LOCUS       NM_001106887             849 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus guanylate cyclase activator 1A (Guca1a), mRNA.
ACCESSION   NM_001106887 XM_001064891 XM_006244428 XM_217341
VERSION     NM_001106887.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 849)
  AUTHORS   Arshavsky,V.Y. and Burns,M.E.
  TITLE     Photoreceptor signaling: supporting vision across a wide range of
            light intensities
  JOURNAL   J Biol Chem 287 (3), 1620-1626 (2012)
   PUBMED   22074925
  REMARK    Review article
REFERENCE   2  (bases 1 to 849)
  AUTHORS   Hagstrom,S.A., Watson,R.F., Pauer,G.J. and Grossman,G.H.
  TITLE     Tulp1 is involved in specific photoreceptor protein transport
            pathways
  JOURNAL   Adv Exp Med Biol 723, 783-789 (2012)
   PUBMED   22183407
REFERENCE   3  (bases 1 to 849)
  AUTHORS   McCue,H.V., Haynes,L.P. and Burgoyne,R.D.
  TITLE     The diversity of calcium sensor proteins in the regulation of
            neuronal function
  JOURNAL   Cold Spring Harb Perspect Biol 2 (8), a004085 (2010)
   PUBMED   20668007
  REMARK    Review article
REFERENCE   4  (bases 1 to 849)
  AUTHORS   Codega,P., Della Santina,L., Gargini,C., Bedolla,D.E.,
            Subkhankulova,T., Livesey,F.J., Cervetto,L. and Torre,V.
  TITLE     Prolonged illumination up-regulates arrestin and two guanylate
            cyclase activating proteins: a novel mechanism for light adaptation
  JOURNAL   J Physiol 587 (Pt 11), 2457-2472 (2009)
   PUBMED   19332500
  REMARK    GeneRIF: Prolonged illumination up-regulates retinal arrestin and
            Guca1a/b: a novel mechanism for light adaptation.
REFERENCE   5  (bases 1 to 849)
  AUTHORS   Palczewski,K., Sokal,I. and Baehr,W.
  TITLE     Guanylate cyclase-activating proteins: structure, function, and
            diversity
  JOURNAL   Biochem Biophys Res Commun 322 (4), 1123-1130 (2004)
   PUBMED   15336959
  REMARK    Review article
REFERENCE   6  (bases 1 to 849)
  AUTHORS   Dejda,A., Matczak,I. and Gorczyca,W.A.
  TITLE     p19 detected in the rat retina and pineal gland is a guanylyl
            cyclase-activating protein (GCAP)
  JOURNAL   Acta Biochim Pol 49 (4), 899-905 (2002)
   PUBMED   12545196
REFERENCE   7  (bases 1 to 849)
  AUTHORS   Mendez,A., Burns,M.E., Sokal,I., Dizhoor,A.M., Baehr,W.,
            Palczewski,K., Baylor,D.A. and Chen,J.
  TITLE     Role of guanylate cyclase-activating proteins (GCAPs) in setting
            the flash sensitivity of rod photoreceptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9948-9953 (2001)
   PUBMED   11493703
REFERENCE   8  (bases 1 to 849)
  AUTHORS   Duda,T., Venkataraman,V., Krishnan,A., Nagele,R.G. and Sharma,R.K.
  TITLE     Negatively calcium-modulated membrane guanylate cyclase signaling
            system in the rat olfactory bulb
  JOURNAL   Biochemistry 40 (15), 4654-4662 (2001)
   PUBMED   11294632
REFERENCE   9  (bases 1 to 849)
  AUTHORS   Cuenca,N., Lopez,S., Howes,K. and Kolb,H.
  TITLE     The localization of guanylyl cyclase-activating proteins in the
            mammalian retina
  JOURNAL   Invest Ophthalmol Vis Sci 39 (7), 1243-1250 (1998)
   PUBMED   9620085
REFERENCE   10 (bases 1 to 849)
  AUTHORS   Payne,A.M., Downes,S.M., Bessant,D.A., Taylor,R., Holder,G.E.,
            Warren,M.J., Bird,A.C. and Bhattacharya,S.S.
  TITLE     A mutation in guanylate cyclase activator 1A (GUCA1A) in an
            autosomal dominant cone dystrophy pedigree mapping to a new locus
            on chromosome 6p21.1
  JOURNAL   Hum Mol Genet 7 (2), 273-277 (1998)
   PUBMED   9425234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Jul 26, 2021 this sequence version replaced
            XM_006244428.4, NM_001106887.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               JAXUCZ010000009.1  21086642-21086980
            340-489             JAXUCZ010000009.1  21094587-21094736
            490-583             JAXUCZ010000009.1  21095576-21095669
            584-849             JAXUCZ010000009.1  21095956-21096221
FEATURES             Location/Qualifiers
     source          1..849
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..849
                     /gene="Guca1a"
                     /note="guanylate cyclase activator 1A"
                     /db_xref="GeneID:301233"
                     /db_xref="RGD:1308712"
     exon            1..339
                     /gene="Guca1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..747
                     /gene="Guca1a"
                     /note="guanylate cyclase activator 1a (retina)"
                     /codon_start=1
                     /product="guanylyl cyclase-activating protein 1"
                     /protein_id="NP_001100357.1"
                     /db_xref="GeneID:301233"
                     /db_xref="RGD:1308712"
                     /translation="MGNVVEGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFG
                     LKNLSPSASQYVEQMFETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLRWYFKLYDVD
                     GNGCIDRDELLTIIRAIRTINPWSDSSMSAEEFTDTVFAKIDINGDGELSLEEFMEGV
                     QKDQMLLDTLTRSLDLTRIVRRLQNGEQEEAGAGDLAAEAAG"
     exon            340..489
                     /gene="Guca1a"
                     /inference="alignment:Splign:2.1.0"
     exon            490..583
                     /gene="Guca1a"
                     /inference="alignment:Splign:2.1.0"
     exon            584..849
                     /gene="Guca1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccgactc acccggctat ctttgcttag gtgggtgaga ggggaggtca agtttctgaa
       61 agccaagcca cccttgtgca ggggacatta ggaaataggg cggtctgtcc atctgtccgt
      121 ctctcgtgag cctggaccat gggcaacgtc gtggagggca agtcggtgga ggagctgagt
      181 agcaccgaat gccatcagtg gtacaagaaa ttcatgacgg agtgcccctc tggccagctc
      241 accctctacg aattccgcca attctttggc ctcaagaacc tgagcccctc agccagccag
      301 tatgtggaac agatgttcga gacctttgac ttcaacaagg atggctatat tgacttcatg
      361 gagtacgtgg ccgccctcag cctggttctc aagggcaagg tggaacagaa gttgcgttgg
      421 tatttcaagc tctacgacgt ggacggcaac gggtgcatag accgggacga gctgctcacc
      481 atcatccggg ccatccgaac cattaatccc tggagcgact catccatgag cgctgaagaa
      541 ttcacagata ccgtgtttgc caagatcgac atcaacgggg atggggaact gtctctggag
      601 gagttcatgg aaggtgtcca gaaggaccag atgctcctgg acacgctgac ccgaagcctg
      661 gacttgaccc gcattgtgcg cagacttcag aacggcgagc aggaggaggc aggcgctggc
      721 gacctggcag cggaggctgc cggttgagcc tcaccctgtg gtctgggtgc tgagggctgg
      781 ccccctgcgg tgcctggtgt agttgttctg ttcttgtctt aacattacat agaacctccc
      841 gaacacaga
//
