LOCUS       NM_001108198            1677 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus guanylate cyclase activator 1B (Guca1b), mRNA.
ACCESSION   NM_001108198 XM_001064944 XM_236951
VERSION     NM_001108198.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1677)
  AUTHORS   Daiger SP, Sullivan LS and Bowne SJ.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   2  (bases 1 to 1677)
  AUTHORS   Arshavsky VY and Burns ME.
  TITLE     Photoreceptor signaling: supporting vision across a wide range of
            light intensities
  JOURNAL   J Biol Chem 287 (3), 1620-1626 (2012)
   PUBMED   22074925
  REMARK    Review article
REFERENCE   3  (bases 1 to 1677)
  AUTHORS   McCue HV, Haynes LP and Burgoyne RD.
  TITLE     The diversity of calcium sensor proteins in the regulation of
            neuronal function
  JOURNAL   Cold Spring Harb Perspect Biol 2 (8), a004085 (2010)
   PUBMED   20668007
  REMARK    Review article
REFERENCE   4  (bases 1 to 1677)
  AUTHORS   Wright AF, Chakarova CF, Abd El-Aziz MM and Bhattacharya SS.
  TITLE     Photoreceptor degeneration: genetic and mechanistic dissection of a
            complex trait
  JOURNAL   Nat Rev Genet 11 (4), 273-284 (2010)
   PUBMED   20212494
  REMARK    Review article
REFERENCE   5  (bases 1 to 1677)
  AUTHORS   Codega P, Della Santina L, Gargini C, Bedolla DE, Subkhankulova T,
            Livesey FJ, Cervetto L and Torre V.
  TITLE     Prolonged illumination up-regulates arrestin and two guanylate
            cyclase activating proteins: a novel mechanism for light adaptation
  JOURNAL   J Physiol 587 (Pt 11), 2457-2472 (2009)
   PUBMED   19332500
  REMARK    GeneRIF: Prolonged illumination up-regulates retinal arrestin and
            Guca1a/b: a novel mechanism for light adaptation.
REFERENCE   6  (bases 1 to 1677)
  AUTHORS   Palczewski K, Sokal I and Baehr W.
  TITLE     Guanylate cyclase-activating proteins: structure, function, and
            diversity
  JOURNAL   Biochem Biophys Res Commun 322 (4), 1123-1130 (2004)
   PUBMED   15336959
  REMARK    Review article
REFERENCE   7  (bases 1 to 1677)
  AUTHORS   Makino CL, Dodd RL, Chen J, Burns ME, Roca A, Simon MI and Baylor
            DA.
  TITLE     Recoverin regulates light-dependent phosphodiesterase activity in
            retinal rods
  JOURNAL   J Gen Physiol 123 (6), 729-741 (2004)
   PUBMED   15173221
  REMARK    Erratum:[J Gen Physiol. 2005 Jul;126(1):81]
REFERENCE   8  (bases 1 to 1677)
  AUTHORS   Mendez A, Burns ME, Sokal I, Dizhoor AM, Baehr W, Palczewski K,
            Baylor DA and Chen J.
  TITLE     Role of guanylate cyclase-activating proteins (GCAPs) in setting
            the flash sensitivity of rod photoreceptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9948-9953 (2001)
   PUBMED   11493703
REFERENCE   9  (bases 1 to 1677)
  AUTHORS   Cuenca N, Lopez S, Howes K and Kolb H.
  TITLE     The localization of guanylyl cyclase-activating proteins in the
            mammalian retina
  JOURNAL   Invest Ophthalmol Vis Sci 39 (7), 1243-1250 (1998)
   PUBMED   9620085
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473987.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001064944.1, XM_236951.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680422
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1677
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..1677
                     /gene="Guca1b"
                     /note="guanylate cyclase activator 1B"
                     /db_xref="GeneID:316218"
                     /db_xref="RGD:1308191"
     exon            1..301
                     /gene="Guca1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..700
                     /gene="Guca1b"
                     /codon_start=1
                     /product="guanylyl cyclase-activating protein 2"
                     /protein_id="NP_001101668.1"
                     /db_xref="GeneID:316218"
                     /db_xref="RGD:1308191"
                     /translation="MGQQFSWEEAEASGEMDVAELQEWYKKFVVECPSGTLFMHEFKR
                     FFKVTGNEEATQYVEGMFRAFDKNGDNTIDFLEYVAALNLVLRGTLEHKLKWTFKIYD
                     KDRNGCIDRLELLDIVEAIYKLKKACRAELDLEQQGQLLTPEEVVDRIFLLVDENGDG
                     QLSLTEFIEGARRDKWVMKMLQMDVNPGGWITQQRRRSAMF"
     exon            302..451
                     /gene="Guca1b"
                     /inference="alignment:Splign:2.1.0"
     exon            452..572
                     /gene="Guca1b"
                     /inference="alignment:Splign:2.1.0"
     exon            573..1677
                     /gene="Guca1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaaacgact gctcagagca aggagagagg agcctaaggt cagcagagga cttggacgag
       61 gcaccccgcc tggctccctc gaattctaga agccatggga cagcagttca gctgggagga
      121 ggcggaggct tccggggaga tggatgtggc agagctgcag gagtggtaca agaagtttgt
      181 cgtggagtgt cccagcggga cgctcttcat gcacgagttc aagcgcttct tcaaggtcac
      241 tggtaatgag gaggccaccc agtatgtgga gggcatgttc cgagccttcg acaagaatgg
      301 ggacaacacc attgacttcc tggagtatgt ggcggccctg aacctcgtgc tgaggggtac
      361 cctggaacac aagctcaagt ggaccttcaa gatctacgac aaggaccgca atggctgcat
      421 cgaccgcctg gagctactgg acatcgtgga ggcaatctac aagctgaaga aagcctgccg
      481 agcagagctg gacctggagc agcagggcca gctgctcacg cctgaggagg ttgtggacag
      541 gatcttcctc ctggtggatg agaatggaga cggtcagctg tctctgacgg agttcattga
      601 aggcgcccgt cgggataagt gggtaatgaa gatgcttcag atggatgtca accccggcgg
      661 ctggatcact cagcagaggc ggagaagcgc catgttctga gaacccgggg accctgcagg
      721 ggcccacact cccctccaag acgcctccag ggtcccccag gtttacaacg tagcaggagg
      781 cccccgcttg ttggctcaag cctccctgtt gtggacttcc tgacactccc agtaagggga
      841 agcaaggggc aagcagtggc tgctggggct gaagaagccc agtggggttc agtccattct
      901 tcagcattta ctagcattgt aggagtacgt tactctgctc cacggctgct cctggatgaa
      961 cggggctttg gctaggagat gtggggttcc tactaatctt aaggtgttct cagaggaaat
     1021 ggggcagctg gagggggggt ggagcaaaga ctggtagaac gcagtcggga aagaaagcaa
     1081 ggacagggaa ggatcataac aacccagccc taccttcctg agcactggct ggggaggact
     1141 ctccccagct cctccccagg gtgtcctcac caatgatgat aaaagggaag gctgcctctg
     1201 tgatcttcct cccttggagg cctggtgggc ttacagggga tgtttcagct ctgcttggtg
     1261 ctgctcccca gttccttctc ctcatcccat ctctagcgtg acccggtacc attcccagcc
     1321 atatgcccac gtgtctcctc aaggatggag acttctcttc atctctgagg ggaacctgac
     1381 gtttgagttt caggccagag tttgcctccc aacagtcgtt ggactcccta acctccttcg
     1441 ggtccactag acagtttcca ggttatcatg taaatgtcct taatgcaccc aacatagaag
     1501 ctaccaggga acctctctgc ctttctctgc ccctttccat ctctgcgact ggggaaggca
     1561 cctcacagga taggaagtag aacccatgtg tcacacttaa tgatgctctc tggagcctga
     1621 tgaattactg ctgttatctt gactagacat acacttcata ttaaaataca atacact
//
