., Kato,J., Moore,R.J., Hamra,F.K., Duffin,K.L.
            and Smith,C.E.
  TITLE     Guanylin: an endogenous activator of intestinal guanylate cyclase
  JOURNAL   Proc Natl Acad Sci U S A 89 (3), 947-951 (1992)
   PUBMED   1346555
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M95493.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M95493.1, C06754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMN06680435
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..567
                     /gene="Guca2a"
                     /gene_synonym="GUANYL; Guanylin; Guca2"
                     /note="guanylate cyclase activator 2A"
                     /db_xref="GeneID:25656"
                     /db_xref="RGD:2766"
     exon            1..87
                     /gene="Guca2a"
                     /gene_synonym="GUANYL; Guanylin; Guca2"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..360
                     /gene="Guca2a"
                     /gene_synonym="GUANYL; Guanylin; Guca2"
                     /note="guanylate cyclase activator 2 (guanylin); guanylate
                     cyclase activator 2a (guanylin)"
                     /codon_start=1
                     /product="guanylin precursor"
                     /protein_id="NP_037250.1"
                     /db_xref="GeneID:25656"
                     /db_xref="RGD:2766"
                     /translation="MNAWLLSVLCLLGALAVLVEGVTVQDGDLSFPLESVKQLKHLRE
                     VQEPTLMSHKKFALRLPKPVAPELCSQSAFPEALRPLCEKPNAEEILQRLEAIAQDPN
                     TCEICAYAACTGC"
     exon            88..295
                     /gene="Guca2a"
                     /gene_synonym="GUANYL; Guanylin; Guca2"
                     /inference="alignment:Splign:2.1.0"
     exon            296..558
                     /gene="Guca2a"
                     /gene_synonym="GUANYL; Guanylin; Guca2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catactgctg ccatgaatgc ctggttgctg tctgtgctgt gcctcctggg tgccttggct
       61 gtcctggtag aaggggtcac tgtgcaggat ggagaccttt cctttcctct ggagtcagtg
      121 aaacaactta agcacctccg ggaagtacag gagcccacac tgatgagtca caagaagttt
      181 gctctcaggc ttccgaagcc tgtggcacca gagctatgta gccaatctgc atttccagaa
      241 gcactgaggc ccctctgcga gaaacccaac gccgaggaga tcctgcagag gctagaggcc
      301 attgctcagg acccaaacac atgtgaaatc tgtgcctatg ctgcctgcac gggatgctag
      361 agtgacatca cttgccttcc tctcagccca cgtggaagcc ccttctactt tctagaagca
      421 gcaaggctaa caaactcata cccccagctt ctcagcctac cctggacact gtggggagga
      481 ggatgaggag acaactaccc cggggaagcc ttgcctaggg gctatgctaa ccctctgtca
      541 ataaatggag ctactgtaaa aaaaaaa
//
