LOCUS       NM_212501               1692 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus general transcription factor 2H subunit 4
            (Gtf2h4), mRNA.
ACCESSION   NM_212501 XM_215299
VERSION     NM_212501.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1692)
  AUTHORS   He,Y., Yan,C., Fang,J., Inouye,C., Tjian,R., Ivanov,I. and
            Nogales,E.
  TITLE     Near-atomic resolution visualization of human transcription
            promoter opening
  JOURNAL   Nature 533 (7603), 359-365 (2016)
   PUBMED   27193682
REFERENCE   2  (bases 1 to 1692)
  AUTHORS   Egly,J.M. and Coin,F.
  TITLE     A history of TFIIH: two decades of molecular biology on a pivotal
            transcription/repair factor
  JOURNAL   DNA Repair (Amst) 10 (7), 714-721 (2011)
   PUBMED   21592869
  REMARK    Review article
REFERENCE   3  (bases 1 to 1692)
  AUTHORS   Kershnar,E., Wu,S.Y. and Chiang,C.M.
  TITLE     Immunoaffinity purification and functional characterization of
            human transcription factor IIH and RNA polymerase II from clonal
            cell lines that conditionally express epitope-tagged subunits of
            the multiprotein complexes
  JOURNAL   J Biol Chem 273 (51), 34444-34453 (1998)
   PUBMED   9852112
REFERENCE   4  (bases 1 to 1692)
  AUTHORS   Marinoni,J.C., Roy,R., Vermeulen,W., Miniou,P., Lutz,Y., Weeda,G.,
            Seroz,T., Gomez,D.M., Hoeijmakers,J.H. and Egly,J.M.
  TITLE     Cloning and characterization of p52, the fifth subunit of the core
            of the transcription/DNA repair factor TFIIH
  JOURNAL   EMBO J 16 (5), 1093-1102 (1997)
   PUBMED   9118947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK472761.1 and BC127469.1.
            
            On Oct 3, 2009 this sequence version replaced NM_212501.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127469.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-443               CK472761.1         1-443
            444-1692            BC127469.1         416-1664
FEATURES             Location/Qualifiers
     source          1..1692
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1692
                     /gene="Gtf2h4"
                     /note="general transcription factor 2H subunit 4"
                     /db_xref="GeneID:294236"
                     /db_xref="RGD:1303309"
     exon            1..168
                     /gene="Gtf2h4"
                     /inference="alignment:Splign:2.1.0"
     exon            169..311
                     /gene="Gtf2h4"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1563
                     /gene="Gtf2h4"
                     /note="TFIIH transcription/DNA repair factor p52 subunit;
                     general transcription factor II H, polypeptide 4"
                     /codon_start=1
                     /product="general transcription factor IIH subunit 4"
                     /protein_id="NP_997666.1"
                     /db_xref="GeneID:294236"
                     /db_xref="RGD:1303309"
                     /translation="MEITPARGGLNRAHLQCRNLQEFLGGLSPGVLDRLYGHPATCLA
                     VFRELPSLAKNWVMRMLFLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLL
                     PGGLQGLILNPVFRQNLRIALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVV
                     LHFMVGSPSAAVSQDLAQLLSQAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFML
                     QYLQTAQSRGMDLVEILSFLFQLSFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRK
                     RKSRRYYPTRLAINLSSGVSGAGGTVHQPGFIVVETNYRLYAYTESELQIALIALFSE
                     MLYRFPNMVVAQVTRESVQQAIASGITAQQIIHFLRTRAHPVMLKQTPVLPPTITDQI
                     RLWELERDRLRFTEGVLYNQFLSQVDFELLLAHARELGVLVFENSAKRLMVVTPAGHS
                     DVKRFWKRQKHSS"
     exon            312..416
                     /gene="Gtf2h4"
                     /inference="alignment:Splign:2.1.0"
     exon            417..548
                     /gene="Gtf2h4"
                     /inference="alignment:Splign:2.1.0"
     exon            549..645
                     /gene="Gtf2h4"
                     /inference="alignment:Splign:2.1.0"
     exon            646..734
                     /gene="Gtf2h4"
                     /inference="alignment:Splign:2.1.0"
     exon            735..846
                     /gene="Gtf2h4"
                     /inference="alignment:Splign:2.1.0"
     exon            847..915
                     /gene="Gtf2h4"
                     /inference="alignment:Splign:2.1.0"
     exon            916..999
                     /gene="Gtf2h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1132
                     /gene="Gtf2h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1263
                     /gene="Gtf2h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1311
                     /gene="Gtf2h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1390
                     /gene="Gtf2h4"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1672
                     /gene="Gtf2h4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttactcttg acactttttc tgcgctccct tctctttggg ctgctttttg gctgggtcct
       61 gtctgtgaag ttctccgcgg ttctcccacg ttttagaatt ttcatctttt atttccagga
      121 gtcaatgcga gacattagct ctgattaggc gacggctggt gacccggggt gatggagatc
      181 acccccgcga ggggtggact gaaccgagca cacctacaat gcaggaatct acaggagttc
      241 ttaggcggcc tgagccctgg ggtgctggac cgattgtatg gacaccctgc cacttgtctg
      301 gctgtcttca gggagctccc ttccttggct aagaactggg tgatgagaat gctctttctg
      361 gagcagcctc taccacaggc tgccgtggcc ctgtgggtga agaaggagtt cagcaaggct
      421 caggaggaaa gtaccgggct gttgagtggc ctccgtattt ggcataccca gctgctcccc
      481 ggtggactcc agggcctcat cttgaaccct gtcttccgcc agaacctccg aattgctctt
      541 ctgggtgggg gcaaggcctg gtctgatgac acaagtcagc tgggaccaga caagcacgcc
      601 cgggatgtcc cctcacttga taagtacgcc gaggagcgct gggaggtggt cttgcatttc
      661 atggtgggct cccccagtgc agctgtcagc caggacctgg ctcaactcct cagccaggcc
      721 gggcttatga aaagcaccga acccggagag ccaccgtgta tcacttccgc tggcttccag
      781 ttcctgctcc tagacacgcc tgcccagctc tggtacttca tgctgcagta tctgcagaca
      841 gcccagagtc ggggcatgga tctagtggag attctctcct tccttttcca gctcagtttc
      901 tctactcttg gcaaggacta ctccgtggag gggatgagtg attctttgtt gaacttcctg
      961 caacacctgc gtgaattcgg gcttgttttc cagaggaaga ggaagtcccg gcgttactac
     1021 cccacacgcc tggccatcaa cctctcatct ggtgtctccg gggctggggg cactgtgcac
     1081 cagcctggct tcattgtcgt cgaaaccaat tacagactgt atgcctatac cgagtcggag
     1141 ctgcagatcg ccctcattgc tcttttctcc gagatgctct atcgattccc caacatggtg
     1201 gtggcacaag tgacccggga gagcgtgcag caggccatcg ccagtggcat cactgcccag
     1261 cagattatcc atttcctaag gaccagggcc catccagtga tgctcaaaca gactcctgtg
     1321 ctgcccccca ccataacaga ccagattcgg ctgtgggagc tggaaaggga cagacttcgg
     1381 ttcactgaag gcgttctgta caaccagttc ctatcgcaag tggactttga attgctgctg
     1441 gcccacgcgc gggagctggg cgtgctcgtg ttcgagaact cggccaagcg gctgatggtg
     1501 gtgacaccgg cggggcacag cgacgtcaag cgcttctgga agcggcagaa gcacagctcc
     1561 tgagccggct gggtccggcc cggggcgggc gagcgggcgg gcagctttcc aactcaggtg
     1621 tattttgttt acacatcggg acatttcttg tttaataaaa ttgtggaaaa aaaaaaaaaa
     1681 aaaaaaaaaa aa
//
