LOCUS       NP_001388138             979 aa            linear   ROD 01-APR-2024
DEFINITION  general transcription factor II-I isoform 2 [Rattus norvegicus].
ACCESSION   NP_001388138 XP_017453850
VERSION     NP_001388138.1
DBSOURCE    REFSEQ: accession NM_001401209.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 979)
  AUTHORS   Shirai,Y., Watanabe,M., Sakagami,H. and Suzuki,T.
  TITLE     Novel splice variants in the 5'UTR of Gtf2i expressed in the rat
            brain: alternative 5'UTRs and differential expression in the
            neuronal dendrites
  JOURNAL   J Neurochem 134 (3), 578-589 (2015)
   PUBMED   25913238
  REMARK    GeneRIF: We identified seven novel Gtf2i transcripts with
            alternatively spliced 5'UTRs in the rat brain. In situ
            hybridization demonstrated a differential
REFERENCE   2  (residues 1 to 979)
  AUTHORS   Palmer,S.J., Taylor,K.M., Santucci,N., Widagdo,J., Chan,Y.K.,
            Yeo,J.L., Adams,M., Gunning,P.W. and Hardeman,E.C.
  TITLE     GTF2IRD2 from the Williams-Beuren critical region encodes a
            mobile-element-derived fusion protein that antagonizes the action
            of its related family members
  JOURNAL   J Cell Sci 125 (Pt 21), 5040-5050 (2012)
   PUBMED   22899722
REFERENCE   3  (residues 1 to 979)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (residues 1 to 979)
  AUTHORS   Mammoto,A., Connor,K.M., Mammoto,T., Yung,C.W., Huh,D.,
            Aderman,C.M., Mostoslavsky,G., Smith,L.E. and Ingber,D.E.
  TITLE     A mechanosensitive transcriptional mechanism that controls
            angiogenesis
  JOURNAL   Nature 457 (7233), 1103-1108 (2009)
   PUBMED   19242469
REFERENCE   5  (residues 1 to 979)
  AUTHORS   Enkhmandakh,B., Makeyev,A.V., Erdenechimeg,L., Ruddle,F.H.,
            Chimge,N.O., Tussie-Luna,M.I., Roy,A.L. and Bayarsaihan,D.
  TITLE     Essential functions of the Williams-Beuren syndrome-associated
            TFII-I genes in embryonic development
  JOURNAL   Proc Natl Acad Sci U S A 106 (1), 181-186 (2009)
   PUBMED   19109438
REFERENCE   6  (residues 1 to 979)
  AUTHORS   Hakre,S., Tussie-Luna,M.I., Ashworth,T., Novina,C.D., Settleman,J.,
            Sharp,P.A. and Roy,A.L.
  TITLE     Opposing functions of TFII-I spliced isoforms in growth
            factor-induced gene expression
  JOURNAL   Mol Cell 24 (2), 301-308 (2006)
   PUBMED   17052463
REFERENCE   7  (residues 1 to 979)
  AUTHORS   Caraveo,G., van Rossum,D.B., Patterson,R.L., Snyder,S.H. and
            Desiderio,S.
  TITLE     Action of TFII-I outside the nucleus as an inhibitor of
            agonist-induced calcium entry
  JOURNAL   Science 314 (5796), 122-125 (2006)
   PUBMED   17023658
  REMARK    GeneRIF: observations suggest a model in which TFII-I suppresses
            agonist-induced calcium entry by competing with TRPC3 for binding
            to phospholipase C-gamma
REFERENCE   8  (residues 1 to 979)
  AUTHORS   Danoff,S.K., Taylor,H.E., Blackshaw,S. and Desiderio,S.
  TITLE     TFII-I, a candidate gene for Williams syndrome cognitive profile:
            parallels between regional expression in mouse brain and human
            phenotype
  JOURNAL   Neuroscience 123 (4), 931-938 (2004)
   PUBMED   14751286
REFERENCE   9  (residues 1 to 979)
  AUTHORS   Olofsson,P., Holmberg,J., Tordsson,J., Lu,S., Akerstrom,B. and
            Holmdahl,R.
  TITLE     Positional identification of Ncf1 as a gene that regulates
            arthritis severity in rats
  JOURNAL   Nat Genet 33 (1), 25-32 (2003)
   PUBMED   12461526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Feb 4, 2022 this sequence version replaced XP_017453850.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.44942.1,
                                           SRR26643297.39701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..979
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     Protein         1..979
                     /product="general transcription factor II-I isoform 2"
                     /note="TFII-I; GTFII-I"
                     /calculated_mol_wt=110084
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            19
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          103..197
                     /region_name="GTF2I-like 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            103
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          112..186
                     /region_name="GTF2I"
                     /note="GTF2I-like repeat; pfam02946"
                     /db_xref="CDD:460759"
     Site            130
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q9ESZ8; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          205..231
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            210
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            214
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            228
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            248
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by BTK.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          250..325
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          300..307
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          333..427
                     /region_name="GTF2I-like 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            334
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q9ESZ8; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          342..416
                     /region_name="GTF2I"
                     /note="GTF2I-like repeat; pfam02946"
                     /db_xref="CDD:460759"
     Site            379
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by BTK.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            393
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKG/PRKG1.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            431
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q9ESZ8; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          438..532
                     /region_name="GTF2I-like 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          447..521
                     /region_name="GTF2I"
                     /note="GTF2I-like repeat; pfam02946"
                     /db_xref="CDD:460759"
     Site            484
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by BTK.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            498
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            537
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9ESZ8; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            539
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          543..637
                     /region_name="GTF2I-like 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          552..626
                     /region_name="GTF2I"
                     /note="GTF2I-like repeat; pfam02946"
                     /db_xref="CDD:460759"
     Region          642..695
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            649
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            655
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            696
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q9ESZ8; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            703
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          705..799
                     /region_name="GTF2I-like 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          714..778
                     /region_name="GTF2I"
                     /note="GTF2I-like repeat; pfam02946"
                     /db_xref="CDD:460759"
     Site            765
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKG/PRKG1.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          797..818
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Site            804
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P78347; propagated from
                     UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          840..934
                     /region_name="GTF2I-like 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     Region          849..923
                     /region_name="GTF2I"
                     /note="GTF2I-like repeat; pfam02946"
                     /db_xref="CDD:460759"
     Region          940..979
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2Y1.2)"
     CDS             1..979
                     /gene="Gtf2i"
                     /gene_synonym="Gtf2ird1"
                     /coded_by="NM_001401209.1:364..3303"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:353256"
                     /db_xref="RGD:727961"
ORIGIN      
        1 maqvamsalp aedeessesr mvvtflmsal esmckelaks kaevaciavy etdvfvvgte
       61 rgrafvntrk dfqkdfvkyc veeeekaaem hkmkcttqan rmsvdaveie tlrktvedyf
      121 cfcygkalgk stvvpvpyek mlrdqsavav qglpegvafk hpehydlatl kwilenkagi
      181 sfiikrpfle pkkhlggrvm aadadrpmls pggscgpikv kteptedsgi slemaavtvk
      241 eesedpdyyq yniqgshhss egnegaevev paedstqhvp setsedpeve vtiedddysp
      301 ptkrpkssep pppppvpept nagkrkvref nfekwnarit dlrkqveelf erkyaqaika
      361 kgpvtipypl fqshvedlyv eglpegipfr rpstygiprl erillakeri rfvikkhell
      421 nstredlqld kpasgvkeew yaritklrkm vdqlfckkfa ealgsteaka vpyqkfeayp
      481 ndlyveglpe nipfrspswy giprlekiiq vgnrikfvik rpellthstt evtqprtntp
      541 vkedwnvrit klrkqveeif nlkfaqalgl teavkvpypv fesnpeflyv eglpegipfr
      601 sptwfgiprl erivrgsnki kfvvkkpelv vsylppgmas kintkalqsp krprspgsns
      661 kvpeievtve gpnnnspqts tvrtptqtng snvpfkprgr efsfeawnak itdlkqkven
      721 lfnekcgeal glkqavkvpf alfesfpedf yveglpegvp frrpstfgip rlekilrnka
      781 kikfiikkpe mfetaikest sskspprktn sspsvnttas gvedlniiqv tipdddnerl
      841 skvekarqlr eqvndlfsrk fgeaigmgfp vkvpyrkiti npgcvvvdgm ppgvsfkaps
      901 yleissmrri ldsaefikft virpfpglvi nnqlvdqnes egpviqesae asqlevpate
      961 eiketdgssq ikqepdptw
//
