LOCUS       NM_001126088            1655 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus general transcription factor IIH subunit 5
            (Gtf2h5), mRNA.
ACCESSION   NM_001126088 XM_001067341 XM_577689
VERSION     NM_001126088.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1655)
  AUTHORS   He,Y., Yan,C., Fang,J., Inouye,C., Tjian,R., Ivanov,I. and
            Nogales,E.
  TITLE     Near-atomic resolution visualization of human transcription
            promoter opening
  JOURNAL   Nature 533 (7603), 359-365 (2016)
   PUBMED   27193682
REFERENCE   2  (bases 1 to 1655)
  AUTHORS   Nonnekens,J., Perez-Fernandez,J., Theil,A.F., Gadal,O., Bonnart,C.
            and Giglia-Mari,G.
  TITLE     Mutations in TFIIH causing trichothiodystrophy are responsible for
            defects in ribosomal RNA production and processing
  JOURNAL   Hum Mol Genet 22 (14), 2881-2893 (2013)
   PUBMED   23562818
REFERENCE   3  (bases 1 to 1655)
  AUTHORS   Theil,A.F., Nonnekens,J., Steurer,B., Mari,P.O., de Wit,J.,
            Lemaitre,C., Marteijn,J.A., Raams,A., Maas,A., Vermeij,M.,
            Essers,J., Hoeijmakers,J.H., Giglia-Mari,G. and Vermeulen,W.
  TITLE     Disruption of TTDA results in complete nucleotide excision repair
            deficiency and embryonic lethality
  JOURNAL   PLoS Genet 9 (4), e1003431 (2013)
   PUBMED   23637614
REFERENCE   4  (bases 1 to 1655)
  AUTHORS   Kamileri,I., Karakasilioti,I. and Garinis,G.A.
  TITLE     Nucleotide excision repair: new tricks with old bricks
  JOURNAL   Trends Genet 28 (11), 566-573 (2012)
   PUBMED   22824526
  REMARK    Review article
REFERENCE   5  (bases 1 to 1655)
  AUTHORS   Egly,J.M. and Coin,F.
  TITLE     A history of TFIIH: two decades of molecular biology on a pivotal
            transcription/repair factor
  JOURNAL   DNA Repair (Amst) 10 (7), 714-721 (2011)
   PUBMED   21592869
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474077.2.
            
            On or before Apr 30, 2008 this sequence version replaced
            XM_001067341.1, XM_577689.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: FQ212207.1, FQ081678.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00132268, SAMD00132291 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1655
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1655
                     /gene="Gtf2h5"
                     /gene_synonym="RGD1560991"
                     /note="general transcription factor IIH subunit 5"
                     /db_xref="GeneID:502227"
                     /db_xref="RGD:1560991"
     exon            1..148
                     /gene="Gtf2h5"
                     /gene_synonym="RGD1560991"
                     /inference="alignment:Splign:2.1.0"
     exon            149..221
                     /gene="Gtf2h5"
                     /gene_synonym="RGD1560991"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..402
                     /gene="Gtf2h5"
                     /gene_synonym="RGD1560991"
                     /note="general transcription factor IIH, polypeptide 5"
                     /codon_start=1
                     /product="general transcription factor IIH subunit 5"
                     /protein_id="NP_001119560.1"
                     /db_xref="GeneID:502227"
                     /db_xref="RGD:1560991"
                     /translation="MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVF
                     VIAELVNVLQERVGELMDQNAFSLTQK"
     exon            222..1655
                     /gene="Gtf2h5"
                     /gene_synonym="RGD1560991"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttggggctct gcggcgtcgg aaataaggcg gggaggagca agaaaacagg gatcctccag
       61 tcgtgtggac cgacccgagt cccgcaccct ttttaaggcc tgtgttgcgg atccgcgcgg
      121 ccatcacgca ttgcatcacg gttttactaa ttcttgaagt catccgcact gtctgcctga
      181 ggaaagatgg tcaacgtctt gaaaggagtg cttatagaat gcgatcccgc catgaagcag
      241 tttttgctgt acttggatga gtccaatgcc ttggggaaga agttcatcat tcaagacatt
      301 gatgacacac atgtctttgt cattgcggaa ctggttaatg ttctccagga gcgagtaggg
      361 gaactgatgg accagaatgc cttttctctt acccagaagt gagagctcta gtgttaagca
      421 cttggcaatc ccaaccacag acaggagaga ggcctgctta gtgtctcctg gagtttagac
      481 ttgttacaag catttggtgg gaaaggctgc tgcagggtca ttcactcaga tgtaagctcc
      541 caactgattt tgatggacca ttaaaaaaat ctttgtaaag aagaatttta acaactggct
      601 gcaatttggc ttttactgtt tgttattaaa atataatcat agctgtgctg gtgggatggc
      661 tcagttggta aaggcccttg ccactaagcc agacaccctg accacactac aaggtgagaa
      721 ctctgcaggt tgtcctctga ccctcgtgtg tgtagctccc tcctgcacaa ataagtaaat
      781 gtaataaaat gtaatcataa atgttttccc tgccttttta aaacaccaat taaatacacc
      841 agaaaaatat tggagtttgg ttaagttacc attttaacct gggtatcatt aattttgctt
      901 gttcctaata acaagtgcac atttttagta ccacagagtt agaaaccagt gggacagaga
      961 actctgcttt gcatcttcag ttttcgcctt tcacactaca tcggggacgc tttcctatga
     1021 aggtgggtgt tcctcggtag tgcaaggtac agcagaagta cgtgtacatg tgtgtgtaaa
     1081 actaacagat cggaagataa ctgcaattat ccttagtatt tggagagtag gattggaaga
     1141 cttgcatgtg tgtgaactct tacatcgtct gaaactatta atgtagataa acaaaatagg
     1201 taatataaag gttcaaacaa aaacgcagca agatcagcct caatggggat aaatgttata
     1261 tttttatcca tatgctctga tgcaattaaa ccaagtatta ctctttttat gctgtttggc
     1321 aagctaccta aatatacttt tcagaatgat gaaattaaaa gcatgaaaca aaatacaggg
     1381 gtgggcatgg tggcacacac cgttaatccc agcattcagg agacagaggc aggcaattct
     1441 agaagctagt ctggtctcta tagcaagttc caggatagtc aggaatacat aatgagaccc
     1501 tgtctcaata aacaaaaaca agccatgtga tttcataggt tacattaaaa attcatgtct
     1561 ttaatcccag taatagagaa gccgaggcag acagatctgt gagttcaaga ttgacctggt
     1621 ctacagagtg agttccaaaa cagacaggac tacac
//
